長庚大學

經歷

長庚大學 研發長（現職）
長庚大學免疫轉譯醫學研究所 教授(現職)
長庚大學醫學系 教授 (現職)
林口長庚紀念醫院醫學研究發展部 主任 (現職)
林口長庚紀念醫院尖端免疫實驗室 主任 (現職)
林口長庚紀念醫院腎臟科 主治醫師/教授 (現職) 
中央研究院基因體研究中心 合聘研究員（現職）
韓國科學技術院KAIST 兼任教授（現職）

學歷

美國約翰霍普金斯大學 博士
台北醫學院 醫學士

榮譽

。Notable Advances 2011 by Nature Medicine  
。ILS NIH Award, 8th Scientific Meeting of International Leptospirosis Society  
。AAI Early Career Faculty Travel Award, The Annual Meeting of the American Association of Immunologists
。Wan-Yu Chen Award, Taiwan Society of Nephrology  
。Outstanding Research Scholar Award, The Chinese Society of Immunology  
。Academia Sinica Scholar Award  
。National Innovation Award (NIA)

研究方向

• microRNA and Epigenetic immune regulation
• 代謝性腎病（Metabolic Nephropathy）
• 多囊腎疾病（Polycystic Kidney Disease）
• 慢性腎臟病進展（Progression of CKD）
• 癌症與免疫 (Cancer and Immunology)

研究論文(選錄)

1. Chang HC, Tsai CY, Hsu CL, Tai TS, Cheng ML, Chuang YM, Tang HY, Lin KJ, Chen JJ, Chang SH, Ko YC, Chi YW, Liu H, Tan BC, Shen CR, Yang CW, Ho PC*, Yang HY*. Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations. Nat Metab. 2025 May;7(5):918-927. (SCI；IF=27.5；ENDOCRINOLOGY & METABOLISM 4/198)
2. Chen JJ, Lee TH, Yang HY*. Exploring nontraditional cardiorenal advantages of SGLT-2 inhibitors and GLP-1 receptor agonists. Kidney Int. 2024 Mar;105(3):442-444. (SCI；IF=21.8；UROLOGY & NEPHROLOGY 5/133)
3. Chen JJ, Wu CY, Jenq CC, Lee TH, Tsai CY, Tu HT, Huang YT, Yen CL, Yen TH, Chen YC, Tian YC, Yang CW, Yang HY*. Association of Glucagon-Like Peptide-1 Receptor Agonist vs Dipeptidyl Peptidase-4 Inhibitor Use With Mortality Among Patients With Type 2 Diabetes and Advanced Chronic Kidney Disease. JAMA Netw Open. 2022 Mar 1;5(3):e221169. (SCI；IF=11.7；MEDICINE, GENERAL & INTERNAL 12/336)
4. Yen CL, Wu CY, See LC, Li YJ, Tseng MH, Peng WS, Liu JR, Chen YC, Yen TH, Tian YC, Yang CW, Gerard F. Anderson, Yang HY*. Pioglitazone Reduces Mortality and Adverse Events in Patients with Type 2 Diabetes and with Advanced Chronic Kidney Disease: National Cohort Study. Diabetes Care. 2020 Oct;43(10):e152-e153. (SCI；IF=22.6；ENDOCRINOLOGY & METABOLISM 6/198)
5. Chi HC, Tsai CY, Wang CS, Yang HY, Lo CH, Wang WJ, Lee KF, Lai LY, Hong JH, Chang YF, Tsai MM, Yeh CT, Wu CH, Hsieh CC, Wang LH*, Chen WJ*, and Lin KH*. DOCK6 promotes chemo- and radio-resistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Oncogene. 2020 Aug. 39, 5933–5949. (Co-First) (SCI；IF=9.1；GENETICS & HEREDITY 11/192)
6. Yang HY, Barbi J, Wu CY, Zheng Y, Vignali P D.A., Wu X, Tao JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, Yang CW, Pardoll DM*, Li HB, Pan F*. MicroRNA-17 modulates regulatory T cell function by targeting co-regulators of the Foxp3 transcription factor. Immunity. 2016 Jul；45(1): 83-93 (SCI；IF=30.6；IMMUNOLOGY 3/183)
7. Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F*, Li B*. The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3. Immunity. 2013；39(2): 272-85. (SCI；IF=30.6；IMMUNOLOGY 3/183)
8. Yang HY, Dang EV, Barbi J, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM*, Pan F*. Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1. Cell. 2011；146(5): 772-784. (Co-First) (SCI；IF=45.1；BIOCHEMISTRY & MOLECULAR BIOLOGY 3/328)