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生物科技產業碩-博士學位學程

生物科技產業碩-博士學位學程
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張中明

張中明 / Chung-Ming Chang

職稱： 助理教授

現職： 生物科技產業碩士學位學程 助理教授 / Assistant professor

信箱： cmchang@mail.cgu.edu.tw ; chungming.chang@gmail.com

電話： 3584

學歷： 法國國立農業Paris-Grignon研究院 動物遺傳學博士

專長領域： 一個健康(One Health)、人畜共通疾病、檢驗試劑開發及商品化

個人網頁： https://cmclabtw.wixsite.com/cmclab

研究方向及研究室特色

張中明助理教授是法國動物遺傳學博士，也是具有豐富臨床經驗的小動物及禽病臨床獸醫師。目前在長庚大學醫學生物技術暨檢驗學系任專任助理教授。主要研究領域是自體免疫疾病及癌症研究、動物分子遺傳學、分子病毒流行病學、基因體學、人畜共通傳染病，實驗動物及經濟動物獸醫學，以及奈米和光電生物科技結合醫學的臨床應用：

1. 自體免疫疾病及癌症之研究：利用次世代定序和生物資訊學在自體免疫疾病及癌症，遺傳學、基因體學及醫學研究應用。現擔任103至105年度科技部計畫台法雙邊協議專案型國際合作研究計畫，生物資訊與醫療資訊學門計畫 : 以缺少FAS與P2X7接收器之新穎小鼠品系鑑定自體免疫淋巴細胞增生症之關鍵基因與調控路徑之三年計畫的共同計畫主持人。

2. 動物遺傳學、基因體學、生物醫學、分子生物學及分子醫學：專長於病毒學、流行病學、基因體學及分子遺傳學之診斷醫學。具優良的新興病毒學、醫學生物和分子生物技術，還有血清學和免疫學診斷技術及細胞培養技術等。

3. 實驗動物及經濟動物獸醫學：具動物遺傳學博士學位、國家獸醫師執照、台大家畜醫院兼任住院醫師經歷。專精於小動物疾病之預防診斷和治療，小動物外科操作，實驗動物管理。並取得法國專業臨床禽病獸醫師證書，專精於禽病學，同時具備臨床及基礎研究能力。

4. 高等生物安全實驗室設計、操作及管理：在法國巴斯德研究所接受過完整高等安全生物實驗室設計、操作及管理的訓練，更有在第三級高等生物安全實驗室(P3)操作過高病原性禽流感病毒(H5N1)的實際經驗。

5. 奈米和光電生物科技結合醫學的臨床應用：擔任歐盟科研架構計畫主題國家聯絡據點團隊計畫，健康領域主題國家聯絡據點之共同計畫主持人 和國內外的生物科技學術和產業界有良好和密切的接觸，利用奈米和光電生物科技結合醫學的臨床應用經驗。

自2011年至2013年六月，因為具有精通法語和英語兩種重要的國際語言，及特別和歐洲國家有良好的國際聯繫網路的優勢，因而擔任臺灣歐盟科研架構計畫健康醫療主題國家聯絡據點團隊的協同計畫主持人。同時也是現任法國在台協會之台法科學與高等教育學術合作與文化交流，生物及科技領域召集人及諮詢委員。

跨領域研究和執行國際合作計畫的經驗，張中明博士深知跨多重領域的研究和建立國際間堅實的合作網路的重要性。國際化合作及研究非常重要，研究員和研究生能積極參與國際學術會議，還有直接與國際頂尖的研究中心作密切雙向的實質合作，才能真正使研究的團隊的研究成果和努力，在相對的時間內受到國際間的肯定。將致力於國際學術課程規劃和交流，更充實和開拓我們學術人員及學生的國際觀和視野。在科學工作之際，張中明博士很樂意教導學生學習法文，擁有英文外第二外語優勢，可帶學生體驗法國巴黎的豐富的人文活動和素養，培育學生成為科技與人文並重的人才。

