Graduate Institute of Biomedical Sciences

Research outline：

Areas of research interest:

1. Tumor cell biology

2. Protein glycosylation in cell biology

Glycosylation of proteins is one of the most common post-translational modification. It creates diverse proteoforms with different functions and greatly amplifies the proteome. The known glycan structures of proteins are generated through 14 different glycosylation pathways, including N-glycosylation, 11 types of O-glycosylation, C-mannosylation and generation of GPI-anchored proteins. To date, there are at least 168 distinct glycosyltransferases were discovered to conduct these protein glycosylation pathways. Plenty of studies elucidated that aberrant expression of these glycosyltransferases was associated with malignancy in many cancers. However, the specific underlying mechanisms of these glycosyltransferases in cancers remain unknown, it is worth investigating its specific role in cancers.

Publications:

1. Kuo TC, Wu MH, Yang SH, Chen ST, Hsu TW, Jhuang JY, Liao YY, Tien YW*, Huang MC*. C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. Oncogene, 2021 Jan 8. doi: 10.1038/s41388-020-01594-4.

2. Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC* (2020, Jan). C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene, 2020 Mar;39(13):2724-2740.

3. Chen ST, Kuo TC, Liao YY, Lin MC, Tien YW*, Huang MC* (2018, Nov). Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. Oncogene, 37(46):6041-6053.  

4. Lin MC, Chien PH, Wu HY, Chen ST, Juan HF, Lou PJ*, Huang MC* (2018, Oct). C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer. Oncogene, 37(43):5780-5793.

5. Lin TC#, Chen ST#, Huang MC, Huang J, Hsu CL, Juan HF, Lin HH, Chen CH* (2017, Jun). GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity. Oncotarget, 8(26):42588-42601. 

6. Lin MC, Lin YC, Chen ST, Young TH, Lou PJ (2017, Jan). Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1-expressing tumor growth and metastasis in vivo. BMC Cancer, 5;17(1):18.