Graduate Institute of Biomedical Sciences

Research interests：

 I explore the molecular mechanisms of human metabolic diseases (in the broad sense), discover clinically relevant biomarkers, and develop personalized treatment strategies. I have played a key role in several national and international scientific initiatives that have led to significant advancements in precision medicine. Currently, I lead a collaborative team at the Pharmaco-Omics Lab. We conduct a range of multi-omics-empowered translational and clinical research. We have a strong history of effectively collaborating with scientists from diverse backgrounds, spanning from laboratory research to clinical implementation.

Selected Publications (Recent 5 years)：

1.       Tien NTN, Yen NTH, Phat NK, Anh NK, Thu NQ, Eunsu C, Kim HS, Hoa VD, Nguyen DN, Kim DH, Oh JY, Long NP. Multiomics and Machine Learning Identify Immunometabolic Biomarkers for Active Tuberculosis Diagnosis Against Nontuberculous Mycobacteria and Latent Tuberculosis Infection. J Proteome Res. 2025 Aug 1;24(8):3783-3797. doi: 10.1021/acs.jproteome.4c00989. Epub 2025 Jul 1. PMID: 40598791.

2.       Thu NQ, Oh JH, Tien NTN, Park SM, Yen NTH, Phat NK, Hung TM, Nguyen HT, Nguyen DN, Yoon S, Kim DH, Long NP. The lipidome landscape of amiodarone toxicity: An in vivo lipid-centric multi-omics study. Toxicol Appl Pharmacol. 2025 Jun;499:117341. doi: 10.1016/j.taap.2025.117341. Epub 2025 Apr 9. PMID: 40216313.

3.       Nhung TTM, Phat NK, Anh TT, Nghi TD, Thu NQ, Lee A, Nam Tien NT, Anh NK, Nguyen HT, Kim K, Nguyen DN, Kim DH, Park SK, Long NP. Endoplasmic reticulum stress inhibition preserves mitochondrial function and cell survival during the early onset of isoniazid-induced oxidative stress. Chem Biol Interact. 2025 Apr 25;411:111448. doi: 10.1016/j.cbi.2025.111448. Epub 2025 Feb 25. PMID: 40015660.

4.       Tien NTN, Thu NQ, Kim DH, Park S^#, Long NP^#. EasyPubPlot: A Shiny Web Application for Rapid Omics Data Exploration and Visualization. J Proteome Res. 2025 Apr 4;24(4):2188-2195. doi: 10.1021/acs.jproteome.4c01068. Epub 2025 Mar 7. PMID: 40053871.

5.       Tien NTN, Choi EJ, Thu NQ, Yu SJ, Nguyen DN, Kim DH, Long NP^#, Lee HS^#. An exploratory multi-omics study reveals distinct molecular signatures of ulcerative colitis and Crohn's disease and their correlation with disease activity. J Pharm Biomed Anal. 2025 Mar 15;255:116652. doi: 10.1016/j.jpba.2024.116652. Epub 2024 Dec 25. PMID: 39740478.

6.       Wu Z, Tien NTN, Bæk O, Zhong J, Klabunde B, Nguyen TT, Yen NTH, Long NP^#, Nguyen DN^#. Regulation of host metabolism and defense strategies to survive neonatal infection. Biochim Biophys Acta Mol Basis Dis. 2024 Dec;1870(8):167482. doi: 10.1016/j.bbadis.2024.167482. Epub 2024 Aug 29. PMID: 39213794.

7.       Tien NTN, Anh TT, Yen NTH, Anh NK, Nguyen HT, Kim HS, Oh JH, Kim DH, Long NP. Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A. Toxicol Mech Methods. 2024 Nov;34(9):1010-1021. doi: 10.1080/15376516.2024.2371894. Epub 2024 Jun 27. PMID: 38937256.

8.       Yen NTH, Tien NTN, Anh NTV, Le QV, Eunsu C, Kim HS, Moon KS, Nguyen HT, Kim DH^#, Long NP^#. Cyclosporine A-induced systemic metabolic perturbations in rats: A comprehensive metabolome analysis. Toxicol Lett. 2024 May 1;395:50-59. doi: 10.1016/j.toxlet.2024.03.009. Epub 2024 Mar 28. PMID: 38552811.

