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臨床醫學研究所

臨床醫學研究所
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張國志副教授

張國志

職稱： 副教授

現職： 長庚大學副教授

信箱： gjchang@mail.cgu.edu.tw

電話： 3481, 3497

學歷： 台灣大學 Ph.D.

專長領域： 藥理學、電生理學、心血管藥理

個人網頁： https://www.researchgate.net/profile/Gwo-Jyh_Chang

研究室

心血管藥理電生理實驗室

研究方向

  1. 探討心血管系統藥物或新藥如抗心律不整、抗心衰竭與血管鬆弛活性之藥理與電生理學作用機制。
  2. 建立小動物導致慢性心臟疾病如心肌肥大及心衰竭之不同病因心臟壓力超負載、糖尿病、心肌梗塞或肺高壓模式，探討藥物或新藥對之心臟電生理學重整作用，與心房或心室心律不整感受性之改善效果及分子機制。
  3. 與臨床醫師合作研究心律不整如心房纖維顫動(atrial fibrillation)之病理機制及創新治療策略發展。

研究特色

本研究室應用各種研究技術，由活體動物、器官、組織及單細胞等不同層次，全面性探討藥物作用之電生理學與分子機制。抗心律不整藥物的研究上，以單細胞離子通道電生理學的研究技術來評估藥效與探討機轉是最為直接與適用的途徑。單細胞膜電位箝定(patch-clamping)技術探索胞膜離子通道調控的技術極具特色，在1970年代由Neher及Sakmann等人發展之後，已廣為全球生醫科學界所應用。本研究室設備廣泛應用於心肌、平滑肌及細胞株膜電位與離子流動調控之研究，並應用於探討慢性心血管疾病細胞電生理重塑作用之機制，協助解決心血管科學研究上所見之相關問題。

