研究室資料

研究主題

1. 肥胖與脂肪肝

2. 中醫複方保肝機轉研究

3. 能量代謝與老化

4. 結腸炎

論文著作

Publication Lists: (2011-present)

*, corresponding author

1. Ko-Chen Lee, Hen-Hong Chang, Ying-Hui Chung, Tzung-Yan Lee. Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. Journal of Ethnopharmacology. 2011,135(3):678-84. (I.F.: 5.195; R/C= 4/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

2. Jong-Jen Kuo, Hen-Hong Chang, Tung-Hu Tsai, Tzung-Yan Lee. Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. International Journal of Molecular Medicine. 2012, 30(3): 643-9. (I.F.: 5.314; R/C= 53/139 in MEDICINE, RESEARCH & EXPERIMENTAL)

3. Jong-Jen Kuo, Hen-Hong Chang, Tung-Hu Tsai, Tzung-Yan Lee. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. International Journal of Molecular Medicine. 2012, 30(3): 673-9. (I.F.: 5.314; R/C= 53/139 in MEDICINE, RESEARCH & EXPERIMENTAL)

4. Chorng-Kai Wen, Tzung-Yan Lee. Electroacupuncture decreases the leukocyte infiltration to white adipose tissue and attenuates inflammatory response in high fat diet-induced obesity rats. Evidence-Based Complementary and Alternative Medicine. 2014; 2014: 473978. (I.F.: 2.650; R/C= 16/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

5. Tzung-Yan Lee, Hen-Hong Chang, Chorng-Kai Wen, Tse-Hung Huang, Ya-Shu Chang. Modulation of thioacetamide-induced hepatic inflammations, angiogenesis and fibrosis by andrographolide in mice. Journal of Ethnopharmacology. 2014, 158: 423-30. (I.F.: 5.195; R/C= 4/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

6. Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model. Biochemical and Biophysical Research Communications. 2015, 460(4): 1063-8. (I.F.: 3.322; R/C= 39/72 in BIOPHYSICS)

7. Chorng-Kai Wen, Tzung-Yan Lee. Electroacupuncture prevents white adipose tissue inflammation through modulation of hypoxia-inducible factors-1α-dependent pathway in obese mice. BMC Complementary Medicine and Therapies. 2015, 15: 452. (I.F.: 2.838; R/C= 15/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

8. Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity. International Journal of Molecular Sciences. 2016, 37(3): 743-54. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

9. Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Using proteomics to discover novel biomarkers for fatty liver development and response to CB1R antagonist treatment in an obese mouse model. Proteomics. 2017, 17(1-2). (I.F.: 5.393; R/C= 15/79 in BIOCHEMICAL RESEARCH METHODS)

10. Tse-Hung Huang, Chin-Chang Chen, Hsuan-Miao Liu, Tzung-Yan Lee, Sue-Heui Shieh. Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice. Scientific Reports. 2017, 7(1):  2705. (I.F.: 4.996; R/C= 19/73 in MULTIDISCIPLINARY SCIENCES)

11. Hsuan-Miao Liu, Jyh-Fei Liao, Tzung-Yan Lee. Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. Biochemical and Biophysical Research Communications. 2017, 490(3): 841-848. (I.F.: 3.322; R/C= 39/72 in BIOPHYSICS)

12. Tzung-Yan Lee, Yann-Lii Leu, Chorng-Kai Wen. Modulation of HIF-1α and STAT3 signaling contributes to anti-angiogenic effect of YC-1 in mice with liver fibrosis. Oncotarget. 2017, 8(49): 86206-86216. (I.F.: 5.168; R/C= 44/217 in ONCOLOGY)

13. Hsuan-Miao Liu, Jyh-Fei Liao, Tzung-Yan Lee. GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice. International Journal of Molecular Medicine. 2018, 41(3): 1455-1462. (I.F.: 5.314; R/C= 53/139 in MEDICINE, RESEARCH & EXPERIMENTAL)

