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醫學影像暨放射科學系

醫學影像暨放射科學系
 
Mei-Ping Kung, PhD.
 

Associate Professor, The University of Pennsylvania

Born in Taipei, Taiwan in 1949, earned Ph.D. in 1982 and Master
Degree in 1975 in Biochemical Pharmacology from State University of New York at Buffalo, NY, USA; Bachelor Degree in 1972 in Agricultural Chemistry from National Taiwan University.
 

E-mail :  kungmp@gmail.com

Office Address:      Department of Radiology

                                 1 Donner, Philadelphia, PA 19104

                                 Tel.: (215) 662-3021

 

Education:

         1968-1972       B.S.     National Taiwan University, Agricultural Chemistry

         1973-1975       M.S.    State University of New York at Buffalo, Biochemical Pharmacology

         1978-1982       Ph.D.   State University of New York at Buffalo, Biochemical Pharmacology

 

Postgraduate Training:

         1975-1977       Research Associate, Department of Biochemical Pharmacology, State University of         New York at Buffalo

         1977-1978       Senior Research Assistant, Department of Pediatrics, Children's Hospital,

                                 State University of New York at Buffalo

         1978-1982       Research Assistant, Department of Biochemical Pharmacology, State University of         New York at Buffalo (part time)

         1984-1985       Postdoctoral Pharmacologist, Department of Nuclear Medicine, State University of         New York at Buffalo

         1987-1988       Senior Research Scientist, Department of Radiology, University of Pennsylvania

         1988-1989       Research Associate, Department of Psychiatry, University of Pennsylvania

 

Faculty Appointments:

1985-1987       Research Assistant Professor, Department of Pharmacology and Therapeutics, SUNY Buffalo

1989-1993       Research Assistant Professor of Pharmacology, Department of Psychiatry, University of Pennsylvania

1993-1995       Research Assistant Professor of Biochemical Pharmacology, Department of Radiology, University of Pennsylvania

1995-2009       Research Associate Professor of Biochemical Pharmacology, Department of Radiology, University of Pennsylvania

2007-2008       Adjunct Professor, Department of Radiopharmaceutical Science, Beijing Normal University, Beijing, China.

         2007-present   Adjunct Professor, Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.

         2009-present   Adjunct faculty, Department of Radiology, University of Pennsylvania

         2009-present   Adjunct Professor, Department of Biomedical Engineering and Environment                    Science, National Tsing Hua University, Taiwan.

        

 

Memberships in Professional and Scientific Societies:

         Society of Neuroscience

 

Awards:

         Springer Award by European Journal of Nuclear Medicine—Best Basic Paper Science in 1997

         Society of Nuclear Medicine-Best animal picture of the year, 2007

 

