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Chang Gung University
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Huang-Yu Yang Ph.D.

Huang-Yu Yang Ph.D.

JobTitle： Professor

CurrentJob： Attending Physician, Department of Nephrology, Chang Gung Memorial Hospital

E-mail： hyyang01@gmail.com

Phone： 03-2118800 #7740

Education： Ph.D., Johns Hopkins University, USA

Expertise： Regulatory Immunology; Immunometabolism

Professional Experience

  • Dean of Research, Office of Research and Development, Chang Gung University, Taiwan
  • Professor, Institute of Immunology and Translational Medicine, Chang Gung University
  • Professor, College of Medicine, Chang Gung University
  • Director, Department of Medical Research and Development, Linkou Chang Gung Memorial Hospital
  • Director, Advanced Immunology Laboratory, Linkou Chang Gung Memorial Hospital
  • Attending Physician / Professor, Department of Nephrology, Linkou Chang Gung Memorial Hospital
  • Adjunct Research Fellow, Genomics Research Center, Academia Sinica, Taiwan
  • Adjunct Professor, Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea

Education

  • Ph.D., Johns Hopkins University, USA
  • M.D., Taipei Medical University, Taiwan

Honors and Awards

  • Notable Advances 2011 by Nature Medicine  
  • ILS NIH Award, 8th Scientific Meeting of International Leptospirosis Society  
  • AAI Early Career Faculty Travel Award, The Annual Meeting of the American Association of Immunologists
  • Wan-Yu Chen Award, Taiwan Society of Nephrology  
  • Outstanding Research Scholar Award, The Chinese Society of Immunology  
  • Academia Sinica Scholar Award  
  • National Innovation Award (NIA)

Research Interests

  • microRNA and Epigenetic immune regulation
  • Metabolic Nephropathy
  • Polycystic Kidney Disease
  • Progression of CKD
  • Cancer and Immunology


研究論文選錄

  1. Chang HC, Tsai CY, Hsu CL, Tai TS, Cheng ML, Chuang YM, Tang HY, Lin KJ, Chen JJ, Chang SH, Ko YC, Chi YW, Liu H, Tan BC, Shen CR, Yang CW, Ho PC*, Yang HY*. Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations. Nat Metab. 2025 May;7(5):918-927. (SCI；IF=27.5；ENDOCRINOLOGY & METABOLISM 4/198)
  2. Chen JJ, Lee TH, Yang HY*. Exploring nontraditional cardiorenal advantages of SGLT-2 inhibitors and GLP-1 receptor agonists. Kidney Int. 2024 Mar;105(3):442-444. (SCI；IF=21.8；UROLOGY & NEPHROLOGY 5/133)
  3. Chen JJ, Wu CY, Jenq CC, Lee TH, Tsai CY, Tu HT, Huang YT, Yen CL, Yen TH, Chen YC, Tian YC, Yang CW, Yang HY*. Association of Glucagon-Like Peptide-1 Receptor Agonist vs Dipeptidyl Peptidase-4 Inhibitor Use With Mortality Among Patients With Type 2 Diabetes and Advanced Chronic Kidney Disease. JAMA Netw Open. 2022 Mar 1;5(3):e221169. (SCI；IF=11.7；MEDICINE, GENERAL & INTERNAL 12/336)
  4. Yen CL, Wu CY, See LC, Li YJ, Tseng MH, Peng WS, Liu JR, Chen YC, Yen TH, Tian YC, Yang CW, Gerard F. Anderson, Yang HY*. Pioglitazone Reduces Mortality and Adverse Events in Patients with Type 2 Diabetes and with Advanced Chronic Kidney Disease: National Cohort Study. Diabetes Care. 2020 Oct;43(10):e152-e153. (SCI；IF=22.6；ENDOCRINOLOGY & METABOLISM 6/198)
  5. Chi HC, Tsai CY, Wang CS, Yang HY, Lo CH, Wang WJ, Lee KF, Lai LY, Hong JH, Chang YF, Tsai MM, Yeh CT, Wu CH, Hsieh CC, Wang LH*, Chen WJ*, and Lin KH*. DOCK6 promotes chemo- and radio-resistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Oncogene. 2020 Aug. 39, 5933–5949. (Co-First) (SCI；IF=9.1；GENETICS & HEREDITY 11/192)
  6. Yang HY, Barbi J, Wu CY, Zheng Y, Vignali P D.A., Wu X, Tao JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, Yang CW, Pardoll DM*, Li HB, Pan F*. MicroRNA-17 modulates regulatory T cell function by targeting co-regulators of the Foxp3 transcription factor. Immunity. 2016 Jul；45(1): 83-93 (SCI；IF=30.6；IMMUNOLOGY 3/183)
  7. Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F*, Li B*. The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3. Immunity. 2013；39(2): 272-85. (SCI；IF=30.6；IMMUNOLOGY 3/183)
  8. Yang HY, Dang EV, Barbi J, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM*, Pan F*. Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1. Cell. 2011；146(5): 772-784. (Co-First) (SCI；IF=45.1；BIOCHEMISTRY & MOLECULAR BIOLOGY 3/328)