生物醫學研究所

個人網頁

• https://reurl.cc/bVMZDv

研究方向及研究室特色

研究題目: Drug discovery against RNA viruses 

研究方向:

1.我們實驗室從事抗病毒中藥與小分子藥物的開發，希望從臨床中藥複方或單味中藥，來開發與篩選具抗流行性感冒病毒、新冠病毒與腸病毒的抑制藥物，並研究其機轉，以因應可能爆發之疫情。

2. 利用定量蛋白質體學技術/高通量次世代定序，鑑定藥物之靶標蛋白質，透過miRNA/lncRNA表現差異，誘發訊號傳遞，了解宿主-病毒的相互調控，並研究其相關的抗病毒機制。

最近五年所發表論文

1. Parthiena M Keddis, Tuong-Khanh My Tu, Hugo Scherer, Andreas M Kany, Donia E Hafez, Sarah S Darwish, Ashraf H Abadi, Anna K H Hirsch, Matthias Engel, Mostafa M Hamed, Jim-Tong Horng*, Mohammad Abdel-Halim* (2025, Apr). From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds. European Journal of Medicinal Chemistry, 287:117348. (SCI, 8/72). 
2. Tang W-F, Chang Y-H, Lin C-C, Jheng J-R, Hsieh C-F, Chin Y-F, Chang T-Y, Lee J-C, Liang P-H, Lin C-Y, Lin G-H, Cai J-Y, Chen Y-L,…. Horng J-T* (2024, Apr). BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir. Antimicrobial Agents and Chemotherapy, 68(4):e0095623. 
3. Wen-Fang Tang, Anh-Tu Tran, Ling-Yu Wang, Jim-Tong Horng* (2023, Apr). SARS-CoV-2 pandemics: An update of CRISPR in diagnosis and host-virus interaction studies. Biomedical Journal, 46(2):100587. 本人為通訊作者.
4. Chung-Fan Hsieh, Yu-Li Chen, Guan-Hua Lin, Yoke Fun Chan, Pei-Wen Hsieh, Jim-Tong Horng (2022, Apr). 3,4-Dicaffeoylquinic Acid from the Medicinal Plant Ilex kaushue Disrupts the Interaction Between the Five-Fold Axis of Enterovirus A-71 and the Heparan Sulfate Receptor. Journal of Virology, 96(7):e0054221.本人為通訊作者.
5. Chung-Fan Hsieh, Jia-Rong Jheng, Guan-Hua Lin, Yu-Li Chen, Jin-Yuan Ho, Chien-Jou Liu, Kuei-Yang Hsu, Yuan-Siao Chen, Yoke Fun Chan, Hui-Ming Yu, Pei-Wen Hsieh, Jyh-Haur Chern, Jim-Tong Horng* (2020, Dec). Rosmarinic Acid Exhibits Broad Anti-Enterovirus A71 Activity by Inhibiting the Interaction between the Five-Fold Axis of Capsid VP1 and Cognate Sulfated Receptors. Emerging Microbes & Infections, 9:1194-1205.本人為通訊作者.