論文與著作

  1. Vidic, J., Manzano, M., Chang, C.M. and Jaffrezic Renault, N. (2017). Advanced biosensors for detection of pathogens related to livestock and poultry. Veterinary Research. 48:11. (SCI)
  2. Zhang, H., Chang, C.M., Shen K.N., Xian, W., Hsiao, C.D (2016). Identification of myogenic regulatory genes in the muscle transcriptome of beltfish (Trichiurus lepturus): A major commercial marine fish species with robust swimming ability. Genomics Data. 8, 81-84 (co-first author)
  3. Luo J.D., Chang Y.J., Chang C.M., You, J.F., Wei, P.L., Chiou, C.C (2016). GeneGazer: A Toolkit integrating two pipelines for personalized profiling and biosignature identification. Cancer Genomics Proteomics. 03-04;13(2):141-150 (SCI)
  4. Tseng, C.H., Tsai, H.J., and Chang, C.M* (2014). A Complete Molecular Diagnostic Procedure for Applications in Surveillance and Subtyping of Avian Influenza Virus.Biomed Research International. 2014, 653056. (SCI) (*correspondence)
  5. Pačes J., Huang Y-T., Pačes V., Ridl J and Chang, C-M* (2013) New Insight into Transcription of Human Endogenous Retroviral Elements. New Biotechnology, 30(3): 314-318.(SCI) (*correspondence)
  6. Su, L-C., Chang, C-M., Tseng, Y-L., Chang, Y-F., Li, Y-C., Chang, Y-S., Chou, C (2012)  Rapid and Highly Sensitive Method for Influenza A (H1N1) Virus Detection. Analytical Chemistry. 84, 3914-3920. (SCI) (Co-First Author)
  7. Chang C-S., Chen C-F., Berthouly-Salazar C., Chazara  O., Lee Y-P., Chang C-M., Chang K-H., Bed_Hom B., and Tixier-Boichard M (2011) A global analysis of molecular markers and phenotypic traits in local chicken breeds in Taiwan. Animal Genetics, 43, 172–182 (SCI)
  8. Chen Y-T, Tsao Z, Chang S-T, Juang R-H, Wang L-C, Chang C-M, Wang C-H. (2012) Development of an antigen-capture enzyme-linked immunosorbent assay using monoclonal antibodies for detecting H6 avian influenza viruses. Journal of Microbiology, Immunology and Infection. 45, 243-247 (SCI)
  9. Tsai T-S., Huang M-Y, Chang Y-T, Wang C-Y, Lin J-L, Hung P-C, Lin S-P, Sun C-F, Wang W-S, Chang C-M, Chang S-C, and Chu D-C (2011). High-resolution melting analysis is a more effective approach for screening TSC genes mutations. Genetic Testing and Molecular Biomarkers 15, 415-421. (SCI)
  10. 10.Wu Y P., Chang C-M., Hung C Y., Tsai M C, Schuyler S C., and Wang R Y. (2011). Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity. Virology Journal  8, 128. (SCI)(Co-First authur)
  11. Chang S-C, Chang C-M, Huang Y-C, Chiu C-H, Shih S-R, and Lin T-Y (2010). Preexisting antibodies against pandemic H1N1 2009 virus in Taiwan. Clinical Infectious Diseases 51,1465-7. (SCI)
  12. Chiou C-C., Chen T-L., Tsao K-C., Shih S-R., Huang C-G., Huang Y-L & Chang C-M*. (2010) Detection of pandemic (H1N1) 2009 influenza virus by allele discrimination. Clinica Chimica Acta 411:1080-3.(SCI) (*correspondence)
  13. Huang K.S., Lee S.E., Yeh Y., Shen G.S., Mei E. & Chang C-M*. (2010) Taqman real-time quantitative PCR for identification of western flower thrip (Frankliniella occidentalis) for plant quarantine. Biology Letters,  6:555-7 (SCI)(*correspondence)
