長庚大學

研究方向及研究室特色

高通量(high-throughput)生物實驗技術揭開後基因體世代 (post-genomic era)的序幕，而近年呈現爆炸性發展的次世代定序生物技術，更進一步將生物實驗技術推向高效率、高精度、高準確性之境界，為生命科學研究領域創造極佳的契機。次世代定序方法 (Next generation sequencing, NGS)目前也已被廣泛應用於各類型的生命科學研究工作上，研究人員可針對DNA與RNA進行高速定序，搭配後端生物資訊 (bioinformatics)的應用，進行基因序列變異、結構異常、差異表現量、微小RNA (small RNA)表現量、基因體表觀遺傳修飾分析等之研究。

本實驗室的研究主要在建立和應用各種次世代定序技術平台於癌症之基因體及轉錄體上的研究，搭配生物資訊的分析，系統性的找出癌症重要的“生物特徵”及相關病理特徵，利用大數據庫運算，建構其可能參與之調控網絡，並利用細胞和動物模式進行深入的分子機制探討及驗証。近年主要研究包括：

建立台灣本土癌症組織之功能性基因體體學數據庫

建立完整的台灣本土癌症組織(口腔癌/食道癌/大腸直腸癌/腦癌)之功能性基因體體學數據庫，並利用生物資訊方式，結合國外大數據庫，系統性的分析找出與臨床的早期診斷、疾病的治療與用藥、抗藥性、存活率與再復性相關的重要分子，完整的描繪這些變體的病理作用機制以及調控網絡。針對其中重要的變異基因，進一步使用細胞和動物模式研究來深入探討及驗証這些癌症相關標的之分子機制。

開發分析非編碼RNA調控網絡之生物資訊工具

利用非編碼RNA已知之生物特性 (long noncoding RNA/circRNA/miRNA)，結合大數據庫，開發分析非編碼RNA調控網路之生物資訊分析平台。進一步結合細胞和動物模式，驗証其中新穎之非編碼RNA的調控分子機制。

開發次世代定序法於癌症液態檢體之應用

外泌體組成不僅反應了起源細胞，且富含與細胞轉化相關的生物分子，因此已成為近年來液體活檢方法中最有潛力的目標。實驗室建構了一套只需1 cc的血漿，即可快速提取外泌核糖核酸方法，利用次世代定序法驗証了此方法明顯優化並提升樣本製備的穩定性。我們更進一步全面性的建立了健康人及多種癌症之外泌微核糖核酸體學數據庫 (口腔癌、食道癌、肺癌、大腸直腸癌)，結合臨床資訊，系統性的尋找具早檢測、長期監測治療反應以及預後之多面向的生物標誌。因應精準醫學方面之應用，更進一步開發一套快速檢測晶片系統，可精準且多面向的監測癌症及治療進程。利用多種生物資訊工具，完整描繪出外泌微核糖核酸在癌症進程所扮演的功能角色，並在細胞及動物模式上進行深入的機制研究。

