天然藥物碩士班

職稱： 專任教授 現職： 中醫學系天然藥物碩士班 / Full-time Professor 信箱： pewehs@mail.cgu.edu.tw 電話： 分機3105 學歷： 高雄醫學大學藥學所博士 專長領域： 藥物化學、天然物化學、微生物天然物 個人網頁： https://pure.lib.cgu.edu.tw/en/persons/pei-wen-hsieh-2 研究室：藥物化學研究室/Medicinal Chemistry Laboratory 研究室成員： 博士班研究生2人、碩士班研究生2人、專任研究助理1人

Tsong-Long Hwang, Pei-Wen Hsieh, Huang-Ping Yu。苯并雜氧嗪酮衍生物，其製備方法以及包含有此等衍生物的藥學組成物。中華民國專利I419884號。 Ching-Ping Tseng，Pei-Wen Hsieh，Yao-Wen Chang，一種含有5-nitrobenzoate之衍生物，透過抑制腫瘤細胞誘發血小板凝集反應作為癌症轉移治療方式。中華民國專利I444358號。 Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang, Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same. US 9,073,833. Pei-Wen Hsieh，Tsong-Long Hwang，Wen-Hui Wang，Ting-Yi Wang，2-胺基苯甲醛肟衍生物及其製備方法與用途。中華民國專利I508938號。 Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang, Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same. JP 5890512。 Pei-Wen Hsieh，Tsong-Long Hwang，Wen-Hui Wang，Ting-Yi Wang，2-胺基苯甲醛肟衍生物及其製備方法與用途。中華人民共和國專利CN104803894號。 Tsong-Long Hwang，Pei-Wen Hsieh，Yin-Ting Huang，Chih-Hao Hung，FPR1拮抗劑的衍生物及其用途。中華民國專利I537251號。 Tsong-Long Hwang, Pei-Wen Hsieh, Yin-Ting Huang, Chih-Hao Hung. FPR1 antagonist derivatives and use thereof. US 9,593,114. 葉宏一、鍾鏡湖、王士維、謝珮文，橙黃醯胺雙肽衍生物用於治療或預防血管新生相關疾病。中華民國專利申請號104143726號（領證中）。 Ching-Ping Tseng, Pei-Wen Hsieh, Yao-Wen Chang. Composition of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation. US 9,604,910. Ching-Ping Tseng, Pei-Wen Hsieh, Yao-Wen Chang. A compostion of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation. US 20170172949. Pei-Wen Hsieh, Ching-Ping Tseng, Yun-Zhan Tsai, Yu-Ling Hung, Yao-Wen Chang. Compounds, compositions and methods for treating tumors. US 20170183294. 葉宏一、鍾鏡湖、王士維、Pei-Wen Hsieh. Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases. USA application no. 14/981178. Ching-Ping Tseng, Pei-Wen Hsieh, Yao-Wen Chang. Composition of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation. US 9,956,191. Pei-Wen Hsieh, Ching-Ping Tseng, Yun-Zhan Tsai, Yu-Ling Hung, Yao-Wen Chang. Compounds, compositions and methods for treating tumors. US 20170183294.

