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Graduate Institute of Biomedical Sciences

Graduate Institute of Biomedical Sciences
:::
Yang Huang-Yu

Yang Huang-Yu

JobTitle： Ph.D.; M.D.

CurrentJob： Associate Professor

E-mail： hyyang01@gmail.com

Phone： 03-3281200 #7740

Education： Johns Hopkins University / USA

Expertise： Chang Gung Kidney Research Center

Research interests:

Mechanism of T cell tolerance

  1. laboratory is interested in the biochemical and molecular mechanisms of T cell activation, differentiation, and tolerance, which could help reach immune tolerance in autoimmune disease and transplantation. Current project focus on metabolic cues such as HIF-1 a and glutamine modulation. We are also interested in microRNA and epigenetic regulation in immune system.

SELECTED PUBLICATIONS

  1. Yen CL, Wu CY, See LC, Li YJ, Tseng MH, Peng WS, Liu JR, Chen YC, Yen TH, Tian YC, Yang CW, Anderson GF, Yang HY*. Pioglitazone Reduces Mortality and Adverse Events in Type 2 Diabetes Mellitus Patients with Advanced Chronic Kidney Disease: National cohort study. Diabetes Care. 2020 (In press) (SCI；IF=16.019；ENDOCRINOLOGY AND METABOLISM 4/143 4/143）(Corresponding)
  2. Yang HY*, Wu CY, Powell JD, Lu KL. Manipulation of Metabolic Pathways and Its Consequences for Anti-Tumor Immunity: A Clinical Perspective. Int. J. Mol. Sci. 2020, 21, 4030 (SCI；IF=4.556；BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297）(Corresponding)
  3. Yang HY, Barbi J, Wu CY, Zheng Y, Vignali P D.A., Wu X, Tao JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, Yang CW, Pardoll DM, Li HB, Pan F. The MicroRNA miR-17 modulates regulatory T cell activity by targeting Foxp3 Co-regulators.

Immunity. 2016 Jul; 45(1): 83-93 （SCI；IF=24.082；IMMUNOLOGY 3/148）

  1. Yang HY, Hung CC, Liu SH, Guo YG, Chen YC, Ko YC, Huang CT, Chou LF, Tian YC, Chang MY, Hsu HH, Lin MY, Hwang SJ, Yang CW. Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-based Survey and Epidemiological Cohort Evidence.

PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004105（SCI；IF=4.446；TROPICAL MEDICINE 1/19）

  1. Yang HY, Dang EV, Barbi J, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM*, Pan F*.Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1.

Cell. 2011; 146(5): 772-784.（SCI；IF=32.242；BIOCHEMISTRY & MOLECULAR BIOLOGY 1/289）