中醫學系

研究主題

1.inflammation

2.acupuncture

論文著作

1.     Yang, C.C., Lee, I.T., Lin, Y.J., Wu, W.B., Hsiao, L.D., Yang, C.M.*. Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation. Int. J. Mol. Sci. 2023, 24(20), 15130; https://doi.org/10.3390/ijms242015130. 2023 Oct. (SCI; IF=5.6; Biochemistry & Molecular Biology, 66/285 =23.1%)

2.     Lin, Y.J., Yang, C.C, Lee, I.T., Wu, W.B., Lin, C.C., Hsiao, L.D., Yang, C.M.*. Reactive Oxygen Species-Dependent Activation of EGFR/Akt/p38 Mitogen-Activated Protein Kinase and JNK1/2/FoxO1 and AP-1 Pathways in Human Pulmonary Alveolar Epithelial Cells Leads to Up-Regulation of COX-2/PGE2 Induced by Silica Nanoparticles. Biomedicines, 2023 Sep; 11(10), 2628; https://doi.org/10.3390/biomedicines11102628. 2023. (SCI; IF=4.7; Biochemistry & Molecular Biology: 92/315=29.2%)

3.     Lin, C.C.; Chen, H.Y.; Tseng, C.Y.; Yang, C.C.*. Effect of Acupuncture on Recovery of Consciousness in Patients with Acute Traumatic Brain Injury: A Multi-Institutional Cohort Study. Healthcare 2023, 11(16), 2267; pages 1-12. DOI: 10.3390/healthcare11162267. 2023 Aug. (SCI; IF= 2.8; Health Care Sciences & Services 56/105=53.3%)

4.     Yang, C.M.*, Yang, C.C., Hsu, W.H., Hsiao, L.D., Tseng, H.C., Shih, Y.F. (本人為共同第一作者) Tumor Necrosis Factor-α-Induced CC Motif Chemokine Ligand 20 Expression through TNF Receptor 1-Dependent Activation of EGFR/p38 MAPK and JNK1/2/FoxO1 or the NF-κB Pathway in Human Cardiac Fibroblasts. Int. J. Mol. Sci. 23 (16), 9086. 2022 Aug. (SCI; IF=5.6; Biochemistry & Molecular Biology, 66/285 =23.1%)

5.     Yang, C.C., Hsiao, L.D., Shih, Y.F., Hsu, C.K., Hu, C.Y. and C.M. Yang*. Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells. Mediators. Inflamm. 2022: 4600029. doi.org/10.1155/2022/4600029. 2022 Apr. (SCI; IF= 4.6; Cell Biology, 86/191=45%)

6.     Yang, C.C., Hsiao, L.D., Wang, C.Y., Lin, W.N., Shih, Y.F., Chen, Y.W., Cho, R.L., Tseng, H.C. and C.M. Yang*. HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells. Antioxidants. 11(4): E782; doi.org/10.3390/antiox11040782, 2022 Apr. (SCI; IF=7.0; Chemistry, Medicinal 6/60=10 %)

7.     Yang, C.C., Hsiao, L.D., Shih, Y.F., Chang, C.I. and C.M. Yang*. Induction of Heme Oxygenase-1 by 15d-Prostaglandin J2 Mediated via a ROS-Dependent Sp1 and AP-1 Cascade Suppresses Lipopolysaccharide-Triggered Interleukin-6 Expression in Mouse Brain Microvascular Endothelial Cells. Antioxidants. 11(4): E719; doi.org/10.3390/antiox11040719. 2022 Apr. (SCI; IF=7.0; Chemistry, Medicinal 6/60=10%) 

8.     Yang, C.C., Hsiao, L.D., Shih, Y.F., Lin H.Hui. and C.M. Yang*. 5, 8-Dihydroxy-4’,7-Dimethoxyflavone Attenuates TNF- Induced Expression of Vascular Cell Adhesion Molecule-1 through EGFR/PKC/PI3K/Akt/Sp1-Dependent Induction of Heme Oxygenase-1 in Human Cardiac Fibroblasts. Oxidative Med. Cell. Longev. 2022: 1372958. doi.org/10.1155/2022/1372958. 2022 Mar.

9.     Yang, C.C., Hsiao, L.D., Shih, Y.F., Su, M.H. and C.M. Yang*. Sphingosine 1-Phosphate Upregulated COX-2/PGE2 System Contributes to Human Cardiac Fibroblast Apoptosis: Involvement of MMP-9-Dependent Transactivation of EGFR Cascade. Oxidative Med. Cell. Longev. 2022: 7664290. doi: 10.1155/2022/7664290. 2022 Feb.

