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長庚大學
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蔡雨寰博士

蔡雨寰 助理教授 / Yu-Huan Tsai Ph.D.

職稱： 助理教授

現職： 長庚大學醫學生物技術暨檢驗學系

信箱： yuhuan.tsai@cgu.edu.tw

電話： 03-2118800 #3585

學歷： 法國巴黎第七大學真核與原核微生物學系博士

專長領域： 反轉譯疾病免疫、屏障組織免疫

經歷

2024-present Assistant professor, Laboratory of Host-microbe interactions and cell dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University (Principal investigator), Taoyuan, Taiwan

2021-2024 Assistant professor, Laboratory of Host-microbe interactions and cell dynamics, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University (Principal investigator), Taipei, Taiwan

2018-2021 Assistant professor, Laboratory of Host-microbe interactions and cell dynamics, Institute of Microbiology and Immunology, National Yang-Ming University (Principal investigator), Taipei, Taiwan

2017-2018 Postdoctoral research scholar, Laboratory of Human Immunology and Infectious Diseases Graduate Institute of Clinical Medical Sciences, Chang Gung University (Cheng-Lung Ku, PhD), Taoyuan, Taiwan

2015-2017 Postdoctoral fellow, Department of Medical Biotechnology and Laboratory Science, Chang Gung University (Hsin-Chih Lai, PhD), Taoyuan, Taiwan

201409-12 Postdoctoral fellow, Institut Pasteur, Biology of infection unit, INSERM U1117 (Marc Lecuit, MD PhD), Paris, France

2008-2009 Medical Technology Officer (Military service), Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan


學歷

2010-2014 Ph.D, B3MI doctoral school, University Paris 7, France.
(Pasteur-Paris University International doctoral program)
Institut Pasteur, Biology of infection unit, INSERM U1117

2006-2008 M.Sc., Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, College of Medicine, Taipei, Taiwan

2002-2006 B.Sc., Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan


榮譽

2024              Project for Excellent Junior Research Investigators (優秀年輕學者研究計畫), NSTC, Taiwan
2023              Fellow of Higher Education Academy, United Kingdom
2023              Excellent Teaching Award, National Yang Ming Chiao Tung University
2020              Excellent Teaching Award, National Yang Ming Chiao Tung University
2017-2020     Postdoctoral research scholar(獨立博士後研究學者計畫), MOST, Taiwan
2010-2013     Institut Carnot/Pasteur-Paris University International doctoral program, France

研究論文(選錄)

  • Tseng KY, Huang YT, Huang YT, Su YT, Wang AN, Weng WY, Ke CL, Yeh YC, Wang JJ, Du SH, Gu ZQ, Chen WL, Lin CH, Tsai YH*. Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis. PLoS Pathog. 2024 Jun 17;20(6):e1012319.
  • Tsai YH*, Moura A*, Gu ZQ, Chang JH, Liao YS, Teng RH, Tseng KY, Chang DL, Liu WR, Huang YT, Leclercq A, Lo HJ, Lecuit M, Chiou CS. Genomic surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019. Microbiol Spectr. 2022 Dec 21;10(6):e0182522.
  • Herrera-Heredia SA, Hsu HP, Kao CY, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL. Heparin is required for the formation of granules in connective tissue mast cells. Front Immunol. 2022 Nov 9;13:1000405.
  • Shih HP, Ding JY, Sotolongo Bellón J, Lo YF, Chung PH, Ting HT, Peng JJ, Wu TY, Lin CH, Lo CC, Lin YN, Yeh CF, Chen JB, Wu TS, Liu YM, Kuo CY, Wang SY, Tu KH, Ng CY, Lei WT, Tsai YH, Chen JH, Chuang YT, Huang JY, Rey FA, Chen HK, Chang TW, Piehler J, Chi CY, Ku CL. Pathogenic autoantibodies to IFNγ act through the impedance of receptor assembly and Fc-mediated response. J Exp Med. 2022 Sep 5;219(9):e20212126.
  • Maudet C, Kheloufi M, Levallois S, Gaillard J, Huang L, Gaultier C, Tsai YH, Disson O, Lecuit M. Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence. Nature. 2022 Mar;603(7903):900-906.
  • Huang YT, Kuo YW, Lee MR, Tsai YH, Teng LJ, Tsai MS, Liao CH, Hsueh PR. Clinical and molecular epidemiology of human listeriosis in Taiwan. Int J Infect Dis. 2021 Jan 28;104:718-724.
  • Guo J, Ning XQ, Ding JY, Zheng YQ, Shi NN, Wu FY, Lin YK, Shih HP, Ting HT, Liang G, Lu XC, Kong JL, Wang K, Lu YB, Fu YJ, Hu R, Li TM, Pan KS, Li XY, Huang CY, Lo YF, Chang IY, Yeh CF, Tu KH, Tsai YH, Ku CL, Cao CW. Anti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections. J Exp Med. 2020 Dec 7;217(12):e20190502.
  • Tsai YH* and Chen WL. Host lipid rafts as the gates for Listeria monocytogenes infection: a minireview. Front Immunol. 2020 Aug 11;11;1666.
  • Gu ZQ, Tseng KY, and Tsai YH*. Candida gut commensalism and inflammatory disease. Medicine in Microecology 2020 Mar;3:100008.
  • Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, and Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes. (Lond) 2018 Feb;42(2):231-243.
  • Wei CF*, Tsai YH*, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75.
  • Lin CS*, Tsai YH*, Chen CC, Chang WW, Lin YC, Chang CJ, Tseng SF, Wu TR, Lu CC, Horng JT, Martel J, Ojcius DM, Young JD, Lai HC. An iron detection system determines bacterial swarming initiation and biofilm formation. Sci Rep. 2016 Nov 15;6:36747.
  • Maury MM*, Tsai YH*, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Rousse S, Brisabois A, Disson O, Rocha EP, Brisse S, Lecuit M. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet. 2016 Mar 48(3)308-13.
  • Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med. 2015 Feb 9;212(2):165-83.