9.       Anh NK, Yen NTH, Tien NTN, Phat NK, Park YJ, Kim HS, Vu DH, Oh JY, Kim DH, Long NP. Metabolic phenotyping and global functional analysis facilitate metabolic signature discovery for tuberculosis treatment monitoring. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167064. doi: 10.1016/j.bbadis.2024.167064. Epub 2024 Feb 10. PMID: 38342417.

10.   Phat NK, Tien NTN, Anh NK, Yen NTH, Lee YA, Trinh HKT, Le KM, Ahn S, Cho YS, Park S, Kim DH, Long NP^#, Shin JG^#. Alterations of lipid-related genes during anti-tuberculosis treatment: insights into host immune responses and potential transcriptional biomarkers. Front Immunol. 2023 Oct 31;14:1210372. doi: 10.3389/fimmu.2023.1210372. PMID: 38022579; PMCID: PMC10644770.

11.   Thi My Nhung T*, Long NP*, Diem Nghi T, Suh Y, Hoang Anh N, Jung CW, Minh Triet H, Jung M, Woo Y, Yoo J, Noh S, Kim SJ, Lee SB, Park S, Thomas G, Simmen T, Mun J, Rhee HW, Kwon SW, Park SK. Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca²⁺ dynamics linked to DEE66. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2303402120. doi: 10.1073/pnas.2303402120. Epub 2023 Jul 31. PMID: 37523531; PMCID: PMC10410754.

12.   Yen NTH, Phat NK, Oh JH, Park SM, Moon KS, Thu VTA, Cho YS, Shin JG, Long NP^#, Kim DH^#. Pathway-level multi-omics analysis of the molecular mechanisms underlying the toxicity of long-term tacrolimus exposure. Toxicol Appl Pharmacol. 2023 Aug 15;473:116597. doi: 10.1016/j.taap.2023.116597. Epub 2023 Jun 13. PMID: 37321324.

13.   Yen NTH, Oh JH, Van Anh NT, Le QV, Park SM, Park YJ, Cho YS, Moon KS, Nguyen HT, Shin JG, Long NP^#, Kim DH^#. Systems-level multi-omics characterization provides novel molecular insights into indomethacin toxicity. Chem Biol Interact. 2023 Apr 25;375:110430. doi: 10.1016/j.cbi.2023.110430. Epub 2023 Mar 1. PMID: 36868495.

14.   Anh NK, Phat NK, Yen NTH, Jayanti RP, Thu VTA, Park YJ, Cho YS, Shin JG, Kim DH, Oh JY^#, Long NP^#. Comprehensive lipid profiles investigation reveals host metabolic and immune alterations during anti-tuberculosis treatment: Implications for therapeutic monitoring. Biomed Pharmacother. 2023 Feb;158:114187. doi: 10.1016/j.biopha.2022.114187. Epub 2023 Jan 3. PMID: 36916440.

15.   Yen NTH, Park SM, Thu VTA, Phat NK, Cho YS, Yoon S, Shin JG, Kim DH, Oh JH^#, Long NP^#. Genome-wide gene expression analysis reveals molecular insights into the drug-induced toxicity of nephrotoxic agents. Life Sci. 2022 Oct 1;306:120801. doi: 10.1016/j.lfs.2022.120801. Epub 2022 Jul 16. PMID: 35850247.

16.   Long NP, Oh JH, Park SM, Yen NTH, Phat NK, Cho YS, Kim HM, Yoon S, Shin JG, Kim DH. Delineation of the molecular mechanisms underlying Colistin-mediated toxicity using metabolomic and transcriptomic analyses. Toxicol Appl Pharmacol. 2022 Mar 15;439:115928. doi: 10.1016/j.taap.2022.115928. Epub 2022 Feb 19. PMID: 35189178.

17.   Long NP, Phat NK, Yen NTH, Park S, Park Y, Cho YS, Shin JG. A 10-gene biosignature of tuberculosis treatment monitoring and treatment outcome prediction. Tuberculosis (Edinb). 2021 Dec;131:102138. doi: 10.1016/j.tube.2021.102138. Epub 2021 Oct 8. PMID: 34801869.

18.   Long NP, Heo D, Kim HY, Kim TH, Shin JG, Lee A, Kim DH. Metabolomics-guided global pathway analysis reveals better insights into the metabolic alterations of breast cancer. J Pharm Biomed Anal. 2021 Aug 5;202:114134. doi: 10.1016/j.jpba.2021.114134. Epub 2021 May 13. PMID: 34052553.