天然藥物碩士班

研究室資料

研究主題

1.延長壽命藥物之研發

2.中草藥標準品之製備

論文著作

1. Tsung-Ru Wu, Tsung-Teng Huang, Jan Martel, Jian-Ching Liaug, Chen-Yaw Chiu, Yann-Lii Leu, Wei-Ting Jian, I-Te Chang, Chia-Chen Lu, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai, John D. Young “Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells” Journal of Ethnopharmacology, 201, 117-122 (2017).

2. Sin-Guang Chen, Mei-Ling Cheng, Kuan-Hsing Chen, Jim-Tong Horng, Ching-Chuan Liu, Shih-Min Wang, Hiroaki Sakurai, Yann-Lii Leu, Shulhn-Der Wang, Hung-Yao Ho “Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo” Scientific Reports | 7:935 | DOI: 10.1038 /s41598-017-01110-x (2017).

3. Sin-Guang Chen, Yann-Lii Leu, Mei-Ling Cheng, Siew Chin Ting, Ching-Chuan Liu, Shulhn-Der Wang, Cheng-Hung Yang, Cheng-Yu Hung, Hiroaki Sakurai, Kuan-Hsing Chen, Hung-Yao Ho  “Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid” Scientific Reports | 7:12264 | DOI:10.1038/s41598-017-12388-2 (2017).

4. Tzung-Yan Lee*, Yann-Lii Leu* and Chorng-Kai Wen “Modulation of HIF-1α  and STAT3 signaling contributes to anti-angiogenic effect of YC-1 in mice with liver fibrosis” Oncotarget, 8, 86206-86216 (2017)

5. Chung-Ju Yeh, Chin-Chuan Chen, Yann-Lii Leu, Ming-Wei Lin, Mei-Miao Chiu, Shu-Huei Wang “The effects of artocarpin on wound healing: in vitro and in vivo studies” Scientific Reports | 7:15599 | DOI:10.1038/s41598-017-15876-7 (2017).

6. Chin-Chuan Chen, Ju-Sui Huang, Tong-Hong Wang, Chen-Hsin Kuo, Chia-Jen Wang, Shu-Huei Wang,* and Yann-Lii Leu* “Dihydrocoumarin, an HDAC inhibitor, increases DNA damage sensitivity by inhibiting Rad52” International Journal Molecular Sciences, 18, 2655-2672 (2017).

7. Yu-Hsuan Lan, Hsiu-Hui Chan, Chuan-Nien Chuang, Tran-Dinh Thang, Yann-Lii Leu* “Three new chemical constituents of Korthalsella japonica” Phytochemistry Letters, 23, 132-136 (2018).

8. Jih-Tung Pai, Yi-Chin Lee, Si-Ying Chen, Yann-Lii Leu*, Meng-Shih Weng* “Propolin C inhibited migration and invasion via suppression of EGFR-mediated epithelial-to-mesenchymal transition in human lung cancer cells” Evidence-Based Complementary and Alternative Medicine, Article ID 7202548, 15 pages (2018).

9. Chi-Yuan Chen, Chin-Chuan Chen, Tzong-Ming Shieh, Chuen Hsueh, Shu-Huei Wang, Yann-Lii Leu, Jang-Hau Lian and Tong-Hong Wan* “Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by long noncoding RNA GAS5” International Journal Molecular Sciences, 19, 380-392 (2018).

10. Ahmed Alalaiwe, Chi-Feng Hung, Yann-Lii Leu, Kohei Tahara, Hi-Han Chen, Kai-Yin Hu and Jia-You Fang* “The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption” European Journal of Pharmaceutical Sciences, 124, 114-126 (2018).

11. Hung-Yuan Li1, Yann-Lii Leu1, Ya-Chieh Wu, Shu-Huei Wang* “Melatonin inhibits in vitro smooth myscle cell inflammation and proliferation and atherosclerosis in apolipoprotein E-deficient mice” Journal of Agricultural and Food Chemistry, 67, 1889-1901 (2019)

12. Chin-Chuan Chen, Ting-Yau Lee, Yann-Lii Leu and Shu-Huei Wang* “Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice” Translational Research, 210, 26-42 (2019).

13. Po-Jen Chen, I-Ling Ko, Chia-Lin Lee, Hao-Chun Hu, Fang-Rong Chang, Yang-Chang Wu, Yann-Lii Leu, Chih-Ching Wu, Cheng-Yu Lin, Chang-Yu Pan, Yung-Fong Tsai and Tsong-Long Hwang* “Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation” EBioMedicine, 40, 528-540 (2019).

14. Yi-Hsuan Lin, Helen Luck, Saad Hhan, Pierre H, H, Schneeberger, Sue Tsai, Xavier Clemente-Casares, Helena Lei, Yann-Lii Leu, Yi-Tao Chan, Hsing-Yu Chen, Sien-Hung Yang, Bryan Cobum, Shawn Winer, Daniel A, Winer* “Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity” International Journal of Obesity, 2019 Apr 3. doi: 10.1038/s41366-019-0340-1

15. Chen-Hsin Kuo1, Yann-Lii Leu1, Tong-Hong Wang, Wei-Che Tseng, Chun-Hao Feng, Shu-Huei Wang, Chin-Chuan Chen “A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels”  DNA repair, 82, 102690-102700 (2019).