最近五年所發表論文

Yang YE, Lin YA, Ling LL, Kuo IY, Kuo WT, Liu H, Wang YC. Rab37-mediated OPN secretion
enriches SPP1+ macrophages through autocrine-paracrine signaling to drive lung tumor progression.
Oncogenesis. 2026 Jan 14;15(1):4. (IF: 6.4, 50/328 ONCOLOGY)
2. Liu YH, Chen YT, Chen YC, Chin E, Lai YY, Ma CP, Chang Ian YF, Tan CM, Hsu PT, Lai YH, Tsai
WS, Yang CY, Yu JS, Hsu HC, Liu H. Functional Dynamic Modulation of Colorectal Cancer Initiation
and Metastatic Capacity by a Novel MiR-7974 Regulatory Axis. Biomed J. 2025 Nov 28:100934. doi:
10.1016/j.bj.2025.100934. Online ahead of print (Corresponding author). (IF:4.5, 85/320
BIOCHEMISTRY & MOLECULAR BIOLOGY)
3. Sullivan SA, Orosco JC, Callejas-Hernández F, Blow F, Lee H, Ranallo-Benavidez TR, Peters A, Raidal
SR, Girard YA, Johnson CK, Rogers KH, Gerhold R, Mangelson H, Liachko I, Srivastava H, Chandler
C, Berenberg D, Bonneau RA, Huang PJ, Yeh YM, Lee CC, Liu H, Chen TW, Tang P, Chiu CH, Schatz
MC, Carlton JM. Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in
spillover from birds to humans. Nat Commun. 2025 Jul 24;16(1):6487. (IF:15.7, 7/136
MULTIDISCIPLINARY SCIENCES)
4. Teng W, Ku WT, Lin PT, Chen GT, Chu LJ, Liu H, Lin YC, Lin CY. Baseline serum EV-miR-1-3p as a
protective factor and biomarker for hepatocellular carcinoma development after HCV eradication. J
Transl Med. 2025 Jul 1;23(1):722. (IF: 7.5, 20/195 MEDICINE, RESEARCH & EXPERIMENTAL)
5. Chang HC, Tsai CY, Hsu CL, Tai TS, Cheng ML, Chuang YM, Tang HY, Lin KJ, Chen JJ, Chang SH,
Ko YC, Chi YW, Liu H, Tan BC, Shen CR, Yang CW, Ho PC, Yang HY. Asparagine deprivation
enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations. Nat
Metab. 2025 May;7(5):918-927. (IF: 20.8, 5/193 ENDOCRINOLOGY & METABOLISM)
6. Wu CS, Li HP, Hsieh CH, Lin YT, Chang IY, Chung AK, Huang Y, Ueng SH, Hsiao YC, Chien KY, Luo
JD, Chen CH, Liao WC, Hung JL, Yuan SN, OuYang CN, Chiang WF, Chien CY, Chuang HC, Chu LJ,
Liu H, Yang CY, Robles AI Rodriguez H, Lin HH, Yang HY, Hsueh C, Chang KP, Yu JS, Chang YS.
Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification
and personalized treatment strategies. Cancer Lett. 2025 Apr 1; 614:217482. (IF: 10.1, 30/328
ONCOLOGY)
7. Tseng YH, Tran TTM, Chang JT, Huang YT, Nguyen AT, Chang IY, Chen YT, Hsieh HW, Juang YL,
Chang PM, Huang TY, Chang YC, Chen YM*, Liu H*, Huang CF*. Utilizing TP53 hotspot mutations
as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer. Cell Death
Discov. 2025 Jan 27;11(1):26. (Corresponding author) (IF: 7.0, 40/204 CELL BIOLOGY)
8. Chen YT, Tsai HJ, Kan CH, Ma CP, Chen HW, Chang IY, Liu H, Wu CC, Chu WY, Wu YC, Chang KP,
Yu JS, Tan BC. Noncanonical formation of SNX5 gene-derived circular RNA regulates cancer growth.
Cell Death Dis. 2024 Aug 18;15(8):599. (IF: 9.6, 29/204 CELL BIOLOGY)
9. Lei KF, Pai PC, Liu H. Development of a Folding Paper System To Enable the Analysis of Gene Profile
of Short- and Long-Distance Cancer Cell Migration. ACS Appl Mater Interfaces. 2024 Jul
31;16(30):38931-38941. (Corresponding author) (IF: 8.2, 83/461 MATERIALS SCIENCE,
MULTIDISCIPLINARY)
10. Chuang WY, Chang H, Shih LY, Lin TC, Yeh CJ, Ueng SH, Kuo MC, Kao HW, Liu H, Chang ST, Lee