Bibliography

Original papers

  1. Ho YK, Kung MP, Bardos TJ. Oligonucleotides containing modified bases. I. Inhibition of DNA and RNA polymerases by partially thiolated oligocytidylic acids. Biochem Biophys Res Commun 73:903-910, 1976.
  2. Kung MP, Ho YK, Bardos TJ. Action of partially thiolated poly-nucleotides on the DNA polymerase-alpha from regenerating rat liver. Cancer Res 36:4537-4542, 1976.
  3. Rattazzi MC, McCullough RA, Downing CJ, Kung MP. Toward enzyme therapy in Gm2 ganglionsidosis: b-hexosaminidase infusion in normal cats. Pediat Res 13:916-923, 1979.
  4. Kung MP, Ho YK, Bardos TJ. 5-mercaptopolyuridylic acid (MPU), a potent inhibitor of the reverse transcriptase from avian myeloblastosis virus. Res Commun Chem Pathol Pharmacol 36:215-228, 1982.
  5. Kung MP, Ho YK, Lalka D, Bardos TJ. Pharmacokinetics and metabolism of partially thiolated polycytidylic acid (MPC) in rodents. Cancer Res 44:4602-4604, 1984.
  6. Kung MP, Kostyniak P, Olson JR, Malone MA, Roth JA. Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes. J Appl Toxicol 7:119-121, 1987.
  7. Kung MP, Roth JA. Cellular localization of soluble and membrane-bound forms of arylsulfatase in rat brain. Brain Res 419:141-146, 1987.
  8. Kung HF, Kasliwal R, Pan S, Kung MP, Mach RH, Guo YZ. Dopamine D2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling and in vitro binding of R-(+) and S-(-)3-iodo-2-hydroxy-6-methoxy- N-[(1-ethyl)-2-pyrrolidinyl)methyl] benzamide (IBZM). J Med Chem 31:1039-1043, 1988.
  9. Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fundam Appl Toxicol 11:519-527, 1988.
  10. Kung MP, Spaulding SW, Roth JA. Desulfation of 3,5,3'-triiodo-thyronine sulfate by microsomal sulfatase from human and rat tissues. Endocrinology 122:1195-1200, 1988.
  11. Billings JJ, Kung MP, Chumpradit S, Pan S, Kung HF. [125I]FISCH: a new CNS D1 dopamine receptor imaging ligand. Life Sci 45:711-718, 1989.
  12. Chumpradit S, Kung HF, Billings JJ, Kung MP, Pan S. [125I]FISCH, (±)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-(4'-[125I] iodophenyl)-1H-3-benzazepine-7-ol: a potential CNS D1 dopamine receptor imaging agent. J Med Chem 32:1431-1435, 1989.
  13. Kung HF, Pan S, Kung MP, Billings JJ, Kasliwal R, Reilley J, Alavi A. In vitro and in vivo evaluation of [123I]IBZM: a potential CNS D2 dopamine receptor imaging agent. J Nucl Med 30:88-92, 1989.
  14. Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth JA. Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to methylmercury. Neurotoxicology 10:41-52, 1989.
  15. Kung MP, Kung HF. Peracetic acid as a superior oxidant for preparation of [123I]IBZM: a potential dopamine D2 receptor imaging agent. J Lab Compds Radiopharm 27:691-700, 1989.
  16. Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Roth JA. Effect of chronic exposure to hexachlorophene on rat brain cell specific marker enzymes. Neurotoxicology 10:201-210, 1989.
  17. Schonwetter BS, Luedtke RR, Kung MP, Billings JJ, Kung HF, Molinoff PB. Characterization of membrane-bound and soluble D2 receptors in canine caudate using [125I]IBZM. J Pharmacol Exp Ther 250:110-116, 1989.
  18. Kung HF, Alavi A, Chang W, Kung MP, Velchik M, Keyes JW Jr, Billings JJ, Pan S, Noto R, Rausch A, Reilley J. In vivo SPECT imaging of D2 dopamine receptors: initial studies with [123I]IBZM in humans. J Nucl Med 31:573-579, 1990.