*, corresponding author Amos C. Hung, Chun-Hao Tsai, Ming-Feng Hou, Wen-Lin Chang, Chie-Hong Wang, Yi-Chen Lee, Alice Ko, Stephen Chu-Sung Hu, Fang-Rong Chang, Pei-Wen Hsieh*, Shyng-Shiou F. Yuan*. The synthetic β-nitrostyrene derivative CYT-rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. Cancer Lett. 2016, 371:251-261. (SCI) (I.F.: 6.508; R/C=29/229 in ONCOLOGY) Jin-Yuan Ho, Jyh-Haur Chern, Chung-Fan Hsieh, Szu-Ting Liu, Chien-Jou Liu, Ya-Sian Wang, Ta-Wei Kuo, Sheng-Ju Hsu, Ten-Kuang Yeh, Shin-Ru Shih, Pei-Wen Hsieh, Chen-Hsun Chiu, Jim-Tong Horng. In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71. J. Antimicrob. Chemother. 2016, 71:1922-1932. (SCI) (I.F.: 4.715; R/C=27/267 in PHARMACOLOGY & PHARMACY) Chien-Chong Hong, Chih-Chung Lin, Chian-Lang Hong, Zi-Xiang Lin, Meng-Hua Chung, Pei-Wen Hsieh. Analyzer with On-Chip molecularly-imprinted biosensors for electrical detection of propofol in plasma samples. Biosens. Bioelectron. 2016, 86:623-629. (SCI) (I.F.: 9.518; R/C=1/84 in CHEMISTRY, ANALYTICAL) Yu-Li Chen, Tsong-Long Hwang, Huang-Ping Yu, Jia-You Fang, Kowit Yu Chong, Yao-Wen Chang, Chun-Yu Chen, Hsuan-Wu Yang, Wen-Yi Chang, Pei-Wen Hsieh*. Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep. 2016, 6:34243. (SCI) (I.F.: 4.011; R/C=15/69 in MULTIDISCIPLINARY SCIENCES) Chung-Fan Hsieh, Yu-Li Chen, Chwan-Fwu Lin, Jin-Yuan Ho, Chun-Hsun Huang, Cheng-Hsun Chiu, Pei-Wen Hsieh, Jim-Tong Horng. An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro. Sci. Rep. 2016, 6:36015. (SCI) (I.F.: 4.011; R/C=15/69 in MULTIDISCIPLINARY SCIENCES) Wen-Chin Chiu, Yi-Chen Lee, Yu-Han Su, Yen-Yun Wang, Chun-Hao Tsai, Yi-An Hou, Chie-Hong Wang, Ying-Fong Huang, Chih-Jen Huang, Shah-Hwa Chou, Pei-Wen Hsieh, Shyng-Shiou F. Yuan. The synthetic β-nitrostyrene derivative CYT-Rx20 inhibits esophageal tumor growth and metastasis via PI3K/AKT and STAT3 pathways. PLoS One 2016, 11:e0166453. (SCI) (I.F.: 2.776; R/C=24/69 in MULTIDISCIPLINARY SCIENCES) Chun-Hao Tsai, Pei-Wen Hsieh, Yi-Chen Lee, Chie-Hong Wang, Wen-Chin Chiu, Chun-Wun Lu, Yen-Yun Wang, Stephen Chu-Sung Hu, Tain-Lu Cheng, Shyng-Shiou F. Yuan*. 3'-Hydroxy-4'-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells. Life Sci. 2017, 172:19-26. (SCI) (I.F.: 3.448; R/C= 76/267 in PHARMACOLOGY & PHARMACY) Shun-Chin Yang, Shih-Hsin Chang, Pei-Wen Hsieh, Yin-Ting Huang, Chiu-Ming Ho, Yung-Fong Tsai, Tsong-Long Hwang. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Rad. Bio. Med. 2017, 106:254-269. (SCI). (I.F.: 5.657; R/C=43/298 in BIOCHEMISTRY & MOLECULAR BIOLOGY) Chun-Hao Tsai, Amos C. Hung, Yuan-Yin Chen, Ya-Wen Chiu, Pei-Wen Hsieh, Yi-Chen Lee, Yu-Han Su, Po-Chih Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan*. 3’-Hydroxy-4’-methoxy-β-methyl-β-nitrostyrene inhibits tumor-igenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. Oncotarget 2017, 8:18106-18117. Pei-Wen Hsieh, Chi-Feng Hung, Chih-Hung Lin, Chang-Wei Huang, Jia-You Fang. Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm. 2017, 114:154-163. (SCI) (I.F.: 4.708; R/C=28/267 in PHARMACOLOGY & PHARMACY) Yen-Yun Wang, Yuk-Kwan Chen, Ya-Ling Hsu, Wen-Chin Chiu, Chun-Hao Tsai, Stephen Chu-Sung Hu, Pei-Wen Hsieh, Shyng-Shiou F. Yuan*. Synthetic β-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Head & Neck 2017, 39:1055-1064. (SCI) (I.F.: 2.442; R/C=10/42 in OTORHINOLARYNGOLOGY) Yen-Yun Wang, Yuk-Kwan Chen, Stephen Chu-Sung Hu, Ya-Ling Hsu, Chun-Hao Tsai, Tsung-Chen Chi, Wan-Ling Huang, Pei-Wen Hsieh, Shyng-Shiou F. Yuan. CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Cancer Chemother. Pharmacol. 