CL, Huang KP, Wang TH, Wan YL, Yu JS, Hsueh C, Chuang SS. Identification of CD5/SOX11 double-
negative pleomorphic mantle cell lymphoma. Virchows Arch. 2024 Aug;485(2):323-334. (IF: 3.1, 26/90
PATHOLOGY)
11. Huang SC, Chang IY, Chang CJ, Liu H, Chen KH, Liu TT, Hsieh TY, Chuang HC, Chen CC, Lin IC, Ng
KF, Huang HY, Chen TC. Association between hepatic angiosarcoma and end-stage renal disease:
nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. J
Pathol. 2023 Jun;260(2):165-176. (IF: 5.2, 7/90 PATHOLOGY)
12. Hsieh CH, Kuan WH, Chang WL, Kuo IY, Liu H, Shieh DB, Liu H, Tan B, Wang YC. Dysregulation of
SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in
esophageal squamous cell carcinoma. J Biomed Sci. 2022 Oct 30;29(1):90. (IF: 12.1, 9/195 MEDICINE,
RESEARCH & EXPERIMENTAL)
13. Yang CK, Hsu HC, Liu YH, Tsai WS, Ma CP, Chen YT, Tan BC, Lai YY, Chang IY, Yang C, Yang CY,
Yu JS, Liu H. (2022, Aug). EV-miRome-wide profiling uncovers miR-320c for detecting metastatic
colorectal cancer and monitoring the therapeutic response. Cell Oncol (Dordr).;45(4):621-638.
(Corresponding author) (IF: 4.8, 75/328 ONCOLOGY)
14. Chen YT, Kan CH, Liu H, Liu YH, Wu CC, Kuo YP, Chang IY, Chang KP, Yu JS, Tan BC. Modular
scaffolding by lncRNA HOXA10-AS promotes oral cancer progression. Cell Death Dis. 2022 Jul
20;13(7):629. (IF: 9.6, 29/204 CELL BIOLOGY)
15. Yen WC, Chang IY, Chang KP, Ouyang CN, Liu CR, Tsai TL, Zhang YC, Wang CI, Wang YH, Yu AL,
Liu H, Wu CC, Chang YS, Yu JS, Yang CY. Genomic and Molecular Signatures of Successful Patient-
Derived Xenografts for Oral Cavity Squamous Cell Carcinoma. Front Oncol. 2022 Apr 4; 12:792297.
(IF: 3.3, 123/328 ONCOLOGY)
16. Chiang SF, Huang HH, Tsai WS, Chin-Ming Tan B, Yang CY, Huang PJ, Yi-Feng Chang I, Lin J, Lu PS,
Chin E, Liu YH, Yu JS, Chiang JM, Hung HY, You JF, Liu H. Comprehensive functional genomic
analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III
colorectal cancer patients. Biomed J. 2022 Apr;45(2):347-360. (Corresponding author) (IF:4.5, 85/320
BIOCHEMISTRY & MOLECULAR BIOLOGY)
17. Lin JH, Peng KY, Kuo YP, Liu H, Tan CB, Lin YF, Chiu HW, Lin YH, Chen YM, Chueh JS, Wu VC.
Aldosterone-producing nodules and CYP11B1 signaling correlate in primary aldosteronism. Endocr
Relat Cancer. 2022 Jan 10;29(2):59-69. (IF: 4.6, 43/193 ENDOCRINOLOGY & METABOLISM)
18. Chen YT, Hsu HC, Lee YS, Liu H, Tan BC, Chin CY, Chang IY, Yang CY. Longitudinal High-
Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic
Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy.
Front Immunol. 2022 Jan 12;12: 743448. (IF: 5.9, 34/183 IMMUNOLOGY)
19. Tsai WS, Hung WS, Wang TM, Liu H, Yang CY, Wu SM, Hsu HL, Hsiao YC, Tsai HJ, Tseng CP.
Circulating tumor cell enumeration for improved screening and disease detection of patients with
colorectal cancer. Biomed J. 2021 Dec;44(6 Suppl 2):S190-S200. (IF:4.5, 85/320 BIOCHEMISTRY &
MOLECULAR BIOLOGY)
20. Tseng MH, Fan WL, Liu H, Yang CY, Ding JJ, Lee HJ, Huang SM, Lin SH, Huang JL. Complement
Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis.