10.   Wang, C.Y., Yang, C.C., Hsiao, L.D. and Yang, C.M.*. (本人為共同第一作者). Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d PGJ2 Attenuates H2O2 Induced IL 6 Expression in Rat Brain Astrocytes. Neurotox. Res. 40 (1): 154-172; doi.org/10.1007/s12640- 002-00318-6. 2022 Feb. (SCI; IF=3.7; Neuroscience, 113/272=41.5%)

11.   Yang, C.C., Hsiao, L.D., Shih, Y.F., Yu, Z.Yao. and C.M. Yang*. Anti-Inflammatory Effects of Rhamnetin on Bradykinin-Induced Matrix Metalloproteinase-9 Expression and Cell Migration in Rat Brain Astrocytes. Int. J. Mol. Sci. 23(2): E609; doi: 10.3390/ijms23020609. 2022 Jan. (SCI; IF=5.6; Biochemistry & Molecular Biology, 66/285 =23.1%)

12.   Yang CM*, Yang CC, Hsiao LD, Yu CY, Tseng HC, Hsu CK, Situmorang JH. Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts. J Inflamm Res. 2021;14:2807-2824 (SCI; IF=4.5; Immunology, 76/161=47.2%) 

13.   Lin, C.C.; Yang, C.C.; Hsiao, L.D.; Yang, C.M*. (本人為共同第一作者). Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes. Oxidative Med. Cell. Longev. 2021, 2021, 5521196.

14.   Yang CC, Yang CM*. Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases. J Inflamm Res. 2021;14:657-687. (SCI; IF=4.5; Immunology, 76/161=47.2%)

15.   Yang, C.C., Hsiao, L.D., Lin, H.H., Tseng, H.C., Situmorang, J. H., Leu, Y.L., & Yang, C.M*. Induction of HO-1 by 5, 8-Dihydroxy-4,7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts. Oxidative Med. Cell. Longev. 2020, 1080168.

16.   Yang, CC, Hsiao LD, Yang CM*. Galangin Inhibits LPS-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent AP-1 and FoxO1 Activation in Rat Brain Astrocytes. J Inflamm Res. 2020(13): Pages 945-960 (SCI; IF=4.5; Immunology, 76/161=47.2%)

17.   Yang, CC, Hsiao LD, Su MH, Yang CM*. Sphingosine 1-Phosphate Induces Cyclooxygenase-2/Prostaglandin E2 Expression via PKCα-dependent Mitogen-Activated Protein Kinases and NF-κB Cascade in Human Cardiac Fibroblasts. Front. Pharmacol., 30 October 2020; P1-19 (SCI; IF=5.6; Pharmacology&Pharmacy, 45/277 =16.2%)

18.   Yang, C.C., Hsiao LD, Tseng HC, Kuo CM, Yang CM*. Pristimerin Inhibits MMP-9 Expression and Cell Migration Through Attenuating NOX/ROS-Dependent NF-κB Activation in Rat Brain Astrocytes Challenged with LPS. J Inflamm Res. 2020:13 325–3412 (SCI; IF= 4.5; Immunology, 76/161=47.2%)

19.   Yang CC, Lin CC, Hsiao LD, Kuo JM, Tseng HC, Yang CM*. Lipopolysaccharide-Induced Matrix Metalloproteinase-9 Expression Associated with Cell Migration in Rat Brain Astrocytes. Int. J. Mol. Sci. 2020 Jan 1; 21(1), 259, page1-25. (SCI; IF=5.6; Biochemistry & Molecular Biology, 66/285 =23.1%).

20.   Lin CC, Lin WN, Cho RL, Yang CC, Yeh YC, Hsiao LD, Tseng HC, Yang CM*. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. J Clin Med. 2020 Jan 15; 9(1):226. (SCI; IF=3.9; Medicine, General & Internal, 58/167 =34.7%).

21.   Yang CM*, Lin CC, Yang CC, Cho RL, Hsiao LD. Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α. Biomolecules. 2020 Mar 1;10(3):381. (SCI; IF=5.5; Biochemistry & Molecular Biology, 70/285=24.5%).

22.   Yang, C.C., Lin, C.C., Jou, M.J., Hsiao, L.D., Yang, C.M*. RTA 408 Inhibits Interleukin-1β-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent NF-κB and AP-1 Activation in Rat Brain Astrocytes. Int. J. Mol. Sci. 2019 Jun 10;20(11). pii: E2826. (SCI; IF=5.6; Biochemistry & Molecular Biology, 66/285 =23.1%).