  14. Lebarbenchon C., Chang C-M., Grandhomme V., Dietrich M., Kayser Y., Elguero E., Renaud F., Thomas F. & van der Werf S., Michel Gauthier-Clerc M. (2010) Avian Influenza Circulation in the Camargue (South of France) During the 2006–07 Season. Avian Diseases 54:446–9, (SCI)
  15. Roche B., Lebarbenchon C., Gauthier-Clerc M., Chang C-M., Thomas F., Renaud F., van der Werf S. & Guégan J.F. (2009) Water-borne transmission drives avian influenza dynamics in wild birds: the case of the 2005-2006 epidemics in the Camargue area. Infection Genetics and Evolution 9, 800-5. (SCI)
  16. Chang C-M*., Lebarbenchon C., Gauthier-Clerc M., Le Bohec C., Beaune D., Le Maho Y. & van der Werf S. (2009) Molecular surveillance for avian influenza A virus in king penguins (Aptenodytes patagonicus). Polar Biology 32, 663-5. (SCI) (*correspondence)
  17. Lebarbenchon C., Chang C-M* (Co-correspondence)., Gauthier-Clerc M., Thomas F., Renaud F. & van der Werf S. (2009) H9N2 avian influenza virus in a Mediterranean gull. Journal of Molecular and Genetic Medicine 3, 121-3.
  18. Lebarbenchon C., van der Werf S., Thomas F., Aubin J.T., Azebi S., Cuvelier F., Jeannin P., Roca V., Chang C-M., Kayser Y., Roche B., Guegan J.F., Renaud F. & Gauthier-Clerc M. (2007) Absence of detection of highly pathogenic H5N1 in migratory waterfowl in southern France in 2005-2006. Infection, genetics and evolution 7, 604-8. (SCI)
  19. Lebarbenchon C., Chang C-M., van der Werf S., Aubin J.T., Kayser Y., Ballesteros M., Renaud F., Thomas F. & Gauthier-Clerc M. (2007) Influenza A virus in birds during spring migration in the Camargue, France. Journal of Wildlife Diseases 43, 789-93. (SCI)
  20. Chang C-M*., Furet J.P., Coville J.L., Coquerelle G., Gourichon D. & Tixier-Boichard M. (2007) Quantitative effects of an intronic retroviral insertion on the transcription of the tyrosinase gene in recessive white chickens. Animal Genetics 38, 162-7. (SCI) (*correspondence)
  21. Chang C-M*., Coville J.L., Coquerelle G., Gourichon D., Oulmouden A. & Tixier-Boichard M. (2006) Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens. BMC Genomics 7, 19. (SCI) (*correspondence)
  22. Wang C-H. & Chang C-M. (2000) Pathogenicity and gene analysis of adenovirus from pigeons with inclusion body hepatitis.  Journal of Veterinary Medical Science 62, 989-93. (SCI)
  23. Wang C.H. & Chang C-M. (2000) Two nucleic acid detecting methods applied in pigeon adenovirus. Journal of the Chinese Society of Veterinary Science 26, 204-12.

榮譽事項

  1. Aquatic Pollutants Joint transnational call 2020-2021. European project consortium member.
  2. Invited grant proposal reviewer for the National Science Center, Poland, 2020
  3. Chief Executive Officer at Chang Gung university of the Global Research & Industry Alliance (GLORIA), Ministry of Science and Technology, Taiwan, from August 2019.
  4. Chief Executive Officer at Chang Gung university of the Global Research & Industry Alliance (GLORIA), Ministry of Science and Technology, Taiwan, from August 2019.
  5. Invited Project reviewer of Canadian Poultry Research Council, 2016
  6. Project evaluator of Ministry of Science and Technology from 2014 to present.
  7. Committee member of Animal medicine, Bureau of Animal and Plant Health Inspection and Quarantine, Council of  Agriculture, Executive Yuan,  2014 to 2016