分子及臨床免疫中心

學歷

2007-2013 美國約翰霍普金斯大學免疫所博士

1991-1998 臺北醫學大學醫學系醫學博士

經歷

2023-至今  林口長庚醫院醫學研究發展部 主任

2023-至今  長庚大學醫學系 教授

2020-至今  林口長庚醫院醫研部尖端免疫實驗室 主任

2003-至今  林口長庚醫院腎臟科 主治醫師

2017-至今  長庚大學醫學系 副教授

榮譽

2021  Chairman of Formosa Immunology Spring School& Symposium 2021 [FISS]

2018  Outstanding Research Scholar Award, The Chinese Society of Immunology

2017  Wan-Yu Chen Award, Annual Meeting of Taiwan Society of Nephrology

2017 AAI Early Career Faculty Travel Grant, The Annual Meeting of the American Association of Immunologists

2016  AAI Award for ICI 2016 International Congress of Immunology 2016

2015  Best Oral Presentation Award, Annual Meeting of Taiwan Society of Nephrology

2013  ILS NIH Award, 8th Scientific Meeting of International LeptospirosisSociety, 2013, in Fukuoka

2013  The AAI Travel Award, 2013 The Annual Meeting of the American Association of Immunologists, 2013, Honolulu, HI

2013  Best Oral Presentation Award, 2013 Annual Meeting of Taiwan Society of Nephrology Micromanging Autoimmune Nephritis: Role ofmiR-17 in modulating Regulatory T cell function

2012  Best oral presentation, 2012 Immunology annual meeting, Johns Hopkins School of Medicine

2011  Notable advances 2011 by naturemedicine, ”2011 Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1.“

2001  Resident of the Year, 2001 Chang Gung Memorial Hospital

2001  Best Teaching, 2001, 2002 Chang Gung Memorial Hospital

1998  Valedictorian, 1998 Taipei Medical University

研究方向

泌尿腎臟醫學

分子及細胞生物學

免疫學

研究論文(選錄)

• Wu CY, Yang HY, Lai JH. Potential therapeutic targets beyondcytokines and Janus kinases for autoimmune arthritis. Biochem Pharmacol. 2023 May 23;213:115622.
• Chou LF, Yang HY, Hung CC, Tian YC, Hsu SH, Yang CW.Leptospirosis Kidney Disease: Evolution from Acute to Chronic Kidney Disease. Biomed J. 2023 May 2:100595.
• Chou LF, Huang CW, Yang HY, Tian YC, Chang MY, Hung CC, ChenKH, Hsu SH, Tsai CY, Ko YC, Chen TW, Yang CW. Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury. Genomics. 2023 Apr 14;115(3):110624.
• Yen CL, Wu CY, Tsai CY, Lee CC, Li YJ, Peng WS, Liu JR, Liu YC, Jenq CC, Yang HY, See LC. Pioglitazone reduces cardiovascular events and dementia butincreases bone fracture in elderly patients with type 2 diabetes mellitus: a national cohort study. Aging (Albany NY).2023 Apr 7;15(7):2721-2733.
• Premarathne SS, Gamage C, Chandrajith R, Ratnatunge NV, Wijetunge S, WazilA, Chou LF, Ko YC, Huang CT, Yang HY, Fonseka A, Sonnadara T,Herath D, Hewavitharane P, Yang CW, Nanayakkara N. Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology. Nephron. 2023 Feb21:1-10.
• Wu CY, Fan WL, Yang HY, Chu PS, Liao PC, Chen LC, Yao TC,Yeh KW, Ou LS, Lin SJ, Lee WI, Huang JL. Contribution of Genetic Variants associated with Primary Immunodeficiencies to Childhood-Onset Systemic Lupus Erythematous. J Allergy Clin Immunol. 2022 Dec 28:S0091-6749(22)02558-1.
• Li YJ, Wang JW, Wu HH, Wang HH, Chiang YJ, Yang HY, Hsu HH,Yang CW, Tian YC. Tumor necrosis factor-alpha blockade suppresses BK polyomavirus replication. Infection. 2022 Dec 13:1–14. 
• Wu IW, Wu YL, Yang HY, Hsu CK, Chang LC, Twu YC, Chang YL,Chung WH, Yang CW, Hsieh WP, Su SC. Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity. Clin Kidney J. 2022 Sep 7;16(1):78-89.
• LiuGH, Zhuo XC, Huang YH, Liu HM, Wu RC, Kuo CJ, Chen NH, Chuang LP, Lin SW, Chen YL, Yang HY*, Lee TY*. Alterations in Gut Microbiota andUpregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation. Biology (Basel). 2022 Jun 25;11(7):962.
• Chen JJ, Wu CY, Jenq CC, Lee TH, Tsai CY, Tu HT, Huang YT, Yen CL, Yen TH,Chen YC, Tian YC, Yang CW, Yang HY*.Association of Glucagon-Like Peptide-1 Receptor Agonist vs Dipeptidyl Peptidase-4 Inhibitor Use With Mortality Among Patients With Type 2 Diabetes and Advanced Chronic Kidney Disease. JAMA Netw Open. 2022 Mar 1;5(3):e221169. 
• Yang HY, Hsu YO, Lee TH, Wu CY, Tsai CY, Chou LF, Tu HT, Huang YT, Chang SH, YenCL, Hsieh MH, Lee CC, Kuo G, Hsiao CY, Lin HL, Chen JJ, Yen TH, Chen YC, Tian YC, Yang CW, Anderson GF*. Reduced Risk of Sepsis and Related Mortality in Chronic Kidney Disease Patients on Xanthine Oxidase Inhibitors: A National Cohort Study. Front Med(Lausanne). 2022 Jan 31; 8:818132.
• Yang HY, Barbi J, Wu CY, Zheng Y, Vignali P D.A., Wu X, TaoJH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, Yang CW, Pardoll DM*, Li HB, Pan F*. MicroRNA-17 modulates regulatory T cell function by targeting co-regulators of the Foxp3 transcription factor. Immunity. 2016 Jul；45(1): 83-93.
• ChenZ, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, ZhangJ, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F*, Li B*. The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3. Immunity. 2013；39(2): 272-85
• Yang HY, Dang EV, Barbi J, Jinasena D, Yu H, Zheng Y, BordmanZ, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM*, Pan F*. Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1. Cell. 2011；146(5): 772-784.