李宗諺 / Tzung-Yan Lee
職稱： 教授
現職： 中醫學系傳統中醫學碩士班 / Full-time Professor
電話： 032118800 分機3389、3537
學歷： 陽明大學傳統醫藥研究所博士
專長領域： 抗氧化醫學、肝臟學、老年化醫學
個人網頁： https://pure.lib.cgu.edu.tw/en/persons/tzung-yan-lee-2
研究室資料
研究室：中醫分子藥理研究室研究室成員：
博士班研究生 5 人、碩士班研究生 2 人
研究主題
1.肥胖與脂肪肝2.脂肪肝與免疫耐受性
3.中醫複方保肝機轉研究
4.能量代謝與老化
5.抗氧化醫學
6.能量代謝與老化
7.老年化醫學
8.肝臟學
論文著作
Publication Lists:
*, corresponding author
1. Ko-Chen Lee, Hen-Hong Chang, Ying-Hui Chung, Tzung-Yan Lee. Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. Journal of Ethnopharmacology. 2011,135(3):678-84. (I.F.: 5.195; R/C= 4/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)2. Jong-Jen Kuo, Hen-Hong Chang, Tung-Hu Tsai, Tzung-Yan Lee. Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. International Journal of Molecular Medicine. 2012, 30(3): 643-9. (I.F.: 5.314; R/C= 53/139 in MEDICINE, RESEARCH & EXPERIMENTAL)
3. Jong-Jen Kuo, Hen-Hong Chang, Tung-Hu Tsai, Tzung-Yan Lee. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. International Journal of Molecular Medicine. 2012, 30(3): 673-9. (I.F.: 5.314; R/C= 53/139 in MEDICINE, RESEARCH & EXPERIMENTAL)
4. Chorng-Kai Wen, Tzung-Yan Lee. Electroacupuncture decreases the leukocyte infiltration to white adipose tissue and attenuates inflammatory response in high fat diet-induced obesity rats. Evidence-Based Complementary and Alternative Medicine. 2014; 2014: 473978. (I.F.: 2.650; R/C= 16/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
5. Tzung-Yan Lee, Hen-Hong Chang, Chorng-Kai Wen, Tse-Hung Huang, Ya-Shu Chang. Modulation of thioacetamide-induced hepatic inflammations, angiogenesis and fibrosis by andrographolide in mice. Journal of Ethnopharmacology. 2014, 158: 423-30. (I.F.: 5.195; R/C= 4/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
6. Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model. Biochemical and Biophysical Research Communications. 2015, 460(4): 1063-8. (I.F.: 3.322; R/C= 39/72 in BIOPHYSICS)
7. Chorng-Kai Wen, Tzung-Yan Lee. Electroacupuncture prevents white adipose tissue inflammation through modulation of hypoxia-inducible factors-1α-dependent pathway in obese mice. BMC Complementary Medicine and Therapies. 2015, 15: 452. (I.F.: 2.838; R/C= 15/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
8. Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity. International Journal of Molecular Sciences. 2016, 37(3): 743-54. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
9. Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Using proteomics to discover novel biomarkers for fatty liver development and response to CB1R antagonist treatment in an obese mouse model. Proteomics. 2017, 17(1-2). (I.F.: 5.393; R/C= 15/79 in BIOCHEMICAL RESEARCH METHODS)
10. Tse-Hung Huang, Chin-Chang Chen, Hsuan-Miao Liu, Tzung-Yan Lee, Sue-Heui Shieh. Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice. Scientific Reports. 2017, 7(1): 2705. (I.F.: 4.996; R/C= 19/73 in MULTIDISCIPLINARY SCIENCES)
11. Hsuan-Miao Liu, Jyh-Fei Liao, Tzung-Yan Lee. Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. Biochemical and Biophysical Research Communications. 2017, 490(3): 841-848. (I.F.: 3.322; R/C= 39/72 in BIOPHYSICS)
12. Tzung-Yan Lee, Yann-Lii Leu, Chorng-Kai Wen. Modulation of HIF-1α and STAT3 signaling contributes to anti-angiogenic effect of YC-1 in mice with liver fibrosis. Oncotarget. 2017, 8(49): 86206-86216. (I.F.: 5.168; R/C= 44/217 in ONCOLOGY)
13. Hsuan-Miao Liu, Jyh-Fei Liao, Tzung-Yan Lee. GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice. International Journal of Molecular Medicine. 2018, 41(3): 1455-1462. (I.F.: 5.314; R/C= 53/139 in MEDICINE, RESEARCH & EXPERIMENTAL)
