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陳星諭 副教授

陳星諭 副教授

職稱: 副教授

現職: 桃園長庚中醫部副部長

信箱: 8705016@cgmh.org.tw

電話: 09-75366119

學歷: 長庚大學中醫學系

專長領域: 胃腸肝膽疾病,睡眠障礙,呼吸胸腔疾病,退化性疾病,腫瘤及一般內科疾患,體質調理

個人網頁: https://pure.lib.cgu.edu.tw/en/persons/hsing-yu-chen

研究主題

1.脂肪吞噬作用在顯影劑腎病之重要性與可能之中藥調控探討

2.發展中醫大數據資料分析及應用模式計畫

3.建立中醫日間照護模式及臨床路徑-代謝症候群防治

4.中草藥經由影響脂肪代謝與吸收以改善脂肪肝:大數據分析與藥理學驗證

實驗室成員與活動照片

專任研究助理 6 人

論文著作

*, corresponding author

First author/Corresponding author*

1.     Cheng YY, Huang YY, Yang TH, Chang YJ, Fu RH, Chen HY*. Acupuncture and Acupoints for Managing Pediatric Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials. Healthcare 2024;12(17):1780. (SCI, IF:2.4, Health Care Sciences & Services 73/174=42.0%)

2.     Lee CW#, Chen HY#, Tsai PH, et al. Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study. J Cancer Res Clin Oncol 2024;150(7):354. (SCI, IF:2.7, Oncology 163/322=50.6%)

3.     Yu WL#, Liao YN#, Yang TH, Yang CW, Kao TI, Lee PW, Hsu CY, Huang LJ, Huang YT and Chen HY*. Laser Acupuncture versus Liraglutide in Treatment of Obesity: A Multi-Institutional Retrospective Cohort Study. Healthcare. 2024;12(13). (SCI, IF:2.4, Health Care Sciences & Services 73/174=42.0%)

4.     Lu YC, Tseng LW, Wu CE, Yang CW, Yang TH, Chen HY*. Can Chinese herbal medicine offer feasible solutions for newly diagnosed esophageal cancer patients with malnutrition? a multi-institutional real-world study. Frontiers in Pharmacology. 2024;15. https://doi.org/10.3389/fphar.2024.1364318 (SCI, IF: 4.4, Pharmacology & Pharmacy 65/354=18.4%)

5.     Chen HY, Wu YH, Wei CY, et al. Incomplete Recovery from the Radiocontrast-Induced Dysregulated Cell Cycle, Adhesion, and Fibrogenesis in Renal Tubular Cells after Radiocontrast (Iohexol) Removal. International Journal of Molecular Sciences. June 2023;24(13):10945. (SCI, IF: 4.9, Biochemistry & Molecular Biology 66/313=21.1%)

6.     Wang MC, Chou YT, Kao MC, Lin QY, Chang SY, Chen HY*. Topical Chinese herbal medicine in treating atopic dermatitis (eczema): A systematic review and meta-analysis with core herbs exploration. Journal of Ethnopharmacology. June 2023;317:116790. (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

7.     Tseng LW, Lu YC, Yang CW, Chen YC, Chen HY*. Identifying the Network Pharmacology of Panax Ginseng in Digestive Diseases: Implications from the National Health Insurance Research Database. Journal of Chinese Medicine. March 2023;34(1):17.

8.     Pan HC#, Chen HY#, Chen HM, Huang YT, Fang JT, Chen YC. Risk factors and 180-day mortality of acute kidney disease in critically ill patients: A multi-institutional study. Frontiers in Medicine. April 2023;10: 1153670. (SCI, IF: 3.1, Medicine, General & Internal 56/325=17.2%)

9.     Chen HY, Fang WC, Chu SC, et al. Circulating Fibroblast Growth Factor-23 Levels Can Predict Rapid Kidney Function Decline in a Healthy Population: A Community-Based Study. Biomolecules. 2023;13(1):31. (SCI, IF: 4.8, Biochemistry & Molecular Biology 67/313=21.4%)

