楊光華/Guang-Huar Young
職稱： 助理教授
現職： 助理教授
電話： 03-2118800#3812
學歷： 國立台灣大學微生物與生化學研究所博士
專長領域： 蛋白質體及代謝體學、自由基與抗氧化物醫學、生物化學
工作經歷
長庚大學 生物醫學系 助理教授 2023/08迄今華安醫學股份有限公司 轉譯醫學處 處長 2018/08-2023/07
華安醫學股份有限公司 科學研發處 科學長 2014/08-2018/07
國立台灣大學 醫學院外科 博士後 2009/08-2014/07
中央研究院 分子生物研究所 博士後 2007/02-2009/07
國防部 後備司令部 少尉化學官 2005/07-2006/09
獲獎
1. 第19屆台塑企業應用技術研討會(2024) 健康醫療與生物科技領域 學校組 優勝
2. The 80th American Diabetes Association (2020). ADA2020 Virtual Highlights.3. The Internal Stroke Conference 2018. Moderated Poster Presentation.
4. The 1st International Congress of Chinese/ Nephrologist (ICCN2015) Highlighted Poster for the Best Poster Award.
5. The 50th European Renal Association—European Dialysis and Transplantation Association (2013) Best Abstracts presented by Young Authors.專利
邱壬乙、陳翰民、林俊材、鄭伊芳、楊光華、黃純芳 (發明專利I792983) 腺嘌呤作為製備治療糖尿病潰瘍藥物的用途研究方向及研究室特色
台灣邁入超高齡化社會後，國人在腎臟疾病的醫療支出始終高居不下，腎臟疾病防治成為我國主要的公共衛生挑戰之一。
腎元是腎臟結構的基本單位，由腎小體與腎小管共同組成，負責調節血液物質的再吸收及尿液排除。成年後的腎元缺乏再生及分化的能力，因而年齡增長將伴隨著腎臟過濾功能逐年下降，而腎臟若發生損傷，會加速慢性腎病的進程而難以挽回。
本實驗室致力於腎臟損傷後的轉譯醫學，整合從基礎到臨床的研究，開發有效的早期預測及治療手段，希望能提升國人的健康福祉。
現階段主要的研究方向如下：
1. 腎臟損傷後的早期預測及藥物治療。
2. 調節嘌呤補救途徑延緩糖尿病腎病變。論文與著作
1. CH Cheng, Hiromi Yatsuda, HH Chen, GH Young, SH Liu and Robert YL Wang. Sensors 2024, 24(20), 6517. Tracking the Risk of Cardiovascular Disease after Almond and Oat Milk Intervene or Statin Medication with a Powerful Reflex SH-SAW POCT Platform.
2. TH Chou , CH Cheng , CJ Lo , GH Young , SH Liu, Robert Y-L Wang. Int J Mol Sci. 2024 Jan 15;25(2):1044. New Advances in Rapid Pretreatment for Small Dense LDL Cholesterol Measurement Using Shear Horizontal Surface Acoustic Wave (SH-SAW) Technology.
3. JY Yang , CC Chen, SC Chang, JT Yeh, HF Huang, HC Lin, SH Lin, YH Lin, LG Wei, Tom J Liu, SY Hung, HM Yang, HH Chang, CH Wang, YS Tzeng, CH Huang, CY Chou, YS Lin, SY Yang, HM Chen, JT Lin, YF Cheng, GH Young, CF Huang, YC Kuo, NT Dai. EClinicalMedicine. 2022 Jul 10;51:101497. ENERGI-F703 gel, as a new topical treatment for diabetic foot and leg ulcers: A multicenter, randomized, double-blind, phase II trial.
4. GH Young, JT Lin, YF Cheng, CF Ho, QY Kuok, RC Hsu, WR Liao, CC Chen, and HM Chen. FASEB J. 2021 Mar; 35(3): e21296. Modulation of adenine phosphoribosyltransferase-mediated salvage pathway to accelerate diabetic wound healing.
