:::
彭湛傑2026

Jhan-Jie Peng, Ph.D. / Chih-Ho Lai Ph.D.

JobTitle： Assistant Researcher

CurrentJob： CMCI / 長庚大學分子及臨床免疫中心助理研究員

E-mail： jjpeng@cgu.edu.tw

Phone： 2612

Education： Ph.D. in Graduate Institute of Clinical Medical Sciences, Chang Gung University

Expertise： Cell Therapy and Immunotherapy

Website： https://pure.lib.cgu.edu.tw/zh/persons/jhan-jie-peng/

Employment Records

2025-         Assistant researcher, Center for Molecular and Clinical Immunology,CGU
2021-2023  Visiting researcher, Laboratory of Dr. Ping-Chih Ho, Department of Fundamental Oncology, University of Lausanne; Ludwig Institute for Cancer Research

Education

Ph.D. in Clinical Medical Sciences, Chang Gung University (CGU)         July 2025
Ph.D. Thesis: “Application of cytokine chimeric autoantibody receptor for treating anti-cytokine autoantibody diseases” 

M.S. in Biochemical Sciences, National Taiwan University (NTU)                   June 2016
Master’s Thesis: “Investigate roles of Drosophila EAAT1-mediated glutamate clearance in the functional integrity of the motor circuit and the formation of the neuromuscular junction”

B.S. in Life Science, NTU                                                   June 2014

Publications

  1. J. J. Peng, J. Y. Ding, Y. Xu, H. P. Shih, Y. N. Lin, T. Y. Wu, Y. F. Lo, C. C. Lo, C. F. Yeh, C. Y. Kuo, K. H. Tu, S. Y. Wang, W. T. Lei, T. S. Wu, H. S.Lin, C. H. Lee, W. C. Huang, Y. C. Chen, Y. M. Liu, Z. Y. Shi, Y. T. Chang, L. S. Syue, P. L. Chen, S. H. Teh, C. H. Chou, M. W. Ho, C. Y. Chi, P. C. Ho, C. L. Ku. Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ. First author. Sci Immunol 10, eadm8186 (2025)
  2. J. J. Peng, L Wang, Z Li, C. L. Ku, P. C. Ho. Metabolic challenges and interventions in CAR T-cell therapy. Co-first author. Sci Immunol 8, eabq3016 (2023).
  3. J.J. Peng, S.H. Lin, Y.T. Liu, H.C. Lin, T.N. Li, C.K. Yao. Circuit-dependent ROS propagation mediates glutamate excitotoxicity to elicit motor system deficits in Drosophila. Co-first author. Elife 8, (2019).
  4. Y. Xu, Y. Shangguan, Y. M. Chuang, T. H. Chang, W. Liu, J. J. Peng, J. Garnica, L. Xie, P. C. Hsueh, M. C. Lin, Y. H. Wang, K. L. Hajdu, Y. Wu, M. Akrami, C. Wang, A. Kohl, A. Zippelius, W. Qi, M. Wang, B. R. Budiarto, S. Y. Chen, Z. Xiao, P. Vardaka, R. Roychoudhuri, Z. Bai, R. Fan, S. Carmona, Y. R. Yu, C. Scheiermann, J. Wang, P. C. Ho, Proteasome-guided haem signalling axis contributes to T cell exhaustion. Nature,  (2026).
  5. X. Li, S. H. Moller, J. Park, Y. M. Chuang, P. C. Hsueh, T. H. Chang, K. C. Kao, H. Gallart-Ayala, Y. H. Wang, J. J. Peng, A. Bevilacqua, Y. R. Yu, Z. Li, Y. Kieffer, D. Peigney, H. Croizer, Y. Xu, A. Zippelius, I. C. Lopez-Mejia, L. Fajas, F. Mechta-Grigoriou, J. Ivanisevic, Z. Xiao, M. C. Ho, Y. C. Shen, P. C. Ho. Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages. J Exp Med 222 (2025).
  6. W. T. Lei, Y. F. Lo, M. Tsumura, J. Y. Ding, C. C. Lo, Y. N. Lin, C. W. Wang, L. H. Liu, H. P. Shih, J. J. Peng, T. Y. Wu, Y. P. Chan, C. X. Kang, S. Y. Wang, C. Y. Kuo, K. H. Tu, C. F. Yeh, Y. J. Hsieh, T. Asano, W. H. Chung, S. Okada, C. L. Ku. Immunophenotyping and Therapeutic Insights from Chronic Mucocutaneous Candidiasis Cases with STAT1 Gain-of-Function Mutations. J Clin Immunol 44, 184 (2024).
  7. Y. F. Lo, S. Y. Wang, Y. H. Wu, M. W. Ho, C. F. Yeh, T. Y. Wu, J. J. Peng, Y. N. Lin, J. Y. Ding, H. P. Shih, C. C. Lo, Y. P. Chan, C. S. Rau, C. Y. Kuo, K. H. Tu, W. T. Lei, Y. C. Chen, C. L. Ku. The Pathogenic Role of Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Nocardiosis with the Central Nervous System Involvement. J Clin Immunol 44, 176 (2024).
  8. A. Jaccard, T. Wyss, N. Maldonado-Perez, J. A. Rath, A. Bevilacqua, J. J. Peng, A. Lepez, C. Von Gunten, F. Franco, K. C. Kao, N. Camviel, F. Martin, B. Ghesquiere, D. Migliorini, C. Arber, P. Romero, P. C. Ho, M. Wenes. Reductive carboxylation epigenetically instructs T cell differentiation. Nature 621, 849-856 (2023).
  9. F. Franco, A. Bevilacqua, R. M. Wu, K. C. Kao, C. P. Lin, L. Rousseau, F. T. Peng, Y. M. Chuang, J. J. Peng, J. Park, Y. Xu, A. Cassotta, Y. R. Yu, D. E. Speiser, F. Sallusto, P. C. Ho. Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8(+) T cell formation. Sci Immunol 8, eadf7579 (2023).
  10. S. Y. Wang, Y. F. Lo, H. P. Shih, M. W. Ho, C. F. Yeh, J. J. Peng, H. T. Ting, K. H. Lin, W. C. Huang, Y. C. Chen, Y. H. Chiu, C. W. Hsu, Y. T. Tseng, L. S. Wang, W. Y. Lei, C. Y. Lin, Y. Aoh, C. H. Chou, T. Y. Wu, J. Y. Ding, C. C. Lo, Y. N. Lin, K. H. Tu, W. T. Lei, C. Y. Kuo, C. Y. Chi, C. L. Ku. Cryptococcus gattii Infection as the Major Clinical Manifestation in Patients with Autoantibodies Against Granulocyte-Macrophage Colony-Stimulating Factor. J Clin Immunol 42, 1730-1741 (2022).
  11. H. P. Shih, J. Y. Ding, J. Sotolongo Bellon, Y. F. Lo, P. H. Chung, H. T. Ting, J. J. Peng, T. Y. Wu, C. H. Lin, C. C. Lo, Y. N. Lin, C. F. Yeh, J. B. Chen, T. S. Wu, Y. M. Liu, C. Y. Kuo, S. Y. Wang, K. H. Tu, C. Y. Ng, W. T. Lei, Y. H. Tsai, J. H. Chen, Y. T. Chuang, J. Y. Huang, F. A. Rey, H. K. Chen, T. W. Chang, J. Piehler, C. Y. Chi, C. L. Ku. Pathogenic autoantibodies to IFN-gamma act through the impedance of receptor assembly and Fc-mediated response. J Exp Med 219, (2022).