10.   Chen SL, Lin WC, Chen YC, Chen JL, Wu YH, Yang SH, Chen HY*. The association between mortality and use of Chinese herbal medicine among incident stage IV esophageal cancer patients: A retrospective cohort study with core herbs exploration. Frontiers in Pharmacology. October 2022;13.; doi: 10.3389/fphar.2022.1018281 (SCI, IF: 4.4, Pharmacology & Pharmacy 65/354=18.4%)

11.   Chen SL, Ho CY, Lin WC, Lee CW, Chen YC, Chen JL, Chen HY*. The Characteristics and Mortality of Chinese Herbal Medicine Users among Newly Diagnosed Inoperable Huge Hepatocellular Carcinoma (≥10 cm) Patients: A Retrospective Cohort Study with Exploration of Core Herbs. International Journal of Environmental Research and Public Health. 2022;19(19):12480.; doi:10.3390/ijerph191912480

12.   Lee CW, Tsai HI, Yu MC, Wang CC, Lee WC, Yeh TS, Yeh CN, Lin CY, Kuo Tony, Chen HY*. A proposal for T1 subclassification in hepatocellular carcinoma: reappraisal of the AJCC 8th edition. Hepatology International. September 2022.; doi: 10.1007/s12072-022-10422-8 (SCI, IF: 5.9, Gastroenterology & Hepatology 22/143=15.4%)

13.   Liao YN#, Chen HY#, Yang CW, et al. Chinese herbal medicine is associated with higher body weight reduction than liraglutide among the obese population: A real-world comparative cohort study. Frontiers in Pharmacology. September 2022;13.; doi: 10.3389/fphar.2022.978814 (SCI, IF: 4.4, Pharmacology & Pharmacy 65/354=18.4%)

14.   Lu YC, Tseng LW, Huang YC, Yang CW, Chen YC, Chen HY*. The Potential Complementary Role of Using Chinese Herbal Medicine with Western Medicine in Treating COVID-19 Patients: Pharmacology Network Analysis. Pharmaceuticals. June 2022;15(7):794.; doi: 10.3390/ph15070794 (SCI, IF: 4.3, Pharmacology & Pharmacy 69/354=19.5%)

15.   Chen HY, Malik J, Wu HT, Wang CL. Is the Median Hourly Ambulatory Heart Rate Range Helpful in Stratifying Mortality Risk among Newly Diagnosed Atrial Fibrillation Patients? Journal of Personalized Medicine. November 2021;11(11):1202.; doi: 10.3390/jpm11111202 (SCI, IF: 3.0, Medicine, General & Internal 58/325=17.8%)

16.   Lee CW, Yu MC, Wang CC, Lee WC, Tsai HI, Kuan FC, Chen CW, Hsieh YC, Chen HY*. Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study. World Journal of Gastrointestinal Surgery. May 2021;13(5):476-492.; doi: 10.4240/wjgs.v13.i5.476 (SCI, IF: 1.8, Surgery 123/290=42.4%)

17.   Wu CW#, Chen HY#, Yang CW, Chen YC. Deciphering the Efficacy and Mechanisms of Chinese Herbal Medicine for Diabetic Kidney Disease by Integrating Web-Based Biochemical Databases and Real-World Clinical Data: Retrospective Cohort Study. JMIR Medical Informatics. May 2021;9(5):e27614.; doi: 10.2196/27614 (SCI, IF: 3.1, Medical informatics 21/44=47.7%)

18.   Hou HI#, Chen HY#, Lu JJ, et al. The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity. Evidence-based Complementary and Alternative Medicine. 2021;2021:1-11.;doi: 10.1155/2021/5510552

