Cheng-En Hsieh Ph.D.
JobTitle： Assistant Professor
CurrentJob： Graduate Institute of Medical Imaging and Radiological Sciences
E-mail： chsieh@cgmh.org.tw
Phone： 03-3281200 # 7000
Education： PhD, Cancer Biology and Immunology, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, TX, USA
Expertise： Cancer Immunology
Education
PhD, Cancer Biology and Immunology, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, TX, USA
MD, School of Medicine, Chang Gung University, Taiwan
Research Interests
Cancer Immunology
Radiation Oncology
Radiobiology
Molecular Imaging in Oncology
Radiobiology
Molecular Imaging in Oncology
Publications
1. Hsieh RCE, Krishnan S, Wu RC et al. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol. 2022 Jun 10;7(72):eabl9330. PMID: 30797890 (IF = 17.6, Immunology: 6/160 = 3.8%)2. Chen PY, Cheng NM, Lin CY, Chang KP, Lu YA, Tsai TY, Chen MF, Fang FM, Hsu CL, Hsieh RCE* (corresponding). Post-radiotherapy Response Assessment Using 18F-FDG PET/CT in Salivary Gland Carcinoma – A Multicenter Study. Clin Nucl Med. 2024 Oct 30. doi: 10.1097/RLU.0000000000005538 (IF = 10.0, Radiology, Nuclear Medicine, and Medical Imaging 5/135 = 3.7%)
3. Hsieh RCE* (corresponding), Lee CH, Huang HC et al. Clinical and Dosimetric Results of Proton or Photon Radiotherapy for Large (>5 cm) Hepatocellular Carcinoma: A Retrospective Analysis. Int J Radiat Oncol Biol Phys. 2024 Mar 1;118(3):712-724 PMID: 37778426 (IF = 6.4, Radiology, Nuclear Medicine, and Medical Imaging :13/135 = 9.6%)
4. Hsieh RCE, Chou YC, Hung CY et al. A multicenter retrospective analysis of patients with salivary gland carcinoma treated with postoperative radiotherapy alone or chemoradiotherapy. Radiother and Oncol. 2023 Sep 1;188:109891. PMID: 37659659 (IF = 4.9, Radiology, Nuclear Medicine, and Medical Imaging 18/135 = 13.3%)
5. Son J, Hsieh RCE (co-first), Lin HY, et al. Inhibition of the CD47-SIRPα axis for cancer therapy: A systematic review and meta-analysis of emerging clinical data. Front Immunol. 2022 Nov 11;13:1027235. PMID: 36439116 (IF = 5.7, Immunology: 37/160= 23.1%)
6. W.-H. Hsu, K. A. LaBella, Y. Lin, P. Xu, R. Lee, C.-E. Hsieh, L. Yang, A. Zhou, J. M. Blecher, C.-J. Wu, K. Lin, X. Shang, S. Jiang, D. J. Spring, Y. Xia, P. Chen, J. P. Shen, S. Kopetz, R. A. DePinho, Oncogenic KRAS drives lipo-fibrogenesis to promote angiogenesis and colon cancer progression. Cancer Discov. 2023 Sep 28. PMID: 37768068 (IF = 29.7, Oncology: 8/242 = 3.3%)
7. Chen CH, Chin RL, Hartley GP, Lea ST, Engel BJ, Hsieh CE, et al. Novel murine glioblastoma models that reflect the immunotherapy resistance profile of human disease. Neuro Oncol. 2023 Jan 27; noad025. PMID: 36705543 (IF = 16.4, Clinical Neurology: 4/211 = 1.9%)
8. B. Venkatesulu, P. Giridhar, L. Pujari, B. Chou, J. H. Lee, A. M. Block, R. Upadhyay, J. S. Welsh, M. M. Harkenrider, S. Krishnan, V. Verma, CE Hsieh, S. Pradhan, W. Small, A. A. Solanki, Lymphocyte sparing normal tissue effects in the clinic (LymphoTEC): A systematic review of dose constraint considerations to mitigate radiation-related lymphopenia in the era of immunotherapy. Radiother and Oncol 177, 81-94 (2022). (IF = 4.9, Radiology, Nuclear Medicine, and Medical Imaging 18/135 = 13.3%)