5. HM Chang, KY Peng, CK Chan , CY Sun , YY Chen , HM Chang, CL Huang , PC Liu , PY Chen , KC Wang, WJ Wang , CC Wu, YF Lin, TS Lai , TM Huang , GH Young, SL Lin, Marlies Ostermann, TS Chu, Jeff S Chueh , VC Wu. Cell Death & Disease. 2021 Apr 17;12(5):409. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling.
6. GH Young, SC Tang, VC Wu, KC Wang, JY Nong, PY Huang, CJ Hu, HY Chiou, JS Jeng, CY Hsu. J Cereb Blood Flow Metab. 2020 Jun; 40(6):1316-1327. The functional role of hemojuvelin in acute ischemic stroke.
7. TTa Wu, CC Chen, JT Lin, GH Young, HC Wang, HM Chen. Biosci Biotechnol Biochem. 2019 Dec; 83(12):2220-2229. The anti-inflammatory function of adenine occurs through AMPK activation and its downstream transcriptional regulation in THP-1 cells.
8. WC Shen, CJ Liang, TM Huang, CW Liu, SH Wang, GH Young, JS Tsai, YC Tseng, YS Peng, VC Wu, YL Chen. Archives of Toxicology. 2016 (90) 2779–2792. Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway.
9. GH Young, JT Lin, YF Cheng, CF Huang, CY Chao, JY Nong, PK Chen and HM Chen, Journal of Proteomics 2015 Apr 29;120:204-14. Identification of Adenine modulating AMPK activation in NIH/3T3 cells by Proteomic Approach.
10. YF Cheng*, GH Young*, JT Lin, HH Jang, CC Chen, JY Nong, PK Chen, CY Kuo, SH Kao, YJ Liang, HM Chen. PLoS One. 2015 Nov 6;10(11):e0142283. Activation of AMP-activated protein kinase by adenine alleviates TNF-alpha-induced inflammation in human umbilical vein endothelial cells.
11. YF Cheng, GH Young, TM Chiu, JT Lin, PR Huang, CY Kuo, YJ Liang, PK Chen, SF Chen, CY Cheng, HM Chen. Experimental Dermatology. 2016 Feb; 25(2):162-4. doi: 10.1111/exd.12881. Adenine supplement delays senescence in cultured human follicle dermal papilla cells.
12. GH Young, TM Huang, CH Wu ,CF Lai, CC Hou, KY Peng, CJ Liang, SL Lin, SC Chang, PR Tsai, KD Wu, VC Wu*, WJ Ko*, the NSARF group. Antioxidants & Redox Signaling.2014 Mar 10;20 (8):1181-94. Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor.
13. CY Sun, GH Young, YT Hsieh, YH Chen, MS Wu, JH Lee, CC Lee. Journal of the American Society of Nephrology. 2015 Feb;26(2):281-90. Protein-bound uremic toxins induce tissue remodeling by targeting epidermal growth factor receptor.
14. CF Lai, SL Lin, WC Chiang, YM Chen, VC Wu, GH Young, WJ Ko, ML Kuo, TJ Tsai, and KD Wu. The American Journal of Physiology-Renal Physiology. 2014 Jun 11. pii: ajprenal.00670.2013. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury.
15. CJ Liang, WC Shen, FB Chang, VC Wu, SH Wang, GH Young, JS Tsai, YC Tseng, YS Peng, YL Chen. Cell Transplantation. 2015;24(7):1363-77. Endothelial progenitor cells derived from Wharton's jelly of human umbilical cord attenuate ischemic acute kidney injury by increasing vascularization and decreasing apoptosis, inflammation, and fibrosis.
16. VC Wu, CK Wu, YC Chang, GH Young, SC Chen, WS Yang, CY Chen, WJ Wang, CY Lin, YH Lin, SL Lin, SC Chueh, KD Wu,TAIPAI study group. Journal of Hypertension 2013 July 31(7):1396-1405. Association of the variations in the HSD3[beta] gene with primary aldosteronism.
