研究方向與特色

2023 Counseling Awards (Medical School) 優良教師/輔導獎

2014 Counseling Awards (Medical School) 優良教師/輔導獎

2012 Teaching Awards (Medical School-Basic Sciences) 優良教師/教學獎

Research Focus:

(1) Epstein Barr Virus (Tumor virus)

(2) Cancer Research

(3) DNA Methylation & Gene Expression Regulation in Nasopharyngeal Carcinoma (NPC)

(4) NPC patient derived xenograft (PDX) and drug screening

(5) OSCC integrated multi-omics analysis

EBV潛伏膜蛋白1（latent membrane protein 1, LMP1）是病毒致癌蛋白，可活化細胞“DNA甲基轉移酶”(DNA methyltransferase 1, DNMT1) 基因的轉錄，導致許多基因過度甲基化和使基因默化(gene silencing)。我們之前的實驗結果證明LMP1透過其蛋白質C-端激活區域2 (C-terminal activation domain 2, CTAR2)最後3個胺基酸YYD區域直接誘導DNMT1啟動子活化(圖1A, B)。 LMP1誘發DNMT1的活化涉及上游JNK激酶的活化，卻不涉及NF-kB和p38 /有絲分裂原激活的蛋白激酶(MAPK)訊號傳導。此外LMP1誘導由DNMT1和histone deacetylase (HDAC)組成的轉錄抑制複合物(transcriptional repression complex, DNMT-HDAC)的形成，該複合物位於E-cadherin基因啟動子上(圖1B)。利用JNK抑制劑SP600125處理NPC細胞可防止這種轉錄抑制複合物的形成。總括而言，我們的結果釐清JNK-AP-1訊號傳導與EBV致癌蛋白LMP1誘導的DNA甲基化之間的機制關聯。(Can Res 2006; 66(24): 11668-76, IF= 12.701; R/C= 17/242 =7.02%; ONCology)
圖1A                                                                                                                  圖1B

Fig.1 (A). EBV oncoprotein latent membrane protein (LMP1) activates at least 5 different oncogenic cellular signaling pathways and promotes NPC tumor progression [adapted from 2010 Human Oncogenic Viruses: Ch5 EBV and its Oncogenesis (World Scientific)]. 1 (B) A model for LMP1-mediated DNMT1 activation via JNK/AP-1 signaling. Activated DNMT1 hypermethylates E-cadherin promoter and recruits a transcriptional repression complex leading to gene silencing. The YYD domain of LMP1 activates the JNK signaling pathway and activated JNK, in turn,phosphorylat es transcription factor c-Jun. Phosphorylated c-Jun of AP-1 complex binds and transactivates the dnmt1 promoter. Elevated DNMT1 expression leads to hypermethylation of E-cadherin gene and formation of a transcriptional repression complex including DNMTs,meth yl-binding proteins (MBD),and HDAC. This LMP1-mediated DNMT1 activation can be blocked by JNK inhibitor SP600125, dominant negative mutant (DN-JNK), and siRNAs (si-JNK, si-c-Jun, si-TRADD and si-LMP1).

發表論文

C-S Wu†, H-P Li*†, C-H Hsieh†, Y-T Lin†, I Y-F Chang†, A-K Chung, Y Huang, S-H Ueng, Y-C Hsiao, K-Y Chien, J-D Luo, C-H Chen, W-C Liao, J-L Hung, S-N Yuan, C-N OuYang, W-F Chiang, C-Y Chien, H-C Chuang, L J Chu, H Liu, C-Y Yang, A I Robles, H Rodriguez, H-H Lin, H-Y Yang, C Hsueh, K-P Chang*, J-S Yu*, Y-S Chang (†co-first authors; *co-corresponding authors)

Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies

Cancer Letters 2025, 614:217482. doi: 10.1016/j.canlet.2025.217482.