  19. Kung HF, Liu BL, Mankoff D, Kung MP, Billings JJ, Francesconi LC, Alavi A. A new myocardial imaging agent: synthesis, characterization and biodistribution of [68Ga]BAT-TECH. J Nucl Med 31:1635-1640, 1990.
  20. Kung HF, Ohmomo Y, Kung MP. Current and future radiopharmaceuticals for brain imaging with single photon emission computed tomography. Sem Nucl Med 10:290-302, 1990.
  21. Kung MP, Kung HF, Billings JJ, Yang Y, Murphy RA, Alavi A. The characterization of IBF as a new selective dopamine D2 receptor imaging agent. J Nucl Med 31:648-654, 1990.
  22. Murphy RA, Kung HF, Kung MP, Billings JJ. Synthesis and characterization of iodobenzamide analogs: potential D2 dopamine receptor imaging agents. J Med Chem 33:171-178, 1990.
  23. Chumpradit S, Kung MP, Billings JJ, Kung HF. Synthesis and resolution of (+)7-chloro-8-hydroxy-1-(3’-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzapine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor. J Med Chem 34:877-883, 1991.
  24. John CS, Kung MP, Billings JJ, Kung HF. Preparation, radiolabeling and biodistribution of a new class of bisaminothiol (BAT) ligands as possible imaging agents. Int J Nucl Med Biol 18:551-556, 1991.
  25. Kung MP, Liu BL, Yang YY, Billings JJ, Kung HF. A kit formulation for the preparation of [123I]IBZM: a new CNS D2 dopamine receptor imaging agent. J Nucl Med 32:339-342, 1991.
  26. McPherson DW, Lisic E, Knapp FF Jr, Ambrose KR, Lambert CR, Kung MP, Kung HF. Synthesis and evaluation of two radioiodinated iodoalkenyl-substituted spiroperidol analogues. Nucl Compact 22:92-98, 1991.
  27. Billings JJ, Kung MP, Chumpradit S, Mozley PD, Alavi A, Kung HF. Characterization of radioiodinated TISCH: a high affinity and selective ligand for mapping CNS D1 dopamine receptor. J Neurochem 58:227-236, 1992.
  28. Chumpradit S, Kung MP, Panyachotipun C, Prapansiri V, Foulon C, Brooks BP, Szabo SA, Tejani-Butt S, Frazer A, Kung HF. Iodinated tomoxetine derivatives as selective ligands for serotonin and norepinephrine uptake sites. J Med Chem 35:4492-4497, 1992.
  29. Kung MP, Chumpradit S, Billings JJ, Kung HF. 4-Iodotomoxetine: a novel ligand for serotonin uptake sites. Life Sci 51:95-106, 1992.
  30. Ohmomo Y, Francesconi LC, Kung MP, Kung HF. New conformationally restricted Tc-99m N2S2 complexes as myocardial perfusion imaging agents. J Med Chem 35:157-162, 1992.
  31. Spaulding SW, Smith TJ, Hinkle PM, Davis FB, Kung MP, Roth JA. Studies on the biological activity of triiodothyronine sulfate. J Clin Endo Metab 74:1062-1067, 1992.
  32. Billings JJ, Guo YZ, Kung MP, Kung HF. Localization of IBF as a D2 dopamine receptor imaging agent in nonhuman primates. Eur J Nucl Med 20(12):1146-1153, 1993.
  33. Canney DJ, Guo YZ, Kung MP, Kung HF. Synthesis and preliminary evaluation of an iodovinyl-tetrabenazine analog as a marker for the vesicular monoamine transporter. J Lab Compds Radiopharm 33:355-368, 1993.
  34. Chumpradit S, Kung MP, Billings JJ, Mach R, Kung HF. Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem 36:221-228, 1993.
  35. Foulon C, Kung MP, Kung HF. Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-(-3'-iodo-2'-propenyl)-N-n-propyl]aminotetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand. J Med Chem 36:1499-1500, 1993.
  36. Guo YZ, Kung MP, Cheng HJ, Pfeiffer N, Mozley PD, Kung HF. A simplified method for quantitation of [123I]IBZM in human plasma: a technical note. Eur J Nucl Med 20:373-378, 1993.
  37. Kung MP, Kung HF, Chumpradit S, Foulon C. In vitro binding of a novel dopamine D3 receptor ligand:[125I]trans-7-OH-PIPAT-A. Eur J Pharmacol 235:165-166, 1993.
