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Ming-Ling Kuo Ph.D.

Ming-Ling Kuo Ph.D.

JobTitle： 所長/特聘教授

CurrentJob： 長庚大學生物醫學研究所

E-mail： mingling@mail.cgu.edu.tw

Phone： 03-2118800 #3319 or 3320

Education： 美國羅格斯大學 博士

Expertise： 過敏免疫、氣喘藥物開發、免疫調節

Employment Records

2024-            長庚大學特聘教授
2022-            長庚大學生物醫學研究所 所長
2021-            Biomedical Journal期刊 主編
2013-            中國免疫學會 理事
2010-            長庚大學微生物及免疫學科 教授
2016-2019  長庚大學研究發展處 處長

Education

1994  美國羅格斯大學 微生物學與分子遺傳學 博士
1988  美國俄亥俄州立大學 微生物及免疫學研究所 碩士
1985  國立台灣大學 農業化學系 學士

Research Interests

人類間質幹細胞的免疫調節功能
開發治療哮喘的新藥
腺相關病毒介導的基因轉移以減弱哮喘反應

[分子免疫研究室]
Laboratory of Molecular Immunology

Publications

  • Ma J, Chiu YF, Kao CC, Chuang CN, Chen CY, Lai CH, Kuo ML*. Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract. Eur Respir Rev. 2024 Sep 4;33(173):230259.
  • Chang-Chien J, Huang JL, Tsai HJ, Wang SL, Kuo ML*, Yao TC. Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells. Respir Res. 2024 Aug 22;25(1):321.
  • Chang-Chien J, Kuo ML, Tseng YL, Huang HY, Tsai HJ, Yao TC. Differential effects of long- and short-term exposure to PM2.5  on accelerating telomere shortening: from in vitro to epidemiological studies. Ecotoxicol Environ Saf. 2024 Aug;281:116650.
  • Chen JC, Ou LS, Kuo ML, Tseng LY, Chang HL. Autoantigen Exposure in Murine Fetuses Elicited Nonpathogenic Autoimmunity. Arch Med Res. 2024 Jul;55(5):103013.
  • Huang YA, Chen JC, Chiang PC, Chen LC, Kuo ML*. Adeno-Associated Viral Vector-Delivered Pannexin-1 Mimetic Peptide Alleviates Airway Inflammation in an Allergen-Sensitized Mouse Model. Hum Gene Ther. 2023 Nov;34(21-22):1107-1117.
  • Ting NC, Chen YH, Chen JC, Huang WC, Liou CJ, Chen LC, Yang SH, Kuo ML*. Perilla Fruit Water Extract Attenuates Inflammatory Responses and Alleviates Neutrophil Recruitment via MAPK/JNK-AP-1/c-Fos Signaling Pathway in ARDS Animal Model. Evid Based Complement Alternat Med. 2022 Jun 30;2022:4444513.
  • Chiang PC, Chen JC, Chen LC, Kuo ML*. Adeno-Associated Virus-Mediated Interleukin-12 Gene Expression Alleviates Lung Inflammation and Type 2 T-Helper-Responses in Ovalbumin-Sensitized Asthmatic Mice. Hum Gene Ther. 2022 Oct;33(19-20):1052-1061.
  • Hsu CY, Chueh YS, Kuo ML, Lee PT, Hsiao HS, Huang JL, Lin SJ. Expansion of invariant natural killer T cells from systemic lupus erythematosus patients by alpha-Galactosylceramide and IL-15. PLoS One. 2021 Dec 22;16(12):e0261727.
  • Lai YR, Chang YF, Ma J, Chiu CH, Kuo ML*, Lai CH. From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin. Front Immunol. 2021 Nov 15;12:760451.
  • Chang-Chien J, Huang JL, Tsai HJ, Wang SL, Kuo ML*, Yao TC. Particulate matter causes telomere shortening and increase in cellular senescence markers in human lung epithelial cells. Ecotoxicol Environ Saf. 2021 Oct 1;222:112484.
  • Hsu LJ, Liu CL, Kuo ML, Shen CN, Shen CR. An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells. Biomedicines. 2021 Sep 26;9(10):1323.
  • Ma J, Liu MX, Chen LC, Shen JJ, Kuo ML*. Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice. Biomed Res Int. 2021 Sep 20;2021:6692772.
  • Chen LC, Tseng HM, Kuo ML, Chiu CY, Liao SL, Su KW, Tsai MH, Hua MC, Lai SH, Yao TC, Yeh KW, Wu AH, Yu HY, Huang JL, Huang SK. Levels of 15-HETE and TXB2 in exhaled breath condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr Allergy Immunol. 2021 Nov;32(8):1673-1680.
  • Chen JC, Chan CC, Ting NC, Kuo ML*. Allergen Exposure in Murine Neonates Promoted the Development of Asthmatic Lungs. Biomedicines. 2021 Jun 18;9(6):688.
  • Huang YA, Chen JC, Wu CC, Hsu CW, Ko AM, Chen LC, Kuo ML*. Reducing Lung ATP Levels and Alleviating Asthmatic Airway Inflammation through Adeno-Associated Viral Vector-Mediated CD39 Expression. Biomedicines. 2021 Jun 8;9(6):656.