(IF=9.1; R/C=33/322=10.2%; ONCOLOGY)

Cheng-Lung Hsu, Yu-Sun Chang, Hsin-Pai Li*

Molecular Diagnosis of Nasopharyngeal Carcinoma: Past and Future

Biomedical Journal 2024, 23:100748, 1-12

https://doi.org/10.1016/j.bj.2024.100748

(IF=5.5, R/C=70/285=24.56%, BIOCHEMISTRY & MOLECULAR BIOLOGY)

Hsin-Pai Li†, Chen-Yang Huang†, Kar-Wai Lui, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee, Yenlin Huang, Tung-Liang Lin, Yung-Chia Kuo, Mei-Yuan Huang, Hsien-Chi Fan, An-Chi Lin, Chia-Hsun Hsieh, Kai-Ping Chang, Chien-Yu Lin, Hung-Ming Wang, Mei Chao, Jai-Shin Liu, Yu-Sun Chang, Cheng-Lung Hsu

Nasopharyngeal carcinoma patient-derived xenograft mouse models reveal potential drugs targeting cell cycle, mTOR, and autophagy pathways

Translational Oncology 2023, 38 (101758), 1-11

https://doi.org/10.1016/j.tranon.2023.101785

(IF=5; R/C=78/318=24.6%; ONCOLOGY)

Chiao‐Yun Lin†, Ren‐Chin Wu†, Chen‐Yang Huang†, Chyong‐Huey Lai, An‐Shine Chao, Hsin‐Pai Li, Chia‐Lung Tsai, Elizabeth Joo‐Wen Kuek, Cheng‐Lung Hsu,* and Angel Chao*

A Patient‐Derived Xenograft Model of Dedifferentiated Endometrial Carcinoma: A Proof‐Of‐Concept Study for the Identification of New Molecularly Informed Treatment Approaches

Cancers 2021 13(23), 5962-5979

https://doi.org/10.3390/cancers13235962

(IF=6.639; R/C=51/242=21%; ONCOLOGY)

Hsin-Pai Li, Chen-Yang Huang, Kar-Wai Lui, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee, Yenlin Huang, Tung-Liang Lin, Yung-Chia Kuo, Mei-Yuan Huang, Yi-Ru Lai, Yuan-Ming Yeh, Hsien-Chi Fan, An-Chi Lin, Jason Chia-Hsun Hsieh, Kai-Ping Chang, Chien-Yu Lin, Hung-Ming Wang, Yu-Sun Chang and Cheng-Lung Hsu

Combination of Epithelial Growth Factor Receptor Blockers and CDK4/6 Inhibitor for Nasopharyngeal Carcinoma Treatment

Cancers 2021 volume 13, issue 12, 2954-2971

2021/6/12

https://doi.org/10.3390/cancers13122954

(IF=6.639; R/C=51/242=21%; ONCOLOGY)

Chi-Sheng Wu, Ian Yi-Feng Chang, Jui-lung Hung, Wei-Chao Liao, Yi-Ru Lai, Kai-Ping Chang, Hsin-Pai Li & Yu-Sun Chang

ASC modulates HIF-1α stability and induces cell mobility in OSCC

Cell Death & Disease 2020 volume 11, Article number: 721 https://www.nature.com/articles/s41419-020-02927-7

(IF= 8.469; R/C=37/195 = 18.9%, CELL BIOLOGY)

Chao-Wei Hsu, Horng-Heng Juang, Chien-Yi Kuo, Hsin-Pai Li, Shan-Bei Iang, Siao-Han Lin, Chau-Ting Yeh and Mei Chao*

Structural Pattern Differences in Unbranched Rod-Like RNA of Hepatitis Delta Virus Affect RNA Editing

Viruses 2019, 11, 934; doi:10.3390/v11100934

www.mdpi.com/journal/viruses

(IF=5.048; R/C=10/36= 27.77%, VIROLOGY)

An‐Ko Chung, Chun‐Nan OuYang, Hsuan Liu, Mei Chao, Ji‐Dung Luo, Cheng‐Yang Lee, Yen‐Jung Lu, I‐Che Chung, Lih‐Chyang Chen, Shao‐Min Wu, Ngan‐Ming Tsang, Kai‐Ping Chang, Cheng‐Lung Hsu, Hsin‐Pai Li*, Yu‐Sun Chang* (*Co-corresponding)

Targeted sequencing of cancer‐related genes in nasopharyngeal carcinoma identifies mutations in the TGF‐β pathway