16. Tong-Hong Wang1, Yann-Lii Leu1, Chin-Chuan Chen, Tzong-Ming Shieh, Jang-Hau Lian, Chi-Yuan Chen* “Psorachromene suppresses oral squamous cell carcinoma progression by inhibiting long non-coding RNA GAS5 mediated epithelial-mesenchymal transition” Frontiers in Oncology, 9, article 1168 (2019).

17. H.N. Li, C.Y. Wang, C.L. Wang, C.H. Chou, Yann-Lii Leu, B.Y. Chen “Antimicrobial effects and mechanisms of ethanol extracts of Psoralea corylifolia seeds against Listeria monocytogenes and methicillin-resistant Staphylococcus aureus” Foodborne Pathogens and Disease, 16, 573-580 (2019).

18. Li-Fang Chou, Chi-Yuan Chen, Wan-Hua Yang, Chin-Chuan Chen, Junn-Liang Chang, Yann-Lii Leu, Miaw-Jene Liou, Tong-Hong Wang* “Suppression of hepatocellular carcinoma progression through FOXM1 and EMT inhibition via hydroxygenkwanin-induced miR-320a expression” Biomolecules, 10, 20-34 (2020)

19. Chi-Yuan Chen, Chi-Chuan Chen, Wen-Yu Chung, Yann-Lii Leu, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh*, Tong-Hong Wang* “Hydroxygenkwanin inhibits class I HDAC expression and synergistically enhances the antitumor activity of Sorafenib in liver cancer cells” Frontiers in Oncology, 10, article 216 (2020).

20. Yann-Lii Leu1, Tong-Hong Wang1, Chin-Ching Wu, Kuo-Yen Huang, Yu-Wen Jiang, Yi-Chiung Hsu*, Chi-Yuan Chen* “Hydroxygenkwanin suppression non-small cell lung cancer progression by enhancing EGFR degradation” Molecules, 25, 941-952 (2020)

21. Yu-Hsuan Lan *, Chia-Hung Yen, Yann-Lii Leu* “Chemical constituents from the aerial parts of Euphorbia formosana Hayata and their chemotaxonomic significance” Biochemical Systematics and Ecology, 88, 103967 (2020)

22. Chin-Chuan Chen, Hung-Yuan Li, Yann-Lii Leu, Yu-Ju Chen, Chia-Jen Wang, Shu-Huei Wang* “Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-deficient mice” Antioxidants, 9, 275 (2020)

23. Chi-Yuan Chen, Jia-You Fang, Chi-Chuan Chen, Wen-Yu Chung, Yann-Lii Leu, Shir-Hwa Ueng, Li-Shan Wei, Shu-Fang Cheng, Chuen Hsueh, Tong-Hong Wang* “2-O-Methylmagnolol, a magnolol derivative, suppresses hepatocellular carcinoma progression via inhibiting class I histone deacetylase expression” Frontiers in Oncology, 10, article 1319 (2020).

24. Chien-Chung Yang, Li-Der Hsiao, Hsin-Hui Lin, Hui-Ching Tseng, Jiro Hasegawa Situmorang, Yann-Lii Leu, Chuen-Mao Yang* “Induction of HO-1 by 5, 8-dihydroxy-4’, 7-dimethoxyflavone via activation of ROS/p38 MAPK/Nrf2 attenuates thrombin-induced connective tissue growth factor expression in human cardiac fibroblasts” Oxidative Medicine and Cellular Longevity, 2000, article ID 1080168, 18 pages (2020)

25. Tong-Hong Wang, Chih-Ching Wu, Kuo-Yen Huang, Yann-Lii Leu, Shuenn-Chen Yang, Ci-Ling Chen, Chi-Yuan Chen “Integrated omics analysis of non-small-cell lung cancer cells harboring the EGFR C797S mutation reveals the potential of AXL as a novel therapeutic target in TKI-resistant lung cancer” Cancers, 13, 111-126 (2021)

26. Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang “Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and b3-AR activation” Pharmacological Research, 164, 105291 (2021)

27. Yung-Fong Tsai, Chun-Yu Chen, I-Wen Lin, Yann-Lii Leu, Shum-Chin Yang, Yu-Ting Syu, Po-Jen Chen, Tsong-Long Hwang “Imperatorin alleviates psoriasiform dermatitis by blocking neutrophil respiratory burst, adhesion, and chemotaxis through selective phosphodiesterase 4 inhibition”  Antioxidants & Redox Signaling, 35, 885-903 (2021).

28. Kuo-Yen Huang, Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Hsin-Jung Li, Cai-Ling Jhong, Chi-Yuan Chen, “Growth suppression in lung cancer cells harboring EGFR-C797S mutation by quercetin”  Biomolecules, 11, 1271-1282 (2021).