  38. Zhuang ZP, Kung MP, Kung HF. Synthesis of (R,S)trans-8-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl) aminotetralin (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. J Med Chem 36:3161-3165, 1993.
  39. Burris KD, Filtz TM, Chumpradit S, Kung MP, Foulon C, Hensler JG, Kung HF, Molinoff PB. Characterization of [125I]trans-7-hydroxy-2-[N-propyl-N-(3’-iodo-2’-propenyl)amino]tetralin binding to dopamine D3 receptors in rat olfactory tubercle. J Pharmacol Exp Ther 268(2):935-942, 1994.
  40. Chumpradit S, Kung MP, Kung HF. Synthesis and optical resolution of (R) and (S)trans-7-hydroxy-2-[N-n-propyl[N[3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand. J Med Chem 36:4308-4312, 1994.
  41. Chumpradit S, Kung MP, Vessotskie JM, Mu M, Kung HF. Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. J Med Chem 37:4245-4250, 1994.
  42. Francesconi LC, Yang YY, Kung MP, Zhang XX, Billings JJ, Guo YZ, Kung HF. Technetium-99m N,N'-bis(2-mercapto-2-methylpropyl)-2-aminobenzylamine: technetium-99m complexes of a novel bis(aminoethanethiol) ligand. J Med Chem 37:3282-3288, 1994.
  43. Garner SE, Kung MP, Foulon C, Chumpradit S, Kung HF. [125I](S)trans-7-OH-PIPAT: a potential SPECT imaging agent for sigma binding sites. Life Sci 54:593-603, 1994.
  44. Goodman MM, Kung MP, Kabalka GW, Kung HF, Switzer R. Synthesis and characterization of radioiodinated N-(3-iodopropen-2-yl)-2ß-carbomethoxy-3ß-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents. J Med Chem 37:1535-1542, 1994.
  45. Kung HF, Kung MP, Clarke W, Maayani S, Zhuang ZP. A potential 5-HT1A receptor antagonist: p-MPPI. Life Sci 55(19):1459-1462, 1994.
  46. Kung MP, Canney DJ, Frederick D, Zhuang Z, Billings JJ, Kung HF. Binding of [125I]iodovinyltetrabenazine ([125I]TBZ) to CNS vesicular monoamine transport sites. Synapse 18:225-232, 1994.
  47. Kung MP, Chumpradit S, Frederick D, Garner SE, Burris KD, Molinoff PB, Kung HF. Characterization of binding sites for [125I]R(+)trans-7-OH-PIPAT in rat brain. Arch Pharmacol 350:611-617, 1994.
  48. Kung MP, Zhuang ZP, Frederick D, Kung HF. In vivo binding of [123I]4-(2’-methoxy-phenyl)-1-[2’-(n-2”-pyridinyl)-p-iodobenzamido-]ethyl-piperazine, p-MPPI, to 5-HT1A receptors in rat brain. Synapse 18:359-366, 1994.
  49. Zhuang ZP, Kung MP, Chumpradit S, Mu M, Kung HF. Derivatives of 4-(2’-methoxy-)phenyl-1-[2’-(N-2”-pyridinyl-)-p-iodobenzamido-]ethyl-piperazine (p-MPPI) as 5-HT1A ligands. J Med Chem 37:4572-4575, 1994.
  50. Zhuang ZP, Kung MP, Kung HF. Synthesis and evaluation of 4-(2’-methoxy)phenyl-1-[2’-(N-2”-pyridinyl-)-p-iodobenzamido-]ethyl-piperazine (p-MPPI): a new iodinated 5-HT1A ligand. J Med Chem 37:1406-1407, 1994.
  51. Burris KD, Pacheco MA, Filtz TM, Kung MP, Kung HF, Molinoff PB. Lack of discrimination by agonists for D2 and D3 dopamine receptors. Neuropsychopharmacology 12(4):335-345, 1995.
  52. Canney DJ, Kung MP, Kung HF. Amino- and amido-tetrabenazine derivatives: synthesis and evaluation as potential ligands for the vesicular monoamine transporter. Nucl Med Biol 22:527-535, 1995.
  53. Chumpradit S, Kung MP, Vessotskie JM, Kung HF. Synthesis, resolution and radioiodination of S(-)trans-5-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (S(-)trans-5-OH-PIPAT): a new dopamine D2-like receptor ligand. J Lab Compds Radiopharm 36:1051-1062, 1995.