Cancer Medicine 2019 8:5116-5127

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718742/pdf/CAM4-8-5116.pdf

(IF= 4.452; R/C=107/242=44.21%; ONCOLOGY) 2019 July 22

Cheng-Lung Hsu, Kar-Wai Lui, Lang-Ming Chi, Yung-Chia Kuo, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee, Yenlin Huang, Tung-Liang Lin, Mei-Yuan Huang, Yi-Ru Lai, Yuan-Ming Yeh, Hsien-Chi Fan, An-Chi Lin, Yen-Jung Lu, Chia-Hsun Hsieh, Kai-Ping Chang, Ngan-Ming Tsang , Hung-Ming Wang, Alex Y Chang, Yu-Sun Chang, Hsin-Pai Li *  (*Corresponding)

Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma

Journal of Experimental & Clinical Cancer Research 2018 37:233

https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0873-5

(IF=11.161; R/C=25/242=10.33%; ONCOLOGY) 2018 Sept. 20

Hsin-Pai Li*†, Chen-Ching Peng†, Chih-Ching Wu, Chien-Hsun Chen, Meng-Jhe Shih, Mei-Yuan Huang, Yi-Ru Lai, Yung-Li Chen, Ting-Wen Chen, Petrus Tang, Yu-Sun Chang, Kai-Ping Chang and Cheng-Lung Hsu (†Co-first author; *Corresponding)

Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma

Journal of Experimental & Clinical Cancer Research 2018 37:102

https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0754-y

(IF=11.161; R/C=25/242=10.33%; ONCOLOGY) 2018 May 10

Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang & Yu-Sun Chang

APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

Nature Communication 2017; 6;8(1):465

(IF=14.919; R/C=4/73=5.48%; MULTIDISCIPLINARY SCIENCES)

I-Che Chung, Chun-Nan OuYang, Sheng-Ning Yuan, Hsin-Pai Li, Jeng-Ting Chen, Hui-Ru Shieh, Yu-Jen Chen, David M. Ojcius, Ching-Liang Chu, Jau-Song Yu, Yu-Sun Chang & Lih-Chyang Chen

Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis

Scientific Reports 2016; 6:36214

(IF=4.379; R/C=17/73=23.29%; MULTIDISCIPLINARY SCIENCES)

Hung-Ming Wang*, Tung-Liang Lin*, Yung-Chia Kuo, Hsin-Pai Li, Kai-Ping Chang, Chien-Yu Lin, Hsien-Chi Fan, An-Chi Lin, Chia-Hsun Hsieh, Ngan-Ming Tsang, Li-Yu Lee, Sheng-Chieh Chan, Kar-Wai Lui, Yu-Sun Chang, Cheng-Lung Hsu

Correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis

Oncotarget 2016; (7)33:53217-53229

(IF=5.168; R/C= 44/217=20.27%; Oncology) 2016-JCR

Mei Chao, Chia-Chi Lin, Feng-Ming Lin, Hsin-Pai Li and Shan-Bei Iang

Whole-genome analysis of genetic recombination of hepatitis delta virus: molecular domain in delta antigen determining trans-activating efficiency

Journal of General Virology 2015, 96:3460–3469

(IF=3.891; R/C= 61/159=38.36%; BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

Chia-Chi Lin, Chi-Ching Lee, Siao-Han Lin, Po-Jung Huang, Hsin-Pai Li, Yu-Sun Chang, Petrus Tang*, Mei Chao*

RNA recombination in Hepatitis delta virus: Identification of a novel naturally occurring recombinant

Journal of Microbiology Immunology and Infection (2015) doi: 10.1016/j.jmii.2015.10.013

(IF= 4.399; R/C= 46/137=33.58%; microbiology)

Cheng-Lung Hsu, Yung-Chia Kuo, Yenlin Huang, Yin-Cheng Huang, Kar-Wai Lui, Kai-Ping Chang, Tung-Liang Lin, Hsien-Chi Fan, An-Chi Lin, Chia-Hsun Hsieh, Li-Yu Lee, Hung-Ming Wang, Hsin-Pai Li, Yu-Sun Chang

