教學大綱
| 教科書 | Glial Physiology and Pathophysiology, edited by Verkhratsky A., Butt A. and published by Wiley-Blackwell in 2013. |
| 教科書ISBN | 0000000000 |
| 參考書 | 1. Introduction to Neuroglia, edited by Verkhratsky A. and Parpura, V. and published by Morgan & Claypool in 2014. 2. 另一個腦 (The other Brain)，原著 Fields, DR; 譯者:楊宗宏，楊凱雯，潘震澤。衛城出版社，2013。 3. Glial Physiology and Pathophysiology, edited by Verkhratsky A., Butt A and published by Wiley-Blackwell in 2013 4. Astrocytes in pathophysiology of the nervous system, edited by Haydon, PG and Parpura, V. and published by Springer in 2009. 5. Recently published research papers. |
| 課程講義網址 | |
| 整體教學目標 | This course aims to let graduate students understand the roles of astroglias in pathophysiology of the central nervous system and how astroglias’ functions integrate into the neuronal networks activity. |
| 教學方法 | 1. Power-points oral presentations by teachers and students. 2. Hands-on electrophysiological recordings of astrocytes. |
| 課程簡介 | 一直以來，分佈於中樞神經系統內的膠細胞(glial cell)[包括星狀膠細胞(astrocytes)及寡突膠細胞(oligodendrocytes)]，被認為只是附著在神經細胞上的輔助細胞 [“Glia”這個字源自希臘字的”gliok”，意思是黏膠 (glue)]。最近十幾年來的研究則發現，膠細胞的細胞膜具有各種神經傳遞物質的受體、離子孔道及轉運蛋白，當膠細胞膜上的受體結合上配合基(ligand)後，膠細胞能被活化，接著產生能沿著膠細胞之間傳播的鈣離子波(calcium wave)達300—400微米遠。膠細胞也能分泌膠細胞傳遞物質(gliotransmitters)，其中包括有麩胺酸(glutamate)及腺嘌呤核甘三磷酸(ATP)等，進一步研究則發現膠細胞與其附著的神經細胞類似，具有促進突觸生成作用(synaptogenesis)，調控神經可塑性(neuronal plasticity)及神經突觸傳遞(synaptic transmission)等功能。 |
| 彈性學習 | 閱讀指定文獻(assigned paper readings) and review by prerecorded MP4 files.。 |
| 成績考核 | 1.Oral presentation. 40%. 2.Hands-on electrophysiological recordings assessment. 20%. 3.Attendance. 20% |
| 師生互動時間 | 星期四17:00~19:00。 梁淑鈴老師聯絡方式：slliang@mail.cgu.edu.tw 分機3688 |
教學進度
| 項次 | 教學主題 |
|---|---|
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1 |
1. 授課主題/授課內容: The glial-neuronal interactions and signaling: an introduction from past to future. 2. 授課教師:梁淑鈴. |
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2 |
1. 授課主題/授課內容:Research approaches for studying astrocytes. 2. 授課教師:梁淑鈴. |
|
3 |
1. 授課主題/授課內容:Mechanism and significance of astrocytic calcium signaling. 2. 授課教師:梁淑鈴. |
|
4 |
1. 授課主題/授課內容:The tripartite synapse: roles of astrocytes in synaptic plasticity. 2. 授課教師:梁淑鈴. |
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5 |
1. 授課主題/授課內容:Roles of astrocytes in the regulation of sexual differentiatione" conducted by SLL. 2. 授課教師:梁淑鈴. |
| 6 |
1. 授課主題/授課內容:Morphological plasticity of astrocytic/neuronal interactions: functional implications. 2. 授課教師:梁淑鈴.
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7 |
Spring Break |
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8 |
1. 授課主題/授課內容:Neurotransmitter receptors in astrocyte: possible functions of glutamate and GABA receptorss. 2. 授課教師:梁淑鈴. |
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9 |
1. 授課主題/授課內容:Ion channels in astrocytes: pH and potassium regulationse. 2. 授課教師:梁淑鈴. |
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10 |
1. 授課主題/授課內容:Gap junctions and specialized neurotransmitter transporters in astrocytes: glutamate uptake and glutamate-induced neurotoxicity. 2. 授課教師:梁淑鈴. |
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11 |
1. 授課主題/授課內容:Mechanisms and regulations of transmitters release from astrocytes. 2. 授課教師:梁淑鈴. |
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12 |
1. 授課主題/授課內容:Astrocytic-neuronal interactions and brain energy metabolism. 2. 授課教師:梁淑鈴. |
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13 |
1. 授課主題/授課內容:Roles of astrocytes in epilepsy and Huntington’s disease. 2. 授課教師:梁淑鈴. |
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14 |
1. 授課主題/授課內容:Student presentation I 2. 授課教師:梁淑鈴. |
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15 |
1. 授課主題/授課內容:Student presentation II 2. 授課教師:梁淑鈴. |
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16 |
1. 授課主題/授課內容:Hands-on electrophysiological recording of astrocytes. 2. 授課教師:梁淑鈴. |
先修課程
| 本課程沒有先修課程規定 |
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