2025 國際先進放射醫學論壇 Series 1
2025 國際先進放射醫學論壇 Series 1
我們誠摯邀請您參與本年度第一場國際論壇，本次特別榮幸邀請到來自 美國德州大學西南醫學中心 的 Kang-Hsin Wang 博士，分享他在小動物光學影像與 Flash 放射治療 領域的前沿研究成果。
📅 活動時間：2025 年 6月11日 中午12:10-13:00
📍 活動地點：大教室 (線上演講)
🌐 線上會議網址: https://reurl.cc/Z4vxo6
🗣️ 主題演講：
"Assessing the Flash Effect in Minimizing Radiation-induced Late Toxicity and Advancing Novel Optical Imaging for Cancer Research"
專題演講介紹:
本次專題演講將聚焦於癌症治療領域中兩項具突破性的創新技術，致力推動更安全且高效的放射治療方法，並實現更精準的癌症早期偵測。演講首先介紹最新的超高劑量率放射治療技術（FLASH-RT）。傳統放療在針對復發性脊椎轉移癌進行重複照射時，常因正常組織的毒性反應而受限。FLASH-RT因其潛在顯著降低副作用的特性，備受期待，但其對晚期反應組織的影響仍有待釐清。演講將分享美國德州大學西南醫學中心關於FLASH脊髓照射的前沿研究成果，涵蓋高精度FLASH系統的開發、動物模型中脊髓耐受性的評估，以及探討FLASH對脊髓微血管保護機制的物理化學模型。這些研究成果將助力推動FLASH-RT於臨床上的安全應用，特別是在脊椎轉移癌的治療領域。
接著，演講將介紹本研究室目前積極發展的多項先進高靈敏度光學影像技術，包括三維生物發光斷層掃描、單像素成像及螢光壽命成像。這些技術能夠精準呈現腫瘤的動態變化及其微環境特性，廣泛應用於早期偵測多處轉移癌、輔助放射治療的精準定位，並有效區分腫瘤與正常組織。這些創新工具將促進癌症基礎研究與臨床應用的深度整合，推動跨領域的合作與發展。
Innovations in radiotherapy and imaging are transforming the landscape of cancer treatment and research. In this talk, I will present 2 significant and highly innovative directions aimed at advancing both safer and effective radiation delivery and pre-clinical cancer detection.
Radiation therapy (RT) is often limited by normal tissue toxicity, particularly in re-irradiation for recurrent vertebral metastases. FLASH-RT (ultra-high dose rate) shows promise in reducing toxicity, offering a transformative approach for safer, more effective re-irradiation. However, its effects on late-responding tissues remain unclear, limiting clinical translation. The spinal cord, given its clinical relevance and well-characterized dose-response in conventional dose rate RT (CONV-RT), serves as an ideal model to assess FLASH-RT’s ability to spare late-responding tissues and its efficacy in re-irradiating spinal metastases. We will provide an overview of ongoing FLASH spinal cord studies conducted at UT Southwestern Medical Center, including the development of a high-precision FLASH platform for in vivo spinal cord irradiation, assessment of FLASH-RT’s impact on spinal cord tolerance using a rat model, and establishment of the physicochemical model elucidating mechanisms of FLASH-mediated microvascular protection in spinal cord. By integrating spinal cord toxicity assessment with robust mechanistic approaches, this proposal will generate critical insights to inform the clinical implementation of FLASH-RT, especially for spinal metastases treatment.
In addition, we will also introduce recent developments in ultrasensitive, high-contrast optical imaging technologies, including 3D bioluminescence tomography, single-pixel imaging, and fluorescence lifetime imaging. These optical techniques enable precise, visualization of tumor dynamics and microenvironment changes. Applications include early detection of multi-focal metastases in vivo, guiding preclinical radiation delivery, and distinguishing tumor boundaries from healthy tissue. These tools are designed to enhance translational studies and offer collaboration opportunities for integrative cancer research