19.   Guo J CL, Pan HC, Yeh BY, Lu YC, Chen JL, Yang CW, Lin YH, Chen HY*. Associations Between Using Chinese Herbal Medicine and Long-Term Outcome Among Pre-dialysis Diabetic Nephropathy Patients: A Retrospective Population-Based Cohort Study. Original Research. Frontiers in Pharmacology. February 2021;12(186): 616522;doi: 10.3389/fphar.2021.616522 (SCI, IF: 4.4, Pharmacology & Pharmacy 65/354=18.4%)

20.   Chen HY, Sun CY, Lee CC, et al. Ketoanalogue supplements reduce mortality in patients with pre-dialysis advanced diabetic kidney disease: A nationwide population-based study. Clinical Nutrition. June 2021;40(6):4149-4160;doi:https://doi.org/10.1016/j.clnu.2021.01.045 (SCI, IF: 6.6, Nutrition & Dietetics 10/114=8.8%)

21.   Lu YC, Yang CW, Lin YH, Hsueh JY, Chen JL, Yang SH, Chen YC, Chen HY*. Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database. Evidence-based Complementary and Alternative Medicine. 2020;2020:1-14. DOI: 10.1155/2020/5979708

22.   Chen HY, Pan HC, Chen YC, et al. Traditional Chinese medicine use is associated with lower end-stage renal disease and mortality rates among patients with diabetic nephropathy: a population-based cohort study. BMC Complementary and Alternative Medicine. April 2019;19(1):81. (SCI, IF: 3.3, Integrative & Complementary Medicine 9/43=20.9%)

23.   Chen HY, Chou C, Chang CH, et al. Urine Cofilin-1 Detection for Predicting Type 1 Cardiorenal Syndrome in the Coronary Care Unit: A Gold Nanoparticle- and Laser-Based Approach. CardioRenal Medicine. August 2018;8(4):302-310. (SCI, IF: 2.4, Urology & Nephrology 46/126=36.5%)

24.   Tsai PJ, Lin YH, Chen JL, Yang SH, Chen YC, Chen HY*. Identifying Chinese Herbal Medicine Network for Endometriosis: Implications from a Population-Based Database in Taiwan. Evidence-based Complementary and Alternative Medicine. 2017;2017: 7501015. DOI: 10.1155/2017/7501015

25.   Chen YC, Lin YH, Hu S, Chen HY*. Characteristics of traditional Chinese medicine users and prescription analysis for pediatric atopic dermatitis: a population-based study. BMC Complementary and Alternative Medicine. June 2016;16(1):1-8. (SCI, IF: 3.3, Integrative & Complementary Medicine 9/43=20.9%)

26.   Chen HY, Lin YH, Chen YC. Identifying Chinese herbal medicine network for treating acne: Implications from a nationwide database. Journal of Ethnopharmacology. February 2016;179:1-8. (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

27.   Chen HY, Lin YH, Huang JW, Chen YC. Chinese herbal medicine network and core treatments for allergic skin diseases: Implications from a nationwide database. Journal of Ethnopharmacology. June 2015;168(0):260-267. (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

28.   Chen HY#, Lin YH#, Hu S, et al. Identifying Chinese Herbal Medicine Network for Eczema: Implications from a Nationwide Prescription Database. Evidence-based Complementary and Alternative Medicine. 2015;2015:3471641.

29.   Chen HY#, Lin YH#, Wu JC, et al. Use of traditional Chinese medicine reduces exposure to corticosteroid among atopic dermatitis children: A 1-year follow-up cohort study. Journal of Ethnopharmacology. January 2015;159:189-196. (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

30.   Chen HY#, Huang BS#, Lin YH, et al. Identifying Chinese herbal medicine for premenstrual syndrome: implications from a nationwide database. BMC Complementary and Alternative Medicine. June 2014;14(1):206. (SCI, IF: 3.3, Integrative & Complementary Medicine 9/43=20.9%)

31.   Chen HY, Lin YH, Su IH, Chen YC, Yang SH, Chen JL. Investigation on Chinese herbal medicine for primary dysmenorrhea: Implication from a nationwide prescription database in Taiwan. Complementary Therapies in Medicine. February 2014;22(1):116-125. (SCI, IF=3.3, Integrative & Complementary Medicine 9/43=20.9%)

32.   Chen HY, Lin YH, Thien PF, Chang SC, Chen YC, Lo SS, et al. Identifying Core Herbal Treatments for Children with Asthma: Implication from a Chinese Herbal Medicine Database in Taiwan. Evidence-based Complementary and Alternative Medicine. 2013;2013:10.