2017, 79:1129-1140. (SCI) (I.F.: 3.008; R/C=101/267 in PHARMACOLOGY & PHARMACY) Po-Hsiung Kung, Pei-Wen Hsieh, Ying-Ting Lin, Jia-Hua Lee, I-Hua Chen, Chin-Chung Wu. HPW-RX40 Prevents Human Platelet Activation by Attenuating Cell Surface Protein Disulfide Isomerases. Redo. Biol. 2017, 13:266-277. (SCI) (I.F.: 7.793; R/C=28/298 in BIOCHEMISTRY & MOLECULAR BIOLOGY) Yen-Yun Wang, Pei-Wen Hsieh, Yuk-Kwan Chen, Stephen Chu-Sung Hu, Ya-Ling Hsu, Chun-Hao Tsai, Shyng-Shiou F Yuan. CYT-Rx20 inhibits cervical cancer cell growth and migration through oxidative stress-induced DNA damage, cell apoptosis, and epithelial-to-mesenchymal transition inhibition. Int. J. Gynecol. Cancer 2017, 27:1306-1317. (SCI) (I.F.: 1.764; R/C=52/83 in OBSTETRICS & GYNECOLOGY) Yu-Li Chen, Tsong-Long Hwang, Jia-You Fang, Yu-Hsuan Lan, Kowit Yu Chong, Pei-Wen Hsieh*. Polysaccharides from Kochia scoparia fruits protect mice from lipopolysaccharide-mediated acute lung injury by inhibiting neutrophil elastase. J. Funct. Foods. 2017, 38:582-590. (SCI) (I.F.: 3.197; R/C=33/135 in FOOD SCIENCE & TECHNOLOGY) Yao-Wen Chang, Ching-Ping Tseng, Chih-Hsun Lee, Tsong-Long Hwang, Yu-Li Chen, Mei-Tzu Su, Kowit-Yu Chong, Ying-Wei Lan, Chin-Chung Wu, Kung-Ju Chen, Fen-Hua Lu, Hsiang-Ruei Liao, Chuen Hsueh, Pei-Wen Hsieh*. β-Nitrostyrene derivatives attenuate LPS-mediated acute lung injury via the inhibition of neutrophil-platelet interactions and NET release. Am. J. Physiol. Lung Cell Mol. Physiol. 2018, 314:L654-L669. (SCI) (I.F.: 4.060; R/C=14/81 in PHYSIOLOGY) Bidyadhar Sethy, Chung-Fan Hsieh, Chieh Yeh, Jim-Tong Horng, Pei-Wen Hsieh*. Design, synthesis and structure-activity relationships of a new class of anti-human enterovirus D68 and A71 agents. Future Med. Chem. 2018, 10:1333-1347. (SCI) (I.F.: 3.617; R/C=19/61 in CHEMISTRY, MEDICINAL) 86.   Zih-Chan Lin, Pei-Wen Hsieh, Tsong-Long Hwang, Chi-Yuan Chen, Calvin T. Sung, Jia-You Fang. Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J. 2018, 32:6783-6795. (SCI) (I.F.: 5.391; R/C=8/87 in Biology) Bidyadhar Sethy, Chung-Fan Hsieh, Ta-Jen Lin, Po-Yuan Hu, Yu-Li Chen, Chia-Yi Lin, Sung-Nain Tseng, Jim-Tong Horng*, Pei-Wen Hsieh*. Design, synthesis, and biological evaluation of itaconic acid derivatives as potential anti-influenza agents. J. Med. Chem. 2019, 62:2390-2403. (SCI) (I.F.: 6.054; R/C=3/61 in CHEMISTRY, MEDICINAL) Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi. A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. PLoS One 2019, 14: e0222331. (SCI) (I.F.: 2.776; R/C=24/69 in MULTIDISCIPLINARY SCIENCES) Ching-Ping Tseng, Yu-Ling Huang, Yao-Wen Chang, Hsiang-Ruei Liao, Yu-Li Chen, Pei-Wen Hsieh*. Polysaccharide-containing fraction from Artemisia argyi inhibits tumor cell-induced platelet aggregation by blocking interaction of podoplanin with C-type lectin-like receptor 2. J. Food Drug Anal. 2019, 28:115-123. (SCI) (I.F.: 4.176; R/C=13/135 in FOOD SCIENCE & TECHNOLOGY) Chung-Fan Hsieh, Jia-Rong Jheng, Guan-Hua LinYu-Li Chen, Jin-Yuan Ho, Chien-Jou Liu, Kuei-Yang Hsu, Yuan-Siao Chen, Yoke Fun Chan, Hui-Ming Yu, Pei-Wen Hsieh, Jyh-Haur Chern, Jim-Tong Horng. Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors. Emerg. Microbes Infec. 2020, 9:1194-1205. (SCI) (I.F.: 19.568; 7/136 in Microbiology) Eman Al-Sayed, Michal Korinek, Ahmed Esmat, Guan-Yu Chen, Yuan-Bin Cheng, Pei-Wen Hsieh, Bing-Hung Chen, Tsong-Long Hwang*. Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides. Phytochemistry 2020, 177:112429. (SCI) (I.F.: 4.004; 53/238 in PLANT SCIENCES) Kung-Ju Chen, Yu-Li Chen, Shir-Hwa Ueng, Tsong-Long Hwang, Liang-Mou Kuo*, Pei-Wen Hsieh*. Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil–induced intestinal mucositis. Biomed. Pharmacother. 2021, 134:111152. (SCI) (I.F.: 7.419; R/C=24/279 in PHARMACOLOGY & PHARMACY) Michal Korinek, Pei-Shan Hsieh, Yu-Li Chen, Pei-Wen Hsieh, Shih-Hsin Chang, Yi-Hsiu Wu, Tsong-Long Hwang*. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem. Pharmacol. 2021, 190:114596. (SCI) (I.F.: 6.100; R/C=46/279 in PHARMACOLOGY & PHARMACY) Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kou, Su-Jane Wang*. Rosmarinic acid, a bioactive phenolic compound, inhibits glutamate release from rat cerebrocortical synaptosomes through GABAA receptor activation. Biomolecules 2021, 11:1029. (SCI) (I.F.: 6.064; R/C=75/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY) Hao-Wei Chu, Bidyadhar Sethy, Pei-Wen Hsieh, Jim-Tong Horng*. Identification of potential drug targets of broad-spectrum inhibitors with a Michael acceptor moiety using shotgun proteomics. Viruses 2021, 13:1756. (SCI) (I.F.: 5.818; 14/37 in VIROLOGY) Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang*. Natural product isoliquiritigenin activates GABAB receptors to decrease voltage-gate Ca2+ channels and glutamate release in rat cerebrocortical nerve terminals. Biomolecules 2021, 11:1537. (SCI) (I.F.: 6.064; R/C=75/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY) Anna Chang, Chi-Feng Hung, Pei-Wen Hsieh, Horng-Huey Ko and Su-Jane Wang*. Eupafolin suppresses P/Q-Type Ca2+ channels to inhibit Ca2+/ calmodulin-dependent protein kinase II and glutamate release at rat cerebrocortical nerve terminals. Biomol. Ther. (Seoul) 2021, 29:630-636. (SCI) (I.F.: 4.231; R/C=106/279 in PHARMACOLOGY & PHARMACY) Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang*. Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-type Ca2+ channel suppression: a possible neuroprotective mechanism. Int. J. Mol. Sci. 2021, 22:11447. (SCI) (I.F.: 6.208; R/C=69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY) Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin*, Su-Jane Wang*. An anthranilate derivative inhibits glutamate release and glutamate excitotoxicity in rats. Int. J. Mol. Sci. 2022, 23:2641. (SCI) (I.F.: 6.208; R/C=69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY) Chung-Fan Hsieh, Yu-Li Chen, Guan-Hua Lin, Yoke Fun Chan, Pei-Wen Hsieh, and Jim-Tong Horng*. 3,4-Dicaffeoylquinic acid from the medicinal plant Ilex kaushue disrupts the interaction between the five-fold axis of enterovirus A-71 and the heparan sulfate receptor. J. Virol. 2022, 96: e0054221. (SCI) (I.F.: 6.549; 11/37 in VIROLOGY) Kung-Ju Chen, Yu-Ling Huang, Liang-Mou Kuo, Yi-Ting Chen, Chi-Feng Hung, Pei-Wen Hsieh*. Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil–induced intestinal mucositis: impact on inflammation and gut microbiota dysbiosis. Phytomedicine 2022, 101:154092. (SCI) (I.F.: 6.656; R/C=1/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