14. Geng-Hao Liu, Meng-Yen Tsai, Gwo-Jyh Chang, Chao-Min Wu, Sheng-Kai Lin, Yu-Sheng Chen, Tzung-Yan Lee. Safety Assessment of the Auto Manipulation Device for Acupuncture in Sprague-Dawley Rats: Preclinical Evaluation of the Prototype. Evidence-Based Complementary and Alternative Medicine. 2018, 2018: 5708393. (I.F.: 2.650; R/C= 16/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
15. Yu-Sheng Chen, Hsuan-Miao Liu, Tzung-Yan Lee. Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice. Cells (IF: 4.37; Q4). 2019, 8(3): 253. (I.F.: 7.666; R/C= 51/194 in CELL BIOLOGY)
16. Zi-Yu Chang, Chin-Chang Chen, Hsuan-Miao Liu, Yuan-Chieh Yeh, Tung-Yi Lin, Tzung-Yan Lee, Tse-Hung Huang. Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice. International Journal of Molecular Sciences. 2019, 20(17): 4181. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
17. Geng-Hao Liu, Hsuan-Miao Liu, Yu-Sheng Chen, Tzung-Yan Lee. Effect of Electroacupuncture in Mice with Dextran Sulfate Sodium-Induced Colitis and the Influence of Gut Microbiota. Evidence-Based Complementary and Alternative Medicine. 2020, 2020: 2087903. (I.F.: 2.650; R/C= 16/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
18. Cheng-Hui Wang, Hsuan-Miao Liu, Zi-Yu Chang, Tse-Hung Huang, Tzung-Yan Lee. Losartan Prevents Hepatic Steatosis and Macrophage Polarization by Inhibiting HIF-1α in a Murine Model of NAFLD. International Journal of Molecular Sciences. 2021, 22(15): 7841. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
19. Hsuan-Miao Liu, Cheng-Hui Wang, Zi-Yu Chang, Tse-Hung Huang, Tzung-Yan Lee. Losartan attenuates insulin resistance and regulates browning phenomenon of white adipose tissue in ob/ob Mice. Current Issues in Molecular Biology. 2021, 3(3): 1828-1843. (I.F.: 2.976; R/C= 216/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
20. Zi-Yu Chang, Hsuan-Miao Liu, Yann-Lii Leu, Chung-Hua Hsu, Tzung-Yan Lee. Modulation of gut microbiota combined with upregulation of intestinal tight junction explains anti-inflammatory effect of Corylin on colitis-associated cancer in mice. International Journal of Molecular Sciences. 2022, 23(5): 2667. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
21. Ching-Chuan Yeh, Hsuan-Miao Liu, Ming-Chung Lee, Yann-Lii Leu, Wei-Han, Chiang, Hen-Hong Chang, Tzung-Yan Lee. Phytochemical-rich herbal formula ATG-125 protects against sucrose-induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice. Molecular Medicine Reports. 2022, 25(2): 57. (I.F.: 3.423; R/C= 97/195 in MEDICINE, RESEARCH & EXPERIMENTAL)
22. Geng-Hao Liu, Xin-Cheng Zhuo, Yueh-Hsiang Huang, Hsuan-Miao Liu, Ren-Chin Wu, Chia-Jung Kuo, Ning-Hung Chen, Li-Pang Chuang, Shih-Wei Lin, Yen-Lung Chen, Huang-Yu Yang, Tzung-Yan Lee. Alterations in Gut Microbiota and Upregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation. Biology-Basel. 2022, 11(7), 962. (I.F.: 5.168; R/C= 21/94 in BIOLOGY)
23. Cheng-Hui Wang, Hsuan-Miao Liu, Zi-Yu Chang, Chung-Hua Hsu, Tzung-Yan Lee. Antioxidants rich herbal formula Ger-Gen-Chyn-Lian-Tang protects lipotoxicity and ameliorates inflammation signaling through regulation of mitochondrial biogenesis and mitophagy in nonalcoholic fatty liver disease mice. Frontiers in Bioscience-Landmark (Landmark Ed). 2022, 27(8):242. (SCI) (I.F.:3.115; R/C= 207/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
24. Yang CW, Liu HM, Chang ZY, Liu GH, Chang HH, Huang PY, Lee TY. Puerarin Modulates Hepatic Farnesoid X Receptor and Gut Microbiota in High-Fat Diet-Induced Obese Mice. Int J Mol Sci. 2024 May 12;25(10):5274. doi: 10.3390/ijms25105274.