33.   Chen HY#, Lin YH#, Wu JC, Chen YC, Thien PF, Chen TJ, et al. Characteristics of Pediatric Traditional Chinese Medicine Users in Taiwan:A Nationwide Cohort Study. Pediatrics. June 2012;129(6):e1485-92 (SCI, IF=6.2, pediatrics 5/186=2.7%)

34.   Chen HY, Lin YH, Wu JC, Chen YC, Yang SH, Chen JL, et al. Prescription patterns of Chinese herbal products for menopausal syndrome: analysis of a nationwide prescription database. Journal of Ethnopharmacology. October 2011;137(3):1261-1266. (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

Co-author

1.     Pan HC, Chen JY, Chen HY, et al. GLP-1 receptor agonists' impact on cardio-renal outcomes and mortality in T2D with acute kidney disease. Nat Commun 2024;15(1):5912. (SCI, IF:  14.7, Multidisciplinary Sciences 8/134=6.0%)

2.     Yu HW, Kuan CH, Tseng LW, Chen HY, Tsai MY, Chen YS. Investigation of the Correlation between Enterovirus Infection and the Climate Factor Complex Including the Ping-Year Factor and El Niño-Southern Oscillation in Taiwan. Viruses. 2024;16(3):471. (SCI, IF:  3.8, Virology 17/41=41.5%)

3.     Pan HC, Chen HY, Teng NC, et al. Recovery Dynamics and Prognosis After Dialysis for Acute Kidney Injury. JAMA Netw Open. 2024;7(3):e240351. (SCI, IF: 10.5, Medicine, General & Internal 10/325=3.1%)

4.     Pan HC, Chen JY, Chen HY, et al. Sodium-Glucose Cotransport Protein 2 Inhibitors in Patients With Type 2 Diabetes and Acute Kidney Disease. JAMA Netw Open. 2024;7(1):e2350050. (SCI, IF: 10.5, Medicine, General & Internal 10/325=3.1%)

5.     Lin CC, Chen HY, Tseng CY, Yang CC. Effect of Acupuncture on Recovery of Consciousness in Patients with Acute Traumatic Brain Injury: A Multi-Institutional Cohort Study. Healthcare. August 2023;11(16):2267. (SCI, IF:2.4, Health Care Sciences & Services 73/174=42.0%)

6.     Fang WC, Chen HY, Chu SC, et al. Serum Cystatin C Levels Could Predict Rapid Kidney Function Decline in A Community-Based Population. Biomedicines. November 2022;10(11):2789; doi: 10.3390/biomedicines10112789. (SCI, IF: 3.9, Pharmacology & Pharmacy 85/354=24.0%)

7.     Chien TP, Huang SF, Chan WH, Pan KT, Yu MC, Lee WC, Tsai HI, Lin PT, Chen HY, Chen JH, Lee CW. The combination of sarcopenia and biochemical factors can predict the survival of hepatocellular carcinoma patients receiving transarterial chemoembolization. Frontiers in Oncology. September 2022;12.; doi: 10.3389/fonc.2022.1005571 (SCI, IF:3.5, Oncology 107/322=33.2%)

8.     Lu YC, Yang CW, Chen JL, Lin YH, Chen HY, Yang SH. Characteristics of Chinese Herbal Medicine and Acupuncture Users Among Allergic Rhinitis Patients: A Population-based Study. Journal of Chinese Medicine. 2022;33(1):20.