新藥研發；如絲胺酸蛋白酶/Cathepsins抑制劑、抗病毒與抗癌相關藥物。 天然物及其相關類似物之合成與活性評估。 中藥老藥新用。

姓名 學位 論 文 題 目 陳Ο利 博士 Identification of Serine Protease Inhibitors from Traditional Chinese Medicines Bidyadhar Sethy 博士 Design and Synthesis of Antivirus Agents 陳Ο儒 博士 Study of Neutrophil Serine Protease Inhibitors Against 5-Fluorouracil Induced Intestinal Mucositis 張Ο婷 碩士 Synthesis and Evaluation of β-Nitrostyrene Derivatives as Anti-platelet Aggregation Agents 王Ο翔 碩士 The Structure-Activity Relationships Study of Anti-inflammatory Anthranilate Derivatives 林Ο庭 碩士 The Total Synthesis of Arenamide B 洪Ο豪 碩士 The Synthesis and Bioactive Evaluation of Dipeptide Derivatives on Superoxide Anion and Elastase Release in Human Neutrophils 劉Ο婷 碩士 The Pharmacokinetics of Anti-inflammatory Anthranilic Acid Derivatives in Rats 王Ο婕 碩士 The Studies on the Chemical and Bioactive Constituents of Endophytic Bacillus licheniformis from Orthosiphon spiralis 王Ο慧 碩士 The Structure-Activity Relationships Study of Anthranilate Analogs as Neutrophil Elastase Inhibitors 胡Ο寬 碩士 Studies on the Chemical and Bioactive Constituents of New Endophytic Rhodotorula taiwanensis sp. nov. from Artemisia argyi 盧Ο華 碩士 The Synthesis and Bioactive Evaluation of 4-O-Benzoyl-3-Methoxy-β-Nitrostyrene Analogs 陳Ο儒 碩士 Study of the Structural Optimization and Pharmacokinetics of Anthranilate-Base Anti-inflammatory Agents 王Ο儀 碩士 Exploring Serine Protease Inhibitors 黃Ο瑩 碩士 Studies on the Chemical and Bioactive Constituents of Stellaria aquatica (L.) Scop. 黃Ο伶 碩士 Studies on the Chemical and Bioactive Constituents of Endophytic Penicillium paxilli from Prunella vulgaris Linn. 蔡Ο真 碩士 Synthesis and Evaluation of 5-Nitrobenzamide Derivatives as Anti-tumor Cells-Induced Platelet Aggregation Agents 林Ο珊 碩士 Bioreduction of Aromatic Ketones by New Endophytic Rhodotorula taiwanensis sp. nov 李Ο勳 碩士 The in vivo Evaluations of Anti-inflammatroy β-Nitrostyrene Derivatives 陳Ο懋 碩士 Synthesis and Bioactive Evaluation on Tryptophan Containing Dipeptide Derivatives as Formyl Peptide Receptor 1 Antagonist 潘Ο佑 碩士 Establishment of Bioactive Evaluation System for Metal Ion Chelating Agents Using Isothermal Titration Calorimetry 林Ο倚 碩士 Design and Synthesis of Sirtinol Analogs that Modulate Multiple Facets of Alzheimer’s Disease 黃Ο淩 碩士 Study on Polysaccharides with Selectively Inhibitory Effect on Podoplanin-induced Platelet Aggregation from Artemisia argyi 鄭Ο倫 碩士 Exploring Neutrophil Elastase Inhibitors from Prunella vulgaris 陳Ο廷 碩士 Exploring Dipeptidyl Peptidase 1 and Neutrophil Elastase Inhibitors from Galla Rhois 謝Ο如 碩士 Exploring Neutrophil Elastase Inhibitors from Inula japonica 陳Ο婷 碩士 Exploring Neutrophil Elastase Inhibitors from Melastoma malabathricum   International Exchange Students  Name School/Nationality Exchange Period Magdalena Al-Ameri Jagiellonian University/ Poland 2017.08.01-2017.08.27 Emil Klink-Breinhild Aalborg University/ Denmark 2018.07.01-2018.07.31 Polina Lemeshko Siberian State Medical University/ Russian Federation 2018.08.01-2018.08.31 Sao Mai Tranová Charles University/ Czech Republic 2019.07.01-2019.07.31 Petra Sossi University of Maribor /Slovenia 2019.07.01-2019.07.31 Joanna Szydełko Medical University of Silesia/Poland 2019.10.01-2019.10.31