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中醫學系

中醫學系
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方嘉佑 教授

方嘉佑 教授

職稱： 教授

現職： 天然藥物研究所教授

信箱： fajy@mail.cgu.edu.tw

電話： 03-2118800轉5521

學歷： 高雄醫學大學藥學所博士

專長領域： 藥劑學、藥物標靶與傳輸、化妝品學、奈米醫學

個人網頁： https://pure.lib.cgu.edu.tw/en/persons/jia-you-fang-2

研究主題

藥劑學研究在日本是屬於醫療藥學領域，在歐美國家則屬藥廠研發實務，其精神在於以既定藥物賦予全新設計的處方、添加物或材料，以使藥物本身之藥理活性最大化或使其毒性及副作用最小化，或是延長藥物於體內的留存時間。其意義在於使臨床上的用藥更加安全及有效，進而改善病患之依順性。藥劑學在藥學研究領域內被視為較下游之藥物研發過程，為一門應用科學，本研究室的主要工作便是為藥物設計新的處方內容並探究其改善傳統劑型缺點之程度與能力。

最近之研究計畫:

  1. 多功能藥物奈米載體經由 retinol-binding protein 4 (RBP4) 傳輸至腎臟以治療抗藥性菌血症誘發之腎損傷
  2. 多效能之藍莓活性成分 pterostilbene 可塑性奈米微脂體：用以促進瓦解 P. acnes 生物膜結構與抗局部感染活性
  3. 接合 NIMP-R14 抗體的脂質奈米載體主動標靶至嗜中性白血球以改善 PDE4 抑制劑之抗乾癬活性
  4. 兼具被動與主動標靶能力之奈米載體傳輸 ciprofloxacin 以治療感染性肺炎：以 IsaB DNA 為配體之非離子微胞
  5. 設計合成含有角鯊烯之前驅藥及其奈米載體開發：以毛囊為標靶位置
  6. 厚朴有效成分之抗發炎及經皮吸收之研究
  7. 牛樟芝萃取物治療異位性皮膚炎之研究：牛樟芝單苯環類化合物在角質細胞中的抗發炎機制
  8. 一系列合成異黃酮類化合物之經皮吸收參數建立與其乾癬治療之活性探究
  9. 中草藥多酚成分之最適分離技術開發

最近之產學合作計畫:

  1. 中部科學園區管理局: 新劑型、新給藥方式之痤瘡 (Acne vulgaris) 用藥-美諾四環 (Minocycline)-505(b)2新藥開發
  2. 台塑生醫: 保養品暨美容儀器經皮吸收及功效性研究
  3. 肌活麗學創研所: 乳鐵蛋白抗白髮胜肽經皮吸收
  4. 大江生醫: LipoMask 之經皮吸收能力評估
  5. 生達化學製藥: VD-T03 處方優化與物理化學性質評估
  6. 信東製藥: 硬鏡去蛋白試驗
  7. 元太科技: 新型藥物貼片平台經皮膚傳導能力可行性
  8. 藥華醫藥：KX-01牛皮癬軟膏之藥物穿透研究
  9. 恩揚生物科技：牛樟芝萃取物應用於治療乾癬及異位性皮膚炎之抗發炎

專利

  1. Fluorescent dye compositions and uses thereof, Chia-Yu Fang, Chih-Jen Wen, US9,855,346 B2, 美國, 2014/11/06-2034/11/06
  2. 使用2,4-二甲氧基-6-甲基苯-1,3-二醇來治療異位性皮膚炎，王東弘、方嘉佑、楊世駿、黃澤宏，I670055，中華民國 2019/9/1-2038/4/10
  3. 使用2,4-二甲氧基-6-甲基苯-1,3-二醇來防止和/或抑制葡萄球菌屬物種的生長以及生物膜形成，王東弘、方嘉佑、楊世駿、黃澤宏，I680756，中華民國 2020/1/1-2038/7/1
  4. 使用2,4-二甲氧基-6-甲基苯-1,3-二醇來預防和/或治療乾癬，王東弘、方嘉佑、楊世駿、莊士億、黃澤宏，I716940，中華民國 2021/1/21-2039/7/22
  5. 凝膠型防曬組成物，吳智元、楊世駿、王東弘、方嘉佑，1760745，中華民國20224/11-2040/5/11

榮譽事蹟

1. 方嘉佑教授獲獎「第33屆王民寧獎」要學類領域肯定
2. 方嘉佑教授再度榮獲2023年公布「全球前2%頂尖科學家榜單(World's Top 2% Scientists)」臨床醫學領域全台灣排名第23名藥學專長殊榮肯定
3. 方嘉佑教授蟬聯2023年公布「全球前2%頂尖科學家榜單(World's Top 2% Scientists)」殊榮肯定
4. 方嘉佑教授再度榮獲2022年公布「全球前2%頂尖科學家榜單(World's Top 2% Scientists)」臨床醫學領域全台灣排名第23名藥學專長殊榮肯定
5. 方嘉佑教授和黃聰龍教授再次同時入榜2022年公布「1960-2021年度學術生涯科學影響力」和「2021年度科學影響力」全球排名前2%頂尖科學家名單(World's Top 2% Scientists)」
6. 方嘉佑教授和黃聰龍教授再次同時入榜2021年公布「1960-2020年度學術生涯科學影響力」和「2020年度科學影響力」全球排名前2%頂尖科學家名單(World's Top 2% Scientists)」

