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林錫賢

林錫賢 / Hsi-Hsien Lin

職稱： 教授

現職： 分子免疫研究室

信箱： hhlin@mail.cgu.edu.tw

電話： 03-211-8800#3321

學歷： 博士

專長領域： 黏合型G蛋白質耦合受體功能與調控 ; 類上皮生長因子七次穿膜受體其特性的研究以及有關於他們特殊結構的探討 ; EMR2、CD97受體的訊息傳導的研究 ; 研究黏合型G蛋白質耦合受體在蝕骨細胞分化與功能所扮演的角色 ; 探討人類腦部前額疾病BFPP的致病基因GPR56的功能與結構的特性 ; 尋找GPR56在細胞上的受質 ; GPR56在腫瘤生物學中所扮演的角色 ; 探討GPR56在免疫細胞表現與功能所扮演的角色 ; 免疫細胞，如巨噬細胞、嗜中性粒细胞的功能以及腫瘤生物方面的的各種生物分析方式

學歷

1997 田納西大學諾克斯維爾分校橡樹嶺生物醫學科學研究院博士

1989 國立台灣大學醫學院生物化學研究所碩士

1987 國立成功大學生物學系學士

 

經歷

1997-1998  田納西大學橡樹嶺國家實驗室 博士後研究員

1998-2000  英國牛津大學威廉鄧恩爵士病理學院 研究員 

2000-2004  英國牛津大學威廉鄧恩爵士病理學院小組 組長/高級研究員

2004-2007  長庚大學微生物與免疫學系分子免疫學實驗室 助理教授/實驗室主任

2007-2011  長庚大學微生物與免疫學系分子免疫學實驗室 副教授/實驗室主任

2011-至今   長庚大學微生物與免疫學系分子免疫學實驗室 教授/實驗室主任

2013-2022  長庚大學醫學院分子醫學研究生課程主任

2016-至今   林口長庚醫院解剖病理科兼任研究員

2016-2017  英國牛津大學甘迺迪風濕病研究所客座教授

2020-至今   基隆長庚醫院風濕病、過敏與免疫科兼任研究員

 

榮譽

2012-至今       Board Member, Adhesion-GPCR Consortium  

2017                106年度國立成功大學生命科學系傑出優秀系友  

2017                106年度財團法人沈水德翁文教基金會學術論文獎(中華民國免疫學會)  

2016                105年度財團法人沈水德翁文教基金會學術論文獎(中華民國免疫學會)  

2016-2022      長庚大學105-111年度科技部補助大專校院獎勵特殊優秀人才獎  

2016                科技部補助任務導向型團隊赴國外研習(龍門)計畫共同主持人  

2015                科技部補助任務導向型團隊赴國外研習(龍門)計畫共同主持人  

2011-2013      長庚大學100-102年度國科會補助大專校院獎勵特殊優秀人才獎  

2002-2004       British Heart Foundation Research Fellowship, UK; Celltech Ltd. Senior Research Fellowship, 

U.K.  


2000-2002      Wellcome Trust Cardiovascular Research Initiative Research Fellowship, U.K.  

1998-2000       University of Tennessee - Knoxville  

1997                Chancellor's Citation for Extraordinary Professional Promise  

                        (The highest honor for a graduate student in the University)  

1992-1997      UT-Oak  Ridge Graduate School of Biomedical Sciences, Pre-doctoral Fellowships   

 

研究方向

黏合型G蛋白質耦合受體功能與調控

類上皮生長因子七次穿膜受體其特性的研究以及有關於他們特殊結構的探討

EMR2、CD97受體的訊息傳導的研究

研究黏合型G蛋白質耦合受體在蝕骨細胞分化與功能所扮演的角色

探討人類腦部前額疾病BFPP的致病基因GPR56的功能與結構的特性

尋找GPR56在細胞上的受質

GPR56在腫瘤生物學中所扮演的角色

探討GPR56在免疫細胞表現與功能所扮演的角色

免疫細胞，如巨噬細胞、嗜中性粒细胞的功能以及腫瘤生物方面的的各種生物分析方式


 

研究論文(選錄)