  54. Kung MP, Essman WD, Frederick D, Meegalla S, Goodman M, Mu M, Lucki I and Kung HF. IPT: a novel iodinated ligand for the CNS dopamine transporter. Synapse 20:316-324, 1995.
  55. Kung MP, Frederick D, Mu M, Zhuang ZP, Kung HF. [125I]p-MPPI (4-(2'-methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido-]ethyl-piperazine) as a new selective imaging radioligand of 5-HT1A sites in rat brain. In vitro binding and autoradiographic studies. J Pharmacol Exp Ther 272:429-437, 1995.
  56. Malison RT, Vessotskie JM, Kung MP, McElgin WT, Romaniello G, Kim HJ, Goodman MM, Kung HF. Striatal dopamine transporter imaging in non-human primates with iodine-123-IPT SPECT. J Nucl Med 36:2290-2297, 1995.
  57. Meegalla SK Plössl K, Kung MP, Stevenson DA, Liable-Sands LM, Rheingold AL, Kung HF. First example of a Tc-99m complex as a dopamine transporter imaging agent. J Am Chem Soc 117:11037-11038, 1995.
  58. Mozley PD, Stubbs JB, Kim HJ, McElgin W, Chumpradit S, Kung MP, Romaniello G, Kung HF. Dosimetry of a D2/D3 dopamine receptor antagonist that can be used with PET or SPECT. J Nucl Med 36:1322-1331, 1995.
  59. Oya S, Kung MP, Frederick D, Kung HF. New bisaminoethanethiol(BAT) ligands which form two interconvertible Tc-99m complexes. Nucl Med Biol 22:749-757, 1995.
  60. Vessotskie JM, Kung MP, Chumpradit S, Romaniello G, McElgin W, Frederick D, Malison RT, Kung HF. In vitro and in vivo characterization of R(+)FIDA2: a novel dopamine D2/D3 imaging agent. J Nucl Med 36:1282-1288, 1995.
  61. Zhuang ZP, Kung MP, Clarke W, Maayani S, Mu M, Kung HF. Synthesis of R(+)- and S(-)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (trans-8-OH-PIPAT): new 5-HT1A receptor ligands. Chirality 7:452-458, 1995.
  62. Kung HF, Frederick D, Kim HJ, McElgin WT, Kung MP, Mu M, Mozley PD, Vessotskie JM, Stevenson DA, Kushner SA, Zhuang ZP. In vivo SPECT imaging of 5-HT1A receptors with [123I]p‑MPPI in nonhuman primates. Synapse 24:273-281, 1996.
  63. Kung HF, Kim HJ, Kung MP, Meegalla SK, Plössl K, Lee HY. Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med 23(11):1527-1530, 1996.
  64. Kung HF, Stevenson DA, Zhuang ZP, Kung MP, Frederick D, Hurt SD. New 5-HT1A receptor antagonist: [3H]p-MPPF. Synapse 23:344-346, 1996.
  65. Kung MP, Mu M, Zhuang ZP, Kung HF. NCS-MPP (4-(2'-methoxy-phenyl)-1-[2'-(N-2''-pyridyl)-p-isothiocyanobenzamido]-ethyl-piperazine): a high affinity and irreversible 5-HT1A receptor ligand. Life Sci 58:177-186, 1996.
  66. Mach RH, Nader MA, Ehrenkaufer RLE, Line SW, Smith CR, Luedtke RR, Kung MP, Kung HF, Lyons D, Merton TE. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: in vitro binding studies and positron emission tomography. Synapse 24:322-333, 1996.
  67. Meegalla SK, Plössl K, Kung MP, Stevenson DA, Frederick D, Kung HF. Tc-99m labeled tropanes as dopamine transporter imaging agents. Bioconj Chem 7:421-429, 1996.
  68. Mozley PD, Stubbs JB, Kim HJ, McElgin WT, Kung MP, Meegalla SK, Kung HF. Dosimetry of an iodine-123-labeled tropane to image dopamine transporters. J Nucl Med 37:151-159, 1996.
  69. Mozley PD, Kim HJ, Gur RC, Tatsch K, Muenz LR, McElgin WT, Kung MP, Mu M, Myers AM, Kung HF. Iodine-123-IPT SPECT imaging of CNS dopamine transporters: nonlinear effects of normal aging on striatal uptake values. J Nucl Med 37:1965-1970, 1996.
  70. Oya S, Kung MP, Frederick D, Kung HF. Novel TcVO(III) N2S2 complexes: interconversion by redox reaction. Nucl Med Biol 23:589-593, 1996.