Application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma

Oncotarget 2015; (6)31: 31323-31334

(IF=5.168; R/C= 44/217=20.27%; Oncology) 2016-JCR

Hsin-Pai Li†*, Hsin-Yi Huang†, Yi-Ru Lai, Jing-Xuan Huang, Kai-Ping Chang, Chuen Hsueh and Yu-Sun Chang (†Co-first author; *Corresponding)

Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma

Oncotarget 2014; (5)17:7610-24

(IF=5.168; R/C= 44/217=20.27%; Oncology) 2017-JCR

Ting-Wen Chen†, Hsin-Pai Li†, Chi-Ching Lee, Ruei-Chi Gan, Po-Jung Huang, Timothy H Wu,

Cheng-Yang Lee, Yi-Feng Chang and Petrus Tang* (†Co-first author)

ChIPseek, a web-based analysis tool for ChIP data

BMC Genomics 2014, 15:539

(IF=3.969; R/C= 57/159 =35.85%; BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

I-Che Chung†, Lih-Chyang Chen†, An-Ko Chung, Mei Chao, Hsin-Yi Huang, Chuen Hsueh, Ngan-Ming Tsang, Kai-Ping Chang, Ying Liang, Hsin-Pai Li* and Yu-Sun Chang* (*Co-corresponding)

Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma

BMC Cancer 2014, 14:348-361

(IF= 4.430; R/C= 109/242=45.04%; ONCOLOGY)

Hsin-Pai Li*†, Chen-Ching Peng+, I-Che Chung, Mei-Yuan Huang, Shao-Tung Huang, Chia-Chun Chen, Kai-Ping Chang, Cheng-Lung Hsu, Yu-Sun Chang (†Co-first author; *Corresponding)

Aberrantly Hypermethylated Homeobox A2 Derepresses Metalloproteinase-9 Through TBP and Promotes Invasion in Nasopharyngeal Carcinoma

Oncotarget 2013; 4: 2154-2165

(IF=5.168; R/C= 44/217=20.27%; Oncology) 2017-JCR

Wen-I Lee*, Jainn-Jim Lin, Meng-Ying Hsieh, Syh-Jae Lin, Tang-Her Jaing, Shih-Hsiang Chen, Iou-Jih Hung, Chao-Ping Yang, Chin-Jung Chen, Yhu-Chering Huang, Hsin-Pai Li, Jing-Long Huang*

Immunologic Difference between Hypersensitivity to Mosquito Bite and Hemophagocytic Lymphohistiocytosis Associated with Epstein-Barr Virus Infection

PLoS ONE 2013; Volume 8 | Issue 10 | e76711

(IF= 3.240; R/C= 26/73=35.61%, MULTIDISCIPLINARY SCIENCES)

Cheng-Lung Hsu, Kai-Ping Chang, Chien-Yu Lin, Hsien-Kun Chang, Cheng-Hsu Wang, Tung-Liang Lin, Chun-Ta Liao, Ngan-Ming Tsang, Li-Yu Lee, Sheng-Chieh Chan, Shu-Hang Ng, Hsin-Pai Li, Yu-Sun Chang and Hung-Ming Wang

Plasma EBV DNA Concentration and Clearance Rate as Novel Prognostic Factors for Metastatic Nasopharyngeal Carcinoma

Head & Neck 2012; 1-8 DOI: 10.1002/hed.21890

(IF=3.135; R/C= 9/42= 21.43%, OTORHINOLARYNGOLOGY)

Chia-Chen Hsu†, Hsin-Pai Li†, Yu-Hung Hung , Yu-Wei Leu , Wu-Hsiung Wu, Feng-Sheng Wang , Kuan-Der Lee , Pey-Jium Chang , Chi-Sheng Wu, Yen-Jung Lu , Tim H.-M. Huang, Yu-Sun Chang, Shu-Huei Hsiao (†Co-first author)

Targeted Methylation of CMV and E1Aviral promoters

Biochemical and Biophysical Research Communications 2010; 402: 228–234

https://www.sciencedirect.com/science/article/pii/S0006291X1001853X?via%3Dihub

(IF=3.575; R/C=30/72 =41.67%, BIOPHYSICS)

Yen-Jung Lu, Chi-Sheng Wu, Hsin-Pai Li*, Hao-Ping Liu, Chang-Yi Lu, Yu-Wei Leu, Chia-Siu Wang, Lih-Chyang Chen, Kwang-Huei Lin, and Yu-Sun Chang* (*Co-corresponding)

Aberrant Methylation Impairs Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B) Tumor Suppressor Function in Gastric Cancer.

