一、主講人：Dean and Distinguished Professor Emeritus,Renaissance School of
Medicine Stony Brook University, Kenneth Kaushansky, M.D.
二、講題：：The Myeloproliferative Neoplasms: Acquired Genetics and a Big
Surprise
三、演講日期：10/31 (五) 14:50-17:00
四、摘要：
The myeloproliferative neoplasms (MPNs) are
a related group of seven marrow disorders characterized by clonal
hematopoiesis, driven by acquired genetic changes, with a variable tendency to
evolve towards frank leukemia. The primary characteristic is overproduction of
one or more myeloid blood cell lineages, with symptoms of the disorders related
not only to the expansion of the various blood cell types, but to their
dysfunction. With the discovery of the Ph1 chromosome in 1960 in virtually all
patients with chronic myelogenous leukemia, and its genetic characterization in
1984, additional chromosomal mutations were discovered in each of the MPNs,
most notably in 2005, when an acquired, activating mutation of the JAK2 kinase
was discovered in patients with polycythemia vera, essential thrombocythemia
and primary myelofibrosis. Occasional patients were also found to possess
congenital, MPN-predisposing mutations, and as their diseases advanced,
secondary acquired genetic mutations. About 10 years ago, based on very large
whole genome or exome sequencing of healthy populations (who served as controls
for genome wide association studies), a fraction of individuals with normal
blood counts and no symptoms were found to possess clonal hematopoiesis, driven
by mutations in many of the same genes found in patients with MPNs,
myelodysplastic syndromes, and frank leukemia. This form of clonal
hematopoiesis was dubbed CHIP (clonal hematopoiesis of indeterminant
potential). The frequency of CHIP was found to be age related, with as many as
15% of healthy octogenarians displaying clonal blood cells of from 2-20%.
Follow-up or look back studies of such individuals revealed an approximate
10-fold increase in the likelihood of such individuals developing acute
leukemia over the subsequent decades, but the surprising finding was a 2-4-fold
increased risk of developing cardiovascular disease (CVD; myocardial
infarction, stroke, peripheral vascular disease), even when controlled for CVD
risk factors. The molecular explanation for these events are under intense
study and will be discussed.
五、 活動流程：
14:50-15:10 報到
15:10-15:15 引言與講者介紹
15:15-17:00 演講與討論
六、主辦單位：醫學生物技術暨檢驗學系
聯絡人：蔡淑貞
聯絡信箱：shuchen@mail.cgu.edu.tw
聯絡電話：5247
注意事項：
1.此次活動研習時數1小時。
2.請教師衡酌時間，確認可全程參與再報名，並準時出席，逾開始時間20分鐘恕不給予簽到。
3.為了對演講者表示尊重，及避免違反學術倫理行為，請現場與會教師全程參加並親自簽到、簽退。未完成簽退者，本次研習將無法納入教師成長時數。