生物科技產業碩-博士學位學程

研究方向及研究室特色

1. 探討異位性皮膚炎及自體免疫葡萄膜炎的免疫調控機制，以開發精準檢驗及相關基因、重組蛋白或細胞療法
2. 建立卵巢癌及黑色素瘤動物模式，開發精準檢驗及相關基因、重組蛋白或細胞療法
3. 開發鏡檢及流式細胞分析數據之人工智慧輔助分析平台

論文與著作

1. Chen YS, Hwang CH, Liu CL, Chen HS, Wu ST, Lee MH, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther 2019 Mar; 30(3):273-285. SCI=5.695 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 15.09%) (CMRPD3B0053, CORPD1F0031-3, BMRP440)
2. Barker NM, Li YX, Lee MM, Shen CR, Krause JA, Sun SS, Lu N, Connick WB, and McMillin DR. Synthesis, luminescence, and structure of a polymorphic polyfluorinated diiodoplatinum (II) diimine complex. Inorg Chem. 2019 Aug; 58(16):10716-10724. SCI=5.165 (CHEMISTRY, INORGANIC & NUCLEAR, 11.11%)
3. Elakkat V, Chang CC, Chen JY, Fang YC, Shen CR (correspondence), Liu LK, Lu N. The first two examples of halogen bonding with a sigma hole-donating fluorine in the Csp3–F⋯Osp3 interaction from polyfluorinated trans-dihalo-palladium(II) di-substituted pyridine complexes. Chem Commun (Camb). 2019 Nov; 55(95):14259-14262.SCI=6.222 (CHEMISTRY, MULTIDISCIPLINARY, 24.72%)(MOST108-2320B-182-032)
4. Lin HC, Chen CY, Kao CW, Wu ST, Chen CL Shen CR, Juang JH, IM Chu. In situ gelling-polypeptide hydrogel systems for the subcutaneous transplantation of MIN6 cells. J Polym Res. 2020 Feb; 27, 64. SCI=3.097 (POLYMER SCIENCES, 40.91%)
5. Shen CR, Chen YS, Hwang YS, Chen HJ, Liu CL. Differential bicistronic gene translation mediated by the internal ribosome entry site element of encephalomyocarditis virus. Biomed J 2020 Jun. doi:10.1016/j.bj.2020.06.006. SCI=4.910 (BIOCHEMISTRY&MOLECULAR BIOLOGY, 31.99%) (MOST105-2221-E-131-035, BMRP440, CMRPD1I0071-2)
6. Chiu CF, Ho JH, Tessema E, Lu Y, Shen CR, Lin CW, Lu N. Short-chained platinum complex catalyzed hydrosilylation under thermomorphic conditions: heterogeneous phase separation at ice temperature.. Molecules 2021 Jan; 26(2):378. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
7. Tessema E, Elakkat V, Chiu CF, Zheng JH, Chan KL, Shen CR, Zhang P, Lu N. Recoverable Phospha-Michael additions catalyzed by a 4-N,N-dimethylaminopyridinium saccharinate salt or a fluorous long-chained pyridine: two types of reusable base catalysts. Molecules 2021 Feb; 26(4):1159. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
8. Tessema E, Elakkat V, Chiu CF, Tsai ZL, Chan KL, Shen CR, Su HC, Lu N. Recoverable palladium‐catalyzed carbon‐carbon bond forming reactions under thermomorphic mode: Stille and Suzuki‐Miyaura reactions. Molecules 2021 Mar; 26(5), 1414. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
9. Juang JH, Lin HC, Chen CY, Kao CW, Chen CL, Wu ST, Lin SH, Shen CR, Wang JJ, Tsai ZT, Chu IM. Noninvasive tracking of mPEG-poly(Ala) hydrogel-embedded MIN6 cells after subcutaneous transplantation in mice. Polymers 2021 Mar; 13(6), 885. SCI=4.329 (POLYMER SCIENCE, 20.45%)
10. Juang JH, Wang JJ, Shen CR (equal to first), Chen CY, Kao CW, Chen CL, Lin SH, Wu ST, Li WC, Tsai ZT. Magnetic resonance imaging of transplanted porcine neonatal pancreatic cell clusters labeled with chitosan-coated superparamagnetic iron oxide nanoparticles in mice. Polymers 2021 Apr; 13(8), 1238. SCI=4.329 (POLYMER SCIENCE, 20.45%)
11. Lo SM, Hwang YS, Liu CL, Shen CN, Hong WH, Yang WC, Lee MH, Shen CR (correspondence). Inhibiting TLR7 expression in the retinal pigment epithelium suppresses experimental autoimmune uveitis. Front Immunol (in revision) 2021. SCI=7.561 (IMMUNOLOGY, 14.81%) (MOST 109-2320-B-182-037, CMRPD1I0071-2, BMRP440)
12. Hsu LJ, Liu CL, Kuo ML, Shen CN, Shen CR (correspondence). An alternative cell therapy for cancers: induced pluripotent stem cell (iPSC)-derived natural killer cells. Biomedicines (in revision) 2021. SCI=6.081 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 14.81%) (MOST 109-2320-B-182-037, CMRPD1H0621, CMRPD1K0491, BMRP440)
13. Juang JH, Shen CR (equal to first),Wang JJ, Wu ST, Lin SH, Chen CY, Kao CW, Chen CL, Wang YM. Exendin-4-conjugated manganese magnetism-engineered iron oxide nanoparticles as a potential magnetic resonance imaging contrast agent for tracking transplanted b-cells. (in revision) 2021.

榮譽事項

2024 醫檢全聯會112年度學生論壇第三名 (擔任指導老師) 
2023
The International Medical Technology Student Research Competition (iMT-SRC) (Thailand) (擔任指導老師)
2020
經濟工業局「AI 智慧應用新世代人才培育計畫」人才解題實證特優獎「以有限數據進行模型訓練以應用於甲狀腺乳突癌偵測」
2020
經濟工業局「AI 智慧應用新世代人才培育計畫」人才解題實證佳作獎「遷移學習 (Transfer Learning) 於肺結核檢驗之有限資料進行偵測與辨識模型建立」
2020
國立成功大學醫學院傑出校友
2019
台灣人工智慧學校北區第四期經理人班結業
2018
科技部106年度大專學生研究計畫研究創作獎(擔任指導老師)
2018
醫檢學會107年度學生論壇第一名 (擔任指導老師, 與郭瑞琳、溫巧尼共同指導)
2017
科技部105年度大專學生研究計畫研究創作獎(擔任指導老師)
2015
長庚大學104年度優良教師教學獎