生物醫學研究所

授課教師

顏秀娟

開課單位

生醫所博士班

年級-班別

1-甲

科目代號(學分)

BMD466(2)

課程名稱

自由基生物醫學

開課序號

64112

主要開課序號

修課學生

本校: 1人；外校: 0人

人數限制

0~60

上課時間地點

核心能力

按此查詢

備註

英文授課

教科書

B. Halliwell and J. M. C. Gutteridge. Free radicals in biology and medicine, 5th Ed., 2015 (electronic version: https://doi.org/10.1093/acprof:oso/9780198717478.001.0001 ).

教科書ISBN

0000000000

參考書

Current literatures indicated in handouts.

課程講義網址

E-learning system

整體教學目標

Free Radical Biology and Medicine or redox biology has been an important subfield invovled in various aspects of biomedical sciences. This course will provide fundamental knowledge for the understanding on the basics of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidant systems in biological systems, role of oxidative stress in the pathogenesis of diseases, and the techniques for evaluating oxidative stress or oxidative damage.

教學方法

This is a class lectured in English, but questions and interaction in Chinese are allowed. Lecturers will prepare handouts for students. Open-book midterm will be given to examine how students understand the basic concepts of this field for the lectures in the first half of the class. As the end of the semester, students will be asked to provide a slide presentation video in class and a written report for the same topic as to how this field can be applied to various subfields in biomedicine of their interests.

課程簡介

上課教室在第一醫學大樓11樓第二會議室。本課程的第一部分專注於自由基生物學之基本知識:ROS/RNS之化學性質和來源; 脂質、核酸、和蛋白氧化傷害及其產物之分析方法; 體內之抗氧化系統。在第二部分，我們會討論此領域的各項應用，包含在培養細胞中和活體內評估氧化壓力之方法; redoxomics之應用; 氧化壓力在病毒感染、G6PD缺乏、心血管疾病、中風、和毒藥物毒性中的角色。最後，學生要做期末口頭和書面報告，討論如何將自由基生物醫學應用在有興趣的主題。

彈性學習

Videos for free radical biology and medicine (2 hours). Links to the videos will be announced on the E-learning system.

成績考核

Midterm exam (open-book exam): 50%; Final slide presentation: 20%; Final written report: 20%; Discussion and quuestions for slide presentation: 10%; Deductions of the final grade (2 points) for each unauthorized absence in the class

師生互動時間

Monday 2-3 pm Contact information of Prof. HC Yen (顏秀娟): yen@mail.cgu.edu.tw; ext. 5207

項次

教學主題

1

1. 授課內容: Introduction to free radicals, reactive oxygen species (ROS)/reactive nitrogen species (RNS), and their roles in basic and clinical medicine 2. 授課老師: 顏秀娟 (HC Yen)

2

1. 授課內容: Chemistry of ROS/RNS and sources of ROS/RNS in biological systems 2. 授課老師: 顏秀娟 (HC Yen)

3

1. Holiday 2. 授課老師: 顏秀娟 (HC Yen)

4

1. 授課內容: Lipid peroxidation 2. 授課老師: 顏秀娟 (HC Yen)

5

1. 授課內容: Oxidative damage to nucleic acids 2. 授課老師: 鄭美玲 (ML Cheng)

6

1. 授課內容: Oxidative damage to proteins 2. 授課老師: 顏秀娟 (HC Yen)

7

1. 授課內容: Antioxidant enzymes 2. 授課老師: 顏秀娟 (HC Yen)

8

1. 授課內容: Low-molecular-weight antioxidants 2. 授課老師: 顏秀娟 (HC Yen)

9

1. 授課內容: Open-book midterm exam 2. 授課老師: 顏秀娟 (HC Yen)

10

1. 授課內容: Redoxomics as a new approach in redox biology 2. 授課老師:何鴻耀 (HY Ho)

11

1. 授課內容: Oxidative stress and viral infection 2. 授課老師: 何鴻耀 (HY Ho)

12

1. 授課內容: Speicial topics on glucose-6-phosphate dehydrogenase (G6PD) 2. 授課老師: 鄭美玲 (ML Cheng)

13

1. 授課內容: Considerations and techniques for accessing oxidative stress in cultured cells, animals, and in clinical studies 2. 授課老師: 顏秀娟 (HC Yen)

14

1. 授課內容: Oxidative stress in stroke and cardiovascular diseases 2. 授課老師: 顏秀娟

15

1. 授課內容: Oxidative stress and toxicity of xenobiotics 2. 授課老師: 顏秀娟 (HC Yen)

16

1. 授課內容: Student presentation for the selected topics 2. 授課老師: 顏秀娟 HC Yen)

本課程沒有先修課程規定