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彭湛傑

彭湛傑 / Jhan-Jie Peng

職稱: 助理研究員

現職: 長庚大學分子及臨床免疫中心助理研究員

信箱: jjpeng@cgu.edu.tw

電話: 2612

學歷: 長庚大學臨床醫學研究所博士

專長領域: 細胞治療 免疫治療

個人網頁: https://pure.lib.cgu.edu.tw/zh/persons/jhan-jie-peng/

學歷

2025   長庚大學臨床醫學研究所博士
2016   國立臺灣大學生化科學研究所碩士
2014   國立臺灣大學生命科學系學士 

經歷

2025   長庚大學分子及臨床免疫中心 博士後研究員
2021 - 2023   瑞士洛桑大學何秉智教授實驗室 訪問學者

榮譽

2025   Best thesis award, 沈水德翁文教基金會

2025   Best thesis award, The 21st Tien Te Lee Biomedical Awards

2021   Excellent performance in oral presentation, General Assembly and Academic Seminar, the Chinese Society of Immunology (CSI)

2019   FIMSA travel grant, The 17th International Congress of Immunology, International Union of Immunological Societies (IUIS)

2019   Excellent performance in oral presentation, General Assembly and Academic Seminar, CSI

2019   Best poster award, Formosa Immunology Spring School (FISS; One of thirty students
    enrolled)

2018   Best poster award, Poster Competition in IBC, Academia Sinica

2016   Best poster award, Poster Competition in Institute of Biochemical Sciences, National Taiwan University

2015   Excellent performance in poster presentation, EMBO conference in Taiwan: neural development.

2015   Excellent poster and oral presentation performance, International Conference on Stem Cells and Developmental Biology Scientific Program.

2014   2nd place in the oral presentation competition, Taiwan Development Biology Retreat

2012   Excellent performance in the oral presentation, NPAS summer internship, Academia Sinica.

研究論文(選錄)

Major publications
1. J. J. Peng, J. Y. Ding, Y. Xu, H. P. Shih, Y. N. Lin, T. Y. Wu, Y. F. Lo, C. C. Lo, C. F. Yeh, C. Y. Kuo, K. H. Tu, S. Y. Wang, W. T. Lei, T. S. Wu, H. S.Lin, C. H. Lee, W. C. Huang, Y. C. Chen, Y. M. Liu, Z. Y. Shi, Y. T. Chang, L. S. Syue, P. L. Chen, S. H. Teh, C. H. Chou, M. W. Ho, C. Y. Chi, P. C. Ho, C. L. Ku. Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ. First author. Sci Immunol 10, eadm8186 (2025)
2. J. J. Peng, L Wang, Z Li, C. L. Ku, P. C. Ho. Metabolic challenges and interventions in CAR T-cell therapy. Co-first author. Sci Immunol 8, eabq3016 (2023).
3. J.J. Peng, S.H. Lin, Y.T. Liu, H.C. Lin, T.N. Li, C.K. Yao 
Circuit-dependent ROS propagation mediates glutamate excitotoxicity to elicit motor system deficits in Drosophila. Co-first author. Elife 8, (2019).
Affiliated publications
1. X. Li, S. H. Moller, J. Park, Y. M. Chuang, P. C. Hsueh, T. H. Chang, K. C. Kao, H. Gallart-Ayala, Y. H. Wang, J. J. Peng, A. Bevilacqua, Y. R. Yu, Z. Li, Y. Kieffer, D. Peigney, H. Croizer, Y. Xu, A. Zippelius, I. C. Lopez-Mejia, L. Fajas, F. Mechta-Grigoriou, J. Ivanisevic, Z. Xiao, M. C. Ho, Y. C. Shen, P. C. Ho. Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages. J Exp Med 222 (2025).
2. W. T. Lei, Y. F. Lo, M. Tsumura, J. Y. Ding, C. C. Lo, Y. N. Lin, C. W. Wang, L. H. Liu, H. P. Shih, J. J. Peng, T. Y. Wu, Y. P. Chan, C. X. Kang, S. Y. Wang, C. Y. Kuo, K. H. Tu, C. F. Yeh, Y. J. Hsieh, T. Asano, W. H. Chung, S. Okada, C. L. Ku. Immunophenotyping and Therapeutic Insights from Chronic Mucocutaneous Candidiasis Cases with STAT1 Gain-of-Function Mutations. J Clin Immunol 44, 184 (2024).
3. Y. F. Lo, S. Y. Wang, Y. H. Wu, M. W. Ho, C. F. Yeh, T. Y. Wu, J. J. Peng, Y. N. Lin, J. Y. Ding, H. P. Shih, C. C. Lo, Y. P. Chan, C. S. Rau, C. Y. Kuo, K. H. Tu, W. T. Lei, Y. C. Chen, C. L. Ku. The Pathogenic Role of Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Nocardiosis with the Central Nervous System Involvement. J Clin Immunol 44, 176 (2024).
4. A. Jaccard, T. Wyss, N. Maldonado-Perez, J. A. Rath, A. Bevilacqua, J. J. Peng, A. Lepez, C. Von Gunten, F. Franco, K. C. Kao, N. Camviel, F. Martin, B. Ghesquiere, D. Migliorini, C. Arber, P. Romero, P. C. Ho, M. Wenes. Reductive carboxylation epigenetically instructs T cell differentiation. Nature 621, 849-856 (2023).
5. F. Franco, A. Bevilacqua, R. M. Wu, K. C. Kao, C. P. Lin, L. Rousseau, F. T. Peng, Y. M. Chuang, J. J. Peng, J. Park, Y. Xu, A. Cassotta, Y. R. Yu, D. E. Speiser, F. Sallusto, P. C. Ho. Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8(+) T cell formation. Sci Immunol 8, eadf7579 (2023).
6. S. Y. Wang, Y. F. Lo, H. P. Shih, M. W. Ho, C. F. Yeh, J. J. Peng, H. T. Ting, K. H. Lin, W. C. Huang, Y. C. Chen, Y. H. Chiu, C. W. Hsu, Y. T. Tseng, L. S. Wang, W. Y. Lei, C. Y. Lin, Y. Aoh, C. H. Chou, T. Y. Wu, J. Y. Ding, C. C. Lo, Y. N. Lin, K. H. Tu, W. T. Lei, C. Y. Kuo, C. Y. Chi, C. L. Ku. Cryptococcus gattii Infection as the Major Clinical Manifestation in Patients with Autoantibodies Against Granulocyte-Macrophage Colony-Stimulating Factor. J Clin Immunol 42, 1730-1741 (2022).
7. H. P. Shih, J. Y. Ding, J. Sotolongo Bellon, Y. F. Lo, P. H. Chung, H. T. Ting, J. J. Peng, T. Y. Wu, C. H. Lin, C. C. Lo, Y. N. Lin, C. F. Yeh, J. B. Chen, T. S. Wu, Y. M. Liu, C. Y. Kuo, S. Y. Wang, K. H. Tu, C. Y. Ng, W. T. Lei, Y. H. Tsai, J. H. Chen, Y. T. Chuang, J. Y. Huang, F. A. Rey, H. K. Chen, T. W. Chang, J. Piehler, C. Y. Chi, C. L. Ku. Pathogenic autoantibodies to IFN-gamma act through the impedance of receptor assembly and Fc-mediated response. J Exp Med 219, (2022).