9.     Wu YH, Chen HY, Hong WC, Wei CY, Pang JH. Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest, and Apoptosis in Megakaryocytes. International Journal of Molecular Sciences. June 2022;23(11):6290.; doi: 10.3390/ijms23116290 (SCI, IF: 4.9, Biochemistry & Molecular Biology 66/313=21.1%)

10.   Kwon SH, Lao WW, Lee CH, Hsu AT, Koide S, Chen HY, et al. Experiences and attitudes toward aesthetic procedures in East Asia: a cross-sectional survey of five geographical regions. Archive Plastic Surgery. November 2021;48(6):660-669.; doi: 10.5999/aps.2020.02565 (SCI, IF: 1.3, Surgery 177/290=61.0%)

11.   Ku TC, Wang PH, Huang JL, Chen HY, et al. The survival outcome of nasopharyngeal cancer patients with traditional Chinese medicine external use: A hospital-based study. Journal of Ethnopharmacology. October 2021:279:114380.; doi: 10.1016/j.jep.2021.114380 (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

12.   Lin YH, Luck H, Khan S, Schneeberger PHH, Tsai S, Clemente-Casares X, Lei H, Leu YL, Chan YT, Chen HY, Yang SH, Coburn B, Winer S, Winer DA. Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity. International Journal of Obesity (Lond.). December 2019:43(12):2407-2421. (SCI, IF:4.2, Endocrinology & Metabolism 40/186=21.5%)

13.   Wang TJ, Yang TH, Tsang NM, et al. Zeng Ye Decoction Mouthwashes With Acupuncture Can Decrease Complications and Body Weight Loss of Head And Neck Cancer Patient Under Radiotherapy With/without Chemotherapy. Journal of Chinese Medicine. December 2019;30(2):48-61.

14.   Yang SH, Lin YH, Lin JR, Chen HY, et al. The Efficacy and Safety of a Fixed Combination of Chinese Herbal Medicine in Chronic Urticaria: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Frontiers in Pharmacology. December 2018;9(1474). (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

15.   Chen W, Chen HY, Yang Y-H, et al. An Investigation of the Prescription Patterns of Chinese Herbal Products for Chronic Glomerulonephritis Patients: A Hospital-Based Cross-Sectional Study. Evidence-based Complementary and Alternative Medicine. November 2018;2018:11.

16.   Yang CW, Chen HY, Chen JL, Yang SH. Therapeutic effiacy of traditional Chinese medicine on quality of life and heart rate variability among patients in long-term care system in Taiwan. Journal of Chinese Medicine. December 2018;29(1):42-59.

17.   Wu YH, Chen HY, Lai C-H, et al. Use of Chinese Herbal Medicine Improves Chemotherapy-Induced Thrombocytopenia among Gynecological Cancer Patients: An Observational Study. Evidence-based Complementary and Alternative Medicine July 2018;2018:8.

18.   Lin YH, Chen HY, Chiu JC, Chen KJ, Ho HY, Yang SH. Immunomodulation Effects of Schizonepeta tenuifolia Briq. on the IgE-Induced Allergic Model of RBL-2H3 Cells. Evidence-based Complementary and Alternative Medicine April 2018;2018:7.

19.   Hsu CY, Lee KH, Huang HC, Chang ZY, Chen HY, Yang TH: Manipulation Therapy Relieved Pain More Rapidly Than Acupuncture among Lateral Epicondylalgia (Tennis Elbow) Patients: A Randomized Controlled Trial with 8-Week Follow-Up. Evidence-based Complementary and Alternative Medicine April 2016, 2016:3079247.

20.   Hsu PY, Yang SH, Tsang NM, et al. Efficacy of Traditional Chinese Medicine in Xerostomia and Quality of Life during Radiotherapy for Head and Neck Cancer: A Prospective Pilot Study. Evidence-based Complementary and Alternative Medicine  August 2016;2016:8359251.

