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蔡雨寰

蔡雨寰 / Yu-Huan Tsai

職稱: 助理教授

現職: 長庚大學醫技系專任教師

信箱: yuhuan.tsai@cgu.edu.tw

電話: 3585

學歷: 法國巴黎第七大學 (巴斯德-巴黎大學國際博士學位學程) 巴黎巴斯德研究院 感染症生物學實驗室

專長領域: 感染性疾病、自體免疫疾病、黏膜免疫、屏障免疫、微生物演化與致病機轉

我們實驗室著重於利用顯微技術研究微生物與宿主組織交互作用,並利用黏膜共生真菌作為模型探討這樣的交互作用對微生物共生、感染與自體免疫疾病的影響。我們亦同時與台灣疾管署、位於巴黎巴斯德研究中心的世界衛生組織李斯特菌歐洲合作實驗室、以及國內各大醫學中心合作,利用基因體學研究李斯特菌全球演化,並進一步結合動物模型及實驗室各種離體模型以了解李斯特菌症。我們歡迎有志於學習並從事感染症研究的學生加入我們的團隊。

Current members (Updated on Nov. 2024)

博士生 PhD students (joined since-graduated)

曾國堯 (2019-2024)

顧子奇 (2020, 2018-2020 as a Master student in the lab)

陳瑋璘 (MMP PhD program; 2021, 2019-2021 as a Master student in the lab)

 

碩士生 (Master students)

王安妮 (2023)

陳婕恩 (2023)

陳宥嫣 (2024)

張庭瑄 (2024)

陳育丞 (2024)

 

論文與著作(Publication)

1.       Hafner L, Gadin E, Huang L, Frouin A, Laporte F, Gaultier C, Vieira A, Maudet C, Varet H, Moura A, Bracq-Dieye H, Tessaud-Rita, Maury M, Dazas M, Legendre R, Gastineau P, Tsai YH, Coppée JY, Charlier C, Patin E, Chikhi R, Rocha E, Leclercq A, Disson O, Hugues Aschard, Lecuit M. Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenesNat Microbiol. 2024 Nov 22. 

2.       Tseng KY, Huang YT, Huang YT, Su YT, Wang AN, Weng WY, Ke CL, Yeh YC, Wang JJ, Du SH, Gu ZQ, Chen WL, Lin CH, Tsai YH*. Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis. PLoS Pathog. 2024 Jun 17;20(6):e1012319. doi: 10.1371/journal.ppat.1012319. *lead contact

3.       Tsai YH*, Moura A*, Gu ZQ, Chang JH, Liao YS, Teng RH, Tseng KY, Chang DL, Liu WR, Huang YT, Leclercq A, Lo HJ, Lecuit M, Chiou CS. Genomic surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019. Microbiol Spectr. 2022 Dec 21;10(6):e0182522. doi: 10.1128/spectrum.01825-22. *co-first author

4.       Herrera-Heredia SA, Hsu HP, Kao CY, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL. Heparin is required for the formation of granules in connective tissue mast cells. Front Immunol. 2022 Nov 9;13:1000405. 

5.       Shih HP, Ding JY, Sotolongo Bellón J, Lo YF, Chung PH, Ting HT, Peng JJ, Wu TY, Lin CH, Lo CC, Lin YN, Yeh CF, Chen JB, Wu TS, Liu YM, Kuo CY, Wang SY, Tu KH, Ng CY, Lei WT, Tsai YH, Chen JH, Chuang YT, Huang JY, Rey FA, Chen HK, Chang TW, Piehler J, Chi CY, Ku CL. Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response. J Exp Med. 2022 Sep 5;219(9):e20212126. doi: 10.1084/jem.20212126. 

6.       Maudet C, Kheloufi M, Levallois S, Gaillard J, Huang L, Gaultier C, Tsai YH, Disson O, Lecuit M. Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence. Nature. 2022 Mar;603(7903):900-906.

7.       Huang YT, Kuo YW, Lee MR, Tsai YH, Teng LJ, Tsai MS, Liao CH, Hsueh PR. Clinical and molecular epidemiology of human listeriosis in Taiwan. Int J Infect Dis. 2021 Jan 28;104:718-724.

8.       Guo J, Ning XQ, Ding JY, Zheng YQ, Shi NN, Wu FY, Lin YK, Shih HP, Ting HT, Liang G, Lu XC, Kong JL, Wang K, Lu YB, Fu YJ, Hu R, Li TM, Pan KS, Li XY, Huang CY, Lo YF, Chang IY, Yeh CF, Tu KH, Tsai YH, Ku CL, Cao CW. Anti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections. J Exp Med. 2020 Dec 7;217(12):e20190502.

9.       Tsai YH* and Chen WL. Host lipid rafts as the gates for Listeria monocytogenes infection: a mini-review. Front Immunol. 2020 Aug 11;11;1666  *lead contact

10.    Gu ZQ, Tseng KY, and Tsai YH*Candida gut commensalism and inflammatory disease. Medicine in Microecology 2020Mar;3:100008 * lead contact

11.    Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, and Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes. (Lond) 2018Feb;42(2):231-243

12.    Wei CF*, Tsai YH*, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 *co-first author

13.    Lin CS*, Tsai YH*, Chen CC, Chang WW, Lin YC, Chang CJ, Tseng SF, Wu TR, Lu CC, Horng JT, Martel J, Ojcius DM, Young JD, Lai HC. An iron detection system determines bacterial swarming initiation and biofilm formation. Sci Rep. 2016Nov 15;6:36747 *co-first author

14.    Maury MM*, Tsai YH*, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Rousse S, Brisabois A, Disson O, Rocha EP, Brisse S, Lecuit M. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet. 2016 Mar 48(3)308-13 *co-first author

15.    Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenesJ Exp Med. 2015 Feb 9;212(2):165-83.

16.    Tsai YH, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog 2013;9(5):e1003381