GENES CHROMOSOMES & CANCER 2010; 49(5):412-24.

(IF= 5.006; R/C= 39/175 =22.29%; GENETICS & HEREDITY)

Chi-Sheng Wu†, Yen-Jung Lu†, Hsin-Pai Li, Chuen Hsueh, Chang-Yi Lu, Yu-Wei Leu, Hao-Ping Liu, Kwang-Huei Lin, Tim Hui-Ming Huang and Yu-Sun Chang (†Co-first author)

Glutamate receptor, ionotropic, kainate 2 silencing by DNA hypermethylation possesses tumor suppressor function in gastric cancer.

International Journal of Cancer 2010; 126(11):2542-52.

(IF=7.396; R/C= 42/242 =17.36%; Oncology)

Hsin-Pai Li, Mei Chao, Su-Jen Chen, Yu-Sun Chang

Human Oncogenic Viruses: Epstein-Barr Virus and Its Oncogenesis (Invited Chapter)

p. 209-267

ISBN: 978-981-283-346-4

World Scientific 2010, Editors: Jing-Hsiung James Ou and T. S. Benedict Yen

Lih-Chyang Chen, Hao-Ping Liu, Hsin-Pai Li, Chuen Hsueh, Jau-Song Yu, Ying Liang, Yu-Sun Chang

Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells.

Oncogene 2009; 28(17):1904-15.

(IF= 9.867; R/C= 29/298 =9.73%; BIOCHEMISTRY & MOLECULAR BIOLOGY)

Wei-Chun Tai, Hsin-Pai Li,Tze-Yi. Chen-Yuan. Lin, and Meng-Tse Wu

Response of extranodal NK/T-cell lymphoma, nasal type, to interferon-a, corticosteroid, and narrowband ultraviolet B phototherapy.

Clinical and Experimental Dermatology 2009 Dec;34(8):e927-30.

(IF= 3.470; R/C= 25/68 =36.76%; dERMATology)

Wen-I Lee, MD, Shih-Hsiang Chen, Iou-Jih Hung, Chao-Ping Yang, Tang-Her Jaing, Chih-Jung Chen, Hsin-Pai Li, and Jing-Long Huang

Clinical Aspects, Immunologic Assessment, and Genetic Analysis in Taiwanese Children With Hemophagocytic Lymphohistiocytosis

Pediatric Infectious Disease Journal 2009 January; 28 (1):30-34

(IF=2.129; R/C= 69/129=53.49%; PEDIATRICS) ISSN 0891-3668

Ka-Po Tse, Nang-Ming Tsang, Kung-Den Chen, Hsin-Pai Li*, Ying Liang, Chuen Hsueh, Kai-Ping Chang, Jau-Song Yu, Sheng-Po Hao, Ling-Ling Hsieh, and Yu-Sun Chang

MCP-1 Promoter Polymorphism at -2518 is Associated with Metastasis of Nasopharyngeal Carcinoma after Treatment.

Clinical Cancer Research 2007; 13:6320-6326.

(IF= 12.531; R/C= 18/242 =7.44%; ONCOLOGY)

Chia-Lung Tsai†, Hsin-Pai Li†, Chuen Hsueh, Ying Liang, Chi-Long Chen, Sai Wah Tsao, Ka-Po Tse, Yen-Jung Lu, Jau-Song Yu and Yu-Sun Chang († Co-first author)

Activation of DNA methyltransferase 1 by Epstein-Barr Virus LMP1 involves JNK signaling.

Cancer Research 2006; 66:11668-11674.

(IF= 12.701; R/C= 17/242 =7.02%; ONCology) 2006 Dec

Lee YN, Chen LK, Ma HC, Yang HH, Li HP*, Lo SY

Thermal aggregation of SARS-CoV membrane protein

J Virological Methods 2005 Jul; 129:152-161

(IF= 2.014; R/C= 59/77 =76.62%; BIOCHEMICAL RESEARCH METHODS)

Li HP, Leu YW, Chang YS.