  71. Allen AR, Singh A, Zhuang ZP, Kung MP, Kung HF, Lucki I. The 5-HT1A receptor antagonist p‑MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors. Pharmacol Biochem Behav 57:301-307, 1997.
  72. Kung MP, Stevenson DA, Plössl K, Meegalla SK, Beckwith A, Essman WD, Mu M, Lucki I, Kung HF. [99mTc]TRODAT‑1: a novel technetium-99m complex as a dopamine transporter imaging agent. Eur J Nucl Med 24:372-380, 1997.
  73. Kung MP, Stevenson DA, Zhuang ZP, Vessotskie JM, Chumpradit S, Sun XM, Kung HF. Characterization of a novel iodinated ligand, IPMPP, for human dopamine D4 receptors in CHO cells. Life Sci 60:91-100, 1997.
  74. Meegalla SK, Plössl K, Kung MP, Chumpradit S, Stevenson DA, Kushner SA, McElgin WT, Mozley PD, Kung HF. Synthesis and characterization of Tc‑99m labeled tropanes as dopamine transporter imaging agents. J Med Chem 40:9-17, 1997.
  75. Shiue CY, Shiue GG, Mozley PD, Kung MP, Zhuang ZP, Kim HJ, Kung HF. p-[18F]MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans. Synapse 25:147-154, 1997.
  76. Staley JK, Talbot JZ, Ciliax BJ, Miller GW, Levey AI, Kung MP, Kung HF, Mash DC. Radioligand binding and immunoautoradiographic evidence for a lack of toxicity to dopaminergic nerve-terminals in human cocaine overdose victims. Brain Res 747:219-229, 1997.
  77. Vessotskie JM, Kung MP, Chumpradit S, Kung HF. Characterization of [125I]S(-)5-OH-PIPAT binding to dopamine D2-like receptors expressed in cell lines. Neuropharmacol 36:999-1007, 1997.
  78. Vessotskie JM, Kung MP, Chumpradit S, Kung HF. Quantitative autoradiographic studies of dopamine D3 receptors in rat cerebellum using [125I]S(-)5-OH-PIPAT. Brain Res 778:89-98, 1997.
  79. Efange SMN, Kamath AP, Khare AB, Kung MP, Mach RH, Parsons SM. N-Hydroxyalkyl derivatives of 3b-phenyltropane and 1-methylspiro[1H-indoline-3,4’-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem 40:3905-3914, 1997.
  80. Goodman MM, Keil R, Shoup TM, Eshima D, Eshima L, Kilts CI, Votaw J, Camp VM, Votaw D, Smith E, Kung MP, E. M, Watts R, Huerkamp M, Wu D, Garcia E, Hoffman JM. Fluorine-18-FPCT: A PET radiotracer for imaging dopamine transporters. J Nucl Med 38:119-126, 1997.
  81. Dresel SHJ, Kung MP, Plössl K, Meegalla SK, Kung HF. Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporter in rats. Eur J Nucl Med 25:31-39, 1998.
  82. Zhuang ZP, Kung MP, Mu M, Kung HF. Isoindolin-1-one analogs of 4-(2’-methoxy-) phenyl-1-[2’-(N-2”-pyridyl-)p-iodobenzamido-]ethylpiperazine (p-MPPI) as 5-HT1A receptor ligands. J Med Chem 41:157-166, 1998.
  83. Meegalla SK, Plössl K, Kung MP, Stevenson DA, Mu M, Kushner S, Liable-Sands LM, Rheingold AL, Kung HF. Specificity of diastereomers of [99mTc]TRODAT-1 as dopamine transporter imaging agents. J Med Chem 41:428-436, 1998.
  84. Oya S, Plössl K, Kung MP, Stevenson DA, Kung HF. Small and neutral TcO(V) BAT, bisaminoethanethiol (N2S2) complexes for developing new brain imaging agents. Nucl Med Biol 25:135-140, 1998.
  85. Kushner SA, McElgin WT, Kung MP, Mozley PD Plössl K, Meegalla SK, Mu M, Dresel SHJ, Vessotskie JM, Lexow N, Kung HF. Kinetic modeling of [99mTc]TRODAT-1: A novel compound for imaging the dopamine transporter.  J Nucl Med 40:150-158, 1998.
  86. Dresel SHJ, Kung MP, Huang XF, Plössl K, Hou C, Meegalla SK, Patselas G, Mu M, Saffer JR, Kung HF. Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. J Nucl Med 40:660-666, 1999.
  87. Zhuang ZP, Plössl K, Kung MP, Mu M, Kung HF. Neutral and stereospecific Tc-99m complexes: [99mTc]N-benzyl-3,4-Di-(N-2-mercaptoethyl)-amino-pyrrolidines. Nucl Med Biol 26:217-224, 1999.