近期發表論文

  1. Chen*, W.J., Yeh, Y.H., Lin, K.H., Chang, G.J. and Kuo, C.T. (2011) Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res. Cardiol., 106: 163-174. (SCI). (IF 11.981, CARDIAC & CARDIOVASCULAR SYSTEMS 8/138).
  2. Yeh, Y.H., Kuo, C.T., Chan, T.H., Chang, G.J., Qi, X.Y., Tsai, F.C., Nattel, S. and Chen*, W.J. (2011) Transforming growth factor- and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes. Cardiovasc. Res., 91: 62-70 (SCI). (IF 8.168, CARDIAC & CARDIOVASCULAR SYSTEMS 12/138).
  3. Wu, Y.H., Chuang, S.Y., Hong, W.C., Lai, Y.J., Chang, G.J. and Pang*, J.H. (2012) Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. Int. J. Immunopathol. Pharmacol., 25(3):741-750. (SCI). (IF 2.209, PHARMACOLOGY & PHARMACY 178/270).
  4. Chang*, G.J., Chang, C.J., Chen, W.J., Yeh, Y.H. and Lee H.Y. (2013). Electrophysiological and mechanical effects of caffeic acid phenethyl ester, a novel cardioprotective agent with antiarrhythmic activity, in guinea-pig heart. Eur. J. Pharmacol., 702: 194-207. (SCI). (IF 3.263, PHARMACOLOGY & PHARMACY 96/270).
  5. Yeh, Y.H., Kuo, C.T., Chang, G.J., Qi, X.Y., Nattel, S. and Chen*, W.J. (2013). Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-. Circ. Arrhythm. Electrophysiol., 6(4): 790-798. (SCI). (IF 4.393, CARDIAC & CARDIOVASCULAR SYSTEMS 34/138).
  6. Lee, C.H., Lin, Y.H., Chang, S.H., Tai, C.D., Liu*, S.J., Chu, Y., Wang, C.J., Hsu, M.Y., Chang, H., Chang, G.J., Hung, K.C., Hsieh, M.J., Lin, F.C., Hsieh, I.C., Wen, M.S. and Huang, Y. (2014). Local sustained delivery of acetylsalicylic acid via hybrid stent with biodegradable nanofibers reduces adhesion of blood cells and promotes reendothelialization of the denuded artery. Int. J. Nanomed., 9: 311–326. (SCI). (IF 5.115, PHARMACOLOGY & PHARMACY 24/270).
  7. Chang*, G.J., Yeh, Y.H., Lin, T.P., Chang, C.J. and Chen, W.J. (2014). Electromechanical and atrial and ventricular antiarrhythmic actions of CIJ-3-2F, a novel benzyl-furoquinoline vasodilator in rat heart. Br. J. Pharmacol., 171: 3918–3937. (SCI). (IF 7.730, PHARMACOLOGY & PHARMACY 9/270).
  8. Hsu, L.A., Yeh, Y.H., Kuo, C.T, Chen, Y.H., Chang, G.J., Tsai, F.C. and Chen*, W.J. (2014) Microsatellite polymorphism in the heme oxygenase-1 gene promoter and the risk of atrial fibrillation in Taiwanese. PLoS ONE, 9: e108773. (SCI). (IF 2.740; MULTIDISCIPLINARY SCIENCES 27/71).
  9. Yeh, Y.H., Kuo, C.T, Chang, G.J., Lai, Y.J., Chen, Y.H. and Chen*, W.J. (2015). Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway. J. Mol. Cell. Cardiol. 82: 84-92. (SCI). (IF 4.133, CARDIAC & CARDIOVASCULAR SYSTEMS 36/138).
  10. Lai, Y.J., Chang, G.J., Yeh, Y.H., Pang, J.H.S., Huang, C.C. and Chen*, W.J. (2015). Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase. PLoS One, 10(9): e0137426. (SCI). (IF 2.740; MULTIDISCIPLINARY SCIENCES 27/71).
  11. Wu, L.S., Chang, S.H., Chang, G.J., Liu, J.R., Chan, Y.H., Lee, H.F., Wen, M.S., Chen, W.J., Yeh, Y.H., Kuo, C.T., See*, L.C. (2016). A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients: a population-based dynamic cohort study in Taiwan. Cardiovasc. Diabetol. 15:56. (SCI). (IF 7.332, ENDOCRINOLOGY & METABOLISM 11/143).
  12. Tsai, F.C., Chang, G.J., Hsu, Y.J., Lin, Y.M., Lee, Y.S., Chen, W.J., Kuo*, C.T. and Yeh*, Y.H. (2016). Proinflammatory gene expression in patients undergoing mitral valve surgery and Maze ablation for atrial fibrillation. J. Thorac. Cardiovasc. Surg. 151(6): 1673-1682. (SCI). (IF 4.451, SURGERY 17/210).
  13. Li, L.F., Chang Y.L., Chen, N.H., Wang, C.Y., Chang, G.J., Lin, M.C., Chang, C.H., Huang, C.C., Chung, J.H., Yang, Y.P., Chiou, S.H., Liu*, Y.Y. (2016). Inhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction. Translational Res. 173: 131–147.e1. (SCI). (IF 5.411, MEDICAL LABORATORY TECHNOLOGY 2/29).
  14. Yeh, Y.H., Hsu, L.A., Chen, Y.H., Kuo, C.T., Chang, G.J., Chen*, W.J. (2016). Protective role of heme oxygenase-1 in atrial remodeling. Basic Res. Cardiol. 111:58 (13 pages) (SCI). (IF 11.981, CARDIAC & CARDIOVASCULAR SYSTEMS 8/138).