21.   Yang SH, Kao TI, Chiang BL, Chen HY, Chen KH, Chen JL. Immune-modulatory effects of bu-zhong-yi-qi-tang in ovalbumin-induced murine model of allergic asthma. PLoS One. June 2015;10(6):e0127636. (SCI, IF:2.9, Multidisciplinary Sciences 31/134=23.1%)

22.   Yeh CS, Chen HY, Yang SH, et al. Influence of Weight Loss on Different Traditional Chinese Medicine Constitutional Types of Patients with Head and Neck Cancer Who Underwent Radiotherapy: An Observational Study. Journal of Chinese Medicine. December 2014;25(2):10.

23.   Yang TH, Chen HY, Yang SH, et al. Utilization Pattern for Traditional Chinese Medicine among Late Stage Chronic Kidney Disease Patients: A Hospital-Based Cross-sectional Study. Journal of Chinese Medicine. June 2014;24(1).

24.   Yeh YC, Chen HY, Yang SH, et al. Hedyotis diffusa combined with Scutellaria barbata are the core treatment of Chinese herbal medicine used for breast cancer patients: a population-based study. Evidence-based Complementary and Alternative Medicine. March 2014;2014:202378.

25.   Yang SH, Yu CL, Chen HY, Lin YH. A Commonly Used Chinese Herbal Formula, Shu-Jing-Hwo-Shiee-Tang, Potentiates Anticoagulant Activity of Warfarin in a Rabbit Model. Molecules. September 2013;18(10):11712-11723. (SCI, IF=4.2, Biochemistry & Molecular Biology 88/313=28.1%)

26.   Lin YH, Chen YC, Hu S, Chen HY, Chen JL, Yang SH. Identifying core herbal treatments for urticaria using Taiwan's nationwide prescription database. Journal of Ethnopharmacology. July 2013;148(2):556-562. (SCI, IF: 4.8, Integrative & Complementary Medicine 4/43=9.3%)

27.   Tsou YK, Lien JM, Chen CK, Lin CH, Chen HY, Lee MS. Esophagogastroduodenoscopy with conscious sedation does not interfere with catheter-based 24-h pH monitoring. World Journal of Gastroenterology. March 2013;19(11):1805-1810. (SCI, IF=4.3, Gastroenterology & Hepatology 29/143=20.3%)

28.   Yang SH, Chen HY, Lin YH, Chen YC. The exploration of disease pattern, Zheng, for differentiation of allergic rhinitis in traditional Chinese medicine practice. Evidence-based Complementary and Alternative Medicine. July 2012;2012:521780.

29.   Hsu PY, Chen JL, Chen HY, Yang SH. Extract of Sporoderm-Broken Germinating Spores of Ganoderma lucidum Activates Human Polymorphonuclear Neutrophils via the P38 Mitogen-activated Protein Kinase Pathway. Biomedical Journal. April 2012;35(2):140-147. (SCI, IF: 4.1, Medicine, Research & Experimental 62/189=32.8%)

30.   Lee MS, Yeh CJ, Chen HY, Tsou YK, Lin CH, Lien JM. Clinical utility of histological examination of gastric ulcer margin to diagnose helicobacter pylori infection. Biomedical Journal. May 2012;35(3):240-246. (SCI, IF: 4.1, Medicine, Research & Experimental 62/189=32.8%)

31.   Hsieh YW, Chen HY, Yang CC. The risk factors for stroke inpatients need emergency medical services in the Traditional Chinese Medicine ward. Journal of Chinese Medicine. December 2012;23(2):133-140.

32.   Yang CW, Yang SH, Wu YH, Chiao SL, Chen HY, Chen JL. The Therapeutic Efficacy of Traditional Chinese Medicine Hospitalization Combined with Conventional Western Medicine Among Cancer patients in Taiwan. Journal of Chinese Medicine. December 2012;23(2):153-163.

33.   Lin YH, Chen HY, Li YC, Chiu JC, Yang SH. Adverse Events Assessment of Traditional Chinese Herbal Product, Guilu Erxian Jiao, In Healthy Volunteers. Journal of Chinese Medicine. May 2011;22(1,2):11.