9. Lee CH, Chen AH, Hung SP, Hsieh CE et al. Proton Beam Therapy in Managing Unresectable Hepatocellular Carcinoma with Bile Duct Invasion. Cancers (Basel). 2022 Mar 23;14(7):1616. PMID: 35406392 (IF = 4.5, Oncology 73/242 = 30.2%)
10. Venkatesulu BP, Chan DP, Giridhar P, Upadhyay R, Sharma A, Elghazawy H, Elumalai T, Mallick S, Hsieh CE. A systematic review and meta-analysis of the impact of radiation-related lymphopenia on outcomes in pancreatic cancer. Future Oncol. 2022 May;18(15):1885-1895. PMID: 35132868. (IF = 3.3, Oncology 135/241 = 56.0%)
11. Hekman L, Barrett A, Ross D, Palaganas E, Giridhar P, Elumalai T, Pragathee V, Block AM, Welsh JS, Harkenrider MM, Saini S, Roy S, Farooq A, Gupta G, Hsieh CE, Venkatesulu BP, Solanki AA. A Systematic Review of Clinical Trials Comparing Radiation Therapy Versus Radical Prostatectomy in Prostate Cancer. Clin Genitourin Cancer. 2024 Jul 11;22(5):102157. PMID: 39084158 (IF = 2.3, Oncology 178/242=73.6%)
12. Elumalai T, Periasamy K, Rajendran I, Yedala A, Giridhar P, Upadhya R, Kim BK, Sharma A, Elghazawy H, Dhanireddy B, Mallick S, Hsieh CE, Johnny C, Venkatesulu BP. A systematic review of radiation-related lymphopenia in genito-urinary malignancies. Cancer Invest. 2021 Oct;39(9):769-776. PMID: 34313522 (IF = 2.4, Oncology 188/241 = 78.0%)
13. Chou YC, Wu YY, Hung SP, Tsang NM, Pai PC, Jaing TH, Lin CY, Hsieh CE, Fan KH, Kao WH, Tseng CK. Treatment of Primary Central Nervous System Germinomas With Short-course Induction Chemotherapy Followed by Low-dose Radiotherapy Without a Tumor Bed Boost: Prognostic Impact of Human Chorionic Gonadotropin. J Pediatr Hematol Oncol. 2021 Oct 1;43(7):e907-e912. PMID: 33235154 (IF = 2.4, Oncology 288/241 =94.6%)
14. Hung SP, Huang BS, Hsieh CE et al. Clinical Outcomes of Patients With Unresectable Cholangiocarcinoma Treated With Proton Beam Therapy. Am J Clin Oncol 2020; 43: 180-186. PMID: 31764017 (IF = 2.6, Oncology 175/241 = 72.6%)
15. Cheng NM, Hsieh CE, Fang YHD et al. Development and validation of a prognostic model incorporating [18 F] FDG PET/CT radiomics for patients with minor salivary gland carcinoma, EJNMMI Res. 2020; 10: 74. PMID: 32632638 (IF = 3.2, Radiology, Nuclear Medicine, and Medical Imaging: 53/135 = 39.2%)
16. Abousaida B, Hsieh CE (co-first), Venkatesulu BP, Krishnan S. Technological Advances in Radiotherapy. Radiotherapy of Liver Cancer. 2021, pp 73-91 (Textbook chapter; Print ISBN: 978-981-16-1814-7)
17. S. Mallick, A. V.R, P. Giridhar, R. Upadhyay, B.-K. Kim, A. Sharma, H. Elghazawy, T. Elumalai, V. Solipuram, CE Hsieh, C. Hentz, A. A. Solanki, J. Li, D. P. Chan, E. Ness, B. P. Venkatesulu, D. R. Grosshans, A Systematic Review and Meta-analysis of the Impact of Radiation-Related Lymphopenia on Outcomes in High-Grade Gliomas. South Asian J Cancer, (2022). PMID: 36756098
18. Venkatesulu BP, Chandrasekar VT,Girdhar P, Advani P, Sharma A, Elumalai T, Hsieh CE, Elghazawy HI, Verma V, and Krishnan S. A systematic review and meta-analysis of cancer patients affected by a novel coronavirus. JNCI Cancer Spectrum 2021; 5, 2 PMID: 32511470
19. Venkatesulu BP, Lester S, Hsieh CE, Verma V, Sharon E, Ahmed M, Krishnan S. Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls. JNCI Cancer Spectrum 2021; 5, 1 PMID: 3343792