  15. Tsai, F.C., Lin, Y.C., Chang, S.H., Chang, G.J., Hsu, Y.J., Lin, Y.M., Lee, Y.S., Wang, C.L., Yeh*, Y.H. (2016) Differential left-to-right atria gene expression ratio in human sinus rhythm and atrial fibrillation: Implications for arrhythmogenesis and thrombogenesis. Int. J. Cardiol. 222: 104–112. (SCI). (IF 30229, CARDIAC & CARDIOVASCULAR SYSTEMS 55/138).
  16. Chuang, W.Y., Chang, H., Chang, G.J., Wang, T.H., Chang, Y.S., Wang, T.H., Yeh, C.J., Ueng, S.H., Chien, H.P., Chang, C.Y., Wan, Y.L., Hsueh*, C. (2017). Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B-cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall. Histopathology. 70(6): 986-999. Mar 10. (SCI). (IF 3.626, PATHOLOGY 18/78).
  17. Lai*, Y.J., Hsu, H.H., Chang, G.J., Lin, S.H., Chen, W.J., Huang, C.C., Pang, J.H.S. (2017) Prostaglandin E1 attenuates pulmonary artery remodeling by activating phosphorylation of the CREB and PTEN signaling pathway. Sci. Rep. 7(1): 9974. 2017 Aug 30 (SCI). (IF 3.998, MULTIDISCIPLINARY SCIENCES 17/71).
  18. Chen*, C.N., Liao, Y.H., Lin, S.Y., Yu, J.X., Li, Z.J., Lin, Y.C., Chang, G.J., Lin, C.H., Wong, A.M. (2017) Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum. Am. J. Physiol. Regul. Integr. Comp. Physiol. 313 (5): R601-R607. 2017 Nov 1. (SCI). (IF 2.992, PHYSIOLOGY 27/81).
  19. Li, H.H., Hsu, H.H., Chang, G.J., Chen, I.C., Ho, W.J., Hsu, P.C., Chen, W.J., Pang, J.H.S., Huang, C.C., Lai*, Y.J. (2018). Prostanoid EP4 agonist, L-902,688, activates PPARγ and attenuates pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 314(3): L349-L359. 2018 Mar 1. (SCI). (IF 4.406, PHYSIOLOGY 12/81).
  20. Chou, W.C., Wu, M.H., Chang, P.H., Hsu, H.C., Chang, G.J., Huang, W.K., Wu, C.E., Hsieh*, Jason C.H. (2018). A prognostic model based on circulating tumour cells is useful for identifying the poorest survival outcome in patients with metastatic colorectal cancer. Int. J. Bio. Sci. 14(2): 137-146. doi: 10.7150/ijbs.2318. Jan. (SCI). (IF 4.858, BIOCHEMISTRY & MOLECULAR BIOLOGY 65/297).
  21. Tsai, W.C., Yu, T.Y., Chang, G.J., Lin, L.P., Lin, M.S., Pang*, J.H.S. (2018). Platelet-rich plasma releasate promotes regeneration and decreases inflammation and apoptosis of injured skeletal muscle. Am. J. Sports Med. 46(8):1980-1986. doi: 10.1177/0363546518771076. Jul. (SCI). (IF 5.810, ORTHOPEDICS 1/82).
  22. Liu, G.H., Tsai, M.Y., Chang, G.J., Wu, C.M., Lin, S.K., Chen*, Y.S., Lee*, T.Y. (2018). Safety assessment of the auto manipulation device for acupuncture in sprague-dawley rats: Preclinical evaluation of the prototype. Evidence-based Complementary & Alternative Medicine. 2018: 9 pages. Article ID 5708393. https://doi.org/10.1155/2018/5708393. Aug. (SCI). (IF 1.813, INTEGRATIVE  & COMPLEMENTARY MEDICINE 16/28).
  23. Chang, P.C., Huang, Y.C., Lee, H.L., Chang, G.J., Chu, Y., Wen, M.S., Chou*, C.C. (2018). Inhomogeneous downregulation of INa underlies piceatannol proarrhythmic mechanism in regional ischemia-reperfusion. Pacing Clin. Electrophysiol. 41(9): 1116-1122. doi: 10.1111/pace.13424. Sep. (SCI). (IF 1.303, ENGINEERING, BIOMEDICAL 69/87).
  24. Gwo-Jyh Chang*, Yung-Hsin Yeh, Wei-Jan Chen, Yu-Shien Ko, Jong-Hwei S. Pang, and Hsiao-Yu Lee (2019). Inhibition of advanced glycation end products formation attenuates cardiac electrical and mechanical remodeling and vulnerability to tachyarrhythmias in diabetic rats. J. Pharmacol. Exp. Ther. 368(1): 66-78. DOI: https://doi.org/10.1124/jpet.118.252080. Jan. (SCI) (IF 3.561, PHARMACOLOGY & PHARMACY 79/270).
  25. Chi-Jen Chang, Hsiu-Chi Hsu, Wan-Jing Ho, Gwo-Jyh Chang, Jong-Hwei S. Pang, Wei-Jan Chen, Chung-Chi Huang, Ying-Ju Lai* (2019). Cathepsin S promotes the development of pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 317(1):L1-L13. Jul 1, 2019. doi: 10.1152/ajplung.00530.2018. (SCI) (IF 4.406, PHYSIOLOGY 12/81).