23.   Yang, C.C., Lin, C.C., Hsiao, L.D., and C.M. Yang*. Galangin inhibits thrombin-induced MMP-9 expression in SK-N-SH cells via protein kinase-dependent NF-kappaB phosphorylation. Int. J. Mol. Sci. 2018 Dec 17;19(12). pii: E4084. (SCI; IF=5.6; Biochemistry & Molecular Biology, 66/285 =23.1%)

24.   Tseng, H.C., C.C. Lin, C.Y. Wang, Yang, C.C., L.D. Hsiao, and C.M. Yang*. Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts. Cell. Mol. Life Sci. 2018 Dec;75(24):4599-4617. (SCI; IF=8.0; Biochemistry & Molecular Biology 36/285=12.6%)

25.   Cho, R.L., Yang, C.C., Tseng, H.C., Hsiao, L.D., Lin, C.C and Yang, C.M.*. HO-1 upregulation by rosiglitazone via ROS-dependent Nrf2-ARE axis or PPARgamma attenuates lipopolysaccharide-mediated lung inflammation. Br. J. Pharmacol. 2018 Oct;175(20):3928-3946. (SCI; IF=7.3; Pharmacology &Pharmacy, 25/277 =9%)

26.   Lee, I.T., Lin, C.C., Yang, C.C., Hsiao, L.D., Wu, M.Y., and C.M. Yang*. Resveratrol attenuates Staphylococcus aureus-induced monocyte adhesion through downregulating PDGFR/AP-1 activation in human lung epithelial cells. Int. J. Mol. Sci. 2018 Oct 7;19(10). pii: E3058. (SCI; Biochemistry & Molecular Biology, 66/285 =23.1%, IF= 5.6)

27.   Lin, C.C., Yang, C.C., Y.W. Chen, L.D. Hsiao, and C.M. Yang*. (本人為共同第一作者). Arachidonic acid induces ARE/Nrf2-dependent heme oxygenase-1 transcription in rat brain astrocytes. Mol. Neurobiol. 2018 Apr;55(4):3328-3343. (SCI; IF=5.1; Neurosciences, 69/272=25.3%)

28.   Cho, R.L., Lin. W.N., Wang, C.Y., Yang, C.C., Hsiao, L.D., Lin, C.C and Yang, C.M.*. Heme oxygenase-1induction by rosiglitazone via PKCalpha/AMPKalpha/ p38MAPKalpha/SIRT1/PPARgamma pathway suppresses lipopolysaccharide-mediated pulmonary inflammation. Biochem. Pharmacol. 2018 Feb; 148:222-237. (SCI; IF=5.8; Pharmacology & Pharmacy, 40/277=14.4%)

29.   Lin, C.C., Chiang, Y.C., Cho, R.L., Lin, W. N., Yang, C.C., Hsiao, L.D, and C.M. Yang*. Up-regulation ofPYK2/PKCα-dependent HO-1 by CO-releasing molecule (CORM)-2 attenuates TNF-α-induced lung inflammation. Br. J. Pharmacol. 2018 Feb;175(3):456-468. (SCI; IF=7.3; Pharmacology &Pharmacy, 25/277 =9%)

30.   Lin, C.C., Yang, C.C., L.D. Hsiao., S.Y. Chen, and C.M. Yang*. (本人為共同第一作者). Heme Oxygenase-1 Induction by Carbon Monoxide Releasing Molecule-3 Suppresses Interleukin-1β-Mediated Neuroinflammation. Front Mol Neurosci. 2017 Nov 20;10:387. (SCI; IF=4.8; Neurosciences, 80/272 =29.4%).

31.   Yang CC, Hsiao LD, Yang CM*, Lin CC*. Thrombin Enhanced Matrix Metalloproteinase-9 Expression and Migration of SK-N-SH Cells via PAR-1, c-Src, PYK2, EGFR, Erk1/2 and AP-1. Mol. Neurobiol. 2017 Jul; 54(5):3476-3491. (SCI; IF=5.1; Neurosciences, 69/272=25.3%)

32.   Yang CC, Lin CC, Chien PT, Hsiao LD, Yang CM*. Thrombin/Matrix Metalloproteinase-9-Dependent SK-N-SH Cell Migration is Mediated Through a PLC/PKC/MAPKs/NF-κB Cascade. Mol. Neurobiol. 2016 Nov; 53(9):5833-5846. (SCI; IF=5.1; Neurosciences, 69/272=25.3%).