29. Chin-Chuan Chen, Chi-Yuan Chen, Shu-Fang Cheng, Tzing-Ming Shieh, Yann-Lii Leu, Wen-Yu Chuang, Kuang-Ting Liu, Shir-Hwa Ueng, Yin-Hwa Shih, Li-Fang Chou, Tong-Hong Wang “Hydroxygenkwanin increase the sensitivity of liver cancer cells to chemotherapy by inhibiting DNA damage response in mouse xenograft models”  International Journal of Molecular Sciences, 22, 9766-9784 (2021).

30. Jih-Tung Pai, Ming-Wei Hsu, Yann-Lii Leu, Kuo-Ting Chang, Meng-Shih Weng “Induction of G2/M cell cycle arrest via p38/p21Waf1/Cip1-dependent signaling pathway activation by bavachinin in non-small-cell lung cancer cells” Molecules, 26, 5161-5172 (2021).

31. Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Yun-Shien Lee, Jang-Hau Lian, His-Lung Hsieh, Chi-Yuan Chen “Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma”  Journal of the Formosan Medical Association, 120, 1695-1705 (2021).

32. Jih-Tung Pai, Xing-Han Chen, Yann-Lii Leu, Meng-Shih Weng “Propolin G-suppressed epithelial-to-mesenchymal transition in triple-negative breast cancer cells via glycogen synthase kinase 3β-mediated snail and HDAC6-regulated vimentin degradation”  International Journal of Molecular Sciences, 23, 1672-1700 (2022).

33. Zi-Yu Chang, Hsuan-Miao Liu, Yann-Lii Leu, Chung-Hua Hsu, Tzung-Yan Lee “Modulation of gut microbiota combined with upregulation of intestinal tight junction explains anti-inflammatory effect of corylin on colitis-associated cancer in mice” International Journal of Molecular Sciences, 23, 2667-2693 (2022).

34. Tong-Hong Wang,1 Yann-Lii Leu,1 Chin-Chuan Chen, Hsin-Jung Li, Shuenn-Chen Yang, Kuo-Yen Huang, Chi-Yuan Chen “Psorachromene induces apoptosis and suppresses tumor growth in NSCLC cells harboring EGFR L858R/T790M/C797S”

Phytotherapy Research, 2022, 1–11 (2022), DOI: 10.1002/ptr.7432

35. Tong-Hong Wang,1 Wei-Che Tseng,1 Yann-Lii Leu,1 Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu,  Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen “The flavonoid corylin exhibits lifespan extension properties in mouse” Nature Communications, 13, 1238-1254 (2022). https://doi.org/10.1038/s41467-022-28908-2

36. Yu-Hsuan Lan, I-Hsiao Chen, Hsin-Hung Lu, Ting-Jing Guo, Tsong-Long Hwang, Yann-Lii Leu* “Euphormins A and B, new pyranocoumarin derivatives from Euphorbia formosana Hayata, and their anti-inflammatory activity” Molecules, 27, 1885-1895 (2022)

37. Ching‑Chuan Yeh, Hsuan‑Miao Liu, Ming‑Chung Lee , Yann‑Lii Leu, Wei‑Han Chiang, Hen‑Hong Chang, Tzung‑Yan Lee “Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice”  Molecular Medicine Reports, 25 (57), 1-20 (2022)

38. Hsiang-Ruei Liao, Yu-Yao Kao, Yann-Lii Leu, Fu-Chao Liu, Ching-Ping Tseng “Larixol inhibits fMLP-induced superoxide anion production and chemotaxis by targeting the βγ subunit of Gi-protein of fMLP receptor in human neutrophils”Biochemical Pharmacology, 201, 1-11 (2022) https://doi.org/10.1016/j.bcp.2022.115091

專利

1. 王瑞瑜，君侃，呂彥禮，專利名稱：一種美白皮膚之組合物，台灣專利證號：I302102，專利期限：2008.10.21-2026.03.05
2. 柯雲飛，馬奕安，廖建清，簡瑋廷，張義德，邱振堯，呂彥禮，吳宗儒，黃宗騰，陸嘉真，歐大衛，賴信志，楊定一，專利名稱：從牛樟菇中分離的化合物、其製備方法及用途，台灣專利證號：I538674，專利期限：2016.06.21-2034.07.13
3. 陳金銓，呂彥禮，黃聰龍，方嘉佑，潘台龍，專利名稱：哺乳類SIRT1的活化劑，台灣專利證號：I556818，專利期限：2016.11.11-2035.08.06
4. 馬蘊華，呂彥禮，吳建德，魏國珍，呂怡青，專利名稱：促進細胞攝入粒子之混合物及其製備方法，台灣專利證號：I583395，專利期限：2017.05.21-2032.05.21
5. 陳金銓，呂彥禮，王淑慧，專利名稱：哺乳類TOR的抑制劑，台灣專利證號：I586351，專利期限：2017.06.11-2036.02.15
6. 李宗諺，張恆鴻，呂彥禮，劉軒妙，江威漢，王政惠，專利名稱：藥學組合物及其於治療帕金森氏症之用途，台灣專利證號：I770608，專利期限：2022.07.11-2040.09.10

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