  26. Yung-Yang Liu, Ning-Hung Chen, Chih-Hao Chang, Shih-Wei Lin, Kuo-Chin Kao, Han-Chung Hu, Gwo-Jyh Chang, Li-Fu Li* (2019). Ethyl pyruvate attenuates ventilation‐induced diaphragm dysfunction through high-mobility group box-1 in a murine endotoxaemia model. J. Cell. Mol. Med. 23(8): 5679-5691. doi: 10.1111/jcmm.14478. Aug 23. (SCI) (IF 4.486, MEDICINE, RESEARCH & EXPERIMENTAL 35/138).
  27. Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo*, Yung-Hsin Yeh* (2019). Atrial fibrillation and its arrhythmogenesis associated with insulin resistance. Cardiovasc. Diabetol. 18: article no. 125, 14 pages. Sep 26. (SCI) (IF 7.332, ENDOCRINOLOGY & METABOLISM 11/143).
  28. Wei-Jan Chen*, Shang-Hung Chang, Yi-Hsin Chan, Jia-Lin Lee, Ying-Ju Lai, Gwo-Jyh Chang, Feng-Chun Tsai, Yung-Hsin Yeh* (2019). Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling. J. Mol. Cell. Cardiol. 135: 67–78. Oct. (SCI) (IF 4.133, CARDIAC & CARDIOVASCULAR SYSTEMS 36/138).
  29. Lung-An Hsu*, Yu-Shien Ko, Yung-Hsin Yeh, Chi-Jen Chang, Yi-Hsin Chan, Chi-Tai Kuo, Hsin-Yi Tsai, Gwo-Jyh Chang (2019). A novel DES L115F mutation identified by whole exome sequencing is associated with inherited cardiac conduction disease. Int. J. Mol. Sci. 20(24): 6227. 13 pages. Dec 10. doi:10.3390/ijms20246227. (SCI) (IF 4.556; BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297).
  30. Wen-Yu Chuang, Sheng-Tsung Chang, Chang-Tsu Yuan, Gwo-Jyh Chang, Hung Chang, Chi-Ju Yeh, Shir-Hwa Ueng, Hsiao-Wen Kao, Tong-Hong Wang, Yung-Liang Wan, Lee-Yung Shih, Shih-Sung Chuang, Chuen Hsueh* (2020). Identification of CD5/cyclin D1 double-negative pleomorphic mantle cell lymphoma: A clinicopathologic, genetic and gene expression study. Am. J. Surg. Pathol. 44(2): 232-240. doi: 10.1097/PAS.0000000000001390. 2020 Feb. (SCI) (IF 4.958, PATHOLOGY 10/78).
  31. Chih-Hao Chiu, Shih-Sheng Chang, Gwo-Jyh Chang, Alvin Chao-Yu Chen, Chun-Ying Cheng, Su-Ching Chen, Yi-Sheng Chan*. (2020). The effect of hyperbaric oxygen treatment on myoblasts and muscles after contusion injury. J. Orthop. Res. 38(2):329–335. doi: 10.1002/jor.24478. Feb. (IF 2.728, ORTHOPEDICS 23/82).
  32. Chih-Hao Chiu, Tsan-Hsuan Chang, Shih-Sheng Chang, Gwo-Jyh Chang, Alvin Chao-Yu Chen, Chun-Ying Cheng, Su-Ching Chen, Jen-Fen Fu, Chih-Jen Wen, Yi-Sheng Chan* (2020). Application of bone marrow–derived mesenchymal stem cells for muscle healing after contusion injury in mice. Am. J. Sports Med. 48(5):1226–1235. DOI: 10.1177/0363546520905853. 2020 Apr. (SCI) (IF 5.810, ORTHOPEDICS 1/82).
  33. Feng-Chun Tsai , Gwo-Jyh Chang, Ying-Ju Lai , Shang-Hung Chang , Wei-Jan Chen, Yung-Hsin Yeh* (2020). Ubiquitin pathway is associated with worsening left ventricle function after mitral valve repair: A global gene expression study. Int. J. Mol. Sci. 21(14), 5073, 16 pages. https://doi.org/10.3390/ijms21145073. 2020 Jul. (SCI) (IF 4.556; BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297).
  34. Lung-An Hsu*, Feng-Chun Tsai, Yung-Hsin Yeh, Chi-Jen Chang, Chi-Tai Kuo, Wei-Jan Chen, Hsin-Yi Tsai and Gwo-Jyh Chang. (2020). Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE. Int. J. Mol. Sci. 21(18), 6678; 13 pages; doi:10.3390/ijms21186678. Sep. 12 (SCI) (IF 4.556; BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297).
  35. Ming-Jer Hsieh, Cheng-Hung Lee, Ho-Yen Chueh, Gwo-Jyh Chang, Hsiu-Yun Huang, Yuling Lin, Jong-Hwei S. Pang*. (2020). Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Sci. Rep. 10, 17078. P1-P11. Oct 13 2020. doi: 10.1038/s41598-020-74022-y.  (SCI). (IF 3.998, MULTIDISCIPLINARY SCIENCES 17/71).
  36. Chung-Chuan Chou, Hui-Ling Lee, Gwo-Jyh Chang, Hung-Ta Wo, Tzung-Hai Yen, Ming-Shien Wen, Yen Chu, Hao-Tien Liu, Po-Cheng Chang*. (2020). Mechanisms of ranolazine pretreatment in preventing ventricular tachyarrhythmias in diabetic db/db mice with acute regional ischemia-reperfusion injury. Sci. Rep. 10(1):20032. P1-P11. Nov 18 2020. doi: 10.1038/s41598-020-77014-0. (SCI). (IF 3.998, MULTIDISCIPLINARY SCIENCES 17/71).