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Hsi-Hsien Lin Ph.D.

Hsi-Hsien Lin Ph.D.

JobTitle： Professor

CurrentJob： Graduate Institute of Biomedical Sciences, Chang Gung University

E-mail： hhlin@mail.cgu.edu.tw

Phone： 03-2118800 #3321

Education： Ph.D., University of Tennessee, USA

Expertise： Basic Immunology

Employment Records

2011–present   Professor, Department of Microbiology and Immunology, Chang Gung University
2007-2011  Associate Professor, Department of Microbiology and Immunology, Chang Gung University
2004-2007  Assistant Professor, Department of Microbiology and Immunology, Chang Gung University
2000-2004  Senior Research Fellow, Sir William Dunn School of Pathology, University of Oxford
1998-2000  Research Fellow, Sir William Dunn School of Pathology, University of Oxford
1997-1998  Postdoctoral Researcher, Oak Ridge National Laboratory

Education

Ph.D. in Biomedical Sciences, University of Tennessee - Oak Ridge Graduate School of Biomedical Sciences, USA (1997)
Master of Science (M.S.) in Biochemistry, College of Medicine, National Taiwan University, Taiwan (1989)
Bachelor of Science (B.S.) in Biology, National Cheng Kung University, Taiwan (1987)

Research Interests

Focus on the function and regulation of Adhesion G Protein-Coupled Receptors (aGPCRs), including:

  • Characterization and Structural Analysis of EGF-TM7 Receptors: Investigation of the unique structural properties and biological characteristics of molecules such as EMR2, CD97, and F4/80.

  • Signal Transduction Pathways: Researching the intracellular signaling mechanisms of EMR2 and CD97 receptors.

  • Bone Biology and Osteoclastogenesis: Exploring the specific roles of aGPCRs in the differentiation and functional activity of osteoclasts.

  • Pathogenesis of BFPP: Functional and structural characterization of GPR56 (ADGRG1), the causative gene associated with the human brain disorder Bilateral Frontoparietal Polymicrogyria (BFPP).

  • Ligand Identification: Searching for and identifying the cellular substrates (ligands) for GPR56.

  • Tumor Biology: Investigating the roles and mechanisms of GPR56 in cancer progression and tumor biology.

  • Immunology: Exploring the expression profiles and functional roles of GPR56 within immune cells.

Publications

  • Lin HH*. Functional partnerships between GPI-anchored proteins and adhesion GPCRs. Bioessays. 2023 Oct;45(10):e2300115. doi: 10.1002/bies.202300115. Epub 2023 Aug 1. PMID: 37526334. 
  • Tseng WY, Stacey M, Lin HH*. Role of Adhesion G Protein-Coupled Receptors in Immune Dysfunction and Disorder. Int J Mol Sci. 2023 Mar 13;24(6):5499.
  • Henderson SR, Horsley H, Frankel P, Khosravi M, Goble T, Carter S, Antonelou M, Evans RDR, Zhang X, Chu TY, Lin HH, Gordon S, Salama AD. Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. Ann Rheum Dis. 2023 Jun;82(6):848-856.
  • Kuo CY, Tsai MH, Lin HH, Wang YC, Singh AK, Chang CC, Lin JJ, Hung PC, Lin KL. Identification and clinical characteristics of a novel missense ADGRG1 variant in bilateral Frontoparietal Polymicrogyria: The electroclinical change from infancy to adulthood after Callosotomy in three siblings. Epilepsia Open. 2023 Mar;8(1):154-164.
  • Chu TY, Zheng-Gérard C, Huang KY, Chang YC, Chen YW, I KY, Lo YL, Chiang NY, Chen HY, Stacey M, Gordon S, Tseng WY, Sun CY, Wu YM, Pan YS, Huang CH, Lin CY, Chen TC, El Omari K, Antonelou M, Henderson SR, Salama A, Seiradake E, Lin HH*. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nat Commun. 2022 Oct 27;13(1):6385. 
  • Lin HH*, Ng KF, Chen TC, Tseng WY. Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharmaceuticals (Basel). 2022 Feb 11;15(2):219.
  • Ng KF, Chen TC, Stacey M, Lin HH*. Role of ADGRG1/GPR56 in Tumor Progression. Cells. 2021 Nov 29;10(12):3352.
  • Singh AK, Lin HH*. The role of GPR56/ADGRG1 in health and disease. Biomed J. 2021 Oct;44(5):534-547.
  • Huang YS, Tseng WY, Clanchy FIL, Topping LM, Ogbechi J, McNamee K, Perocheau D, Chiang NY, Ericsson P, Sundstedt A, Xue ZT, Salford LG, Sjögren HO, Stone TW, Lin HH, Luo SF, Williams RO. Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2100939118.
  • I KY, Tseng WY, Wang WC, Gordon S, Ng KF, Lin HH*. Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes. Front Immunol. 2021 Jan 8;11:602016.
  • Lin HH*, Lo YL, Wang WC, Huang KY, I KY, Chang GW. Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells. Front Cell Dev Biol. 2020 May 26;8:414.
  • Chen PH, Chen YT, Chu TY, Ma TH, Wu MH, Lin HH, Chang YS, Tan BC, Lo SJ. Nucleolar control by a non-apoptotic p53-caspases-deubiquitinylase axis promotes resistance to bacterial infection. FASEB J. 2020 Jan;34(1):1107-1121.
  • Tjong WY, Lin HH*. The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis. Biochem Biophys Res Commun. 2019 Dec 3;520(2):243-249.
  • Tjong WY, Lin HH*. The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci Rep. 2019 Feb 6;9(1):1517.
  • Hsiao CC, Chu TY, Wu CJ, van den Biggelaar M, Pabst C, Hébert J, Kuijpers TW, Scicluna BP, I KY, Chen TC, Liebscher I, Hamann J, Lin HH*. The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions. Front Immunol. 2018 Dec 3;9:2830.