33.   Cho RL, Yang CC, Lee IT, Lin CC, Chi PL, Hsiao LD, Yang CM*. Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-κB pathway in human pulmonary alveolar epithelial cells. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016, 310(7): L639-57. (SCI; IF=4.9; Physiology; 13/79=16.4%).

34.   Lin CC, Yang CC, Cho RL, Wang CY, Hsiao LD, Yang CM*. (本人為共同第一作者). Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells. Frontiers in Pharmacology. 2016 Mar 31; 7:80. (SCI; IF= 5.6; Pharmacology&Pharmacy, 45/277=16.2%).

35.   Lin CC, Yang CC, Wang CY, Tseng HC, Pan CS, Hsiao LD, Yang CM*. NADPH Oxidase/ROS-Dependent VCAM-1Induction on TNF-α-Challenged Human Cardiac Fibroblasts Enhances Monocyte Adhesion. Frontiers in Pharmacology. 2016 Jan 28; 6:310. (SCI; IF=5.6; Pharmacology&Pharmacy, 45/277=16.2%)).

36.   Chen CC, Yang CC, Hu CC, Shih HN, Chang YH, Hsieh PH*. Acupuncture for pain relief after total knee arthroplasty: a randomized controlled trial. Regional Anesthesia and Pain Medicine. 2015 Jan-Feb;40(1):31-6. (SCI; IF=5.1; Anesthesiology; 8/35=22.8%).

37.   Hsieh HL, Chi PL, Lin CC, Yang CC, Yang CM*. Up-regulation of ROS-dependent matrix metalloproteinase-9 from high-glucose-challenged astrocytes contributes to the neuronal apoptosis. Mol. Neurobiol. 2014 Oct; 50(2):520-33. (SCI; IF=5.1; Neurosciences, 69/272=25.3%).

38.   Lin CC, Hsieh HL, Chi PL, Yang CC, Hsiao LD, Yang CM*. Upregulation of COX-2/PGE2 by ET-1 mediated through Ca2+-dependent signals in mouse brain microvascular endothelial cells. Mol. Neurobiol. 2014 Jun; 49(3):1256-69. (SCI; IF=5.1; Neurosciences, 69/272=25.3%).

39.   Lin CC, Lee IT, Wu WB, Liu CJ, Hsieh HL, Hsiao LD, Yang CC, Yang CM*. Thrombin mediates migration of rat brain astrocytes via PLC, Ca²⁺, CaMKII, PKCα, and AP-1-dependent matrix metalloproteinase-9 expression. Mol. Neurobiol. 2013 Dec; 48(3):616-30. (SCI; IF=5.1; Neurosciences, 69/272=25.3%).

40.   王甜如(Tien-ju Wang)；楊宗憲(Tsung Hsien Yang)；曾雁明(Ngan-Ming Tsang)；唐遠雲(Yuan Yun Tang)；許惠菁(Hui Ching Hsu)；劉耕豪(Geng-Hao Liu)；許珮毓(Pei-Yu Hsu)；楊建中(Chien-Chung Yang)；陳星諭(Hsing-Yu Chen)；楊賢鴻(Sien-Hung Yang)；陳俊良(Jiun-Liang Chen)*. Zeng Ye Decoction Mouthwashes With Acupuncture Can Decrease Complications and Body Weight Loss of Head And Neck Cancer Patient Under Radiotherapy With/without Chemotherapy. 中醫藥雜誌；30卷2期 (2019 / 12 / 01)，P48-61 (非SCI).

41.   Kuan CH, Hsu HC, Shiue HS, Yang CC, Tang YY*, Yang SH. No Control, Preliminary Study Evaluating the Effects of Acupuncture and Chinese Medicine in Traditional Chinese Medical Ward for Patients with Stroke or Patients with Traumatic Brain Injury. 中醫藥雜誌；2016, 27: 2, Pd1- 7(非SCI).

42.   Yi-Wen Hsieh, Hsing-Yu Chen, Chien-Chung Yang*. The Risk Factors for Stroke Inpatients Need Emergency Medical Services in the Traditional Chinese Medicine Ward. 中醫藥雜誌(Journal of Chinese Medicine).2012, 23:2, P133-140 (非SCI).

43.   Wang HP, Yang CC, Hsu, HC*. Exploring Resilience and Related Factors Among Patients With Stroke in the Recovery Stage. 護理雜誌；65卷5期 (2018 / 10 / 01)，P56-67(非SCI).