Front Med (Lausanne). 2021 Feb 5;7: 621609. (IF: 3.0, 61/332 MEDICINE, GENERAL & INTERNAL)
21. Wu VC, Peng KY, Kuo YP, Liu H, Tan BC, Lin YH, Lai TS, Chen YM, Chueh JS. TAIPAI. Subtypes of
Histopathologically Classical Aldosterone-Producing Adenomas Yield Various Transcriptomic Signaling
and Outcomes. Hypertension. 2021 Dec;78(6):1791-1800. (IF: 8.2, 8/98 PERIPHERAL VASCULAR
DISEASE)
22. Chen YT, Chang IY, Kan CH, Liu YH, Kuo YP, Tseng HH, Chen HC, Liu H, Chang YS, Yu JS, Chang
KP, Tan BC. circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour
Growth-Regulating Transcriptional Response. Cells. 2020 Aug 10;9(8):1868. doi: 10.3390/cells9081868.
23. Yang CY, Liu CR, Chang IY, OuYang CN, Hsieh CH, Huang YL, Wang CI, Jan FW, Wang WL, Tsai TL,
Liu H, Tseng CP, Chang YS, Wu CC, Chang KP. Cotargeting CHK1 and PI3K Synergistically
Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts.
Cancers (Basel). 2020 Jun 29;12(7):1726. doi: 10.3390/cancers12071726. IF: 6.575, RANK: 60/245
ONCOLOGY.
24. Wu SM, Tsai WS, Chiang SF, Lai YH, Ma CP, Wang JH, Lin J, Lu PS, Yang CY, Tan BC, Liu H.
Comprehensive transcriptome profiling of Taiwanese colorectal cancer implicates an ethnic basis for
pathogenesis. Sci Rep. 2020 Mar 11;10(1):4526. doi: 10.1038/s41598-020-61273-y. IF: 4.997, RANK:
19/74 MULTIDISCIPLINARY SCIENCES. (Corresponding author)
25. Kuo YP, Ma CP, Chen HW, Chen YT, Lai YH, Liu H, Kuo RL, Chin-Ming Tan B. A novel antisense
RNA ASPACT confers multi-level suppression of PACT and associated signalling. RNA Biol. 2019
Sep;16(9):1263-1274. doi: 10.1080/15476286.2019.1624471. Epub 2019 Jun 12. IF: 4.766, RANK:
120/297 BIOCHEMISTRY & MOLECULAR BIOLOGY.
26. Chung AK, OuYang CN, Liu H, Chao M, Luo JD, Lee CY, Lu YJ, Chung IC, Chen LC, Wu SM, Tsang
NM, Chang KP, Hsu CL, Li HP, Chang YS. Targeted sequencing of cancer-related genes in
nasopharyngeal carcinoma identifies mutations in the TGF-beta pathway. Cancer Med. 2019
Sep;8(11):5116-5127.
27. Ma CP, Liu H, Yi-Feng Chang I, Wang WC, Chen YT, Wu SM, Chen HW, Kuo YP, Shih CT, Li CY, Tan
BC. ADAR1 promotes robust hypoxia signaling via distinct regulation of multiple HIF-1alpha-inhibiting
factors. EMBO Rep. 2019 May;20(5): e47107.
28. You GR, Cheng AJ, Lee LY, Huang YC, Liu H, Chen YJ, Chang JT. Prognostic signature associated
with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses. BMC
Cancer. 2019 Jan 14;19(1):64.
29. Lai CY*, Liu H*, Tin KX, Huang Y, Yeh KH, Peng HW, Chen HD, He JY, Chiang YJ, Liu CS, Weng
SY, Tao MH, Yen JJ, Yang-Yen HF. Identification of UAP1L1 as a critical factor for protein O-
GlcNAcylation and cell proliferation in human hepatoma cells. Oncogene. 2019 Jan;38(3):317-331.
(First author) (IF: 7.3, 39/320 BIOCHEMISTRY & MOLECULAR BIOLOGY)
30. Huang YW, Chiang MF, Ho CS, Hung PL, Hsu MH, Lee TH, Chu LJ, Liu H, Tang P, Victor Ng W, Lin
DS. A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element
in Proline Metabolic Disorder. Aging Dis. 2018 Dec 4;9(6):1043-1057.
31. Chao A, Lin CY, Wu RC, Lee YS, Lee LY, Tsai CL, Yang LY, Liu H, Chen SJ, Wang TH, Lai CH. The
combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial
