長庚大學

經歷

學歷

研究方向

1. 類上皮生長因子七次穿膜受體其特性的研究以及有關於他們特殊結構的探討，當中包含下列幾個分子：EMR2、CD97與F4/80。
2. EMR2、CD97受體的訊息傳導的研究。
3. 研究黏合型G蛋白質耦合受體在蝕骨細胞分化與功能所扮演的角色。
4. 探討人類腦部前額疾病BFPP的致病基因GPR56的功能與結構的特性。
5. 尋找GPR56在細胞上的受質。
6. GPR56在腫瘤生物學中所扮演的角色。
7. 探討GPR56在免疫細胞表現與功能所扮演的角色。

研究論文(選錄)

• Lin HH*. Functional partnerships between GPI-anchored proteins and adhesion GPCRs. Bioessays. 2023 Oct;45(10):e2300115. doi: 10.1002/bies.202300115. Epub 2023 Aug 1. PMID: 37526334. 
• Tseng WY, Stacey M, Lin HH*. Role of Adhesion G Protein-Coupled Receptors in Immune Dysfunction and Disorder. Int J Mol Sci. 2023 Mar 13;24(6):5499.
• Henderson SR, Horsley H, Frankel P, Khosravi M, Goble T, Carter S, Antonelou M, Evans RDR, Zhang X, Chu TY, Lin HH, Gordon S, Salama AD. Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. Ann Rheum Dis. 2023 Jun;82(6):848-856.
• Kuo CY, Tsai MH, Lin HH, Wang YC, Singh AK, Chang CC, Lin JJ, Hung PC, Lin KL. Identification and clinical characteristics of a novel missense ADGRG1 variant in bilateral Frontoparietal Polymicrogyria: The electroclinical change from infancy to adulthood after Callosotomy in three siblings. Epilepsia Open. 2023 Mar;8(1):154-164.
• Chu TY, Zheng-Gérard C, Huang KY, Chang YC, Chen YW, I KY, Lo YL, Chiang NY, Chen HY, Stacey M, Gordon S, Tseng WY, Sun CY, Wu YM, Pan YS, Huang CH, Lin CY, Chen TC, El Omari K, Antonelou M, Henderson SR, Salama A, Seiradake E, Lin HH*. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nat Commun. 2022 Oct 27;13(1):6385. 
• Lin HH*, Ng KF, Chen TC, Tseng WY. Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharmaceuticals (Basel). 2022 Feb 11;15(2):219.
• Ng KF, Chen TC, Stacey M, Lin HH*. Role of ADGRG1/GPR56 in Tumor Progression. Cells. 2021 Nov 29;10(12):3352.
• Singh AK, Lin HH*. The role of GPR56/ADGRG1 in health and disease. Biomed J. 2021 Oct;44(5):534-547.
• Huang YS, Tseng WY, Clanchy FIL, Topping LM, Ogbechi J, McNamee K, Perocheau D, Chiang NY, Ericsson P, Sundstedt A, Xue ZT, Salford LG, Sjögren HO, Stone TW, Lin HH, Luo SF, Williams RO. Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2100939118.
• I KY, Tseng WY, Wang WC, Gordon S, Ng KF, Lin HH*. Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes. Front Immunol. 2021 Jan 8;11:602016.
• Lin HH*, Lo YL, Wang WC, Huang KY, I KY, Chang GW. Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells. Front Cell Dev Biol. 2020 May 26;8:414.
• Chen PH, Chen YT, Chu TY, Ma TH, Wu MH, Lin HH, Chang YS, Tan BC, Lo SJ. Nucleolar control by a non-apoptotic p53-caspases-deubiquitinylase axis promotes resistance to bacterial infection. FASEB J. 2020 Jan;34(1):1107-1121.
• Tjong WY, Lin HH*. The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis. Biochem Biophys Res Commun. 2019 Dec 3;520(2):243-249.
• Tjong WY, Lin HH*. The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci Rep. 2019 Feb 6;9(1):1517.
• Hsiao CC, Chu TY, Wu CJ, van den Biggelaar M, Pabst C, Hébert J, Kuijpers TW, Scicluna BP, I KY, Chen TC, Liebscher I, Hamann J, Lin HH*. The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions. Front Immunol. 2018 Dec 3;9:2830.