生物醫學研究所

授課教師

李國銘

開課單位

生醫所博士班

年級-班別

1-甲

科目代號(學分)

BMD403(2)

課程名稱

細胞分子生物學

開課序號

64109

主要開課序號

62563

修課學生

本校: 6人；外校: 0人

人數限制

2~60

上課時間地點

核心能力

按此查詢

備註

英文授課，與新興病毒學程合開

教科書

Lecture slides

教科書ISBN

0000000000

參考書

Molecular cell biology by Harvey Lodish et al., 7th Edition (2013) (ISBN:9781464183393); Molecular Biology by Robert Weaver, 5th Edition (2012) (ISBN:9780071316866); Fields virology by Peter M. Howley et al., 7th Edition (2021) (ISBN: 9781975112578)

課程講義網址

E-learning: https://moocs.cgu.edu.tw/mooc/index.php Microsoft Teams

整體教學目標

The course is aimed to provide a comprehensive introduction about how the various components in a cell cooperate with each other to maintain cell growth and replication by combining textbook with the latest finding in various topics of cell & molecular biology. Based on this, we will further discuss how the virus can successfully replicate by harnessing different host machineries. 本課程旨在藉由搭配教科書知識結合細胞和分子生物學各領域的最新發現，全面介紹細胞中的各種成分如何相互作用以維持細胞生長和複製。並以此為基礎進一步討論病毒如何利用宿主各式各樣的機制進行複製。

教學方法

Lecture and discussion

課程簡介

針對細胞（尤其是真核細胞）中各個基礎組成如何運作以滿足細胞生長復制的需求進行一般性介紹。除了經典分子生物學的中心法則，我們還將關注基因表現相關的各個領域的最新發現，包括轉錄、翻譯、細胞核質的運送、蛋白質運輸和細胞內不同胞器間的交互作用。此外，我們還將討論 如何藉由CRISPR/Cas、調控 RNA、表觀遺傳控制和 RNA 修飾等操作基因的表現。最後，我們將解釋病毒如何與宿主合作或搶奪宿主資源以完成病毒複製。通過這些內容，學生不僅可以了解細胞是如何運作，還可以了解病毒如何利用宿主細胞資源來促進複製。了解這些重要的分子機制，可以為未來的研究或藥物研發提供方向。

彈性學習

Two courses (4 hr): I. 2024/12/24, 1. Flexible learning, on-line and Flipped Classroom, 2. Topic: Prokaryotic and Eukaryotic CRISPR and their Application, 3. Group discussion. II. 2024/12/31, 1. Flexible learning, on-line and Flipped Classroom, 2. Topic: Antiviral Restriction Factors, 3. Group discussion.

成績考核

Group discussion: 30% Flipped Classroom: 50% Attendance/Participation: 20%

師生互動時間

星期二 12:00 pm-13:00 分機 #3727 李國銘老師聯絡方式: Kuo-Ming Lee, g39002007@mail.cgu.edu.tw, x-3727 龔俞安老師聯絡方式: Yu-An Kung, yakung@mail.cgu.edu.tw, x-3039

項次

教學主題

1

1. Physical course 2. Topic: Introduction: I. Overview of the Molecular & Cell Biology, II. Centra dogma of the Molecular Biology 3. Lecturer: Kuo-Ming Lee

2

1. Physical course 2. Topic: Compartmentalization of the Eukaryotic Cell: Nucleus, Nuclear Body, Cytoskeleton, and Extracellular Matrix 3. Lecturer: Kuo-Ming Lee

3

1. Moon Festival 2. Lecturer: Kuo-Ming Lee

4

1. Physical course 2. Topic: Genome Replication, Gene Editing (CRISPR/Cas) and Epigenetic Control 3. Lecturer: Kuo-Ming Lee

5

1. Physical course 2. Topic: Three Major Transcription Machineries of the Cell 3. Lecturer: Kuo-Ming Lee

6

1. Physical course 2. Topic: Transcription Coupled Pre-mRNA Processing (I): Capping and Splicing 3. Lecturer: Kuo-Ming Lee

7

1. Physical course 2. Topic: Transcription Coupled Pre-mRNA Processing (II): Polyadenylation and mRNA Export 3. Lecturer: Kuo-Ming Lee

8

1. Physical course 2. Topic: Translation, Regulatory RNA and RNA Surveillance 3. Lecturer: Kuo-Ming Lee

9

1. Physical course 2. Topic: Virus-Host interaction (I): Cap-independent Translation 3. Lecturer: Yu-An Kung

10

1. Physical course 2. Topic: RNA Modifications and RNA Vaccine 3. Lecturer: Kuo-Ming Lee

11

1. Physical course 2. Topic: I. Protein Maturation and Quality Control, II. Intracellular Protein Traffic: Endocytosis, Exocytosis and Membrane-Bound Extracellular Vesicles 3. Lecturer: Kuo-Ming Lee

12

1. Physical course 2. Topic: Signaling Transduction and Cell Cycle 3. Lecturer: Kuo-Ming Lee

13

1. Physical course 2. Topic: Virus-Host Interaction (II): Pattern Recognition Receptors and Innate Immunity 3. Lecturer: Kuo-Ming Lee

14

1. Physical course 2. Topic: Programmed Cell Death and Necrosis 3. Lecturer: Yu-An Kung

15

1. Physical course 2. Topic: Virus-Host interaction (III): Replication organelles and egress 3. Lecturer: Yu-An Kung

16

1. Physical course 2. Topic: Final Presentaton and Group Discussion 3. Lecturer: Kuo-Ming Lee

本課程沒有先修課程規定