25. Liu HM, Chang ZY, Yang CW, Chang HH, Lee TY. Farnesoid X Receptor Agonist GW4064 Protects Lipopolysaccharide-Induced Intestinal Epithelial Barrier Function and Colorectal Tumorigenesis Signaling through the αKlotho/βKlotho/FGFs Pathways in Mice. Int J Mol Sci. 2023 Nov 29;24(23):16932. doi: 10.3390/ijms242316932.
26. Huang PY, Liu HM, Ko YR, Chang ZY, Lee TY. Electroacupuncture relieves portal hypertension by improving vascular angiogenesis and linking gut microbiota in bile duct ligation rats. Front Microbiol. 2023 Jul 11;14:1207137. doi: 10.3389/fmicb.2023.1207137.
27. Wang CH, Liu HM, Chang ZY, Lee MC, Hsu CH, Lee TY. Antioxidants Rich Herbal Formula Ger-Gen-Chyn-Lian-Tang Protects Lipotoxicity and Ameliorates Inflammation Signaling through Regulation of Mitochondrial Biogenesis and Mitophagy in Nonalcoholic Fatty Liver Disease Mice. Front Biosci (Landmark Ed). 2022 Aug 15;27(8):242. doi: 10.31083/j.fbl2708242.
28. Liu GH, Zhuo XC, Huang YH, Liu HM, Wu RC, Kuo CJ, Chen NH, Chuang LP, Lin SW, Chen YL, Yang HY, Lee TY. Alterations in Gut Microbiota and Upregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation. Biology (Basel). 2022 Jun 25;11(7):962. doi: 10.3390/biology11070962.
指導研究生論文
|
姓名 |
學位 |
論 文 題 目 |
|
陳寶鈴 |
碩士 |
整合型健康促進方案對社區高齡者自癒力影響之研究：中醫整體觀之應用(李宗諺教授、林佩欣教授共同指導) |
|
葉清泉 |
碩士 |
Phytochemicals-rich herbal formula ATG-125 protects against sucrose-induced gastrocnemius muscle atrophy via rescuing inflammatory signaling and improving mitochondrial dysfunction in mice |
|
莊采霓 |
碩士 |
Enteroprotective effects of Ger-Gen-Chyn-Lian-Tang in dextran sulfate sodium induced murine colitis model |
|
張子瑜 |
碩士 |
Hepato-protective effects of Ger-Gen-Chyn-Lian-Tang in thioacetamide-induced liver fibrosis in mice |
|
鄭安斌 |
碩士 |
Ger-Gen-Chyn-Lian-Tang attenuates thioacetamide-induced hepatic injury in mice |
|
劉芷君 |
碩士 |
Modulation of Curcuma longa on hepatic steatosis and lipid dysregulation in ob/ob mice |
|
王文瑜 |
碩士 |
YC-1 modulated hepatic inflammatory responses in bile duct ligation mice with cholestasis |
|
劉軒妙 |
碩士 |
Modulatory effects of curcumin on the hepatic cholesterol 7α-hydroxylase and cytokeratin 19 in cholestasis mice |
|
羅文佳 |
碩士 |
Modulation of Curcuma longa on hepatic steatosis in high-fat-diet induced obesity mice |
|
張雅淑 |
碩士 |
Anti-inflammation effects of andrographolide attenuates hepatic angiogenesis and fibrogenesis in thioacetamide-induced liver injury mice |
|
郭祐睿 |
碩士 |
Butanol extract of Gentiana scabra Bge.has immunomodulatory effects and attenuates pathological signs in MRL/lpr mice. |
|
王政惠 |
博士 |
氯沙坦與葛根芩連湯對於肥胖小鼠非酒精性脂肪肝病肝臟內粒線體生合成調控之研究 |
|
黃伯瑜 |
博士 |
電針調節血管新生與腸道微生物群以改善膽管結紮大鼠的門脈高壓 |
|
劉耕豪 |
博士 |
Effect of electroacupuncture in homeostasis of gut microbiota: through dextran sulfate sodium-induced ulcerative colitis with sleep-fragmented mice |
|
陳怡斌 |
博士 |
Study of cervical cancer treatment with andrographolide |
|
陳玉昇 |
博士 |
Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice |
|
溫崇凱 |
博士 |
Electroacupuncture prevents white adipose tissue inflammation through modulation of hypoxia-inducible factors-1α-dependent pathway in obese animals |