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生物醫學研究所

生物醫學研究所
:::
徐錦源

徐錦源 / Chin-Yuan Hsu

職稱： 教授

現職： 長庚大學

信箱： hsu@mail.cgu.edu.tw

電話： 3416

學歷： 清華大學博士

專長領域： 生理研究;長壽機轉

研究方向及研究室特色：


1. The mechanisms of aging and lifespan extension in honeybees.

2. The mechanism of lifespan extension at ambient temperature reduction.

3. Anti-aging drugs screen. 

     我們實驗室使用蜜蜂研究老化及長壽的分子機轉。因為蜜蜂族群數量大，工蜂壽命短(約1-2個月)，蜂王壽命長(約3-5年)，基因體已解碼，基因組成類似脊椎動物。我們使用工蜂研究老化的分子機轉，蜂王研究長壽的分子機轉。我們以老化指標，粒線體能量代謝，能量調節分子，細胞能量代謝，細胞降解作用，細胞免疫作用，細胞訊息傳遞，分子結構解析及基因調節等主題來探討工蜂老化的分子機轉。同樣地，我們也以這些主題來探討蜂王長壽的分子機轉。透過比較工蜂老化及蜂王長壽的分子機轉及基因體的比對，企圖找出延長人類壽命的分子機轉。

      生物處於低溫環境能延長壽命，相反地，生物處於高溫環境會縮短壽命。我們使用工蜂研究低溫環境延長壽命的分子機轉。我們也以老化指標，粒線體能量代謝，能量調節分子，細胞能量代謝，細胞降解作用，細胞免疫作用，細胞訊息傳遞，分子結構解析及基因調節等主題來探討工蜂處於低溫環境延長壽命及處於高溫環境縮短壽命的分子機轉。透過比較工蜂老化，高溫環境縮短壽命，蜂王長壽及低溫環境延長壽命的分子機轉及基因體的比對，企圖找出延長人類壽命的分子機轉。

      透過比較工蜂老化，高溫環境縮短壽命，蜂王長壽及低溫環境延長壽命的分子機轉及基因體的比對，建立長壽的分子機轉。由分子結構模擬中建構及中草藥中篩選長壽分子機轉的活化劑及老化分子機轉的抑制劑，建立抗老化藥物，以延長人類壽命。

誠摯地歡迎對本實驗室研究主題感興趣的同學加入本實驗室的行列。

Publications:

  1. Lu CY, Weng YT, Tan B, Hsu CY* (2021) The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles. GeroScience.
  2. Hsu CY*, Weng YT (2021) Long-term inhibition of ferritin2 synthesis in trophocytes and oenocytes by ferritin2 double-stranded RNA ingestion to investigate the mechanisms of magnetoreception in honey bees (Apis mellifera). PLoS ONE 16(8):e0256341.
  3. Hsu CY*, Lo HF, Mutti N.S et al. (2019) Ferritin RNA interference inhibits the formation of iron granules in the trophocytes of worker honey bees (Apis mellifera). Sci Rep 9, 10098.
  4. Lu CY, Qiu JT, Hsu CY* (2018) Cellular energy metabolism is maintained during aging in long-living queen bees. Arch. Insect Biochem. Physiol.Doi:10.1002/arch.21468.
  5. Lu CY, Chuang YL, Hsu CY* (2017) Aging results in a decline in cellular energy metabolism in the trophocytes and oenocytes of worker honeybees (Apis mellifera). Apidologie 48:761-775.
  6. Hsu CY*, Qiu JT, Chan YP, (2016) Cellular degradation activity is maintained during aging in long-living queen bees. Biogerontology 17:829-840.
  7. Lu CY, Hsu CY* (2015) Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii). Age doi:10.1007/s11357-015-9775-z.
  8. Hsu CY*, Lu CY (2015) Mitochondrial energy utilization maintains young status in the trophocytes and fat cells of old queen honeybees. Apidologie doi:10.1007/s13592-015-0348-z.
  9. Hsu CY*, Hu TH (2014) Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees. Biogerontology 15:389-400.
  10. Hsu CY*, Chuang YL (2014) Changes in energy-regulated molecules in the trophocytes and fat cells of young and old worker honeybees. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 69:955-964.
  11. Hsu CY*, Hsieh YS (2014) Oxidative stress decreases in the trophocytes and fat cells of worker honeybees during aging. Biogerontology 15:129-137.
  12. Hsu CY*, Chuang YL, Chan YP (2014) Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera) Exp. Gerontol. 50:128-136.
  13. Hsieh YS, Hsu CY* (2013) Oxidative stress and anti-oxidant enzyme activities in the trophocytes and fat cells of queen honeybees (Apis mellifera). Rejuv. Res. 16:295-303.
  14. Chuang YL, Hsu CY* (2013) Changes in mitochondrial energy utilization in young and old worker honeybees. Age 35:1867-1879.
  15. Hsu CY*, Chan YP (2013) The use of honeybees reared in a thermostatic chamber for aging studies. Age 35:149-158.
  16. Hsieh YS, Hsu CY* (2011) The changes of age-related molecules in the trophocytes and fat cells of queen honeybees (Apis mellifera). Apidologie 42:728-739.
  17. Hsu CY*, Chan Y.P. (2011) Identification and localization of proteins associated with biomineralization in the iron deposition vesicles of honeybees (Apis mellifera). PLoS ONE 6(4):e19088. doi:10.1371/journal.pone.0019088
  18. Hsieh YS, Hsu CY* (2011) Honeybee trophocytes and fat cells as target cells for cellular senescence studies. Exp. Gerontol. 46:233-240.
  19. Hsu CY*, Chiu YC (2009) Ambient temperature influences aging in an annual fish (Nothobranchius rachovii). Aging Cell 8:726-737.
  20. Hsu CY*, Chiu YC, Hsu WL, Chan YP (2008) Age-related markers assayed at different developmental stages of the annual fish Nothobranchius rachovii. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 63A:1267-1276.
  21. Hsu CY*) (2008) Antioxidant activity of extracts from Pyrrosia petiolosa. Fitoterapia 79:64-66.
  22. Hsu CY*, Ko FY, Li CW, Fann K, Lue JT (2007) Magnetoreception system in honeybees (Apis mellifera). PLoS ONE 2(4): e395. doi:10.1371/journal.pone.0000395.
  23. Hsu CY* (2004) The processes of iron deposition in the common hornet (Vespa affinis). Biol. Cell 96:529-537.
  24. Liou ML, Hsu CY* (1998) Japanese encephalitis virus transports across the cerebral blood vessels by endocytosis in mouse brain. Cell & Tissue Res. 293:389-394.
  25. Hsu CY, Li CW (1994) Magnetoreception in honeybees (Apis mellifera). Science 265:95-97.

   26. Hsu CY, Li CW (1993) The ultrastructure and formation of iron granules in the honey bee (Apis mellifera). J.           Exp. Biol. 180:1-13.