生物醫學研究所

賴志河 (Chih-Ho Lai)

職稱：教授

研究室名稱：感染免疫研究室

最高學歷：Ph.D.

學校/國家：清華大學/台灣

分機號碼：(lab) 3895/ (office) 5116

電子郵件帳號：chlai@mail.cgu.edu.tw

個人網頁網址：https://sites.google.com/a/gap.cgu.edu.tw/infection-and-immunity/  

研究室現有： 博士後研究員 0 人

博士班研究生  2  人

碩士班研究生 3 人

專任研究助理  2  人

大學部專題生  6  人

研究方向及研究室特色：

我們實驗室主要的研究方向是探討微生物致病機轉與宿主免疫反應，並開發有效之治療藥物。研究之微生物主題包含：幽門螺旋桿菌(Helicobacter pylori)、空腸彎曲桿菌(Campylobacter jejuni)、鏈球菌(Streptococcus pneumoniae)及嗜血桿菌(Haemophilus influenzae)等常見致病菌與免疫細胞之相互作用及導致感染疾病。此外，我們也嘗試開發細菌毒素應用於治療癌幹細胞(cancer stem cells)、探討微生物相(microbiota)與轉譯醫學等臨床議題，希望能將研究成果應用於臨床治療。我們非常歡迎對感染免疫學領域有興趣的大學部專題生、碩、博班研究生一起參與實驗室的研究。

最近五年所發表論文：

1. Kuo CJ, Ke JN, Kuo T, Lin CY, Hsieh SY, Chiu YF, Wu HY, Bui NN, Chiu CH, Chiu CT, Lai CH*. Multiple amino acid substitutions in penicillin-binding protein-1A confer amoxicillin resistance in refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2022; S1684-1182 (22)00104-9.
2. Chou LF, Chen TW, Yang HY, Tian YC, Chang MY, Hung CC, Lai CH, Hsu SH, Tsai CY, Ko YC, Lian JH, Yang CW*. Implication of the IL-10-expression signature in the pathogenicity of Leptospira- infected macrophages. Microbiol Spectr. 2022;10(3):e0259521.
3. Lien HM, Wang YY, Huang MZ, Wu HY, Chen CC, Hung SW, Chiu CH, Lai CH*. Gastroprotective effect of Anisomeles indica on aspirin-induced gastric ulcer in mice. Antioxidants 2022; 11(12):1-13.
4. Lai CH*, Lin TL, Huang MZ, Li SW, Wu HY, Chiu YF, Yang CY, Chiu CH, Lai HC*. Gut commensal Parabacteroides goldsteinii MTS01 Alters gut microbiota composition and reduces cholesterol to mitigate Helicobacter pylori-induced pathogenesis. Front Immunol. 2022;13(916848):1-13.
5. Lo UG, Chen YA, Cen J, Deng S, Luo J, Zhau H, Ho L, Lai CH, Mu P, Chung LWK, Hsieh JT*. The driver role of JAK- STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy- and castration-resistant prostate cancer. Clin Transl Med. 2022;12(8):e978.
6. Chiang MH, Ho SM, Wu HY, Lin YC, Tsai WH, Wu T, Lai CH*, Wu CL*. Drosophila model for studying gut microbiota in behaviors and neurodegenerative diseases. Biomedicines. 2022;10(3):596.
7. Lee CF, Chen YA, Hernandez E, Pong RC, Ma S, Hofstad M, Kapur P, Zhau H, Chung LW, Lai CH, Lin H, Lee MS, Raj GV, Hsieh JT*. The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC. Clin Transl Med. 2022;12(2):e695.
8. Hsu CY, Yeh JY, Chen CY, Wu HY, Chiang MH, Wu CL, Lin HJ, Chiu CH, Lai CH*. Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells. Virulence. 2021;12(1):2341-2351. 
9. Lin TY, Lan WH, Chiu YF, Feng CL, Chiu CH, Kuo CJ, Lai CH*. Statins' regulation of the virulence factors of Helicobacter pylori and the production of ROS may inhibit the development of gastric cancer. Antioxidants. 2021;10(8):1-14.
10. Lai YR, Chang YF, Ma J, Chiu CH, Kuo ML, Lai CH*. From DNA damage to cancer progression: potential effects of cytolethal distending toxin. Front Immunol. 2021;12(760451):1-8.
11. Kuo CJ, Lee CH, Chang ML, Lin CY, Lin WR, Su MY, Chiu CH, Tseng CN, Wu YS, Chiu CT, Lai CH*. Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2021;54(6):1184-1187.
12. Gagliardi MC, Iwabuchi K, Lai CH*. Editorial: Role of lipid rafts in anti-microbial immune response. Front Immunol. 2021;12(654776):1-2.
13. Chen YA, Lai YR, Wu HY, Lo YJ, Chang YF, Hung CL, Lin CJ, Lo UG, Lin H, Hsieh JT, Chiu CH, Lin YH, Lai CH*. Bacterial genotoxin-coated nanoparticles for radiotherapy sensitization in prostate cancer. Biomedicines. 2021;9(2):1-15.
14. Yeh JY, Lin HJ, Kuo CJ, Feng CL, Chou CH, Lin CD, Wu HY, Li CY, Chiu CH, Lai CH*. Campylobacter jejuni cytolethal distending toxin C exploits lipid rafts to mitigate Helicobacter pylori-induced pathogenesis. Front Cell Dev Biol. 2021;8:1-10.
15. Chen YW, Huang MZ, Chen CL, Yang CY, Chiang-Ni C, Chen YY, Wu HY, Kuo ML, Chiu CH, Lai CH*. PM_2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Particle and Fibre Toxicology. 2020;17(1):1-14.
16. Chen YW, Li SW, Lin CD, Huang MZ, Lin HJ, Chin CY, Lai YR, Chiu CH, Yang CY, Lai CH*. Fine particulate matter exposure alters pulmonary microbiota composition and aggravates pneumococcus-induced

    ---

    回上一頁