  88. Oya S, Kung MP, Acton PD, Hou C, Mu M, Kung HF. A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM: 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alchohol. J Med Chem 42:333-335, 1999.
  89. Zhuang ZP, Kung MP, Mu M, Kung HF.99mTc-labeled MIBG derivatives: novel 99mTc complexes as myocardial imaging agents for sympathetic neurons. Bioconj Chem  10:159-168, 1999.
  90. Dresel SHJ, Kung MP, Huang XF, Plössl K, Hou C, Shiue CY, Karp J, Kung HF. In vivo imaging of serotonin transporters with [Tc-99m]TRODAT-1 in non-human primates. Eur J Nucl Med 26:342-347, 1999.
  91. Acton PD, Kushner SA, Kung MP, Mozley PD, Plössl K, Kung HF. Simplified reference region model for the kinetic analysis of [99mTc]TRODAT-1 binding to dopamine transporters in non-human primates using SPECT. Eur J Nucl Med 26:518-526, 1999.
  92. Choi SR, Kung MP, Plössl K, Meegalla S, Kung HF. An improved kit formulation of [Tc-99m]TRODAT-1: a dopamine transporter imaging agent. Nucl Med Biol 26:461-466, 1999.
  93. Kung MP, Hou C, Oya S, Mu M, Acton PD, Kung HF. Characterization of [123I]IDAM as a novel single photon emission tomography tracer for serotonin transporters. Eur J Nucl Med 26: 844-853, 1999.
  94. Acton PD, Kung MP, Mu M, Plössl K, Hou C, Siciliano M, Oya S, Kung HF. Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [123I]IDAM. Eur J Nucl Med 26:854-861, 1999.
  95. Mu M, Kung MP, Plössl K, Acton PD, Mozley PD, Kung HF. A simplified method to determine  [99mTc]TRODAT-1 in human plasma. Nucl Med Biol 26:821-825, 1999.
  96. Xu Y, Choi SR, Kung MP, Kung HF. Synthesis of radioidoinated 1-deoxy-nojirimycin derivatives: novel glucose analogs. Nucl Med Biol 26:833-839, 1999.
  97. Zhuang ZP, Choi SR, Hou C, Mu M, Kung MP, Acton PD, Kung HF. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol(ODAM) Nucl Med Biol 27:169-175, 2000.
  98. Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM-Y. In vivo detection of amyloid plaques in a mouse model of Alzheimer’s disease. PNAS 97:7609-7614, 2000.
  99. Oya S, Choi SR, Hou C, Mu M, Kung MP, Acton PD, Siciliano M, Kung HF. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 27:249-254, 2000.
  100. Wang Y, Xu R, Sasaoka T, Tonegawa S, Kung MP, Sankoorikal E-B. Dopamine D2 long receptor-deficient mice display alterations in straitum-dependent functions. J Neurosci 20(22):8305-8314, 2000.
  101. Choi SR, Hou C, Oya S, Mu M, Kung MP, Siciliano M, Acton PD, Kung HF. Selective in vitro and in vivo binding of [125I]ADAM to serotonin transporters in rat brain. Synapse 38:403-412, 2000.
  102. Kung HF, Wey S-P, Kung MP. SPECT imaging agents for dopamine and serotonin transporters in the brain. Ann Nucl Med Sci 13:165-174, 2000.
  103. Stanwood GD, Artymyshyn RP, Kung MP, Kung HF, Lucki I, McGonigle P. Quantitative autoradiographic mapping of rat brain dopamine D3 binding with. J Pharmacol Exp Ther 295(3):1223-1231, 2000.
  104. Zhuang ZP, Kung MP, Hou C, Skovronsky D, Gur TL, Plössl K, Trojanowski JQ, Lee VM-Y, Kung HF. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem 44:1904-1915,2001.
  105. Lee C-W.; Zhuang, Z.-P.; Kung MP; Plössl, K.;  Skovronsky, D.; Gur, T. L.; Hou, C.; Trojanowski, J. Q.; Lee, V. M.; Kung, H. F. Isomerization of (Z, Z) to (E, E)1-bromo-2,5-bis-(3-hydroxy carbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain. J. Med. Chem. 42:2270-2275, 2001.

