天然藥物碩士班

研究室資料

研究主題

論文著作

*, corresponding author

1. Bidyadhar Sethy, Chung-Fan Hsieh, Ta-Jen Lin, Po-Yuan Hu, Yu-Li Chen, Chia-Yi Lin, Sung-Nain Tseng, Jim-Tong Horng*, Pei-Wen Hsieh*. Design, synthesis, and biological evaluation of itaconic acid derivatives as potential anti-influenza agents. J. Med. Chem. 2019, 62:2390-2403. (SCI) (I.F.: 6.762; R/C=4/72 in CHEMISTRY, MEDICINAL)
2. Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi. A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. PLoS One 2019, 14: e0222331. (SCI) (I.F.: 2.928; R/C=31/134 in MULTIDISCIPLINARY SCIENCES)
3. Ching-Ping Tseng, Yu-Ling Huang, Yao-Wen Chang, Hsiang-Ruei Liao, Yu-Li Chen, Pei-Wen Hsieh*. Polysaccharide-containing fraction from Artemisia argyi inhibits tumor cell-induced platelet aggregation by blocking interaction of podoplanin with C-type lectin-like receptor 2. J. Food Drug Anal. 2020, 28:115-123. (SCI) (I.F.: 2.598; R/C=85/173 in FOOD SCIENCE & TECHNOLOGY)
4. Chung-Fan Hsieh, Jia-Rong Jheng, Guan-Hua LinYu-Li Chen, Jin-Yuan Ho, Chien-Jou Liu, Kuei-Yang Hsu, Yuan-Siao Chen, Yoke Fun Chan, Hui-Ming Yu, Pei-Wen Hsieh, Jyh-Haur Chern, Jim-Tong Horng. Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors. Emerg. Microbes Infec. 2020, 9:1194-1205. (SCI) (I.F.: 8.426; R/C=14/161 in Microbiology)
5. Eman Al-Sayed, Michal Korinek, Ahmed Esmat, Guan-Yu Chen, Yuan-Bin Cheng, Pei-Wen Hsieh, Bing-Hung Chen, Tsong-Long Hwang*. Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides. Phytochemistry 2020, 177:112429. (SCI) (I.F.: 3.153; R/C=68/265 in PLANT SCIENCES)
6. Kung-Ju Chen, Yu-Li Chen, Shir-Hwa Ueng, Tsong-Long Hwang, Liang-Mou Kuo*, Pei-Wen Hsieh*. Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil–induced intestinal mucositis. Biomed. Pharmacother. 2021, 134:111152. (SCI) (I.F.: 6.857; R/C=15/354 in PHARMACOLOGY & PHARMACY)
7. Michal Korinek, Pei-Shan Hsieh, Yu-Li Chen, Pei-Wen Hsieh, Shih-Hsin Chang, Yi-Hsiu Wu, Tsong-Long Hwang*. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem. Pharmacol. 2021, 190:114596. (SCI) (I.F.: 5.280; R/C=34/354 in PHARMACOLOGY & PHARMACY)
8. Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kou, Su-Jane Wang*. Rosmarinic acid, a bioactive phenolic compound, inhibits glutamate release from rat cerebrocortical synaptosomes through GABAA receptor activation. Biomolecules 2021, 11:1029. (SCI) (I.F.: 4.778; R/C=67/313 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
9. Hao-Wei Chu, Bidyadhar Sethy, Pei-Wen Hsieh, Jim-Tong Horng*. Identification of potential drug targets of broad-spectrum inhibitors with a Michael acceptor moiety using shotgun proteomics. Viruses 2021, 13:1756. (SCI) (I.F.: 3.848; R/C=17/41 in VIROLOGY)
10. Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang*. Natural product isoliquiritigenin activates GABAB receptors to decrease voltage-gate Ca2+ channels and glutamate release in rat cerebrocortical nerve terminals. Biomolecules 2021, 11:1537. (SCI) (I.F.: 4.778; R/C=67/313 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
11. Anna Chang, Chi-Feng Hung, Pei-Wen Hsieh, Horng-Huey Ko and Su-Jane Wang*. Eupafolin suppresses P/Q-Type Ca2+ channels to inhibit Ca2+/ calmodulin-dependent protein kinase II and glutamate release at rat cerebrocortical nerve terminals. Biomol. Ther. (Seoul) 2021, 29:630-636. (SCI) (I.F.: 3.007; R/C=136/354 in PHARMACOLOGY & PHARMACY)
12. Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang*. Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-type Ca2+ channel suppression: a possible neuroprotective mechanism. Int. J. Mol. Sci. 2021, 22:11447. (SCI) (I.F.: 4.860; R/C=66/313 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
13. Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin*, Su-Jane Wang*. An anthranilate derivative inhibits glutamate release and glutamate excitotoxicity in rats. Int. J. Mol. Sci. 2022, 23:2641. (SCI) (I.F.: 4.860; R/C=66/313 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
14. Chung-Fan Hsieh, Yu-Li Chen, Guan-Hua Lin, Yoke Fun Chan, Pei-Wen Hsieh, and Jim-Tong Horng*. 3,4-Dicaffeoylquinic acid from the medicinal plant Ilex kaushue disrupts the interaction between the five-fold axis of enterovirus A-71 and the heparan sulfate receptor. J. Virol. 2022, 96: e0054221. (SCI) (I.F.: 4.024; 14/41 in VIROLOGY)
15. Kung-Ju Chen, Yu-Ling Huang, Liang-Mou Kuo, Yi-Ting Chen, Chi-Feng Hung, Pei-Wen Hsieh*. Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil–induced intestinal mucositis: impact on inflammation and gut microbiota dysbiosis. Phytomedicine 2022, 101:154092. (SCI) (I.F.: 6.719; R/C=2/43 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
16. Tse-Hung Huang, Pei-Wen Hsieh, Tsu-Jung Chen, Hui-Ju Tsai, Ju-Chien Cheng, Hsiang-Ruei Liao, Shun-Li Kuo, Ching-Ping Tseng*. Melastoma malabathricum L. suppresses neutrophil extracellular trap formation induced by synthetic analog of viral double-stranded RNA associated with SARS-CoV-2 infection. Pathogens 2023, 12:341. (Equal contribution as first author, I.F.: 3.284; R/C=71/161 in MICROBIOLOGY)
17. Cheng-Wei Lu, Tzu-Yu Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su Jane Wang*. Cynarin, a caffeolyquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosome). Neurochem. Int. 2023, 167:105537. (SCI) (I.F.: 4.414; R/C=73/310 in NEUROSCIENCES)
18. Ganesh Kumar Dhandabani, Pei-Wen Hsieh*, Jeh-Jeng Wang*. Opportunities and challenges in photochemical activation of π-bond system using common transition-metal-catalyzes as a seminal photosensitizer. J. Photochem. Photobiol. C 2023, 55:100589. (SCI) (I.F.: 12.839; R/C=20/178 in CHEMISTRY, PHYSICAL)
19. Tsong-Long Hwang, Jing-Yi Lin, Liang-Mou Kuo, Ganesh Kumar Dhandabani, Pei-Wen Hsieh*. Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors. Bioorg. Med. Chem. Lett. 2024, 97:129544. (SCI). (I.F.: 2.501; R/C=16/58 in CHEMISTRY, ORGANIC) 
20. Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang*. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats. Eur. J. Pharmacol. 2024, 963:176280 (SCI) (I.F.: 4.217; R/C=75/357 in PHARMACOLOGY & PHARMACY)
21. Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp. Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions. Org. Biomol. Chem. 2024, 22:2620-2629. (SCI) (I.F.: 2.857; R/C=13/58 in CHEMISTRY, ORGANIC)
22. Yu-Li Chen, Pei-Yu Chao, Chung-Fan Hsieh, Pei-Wen Hsieh, Jim-Tong Horng*. Novel anti-viral properties of the herbal extract of Davallia mariesii against influenza A virus. Viruses 2024, 16:523. (SCI) (I.F.: 3.848; R/C=17/41 in VIROLOGY)