  • Tai-Ying Chu&, Celine Zheng-Gerard&, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Chien-Hao Huang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R Henderson, Alan Salama, Elena Seiradake*, and Hsi-Hsien Lin* 2022 GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nat. Commun. 13(1):6385 (doi.org/10.1038/s41467-022-34083-1) (co-corresponding author)
  • Hsi-Hsien Lin*, Kwai-Fong Ng, Tse-Ching Chen, Wen-Yi Tseng* 2022 Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharm. 15(2), 219 (doi.org/10.3390/ph15020219)  (co-corresponding author).
  • Yi-Shu Huang, Wen-Yi Tseng, Joy Ogbechi, Louise M. Topping, Felix Clanchy, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhongtian Xue, Leif G. Salford, Hans-Olov Sjögren, Trevor W. Stone, Hsi-Hsien Lin, Shue-Fen Luo* and Richard O. Williams* 2021 Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. PNAS May 11, 118 (19) e2100939118; (doi:10.1073/pnas2100939118) 
  • Kuan-Yu I&, Wen-Yi Tseng&, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng and Hsi-Hsien Lin* 2021 Stimulation of vibratory urticaria-associated adhesion-GPCR, EMR2/ADGRE2, triggers the NLRP3 inflammasome activation signal in human monocytes. Front. immunol 11: 602016 (doi: 10.3389/fimmu.2020.602016) (corresponding author)
  • Kwai-Fong Ng&, Tse-Ching Chen&, Martin Stacey, and Hsi-Hsien Lin* 2021 Role of ADGRG1/GPR56 in tumor progression. Cells 10, 3352 (doi.org/10.3390/cells10123352) (corresponding author).
  • Abhishek Kumar Singh and Hsi-Hsien Lin* 2021 The role of GPR56/ADGRG1 in health and disease. Biomed. J. 44(5):534-547 (doi:10.1016/j.bj.2021.04.012) (corresponding author)
  • Hsi-Hsien Lin*, Yu-Ling Lo, Wen-Chih Wang, Kuan-Yeh Huang, Kuan-Yu I, and Gin-Wen Chang 2020  Overexpression of FAM46A, a non-canonical poly(A) polymerase, promotes hemin-induced hemoglobinization in K562 cells. Front. Cell Dev. Biol. 8: 414 (doi: 10.3389/fcell.2020.00414 )(corresponding author)
  • Po-Hsiang Chen, Yi-Tung Chen, Tai-Ying Chu, Tian-Hsiang Ma, Mei-Hsuan Wu, Hsi-Hsien Lin, Yu-Sun Chang*, Bertrand Chin-Ming Tan* and Szecheng J. Lo* 2020 Nucleolar size control by a non-apoptotic p53-caspases-deubiquitylase axis confers bacterial resistance. FASEB J. 2020; 34(1):1107-1121. (doi.org/10.1096/fj.201901959R)
  • Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The role of the RGD-motif in CD97/ADGRE5- and EMR2/ADGRE2-modulated tumor angiogenesis. BBRC  520:243-249 (doi:10.1016/j.bbrc.2019.09.113) (corresponding author)
  • Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci. Rep. 9:1517 (doi:10.1038/s41598-018-38045-w) (corresponding author)
  • Cheng-Chih Hsiao#, Tai-Ying Chu#, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst, Josée Hébert, Taco W. Kuijpers, Brendon P. Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann*, and Hsi-Hsien Lin* 2018 The adhesion G protein-coupled receptor GPR97/ADGRG3 is expressed in human granulocytes and triggers antimicrobial effector functions. Front. immunol 9: 2830  (doi:10.3389/fimmu.2018.02830) (co-corresponding author)
  • Wen-Yi Tseng, Yeong-Jian Jan Wu, Tai-Yun Yang, Nien-Yi Chiang, Wen-Pin Tsai, Siamon Gordon, Gin-Wen Chang, Chang-Fu Kuo, Shue-Fen Luo*, Hsi-Hsien Lin* 2018 High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis. J. Microbiol. Immunol. Infect. 51(4):485-491(co-corresponding author (http://dx.doi.org/10.1016/j.jmii.2016.11.010)
  • Kuan-Yeh Huang and Hsi-Hsien Lin* 2018 The activation and signaling mechanisms of GPR56/ADGRG1 in melanoma cell. Front. Oncol. 8: 304 (doi:10.3389/fonc.2018.00304) (corresponding author)
  • Yi-Shu Huang, Nien-Yi Chiang, Gin-Wen Chang, Hsi-Hsien Lin* 2018 Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation. Sci. Rep. 8: 4532 (doi:10.1038/s41598-018-22849-x) (SCI, IF=4.996) (corresponding author)
  • Wen-Yi Tseng, I-Shu Huang, Hsi-Hsien Lin, Shue-Fen Luo, Kay McNamee, Felix Clanchy, Richard Williams 2018 TNFR1 and TNFR2 signalling and its clinical implications. Cytokine 101:19-25 (http://dx.doi.org/10.1016/j.cyto.2016.08.027) 
  • Hsi-Hsien Lin*, Cheng-Chih Hsiao, Caroline Pabst, Josée Hébert, Torsten Schöneberg and Jörg Hamann* 2017 Adhesion GPCRs in regulating immune responses and inflammation. Adv. Immunol.  136:163-201 (co-corresponding author) 
  • Kuo-An Wu#, Chih-Ching Wu#, Chi-De Chen, Chi-Ming Chu, Li-Jane Shih, Yu-Ching Liu, Chia-Jung Yu, Hsi-Hsien Lin*, Chia-Yu Yang* 2017 Proteome profiling reveals novel biomarkers to identify parapneumonic effusions. Sci. Rep. 7 (1): 4026 (doi:10.1038/s41598-017-04189-4)(co-corresponding author)
  • Kuan-Yu I, Yi-Shu Huang, Ching-Hsun Hu, Wen-Yi Tseng, Chia-Hsin Cheng, Martin Stacey, Siamon Gordon, Gin-Wen Chang, Hsi-Hsien Lin* 2017 Activation of EMR2/ADGRE2 induces macrophage differentiation and inflammatory responses via Ga16/Akt/MAPK/NF-kB signaling pathways. Front. immunol  8:373 (doi:10.3389/fimmu.2017.00373)  (corresponding author)
  • Nien-Yi Chiang&, Yen-Ming Peng&, Horng-Heng Juang, Tse-Ching Chen, Hsiao-Lin Pan, Gin-Wen Chang, Hsi-Hsien Lin* 2017 GPR56/ADGRG1 activation promotes melanoma cell migration via NTF dissociation and CTF-mediated Gα12/13/RhoA signaling. JID 137:727-736 (corresponding author)