長庚大學

經歷

Academic Appointment：

2021-present      Assistant Professor, School of Medicine, Chang Gung University, Taoyuan, Taiwan                 

Employment Records:

2001-2002         Resident, Department of Internal Medicine, Chang-Gung Memorial Hospital, Kaoshiung, Taiwan

2002-2004         Resident, Department of Internal Medicine, Chang-Gung Memorial Hospital, Linkou, Taiwan

2004-2006         Fellow, Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Linkou, Taiwan  

2006-2009         Attending Physician, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Chiayi, Taiwan

2009-Present      Attending Physician, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Keelung, Taiwan

2018-2023/6      Assistant Professor, Division of Rheumatology, Allergy, Immunology Department of Internal Medicine Chang Gung Memorial Hospital, Keelung, Taiwan

2022-Present      Deputy director, Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan

2022-Present      Deputy director, Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, Keelung, Taiwan

2022-2024/7      Deputy director, Institutional Animal Care and Use Committee, Chang Gung Memorial Hospital, Keelung, Taiwan

2024/7-Present   Director, Institutional Animal Care and Use Committee, Chang Gung Memorial Hospital, Keelung, Taiwan

2023/9-Present   Deputy director, Department of Medical Reasearch and Development, Chang Gung Memorial Hospital, Keelung, Taiwan

2023/7-Present   Associate Professor, Division of Rheumatology, Allergy, Immunology Department of Internal Medicine Chang Gung Memorial Hospital, Keelung, Taiwan

Professional Activities：
2019/12-2022/12 Secretary general of Taiwan Rheumatology Association

學歷

榮譽

專長與研究方向

1. Regulatory control of TNF-α signal transduction on inflammatory arthritis

2. G protein-coupled receptors (GPCRs) as a potential therapeutic target for neutrophil-mediated inflammatory diseases

3. Rheumatoid arthritis

4. Autoimmune diseases

研究論文(選錄)