106.   Schmidt, ML, Schuck T, Sheridan S, Kung MP, Zhuang ZP, Bergeron C, Lamarche JS, Skovronsky D, Giasson BI, Lee VMY and Trojanowski JQ. The fluorescent Congo Red Derivative, (Trans, Trans)-1-Bromo-2,5-Bis-(3-Hydroxycarbony-4-Hydroxy)Styrylbenzene (BSB), labels Diverse b-Pleated Sheet Structures in Postmortem Human Neurodegenerative Disease Brains. Am J. Pathol, 159, 937-943, 2001.

107.   Efange S, Tu Z, von Hohenberg K, Francesconi L, Howell R, Rampersad M, Todaro L, Papke R, Kung MP.  2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)- chromans as Nicotine Agonists: Synthesis and Preliminary Pharmacological Characterization.  J Med Chem 44: 4704-4715, 2001.

108.   Zhuang ZP, Kung MP, Hou C, Plössl K, Skovronsky D, Gur T, Trojanowski J, Lee, VM-Y, Kung HF. IBOX(2-(4’-dimethyl-aminophenyl)-6-iodobenzoxazole):a ligand for imaging amyloid plaques in the brain. Nucl Med Bio 28: 887-894, 2001

109.   Kung HF, Lee CW, Zhuang ZP, Kung MP, Hou C, Plössl K. Novel stilbenes as probes for amyloid plaques. J Am Chem Soc, 123: 12740-12741, 2001.

110.  Kung MP, Hou C, Zhuang ZP, Zhang B, Skovronsky D, Gur T, Trojanowski J, Lee, VM-Y, Kung HF. IMPY: An improved thioflavin-T derivative for in vivo Labeling of -amyloid plaques. Brain Research, 956:202-210, 2002.

111.   Ono M, Kung MP, Hou C, Kung HF. Benzofuran derivatives as Aß-aggregate-specific imaging agents for Alzheimer’s disease. Nucl Med Biol. 29: 633-642, 2002.

112.   Kung MP, Hou C, Zhuang ZP, Skovronsky D, Zhang B, Gur TL, Trojanowski JQ, Lee VMY, Kung HF. Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer’s disease. J Mol Neurosci 19: 7-10, 2002.

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