專利

1. Tsong-Long Hwang, Pei-Wen Hsieh, Huang-Ping Yu。苯并雜氧嗪酮衍生物，其製備方法以及包含有此等衍生物的藥學組成物。中華民國專利I419884號。
2. Ching-Ping Tseng，Pei-Wen Hsieh，Yao-Wen Chang，一種含有5-nitrobenzoate之衍生物，透過抑制腫瘤細胞誘發血小板凝集反應作為癌症轉移治療方式。中華民國專利I444358號。
3. Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang, Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same. US 9,073,833.
4. Pei-Wen Hsieh，Tsong-Long Hwang，Wen-Hui Wang，Ting-Yi Wang，2-胺基苯甲醛肟衍生物及其製備方法與用途。中華民國專利I508938號。
5. Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang, Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same. JP 5890512。
6. Pei-Wen Hsieh，Tsong-Long Hwang，Wen-Hui Wang，Ting-Yi Wang，2-胺基苯甲醛肟衍生物及其製備方法與用途。中華人民共和國專利CN104803894號。
7. Tsong-Long Hwang，Pei-Wen Hsieh，Yin-Ting Huang，Chih-Hao Hung，FPR1拮抗劑的衍生物及其用途。中華民國專利I537251號。
8. Tsong-Long Hwang, Pei-Wen Hsieh, Yin-Ting Huang, Chih-Hao Hung. FPR1 antagonist derivatives and use thereof. US 9,593,114.
9. 葉宏一、鍾鏡湖、王士維、謝珮文，橙黃醯胺雙肽衍生物用於治療或預防血管新生相關疾病。中華民國專利申請號104143726號（領證中）。
10. Ching-Ping Tseng, Pei-Wen Hsieh, Yao-Wen Chang. Composition of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation. US 9,604,910.
11. Ching-Ping Tseng, Pei-Wen Hsieh, Yao-Wen Chang. A compostion of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation. US 20170172949.
12. Pei-Wen Hsieh, Ching-Ping Tseng, Yun-Zhan Tsai, Yu-Ling Hung, Yao-Wen Chang. Compounds, compositions and methods for treating tumors. US 20170183294.
13. 葉宏一、鍾鏡湖、王士維、Pei-Wen Hsieh. Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases. USA application no. 14/981178.
14. Ching-Ping Tseng, Pei-Wen Hsieh, Yao-Wen Chang. Composition of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation. US 9,956,191.
15. Pei-Wen Hsieh, Ching-Ping Tseng, Yun-Zhan Tsai, Yu-Ling Hung, Yao-Wen Chang. Compounds, compositions and methods for treating tumors. US 20170183294.

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