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Huang-Yu Yang Ph.D.

Huang-Yu Yang Ph.D.

JobTitle： Professor

CurrentJob： Attending Physician, Department of Nephrology, Chang Gung Memorial Hospital

E-mail： hyyang01@gmail.com

Phone： 03-2118800 #7740

Education： Ph.D., Johns Hopkins University, USA

Expertise： Regulatory Immunology; Immunometabolism

Professional Experience

  • Director, Department of Medical Research and Development, Chang Gung Memorial Hospital, Linkou (Current)
  • Director, Advanced Immunology Laboratory, Chang Gung Memorial Hospital, Linkou (Current)
  • Attending Physician / Professor, Department of Nephrology, Chang Gung Memorial Hospital, Linkou (Current)

    • Education

  • Ph.D., Johns Hopkins University, USA
  • M.D., Taipei Medical University, Taiwan

    • Honors and Awards

  • Outstanding Research Scholar Award, Taiwanese Society of Immunology
  • Chen Wan-Yu Research Award (Highest Honor, Taiwan Society of Nephrology)
  • Early Career Faculty Award, American Association of Immunologists
  • Best Oral Presentation Award, Johns Hopkins Immunology Annual Meeting

    • Research Interests

    Our laboratory is interested in the biochemical and molecular mechanisms underlying T cell activation, differentiation, and tolerance. The primary focus of our research is T cell tolerance mechanisms, which have important implications for achieving immune tolerance in autoimmune diseases and transplant rejection.

    Current research focuses include:

    • Immunometabolism, including regulation by HIF-1α and glutamine metabolism
    • MicroRNA and epigenetic regulation in the immune system

    研究論文選錄

    • Yen CL, Wu CY, See LC, Li YJ, Tseng MH, Peng WS, Liu JR, Chen YC, Yen TH, Tian YC, Yang CW, Anderson GF, Yang HY*. Pioglitazone Reduces Mortality and Adverse Events in Type 2 Diabetes Mellitus Patients with Advanced Chronic Kidney Disease: National cohort study. Diabetes Care. 2020 (In press)
    • Yang HY*, Wu CY, Powell JD, Lu KL. Manipulation of Metabolic Pathways and Its Consequences for Anti-Tumor Immunity: A Clinical Perspective. Int. J. Mol. Sci. 2020, 21, 4030 
    • Yang HY, Barbi J, Wu CY, Zheng Y, Vignali P D.A., Wu X, Tao JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, Yang CW, Pardoll DM, Li HB, Pan F. The MicroRNA miR-17 modulates regulatory T cell activity by targeting Foxp3 Co-regulators.  Immunity. 2016 Jul; 45(1): 83-93
    • Yang HY, Hung CC, Liu SH, Guo YG, Chen YC, Ko YC, Huang CT, Chou LF, Tian YC, Chang MY, Hsu HH, Lin MY, Hwang SJ, Yang CW. Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-based Survey and Epidemiological Cohort Evidence. PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004105
    • Yang HY, Dang EV, Barbi J, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM*, Pan F*.Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1. Cell. 2011; 146(5): 772-784.