Epigenetic changes in virus-associated human cancers

Cell Research 2005 Apr; 15(4):262-271

https://www.nature.com/articles/7290295

(IF= 25.617; R/C= 8/195 =4.1%; cELL BIology)

Li HP, Chang YS.
Epstein-Barr virus latent membrane protein 1: structure and functions.

J Biomed Sci 2003 Sep-Oct; 10:490–504

(IF= 8.410; R/C=15/140 =10.71%; MEDICINE, RESEARCH & EXPERIMENTAL)

Yu JS, Tsai HC, Wu CC, Weng LP, Li HP, Chung PJ, Chang YS.
Induction of inducible nitric oxide synthase by Epstein-Barr virus B95-8-derived LMP1 inBalb/3T3 cells promotes stress-induced cell death and impairs LMP1-mediated transformation.

Oncogene, 2002 Nov 14;21(52):8047-61

https://www.nature.com/articles/1205990

(IF= 9.867; R/C= 12/175 =6.86%; GENETICS & HEREDITY)

Shi ST, Huang P, Li HP, Lai MM.
Heterogeneous nuclear ribonucleoprotein A1 regulates RNA synthesis of a cytoplasmic virus.

EMBO J 2000 Sep 1;19(17):4701-11

http://emboj.embopress.org/content/19/17/4701.long

(IF= 11.598; R/C= 22/298 =7.38%; BIOCHEMISTRY & MOLECULAR BIOLOGY)

Zhang X, Li HP, Xue W, Lai MM.
Formation of a ribonucleoprotein complex of mouse hepatitis virus involving heterogeneous nuclear ribonucleoprotein A1 and transcription-regulatory elements of viral RNA.

Virology 1999 Nov 10;264(1):115-24

https://www.sciencedirect.com/science/article/pii/S0042682299999701?via%3Dihub

(IF= 3.616; R/C= 19/36 =52.78%; VIROLOGY)

Li HP, Huang P, Park S, Lai MM.
Polypyrimidine tract-binding protein binds to the leader RNA of mouse hepatitis virus and serves as a regulator of viral transcription.

J Virol 1999 Jan;73(1):772-7

https://jvi.asm.org/content/73/1/772.long

(IF= 5.103; R/C= 9/36 =25%; VIROLOGY)

Zhang X, Li HP, Xue W, Lai MM.
Cellular protein hnRNP-A1 interacts with the 3'-end and the intergenic sequence of mouse hepatitis virus negative-strand RNA to form a ribonucleoprotein complex.

Adv Exp Med Biol 1998;440:227-34

https://link.springer.com/chapter/10.1007/978-1-4615-5331-1_28

(IF= 0.663; R/C= 41/93 =44.09% ; BIOLOGY)

Kraeft SK, Chen DS, Li HP, Chen LB, Lai MM.
Mouse hepatitis virus infection induces an early, transient calcium influx in mouse astrocytoma cells.

Exp Cell Res 1997 Nov 25;237(1):55-62 

https://www.sciencedirect.com/science/article/pii/S001448279793768X?via%3Dihub

(IF= 3.905; R/C= 116/244 =55.37%; ONCOLOGY)

Li HP, Zhang X, Duncan R, Comai L, Lai MM.
Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA.

Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9544-9

http://www.pnas.org/content/94/18/9544.long

(IF=11.205; R/C= 8/73 =10.96%; MULTIDISCIPLINARY SCIENCES)

Chen DS, Asanaka M, Yokomori K, Wang F, Hwang SB, Li HP, Lai MM.

A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus.

Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12095-9  

http://www.pnas.org/content/92/26/12095.long

(IF=11.205; R/C= 8/73 =10.96%; MULTIDISCIPLINARY SCIENCES)

Lai MY, Chang HC, Li HP, Ku CK, Chen P J, Sheu J C, Huang G T, Lee PH, Chen DC.

Splicing mutations of the p53 gene in human hepatocellular carcinoma.

Can Res 1993 Apr 1;53(7): 1653-6

http://cancerres.aacrjournals.org/content/53/7/1653.long

(IF= 12.701; R/C= 17/242 =7.02%; ONCology)