分子及臨床免疫中心

學歷

2007 巴黎第五大學免疫學博士

2000 國立陽明大學微生物免疫所碩士

1998 國立台灣大學動物系學士

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經歷

2023-  長庚大學臨床醫學研究所 特聘教授

2021-  長庚大學分子臨床免疫中心 主任

2018-  福爾摩沙免疫春季學校與會議創辦人與執行主席

2023-  林口長庚醫院小兒科 合聘教授

2023-  Elixiron Therapeutic 科學長
 

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榮譽

2022  長庚大學優良教師研究獎

2021  科技部傑出研究獎

2021  長庚大學優良教師研究獎

2020  長庚大學優良教師技合獎

2019  科技部傑出技術移轉貢獻獎

2019  長庚大學優良教師技合獎

2019  科技部優秀年輕學者研究計畫

2017  中央研究院 年輕學者研究著作獎

2017  長庚大學優良教師研究獎

2016  科技部吳大猷先生獎

2016  免疫協會傑出研究獎

2016  長庚大學優良教師研究獎

2016  科技部優秀年輕學者研究計畫
 

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研究方向

抗細胞激素自體抗體與人類疾病

單一B細胞選殖研究

細胞治療
 

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研究論文(選錄)

• Peng JJ, Ding JY, Xu Y, Shih HP, Lin YN, Wu TY, Lo YF, Lo CC, Yeh CF, Kuo CY, Tu KH, Wang SY, Lei WT, Wu TS, Lin HS, Lee CH, Huang WC, Chen YC, Liu YM, Shi ZY, Chang YT, Syue LS, Chen PL, Teh SH, Chou CH, Ho MW, Chi CY, Ho PC, Ku CL*. Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ. Sci Immunol. 2025. 9;10(107):eadm8186. doi: 10.1126/sciimmunol.adm8186.
  
• Peng JJ, Wang L, LiZ, Ku CL*, Ho PC. Metabolic challenges and interventions in CAR T cell therapy. Sci Immunol. 2023. 8(82):eabq3016. doi:10.1126/sciimmunol.abq3016.
• Ng CY, Chiu YC, Chan YP, Lin YJ, Chung PH, Chung WH, Ku CL*. Skin Interstitial Fluid and Plasma Multiplex Cytokine Analysis Reveals IFN-γ Signatures and Granzyme B as Useful Biomarker for Activity, Severity and Prognosis Assessment in Vitiligo. Front Immunol. 2022. 13(872458. doi:10.3389/fimmu.872458.
• Shih HP, Ding JY, Bellón JS, Lo YF, Chung PH, Ting HT, Peng JJ, Wu TY, Lin CH, Lo CC, Lin YN, Yeh CF, Chen JB, Wu TS, Liu YM, Kuo CY, Wang SY, Tu KH, Ng CY, Lei WT, Tsai YH, Chen JH, Chuang YT, Huang JY, Rey FA, Chen HK, Chang TW, Piehler J, Chi CY, Ku CL*. Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response. J Exp Med. 2022. 219 (9): e20212126. 
• Kuo CY, Ku CL*, Lim HK, Hsia SH, Lin JJ, Lo CC, Ding JY, Kuo RL, Casanova JL, Zhang SY, Chang LY*, Lin TY*. Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency. J. Clin. Immunol. 2022. doi:10.1007/s10875-021-01170-9.
• Shih HP, Ding JY, Yeh CF, Chi CY, Ku CL*. Anti-interferon-γ autoantibody-associated immunodeficiency. Curr. Opin. Immunol. 2021. 72:206-214.
• Guo J#, Ning XQ#, Ding JY#, Zheng YQ#, Shi NN, Wu FY, Lin YK, Shih HP, Ting HT, Liang G, Lu XC, Kong JL, Wang K, Lu YB, Fu YJ, Hu R, Li TM, Pan KS, Li XY, Huang CY, Lo YF, Chang IY, Yeh CF, Tu KH, Tsai YH, Ku CL*, Cao CW*. Anti-interferon-γ autoantibodies underlie disseminated Talaromyces marneffei infections. J Exp Med. 2020. 217(12):e20190502. (#共同作者)
• Ku CL*, Chi CY, von Bernuth H, and Doffinger R. Autoantibodies against cytokines: phenocopies of primary immunodeficiencies? Hum Genet. 2020. 139:783-794.
• Kuo CY, Wang SY, Shih HP, Tu KH, Huang WC, Ding JY, Lin CH, Yeh CF, Ho MW, Chang SC, He CY, Chen HK, Ho CH, Lee CH, Chi CY and Ku CL*. Disseminated cryptococcosis due to anti-granulocyte-macrophage colony-stimulating factor autoantibodies in the absence of pulmonary alveolar proteinosis. J. Clin. Immunol. 2017, 37:143-152.
• Lin CH, Chi CY, Shih HP, Ding CT, Wang SY, Kuo CY, Yeh CF, Tu KH, Liu SH, Ho MW, Chen CK, Ho CH, Lee CH, and Ku CL*. Identification of a Major Epitope by Anti-Interferon-γ Autoantibodies in Patients with Mycobacterial Disease. Nat Med. 2016, 22:994-1001. 
• Ku CL*, Lin CH, Chang SW, Chu CC, Chan JF, Kong XF, Lee CH, Rosen EA, Ding JY, Lee WI, Bustamante J, Witte T, Shih HP, Kuo CY, Chetchotisakd P, Kiertiburanakul S, Suputtamongkol Y, Yuen KY, Casanova JL, Holland SM, Doffinger R, Browne SK, and Chi CY. Anti-IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia. J Aller Clin Immunol. 2016, 137:945-948.e948.
•  Chi CY, Chu CC, Liu JP, Lin CH, Ho MW, Lo WJ, Lin PC, Chen HJ, Chou CH, Feng JY, Fung CP, Sher YP, Li CY, Wang JH, and Ku CL*. Anti-IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013, 121:1357-1366. 
• von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, and Casanova JL. Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 2008, 321:691-696.
• Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Marodi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, and Casanova JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007, 204:2407-2422.
• von Bernuth H, Ku CL*, Rodriguez-Gallego C, Zhang S, Garty BZ, Marodi L, Chapel H, Chrabieh M, Miller RL, Picard C, Puel A, and Casanova JL. A fast procedure for the detection of defects in Toll-like receptor signaling. Pediatrics. 2006, 118:2498-2503.
• Ku CL, Dupuis-Girod S, Dittrich AM, Bustamante J, Santos OF, Schulze I, Bertrand Y, Couly G, Bodemer C, Bossuyt X, Picard C, and Casanova JL. NEMO mutations in 2 unrelated boys with severe infections and conical teeth. Pediatrics. 2005, 115:e615-619.
• Ku CL, Yang K, Bustamante J, Puel A, von Bernuth H, Santos OF, Lawrence T, Chang HH, Al-Mousa H, Picard C, and Casanova JL. Inherited disorders of human Toll-like receptor signaling: immunological implications. Immunol Rev. 2005, 203:10-20.
• Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah S, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, and Casanova JL. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science. 2003, 299:2076-2079.