實驗室成員與活動照片

博士班研究生1人
碩士班研究生6人
專任研究助理8人
博士後研究員2人

實驗室介紹連結

論文著作

The selected publications from total 339 articles

*, corresponding author

  1. Tsai, M.J., Lin, C.Y., Trousil, J., Sung, C.T., Lee, M.H., Fang, J.Y.*, Yang, S.C. (2023) Proteinase K/retinoic acid-loaded cationic liposomes as multifunctional anti-acne therapy to disorganize biofilm and regulate keratinocyte proliferation. Int. J. Nanomed., 18, 3879‒3896.
  2. Yang, S.C., Lin, C.F., Alshetaili, A., Aljuffalin, I.A., Chien, M.Y., Fang, J.Y.* (2023) Dual antibacterial and regenerative activities of platelet-rich plasma combined with β-lactam antibiotics are effective to treat MRSA-infected skin wound: the cell- and animal-based studies. Biomed. Pharmacother., 165, 115017.
  3. Huang, T.H., Chen, C.J., Lin, H.C.A., Chen, C.H., Fang, J.Y.* (2023) Self-nanoemulsifying drug delivery system-containing the poorly absorbed drug‒valsartan in post-bariatric surgery. Int. J. Nanomed., 18, 2647‒2658.
  4. Lin, C.Y., Yu, H.P., Chang, Y.T., Lin, Z.C., Alalaiwe, A., Hwang, T.L., Fang, J.Y.* (2023) Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation. Biomater. Sci., 11, 873–893.
  5. Nirmal, G.R., Lin, Z.C., Lin, C.H., Sung, C.T., Liao, C.C., Fang, J.Y.* (2022) Polydopamine/IR820 nanoparticles as topical phototheranostics for inhibiting psoriasiform lesions through dual photothermal and photodynamic treatments. Biomater. Sci., 10, 6172–6189.
  6. Lee, W.R., Chou, W.L., Lin, Z.C., Sung, C.T., Lin, C.Y., Fang, J.Y.* (2022) Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis. J. Control. Release, 347, 590–606.
  7. Tseng, C.H., Lin, C.F., Aljuffali, I.A., Huang, J.R., Yang, S.H., Fang, J.Y.* (2022) The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption. Int. J. Pharm., 617, 121629.
  8. Lee, W.R., Hsiao, C.Y., Chang, Z.Y., Wang, P.W., Aljuffali, I.A., Lin, J.Y., Fang, J.Y.* (2022) Cutaneous delivery of cosmeceutical peptides enhanced by picosecond- and nanosecond-domain Nd:YAG lasers with quick recovery of the skin barrier function: comparison with microsecond-domain ablative lasers. Pharmaceutics, 14, 450.
  9. Fang, J.Y., Huang, T.H., Chen, W.J., Aljuffali, I.A., Hsu, C.Y. (2022) Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis. Biomed. Pharmacother., 146, 112497.
  10. Fang, J.Y., Chou, W.L., Lin, C.F., Sung, C.T., Alalaiwe, A., Yang, S.C. (2021) Facile biofilm penetration of cationic liposomes loaded with DNase I/proteinase K to eradicate Cutibacterium acnes biofilm for treating cutaneous and catheter infections. Int. J. Nanomed., 16, 8121–8138.
  11. Chuang, S.Y., Chen, C.Y., Yang, S.C., Alalaiwe, A., Lin, C.H., Fang, J.Y.* (2021) 2,4-Dimethoxy-6-methylbenzene-1,3-diol, a benzenoid from Antrodia cinnamomea, mitigates psoriasiform inflammation by suppressing MAPK/NF-κB phosphorylation and GDAP1L1/Drp1 translocation. Front. Immunol., 12, 664425.
  12. Nirmal, G.R., Lin, Z.C., Tsai, M.J., Yang, S.C., Alalaiwe, A., Fang, J.Y.* (2021) Photothermal treatment by PLGA-gold nanorod-isatin nanocomplexes under near-infrared irradiation for alleviating psoriasiform hyperproliferation. J. Control. Release, 333, 487–499.
  13. Lin, Z.C., Hwang, T.L., Huang, T.H., Tahara, K., Trousil, J., Fang, J.Y.* (2021) Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics, 11, 4567–4584.
  14. Liao, C.C., Yu, H.P., Yang, S.C., Alalaiwe, A., Dai, Y.S., Liu, F.C., Fang, J.Y.* (2021) Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. J. Nanobiotechnol., 19, 48.
  15. Elzoghby, A.O., Abdelmoneem, M.A., Hassanin, I.A., Abd Elwakil, M.M., Elnaggar, M.A., Mokhtar, S., Fang, J.Y., Elkhodairy, K.A. (2020) Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier and targeting ligand. Biomaterials, 263, 120355.