• Wen-Yi Tseng, Martin Stacey, Hsi-Hsien Lin. Role of Adhesion G Protein-Coupled Receptors in Immune Dysfunction and Disorder. Int J Mol Sci. 2023 Mar 13;24(6):5499.  (SCI；IF=6.208；Biochemistry & Molecular Biology 69/296)  
• Tai-Ying Chu, Céline Zheng-Gérard, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R. Henderson, Alan Salama, Elena Seiradake & Hsi-Hsien Lin. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nature Communications. 2022 Oct 22;13:6385 (SCI: IF=17.694; MULTIDISCIPLINARY SCIENCES 6/74)
• Hsi-Hsien Lin* , Kwai-Fong Ng, Tse-Ching Chen, Wen-Yi Tseng*. Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharmaceuticals (Basel). 2022 Feb 11;15(2):219. (SCI: IF= 5.215; CHEMISTRY, MEDICINAL 16/63)
• Yen Fu Chen, Ao Ho Hsieh, Lian Chin Wang, Yun Ju Huang, Yun Chen Tsai, Wen Yi Tseng, Yu Lun Kuo, Shue Fen Luo, Kuang Hui Yu, Chang Fu Kuo. Fecal microbiota changes in NZB/W F1 mice after induction of lupus disease. Scientific Reports. 2022 Feb 11;15(2):219. (SCI: IF= 4.996; MULTIDISCIPLINARY SCIENCES 19/73)
• Yi-Shu Huang, Wen-Yi Tseng, Felix I L Clanchy, Louise M Topping ,Joy Ogbechi, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhong-Tian Xue, Leif G Salford, Hans-Olov Sjögren, Trevor W Stone, Hsi-Hsien Lin, Shue-Fen Luo, Richard O Williams. Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2100939118. (SCI；IF=12.779；MULTIDISCIPLINARY SCIENCE 9/73)
• Kuan-Yu I †, Wen-Yi Tseng†, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin. Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes. Frontiers in Immunology. 2021; 11:602016. (SCI；IF=8.786；Immunology 33/161)Shue-Fen Luo, Chia-Yin Chin, Ling-Jun Ho, Wen-Yi Tseng, Chang-Fu Kuo, Jenn-Haung Lai. Monosodium urate crystals induced ICAM-1 expression and cellecell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy. Journal of Microbiology, Immunology and Infection. 2020; 53: 23–32. (SCI: IF= 10.273; Immunology 27/161)
• Ming-Jer Hsieh, Cheng-Hung Lee, Ming-Lung Tsai, Chang-Fu Kao, Wen-Ching Lan, Yu-Tung Huang, Wen-Yi Tseng, Ming-Shien Wen, Shang-Hung Chang. Biologic Agents Reduce Cardiovascular Events in Rheumatoid Arthritis Not Responsive to Tumour Necrosis Factor Inhibitors: A National Cohort Study. Canadian Journal of Cardiology. 2020; 36: 1739-1746. (SCI: IF= 6.614; CARDIAC & CARDIOVASCULAR SYSTEMS 37/143)
• Ao-Ho Hsieh, Chang-Fu Kuo, I-Jun Chou, Wen-Yi Tseng, Yen-Fu Chen, Kuang-Hui Yu, Shue-Fen Luo. Human cytomegalovirus pp65 peptide-induced autoantibodies cross-reacts with TAF9 protein and induces lupus-like autoimmunity in BALB/c mice. Scientific Reports. 2020; 10:9662. (SCI: IF= 4.996; MULTIDISCIPLINARY SCIENCES 19/73)
• Wen-Yi Tseng†, Yi-Shu Huang†, Felix Clanchy, Kay McNamee, Dany Perocheau, Joy Ogbechi, Shue-Fen Luo, Marc Feldmann, Fiona E. McCann, Richard O. Williams. TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells. Proceedings of the National Academy of Sciences. 2019; 116(43):21666-21672. (SCI；IF=12.779；MULTIDISCIPLINARY SCIENCE 9/73)
• Ting-Ting Chung, Kuang-Hui Yu, Chang-Fu Kuo, Shue-Fen Luo, Meng-Jiun Chiou, Wen-Ching Lan, Jung-Sheng Chen, Wen-Yi Tseng, Ao-Ho Hsieh, Lian-Chin Wang. Impact of urate-lowering drugs on the progression and recovery from chronic kidney disease among gout patients. Arthritis Research & Therapy (2019) 18;21(1):210. (SCI: IF= 5.607; Rheumatology 8/34)
• Wen-Yi Tseng, Yeong-Jian Jan Wu, Tai-Yun Yang, Nien-Yi Chiang, Wen-Pin Tsai, Siamon Gordon, Gin-Wen Chang, Chang-Fu Kuo, Shue-Fen Luo. Hsi-Hsien Lin. High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis. J Microbiol Immunol Infect. 2018 Aug;51(4):485-491. (SCI: IF= 10.273; Immunology 27/161)
• Richard O. Williams, Wen Yi Tseng. Arming the regulators — new strategies to treat autoimmunity. Nature Reviews Rheumatology 2018; 14: 188–189. (SCI: IF= 32.286; Rheumatology 2/34)
• Ping-Han Tsai, Kuang-Hui Yu, I-Jun Chou, Shue-Fen Luo, Wen-Yi Tseng, Lu-Hsiang Huang, Chang-Fu Kuo. Risk of autism spectrum disorder in children born to mothers with systemic lupus erythematosus and rheumatoid arthritis in Taiwan. Joint Bone Spine 85 (2018) 599–603. (SCI: IF= 5.263; Rheumatology 14/34)
• Kuan-Yu I, Yi-Shu Huang, Ching-Hsun Hu, Wen-Yi Tseng, Chia-Hsin Cheng, Martin Stacey, Siamon Gordon, Gin-Wen Chang, Hsi-Hsien Lin. Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways. Front Immunol. 2017; 8: 373. 
• I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty. Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families. 2016 Schizophrenia Bulletin (epub)