14. Geng-Hao Liu, Meng-Yen Tsai, Gwo-Jyh Chang, Chao-Min Wu, Sheng-Kai Lin, Yu-Sheng Chen, Tzung-Yan Lee. Safety Assessment of the Auto Manipulation Device for Acupuncture in Sprague-Dawley Rats: Preclinical Evaluation of the Prototype. Evidence-Based Complementary and Alternative Medicine. 2018, 2018: 5708393. (I.F.: 2.650; R/C= 16/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

15. Yu-Sheng Chen, Hsuan-Miao Liu, Tzung-Yan Lee. Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice. Cells (IF: 4.37; Q4). 2019, 8(3): 253. (I.F.: 7.666; R/C= 51/194 in CELL BIOLOGY)

16. Zi-Yu Chang, Chin-Chang Chen, Hsuan-Miao Liu, Yuan-Chieh Yeh, Tung-Yi Lin, Tzung-Yan Lee, Tse-Hung Huang. Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice. International Journal of Molecular Sciences. 2019, 20(17): 4181. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

17. Geng-Hao Liu, Hsuan-Miao Liu, Yu-Sheng Chen, Tzung-Yan Lee. Effect of Electroacupuncture in Mice with Dextran Sulfate Sodium-Induced Colitis and the Influence of Gut Microbiota. Evidence-Based Complementary and Alternative Medicine. 2020, 2020: 2087903. (I.F.: 2.650; R/C= 16/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)

18. Cheng-Hui Wang, Hsuan-Miao Liu, Zi-Yu Chang, Tse-Hung Huang, Tzung-Yan Lee. Losartan Prevents Hepatic Steatosis and Macrophage Polarization by Inhibiting HIF-1α in a Murine Model of NAFLD. International Journal of Molecular Sciences. 2021, 22(15): 7841. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

19. Hsuan-Miao Liu, Cheng-Hui Wang, Zi-Yu Chang, Tse-Hung Huang, Tzung-Yan Lee. Losartan attenuates insulin resistance and regulates browning phenomenon of white adipose tissue in ob/ob Mice. Current Issues in Molecular Biology. 2021, 3(3): 1828-1843. (I.F.: 2.976; R/C= 216/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

20. Zi-Yu Chang, Hsuan-Miao Liu, Yann-Lii Leu, Chung-Hua Hsu, Tzung-Yan Lee. Modulation of gut microbiota combined with upregulation of intestinal tight junction explains anti-inflammatory effect of Corylin on colitis-associated cancer in mice. International Journal of Molecular Sciences. 2022, 23(5): 2667. (I.F.: 6.208; R/C= 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

21. Ching-Chuan Yeh, Hsuan-Miao Liu, Ming-Chung Lee, Yann-Lii Leu, Wei-Han, Chiang, Hen-Hong Chang, Tzung-Yan Lee. Phytochemical-rich herbal formula ATG-125 protects against sucrose-induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice. Molecular Medicine Reports. 2022, 25(2): 57. (I.F.: 3.423; R/C= 97/195 in MEDICINE, RESEARCH & EXPERIMENTAL)

22. Geng-Hao Liu, Xin-Cheng Zhuo, Yueh-Hsiang Huang, Hsuan-Miao Liu, Ren-Chin Wu, Chia-Jung Kuo, Ning-Hung Chen, Li-Pang Chuang, Shih-Wei Lin, Yen-Lung Chen, Huang-Yu Yang, Tzung-Yan Lee. Alterations in Gut Microbiota and Upregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation. Biology-Basel. 2022, 11(7), 962. (I.F.: 5.168; R/C= 21/94 in BIOLOGY)

22. Cheng-Hui Wang, Hsuan-Miao Liu, Zi-Yu Chang, Chung-Hua Hsu, Tzung-Yan Lee. Antioxidants rich herbal formula Ger-Gen-Chyn-Lian-Tang protects lipotoxicity and ameliorates inflammation signaling through regulation of mitochondrial biogenesis and mitophagy in nonalcoholic fatty liver disease mice. Frontiers in Bioscience-Landmark (Landmark Ed). 2022, 27(8):242. (SCI) (I.F.:3.115; R/C= 207/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

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