  16. Tang, K.W., Lin, Z.C., Wang, P.W., Alalaiwe, A., Tseng, C.H., Fang, J.Y.* (2020) Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes. J. Dermatol. Sci., 99, 90–99.
  17. Alalaiwe, A., Lin, Y.K., Lin, C.H., Wang, P.W., Lin, J.Y., Fang, J.Y.* (2020) The absorption of polycyclic aromatic hydrocarbons into the skin to elicit cutaneous inflammation: the establishment of structure–permeation and in silico–in vitro–in vivo relationships. Chemosphere, 255, 126955.
  18. Yu, H.P., Liu, F.C., Lin, C.Y., Umoro, A., Trousil, J., Hwang, T.L., Fang, J.Y.* (2020) Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions. Nanomedicine, 15, 773–791.
  19. Wu, C.Y.J., Chen, C.H., Lin, C.Y., Feng, L.Y., Lin, Y.C., Wei, K.C., Huang, C.Y., Fang, J.Y.*, Chen, P.Y. (2020) CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology, 22, 253–266.
  20. Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.* (2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.
  21. Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y.* (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240–251.
  22. Chen, P.Y., Wu, C.Y.J., Fang, J.H., Chen, H.C., Feng, L.Y., Huang, C.Y., Wei, K.C., Fang, J.Y.*, Lin, C.Y. (2019) Functionl change of effector tumor-infiltrating CCR5+CD38+HLA-DR+CD8+ T cells in glioma microenvironment. Front. Immunol., 10, 2395.
  23. Weng, J.R., Huang, T.H., Lin, Z.C., Alalaiwe, A., Fang, J.Y.* (2019) Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomed. Pharmacother., 119, 109398.
  24. Hsiao, C.Y., Yang, S.C., Alalaiwe, A., Fang, J.Y.* (2019) Laser ablation and topical drug delivery: a review of recent advances. Expert Opin. Drug Deliv., 16, 937–952.
  25. Lin, C.Y., Hsu, C.Y., Elzoghby, A.O., Alalaiwe, A., Hwang, T.L., Fang, J.Y.* (2019) Oleic acid as the active agent and lipid matrix in cilomilast-loaded nanocarriers to assist PDE4 inhibition of activated neutrophils for mitigating psoriasis-like lesions. Acta Biomater., 90, 350–361.
  26. Fang, J.Y., Lin, C.H., Huang, T.H., Chuang, S.Y. (2019) In vivo rodent models of type 2 diabetes and their usefulness for evaluating flavonoid bioactivity. Nutrients, 11, 530.
  27. Lin, Z.C., Hsieh, P.W., Hwang, T.L., Chen, C.Y., Sung, C.T., Fang, J.Y.* (2018) Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J., 32, 6783–6795.
  28. Abdelmoneem, M.A., Mahmoud, M., Zaky, A., Helmy, M.W., Sallam, M., Fang, J.Y.*, Elkhodairy, K.A., Elzoghby, A.O. (2018) Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma. J. Control. Release, 287, 78–93.
  29. Elgohary, M.M., Helmy, M.W., Abdelfattah, E.Z.A., Ragab, D.M., Mortada, S.M., Fang, J.Y.*, Elzoghby, A.O. (2018) Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. J. Control. Release, 285, 230–243.
  30. Chuang, S.Y., Lin, C.H., Sung, C.T., Fang, J.Y.* (2018) Murine models of psoriasis and their usefulness for drug discovery. Expert Opin. Drug Discov., 13, 551–562.
  31. Liu, F.C., Yu, H.P., Lin, C.Y., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.* (2018) Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge. J. Nanobiotechnol., 16, 35.
  32. Hsu, C.Y., Sung, C.T., Aljuffali, I.A., Chen, C.H., Hu, K.Y., Fang, J.Y.* (2018) Intravenous anti-MRSA phosphatiosomes mediate enhanced affinity to pulmonary surfactants for effective treatment of infectious pneumonia. Nanomed.-Nanotechnol. Biol. Med., 14, 215-225.
  33. Liu, K.S., Huang, T.H., Aljuffali, I.A., Chen, E.L., Wang, J.J., Fang, J.Y.* (2017) Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia. Int. J. Pharm., 523, 386–397.
  34. Hsieh, P.W., Hung, C.F., Lin, C.H., Huang, C.W., Fang, J.Y.* (2017) Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm., 114, 154–163.