cancer: molecular role of insulin-like growth factor binding protein 2. J Mol Med (Berl). 2018
Nov;96(11):1251-1266.
32. Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ. NPTX2 is a key component in the
regulation of anxiety. Neuropsychopharmacology. 2018 Aug;43(9):1943-1953.
33. Chen YT, Chang IY, Liu H, Ma CP, Kuo YP, Shih CT, Shih YH, Kang L, Tan BC. Tumor-associated
intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation. J Biol Chem.
2018 Jun 29;293(26):10158-10171.
34. Yang CY, Yeh YM, Yu HY, Chin CY, Hsu CW, Liu H, Huang PJ, Hu SN, Liao CT, Chang KP, Chang
YL. Oral Microbiota Community Dynamics Associated with Oral Squamous Cell Carcinoma Staging.
Front Microbiol. 2018 May 3;9: 862.
35. Tsai KW, Lo YH, Liu H, Yeh CY, Chen YZ, Hsu CW, Chen WS, Wang JH. Linc00659, a long
noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer. Mol
Cancer. 2018 Mar 10;17(1):72.
36. Wu SM*, Liu H*, Huang PJ, Chang IY, Lee CC, Yang CY, Tsai WS, Tan BC. circlncRNAnet: an
integrated web-based resource for mapping functional networks of long or circular forms of noncoding
RNAs. Gigascience. 2018 Jan 1;7(1):1-10. (First author)
37. Lai YH, Liu H, Chiang WF, Chen TW, Chu LJ, Yu JS, Chen SJ, Chen HC, Tan BC. MiR-31-5p-ACOX1
Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory
Prostaglandin E2. Theranostics. 2018 Jan 1;8(2):486-504.
38. Chen TW*, Lee CC*, Liu H*, Wu CS, Pickering CR, Huang PJ, Wang J, Chang IY, Yeh YM, Chen CD,
Li HP, Luo JD, Tan BC, Chan TEH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW,
See LC, Tang P, Yu JS, Liao WC, Chiang WF, Rodriguez H, Myers JN, Chang KP, Chang YS.
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion
polymorphism. Nat Commun. 2017 Sep 6;8(1):465. (First author) (IF:15.7, 7/136
MULTIDISCIPLINARY SCIENCES)
39. Yang CC, Chen YT, Chang YF, Liu H, Kuo YP, Shih CT, Liao WC, Chen HW, Tsai WS, Tan BC.
ADAR1-mediated 3' UTR editing and expression control of antiapoptosis genes fine-tunes cellular
apoptosis response. Cell Death Dis. 2017 May 25;8(5): e2833.
40. Chen H, Hsiao YC, Chiang SF, Wu CC, Lin YT, Liu H, Zhao H, Chen JS, Chang YS, Yu JS.
Quantitative analysis of wild-type and V600E mutant BRAF proteins in colorectal carcinoma using
immunoenrichment and targeted mass spectrometry. Anal Chim Acta. 2016 Aug 24;933: 144-55. doi:
10.1016/j.aca.2016.05.037. Epub 2016 Jun 2. IF: 6.911, RANK: 10/87 CHEMISTRY, ANALYTICAL.
41. Yang XZ, Chen JY, Liu CJ, Peng J, Wee YR, Han X, Wang C, Zhong X, Shen QS, Liu H, Cao H, Chen
XW, Tan BC, Li CY. Selectively Constrained RNA Editing Regulation Crosstalks with piRNA
Biogenesis in Primates. Mol Biol Evol. 2015 Dec;32(12):3143-57.
42. Chen WY, Shih HT, Liu KY, Shih ZS, Chen LK, Tsai TH, Chen MJ, Liu H, Tan BC, Chen CY, Lee HH,
Loppin B, Aït-Ahmed O, Wu JT. Intellectual disability-associated dBRWD3 regulates gene expression
through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. EMBO Rep. 2015
Apr;16(4):528-38.
43. Huang PJ, Lee CC, Tan BC, Yeh YM, Huang KY, Gan RC, Chen TW, Lee CY, Yang ST, Liao CS, Liu
H*, Tang P*. Vanno: a visualization-aided variant annotation tool. Hum Mutat. 2015 Feb;36(2):167-74.
(Corresponding author)
44. Huang PJ, Lee CC, Tan BC, Yeh YM, Julie Chu L, Chen TW, Chang KP, Lee CY, Gan RC, Liu H*, Tang
P*. CMPD: cancer mutant proteome database. Nucleic Acids Res. 2015 Jan;43(Database issue): D849-55. (Corresponding author)
45. Liu H, Ma CP, Chen YT, Schuyler SC, Chang KP, Tan BC. Functional Impact of RNA editing and
ADARs on regulation of gene expression: perspectives from deep sequencing studies. Cell Biosci. 2014
Aug 19;4: 44. (First author)
46. Liu YC, Kuo RL, Lin JY, Huang PN, Huang Y, Liu H, Arnold JJ, Chen SJ, Wang RY, Cameron CE, Shih
SR. Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by
entering the nucleus and interfering with Prp8. PLoS Pathog. 2014 Jun 26;10(6): e1004199.
47. C-L Hsieh, Liu H, Y Huang, L Kang, H-W Chen, Y-T Chen, Y-R Wee, S-J Chen, B C-M Tan. ADAR1
deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions. Cell
Death Differ. 2014 May;21(5):707-19.
48. Chen HW, Yang CC, Hsieh CL, Liu H, Lee SC, Tan BC. A functional genomic approach reveals the
transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. Biochim
Biophys Acta. 2013 Dec;1829(12):1309-19.
49. Huang PJ, Yeh YM, Gan RC, Lee CC, Chen TW, Lee CY, Liu H, Chen SJ, Tang P. CPAP. Cancer Panel
Analysis Pipeline. Hum Mutat. 2013 Oct;34(10):1340-6.
50. Lo SJ, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ,
Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-associated X protein regulating
death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013 May;57(5):1893-905.
51. Tan BC, Yang CC, Hsieh CL, Chou YH, Zhong CZ, Yung BY, Liu H. Epigeneitc silencing of ribosomal
RNA genes by Mybbp1a. J Biomed Sci. 2012 Jun 11;19(1):57. (Corresponding author)
52. Yang CC*, Liu H*, Chen SL, Wang TH, Hsieh CL, Huang Y, Chen SJ, Chen HC, Yung BY, Chin-Ming
Tan B. Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses
myogenesis. EMBO J. 2012 Apr 4;31(7):1739-51. (First author)
53. Lin CY, Tan BC, Liu H, Shih CJ, Chien KY, Lin CL, Yung BY. WDHD1 modulates the post-
transcriptional step of the centromeric silencing pathway. Nucleic Acids Res. 2011 May;39(10):4048-62.
54. Lin CY, Tan BC, Liu H, Shih CJ, Chien KY, Lin CL, Yung BY. Dephosphorylation of nucleophosmin by
PP1beta facilitates pRB binding and consequent E2F1-dependent DNA repair. Mol Biol Cell. 2010
Dec;21(24):4409-17.
55. Tan BC*, Liu H*, Lin CL, Lee SC. Functional cooperation between FACT and MCM is coordinated
with cell cycle and differential complex formation. J Biomed Sci. 2010 Feb 16;17(1):11. (First author)
56. Liu H, Tan BC, Tseng KH, Chuang CP, Yeh CW, Chen KD, Lee SC, Yung BY. Nucleophosmin acts as a
novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007
Apr;8(4):394-400. (First author)
57. Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY, Yang-Yen HF. A knockout mouse approach
reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell
type-specific manner. Mol Biol Cell. 2007 Jul;18(7):2525-32.
58. Liu H, Peng HW, Cheng YS, Yuan HS, Yang-Yen HF. Stabilization and enhancement of the
antiapoptotic activity of mcl-1 by TCTP. Mol Cell Biol. 2005 Apr;25(8):3117-26. (First author)

生化暨分子生物學科

劉軒

長庚大學學術能量集萃

研究方向及研究室特色

最近五年所發表論文