17. VC Wu*, GH Young*, PH Huang, SC Lo, KC Wang, CY Sun, CJ Liang, TM Huang, JHan Chen, FC Chang, YL Chen, YS Kuo, JB Chen, JW Chen, YM Chen, WJ Ko, KD Wu. Angiogenesis, 2013 Jul;16(3):609-24. In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin.
18. WC Shen, CJ Liang, VC Wu, SH Wang, GH Young, IR Lai, CL Chien, SM Wang, KD Wu, and YL Chen. Stem Cells and Development. 2013 May 1;22(9):1408-18. Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression.
19. CC Shiao, WJ Ko, VC Wu, TM Huang, CF Lai, YF Lin, CT Chao, TS Chu, HB Tsai, PC Wu, GH Young, TW Kao, JW Huang, YM Chen, SL Lin, MS Wu, PR Tsai, KD Wu, MJ Wang. PLoS One 2012, Aug 7(8):e42952. U-Curve Association between Timing of Renal Replacement Therapy Initiation and In-Hospital Mortality in Postoperative Acute Kidney Injury.
20. GH Young and VC Wu (2012, Apr). Kidney International 2012 Apr;81(7):611-2. KLOTHO methylation is linked to uremic toxins and chronic kidney disease.
21. YC Lin, HM Chen, IM Chou, AN Chen, CP Chen, GH Young, CT Lin, CH Cheng, SC Chang, RH Juang (2012, Apr). PLoS One 2012, 7:e35336. Plastidial Starch Phosphorylase in Sweet Potato Roots Is Proteolytically Modified by Protein-Protein Interaction with the 20S Proteasome.
22. VC Wu, CF Lai, CC Shiao, YF Lin, PC Wu, CT Chao, FC Hu, TM Huang, YC Yeh, IJ Tsai, TW Kao, YY Han, WC Wu, CC Hou, GH Young, WJ Ko, TJ Tsai, KD Wu. PLoS One 2012 Mar 7:e30836. Effect of Diuretic Use on 30-Day Postdialysis Mortality in Critically Ill Patients Receiving Acute Dialysis.
23. VC Wu, TM Huang, PC Wu, WJ Wang, CT Chao, SY Yang, CC Shiao, FC Hu, CF Lai, YF Lin, YY Han, YS Chen, RB Hsu, GH Young, SS Wang, PR Tsai, YM Chen, TT Chao, WJ Ko, KD Wu, the NSARF Group. PLoS One 2012 Jan 7:e27687. Preoperative Proteinuria Is Associated with Long-Term Progression to Chronic Dialysis and Mortality after Coronary Artery Bypass Grafting Surgery.
24. VC Wu, TM Huang, CF Lai, CC Shiao, YF Lin, TS Chu, PC Wu, CT Chao, JY Wang, TW Kao, GH Young, PR Tsai, HB Tsai, CL Wang, MS Wu, WC Chiang, IJ Tsai, FC Hu, SL Lin, YM Chen, TJ Tsai, WJ Ko and KD Wu, on behalf of the NSARF Group Kidney International 2011 Aug 7:e27687. Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality.
25. YH Chou, TM Huang, VC Wu, CY Wang, CC Shiao, CF Lai, HB Tsai, CT Chao, GH Young, WJ Wang, TW Kao, SL Lin, YY Han, Anne Chou, TH Lin, YW Yang, YM Chen, PR Tsai, YF Lin, JW Huang, WC Chiang, NK Chou, WJ Ko, KD Wu, TJ Tsai1 and the NSARF Study Group. Critical Care 2011 Jun 15: R134. Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury.
26. TM Huang*, VC Wu*, GH Young, YF Lin, CC Shiao, PC Wu, WY Li, HY Yu, FC Hu, JW Lin, YS Chen, YH Lin, SS Wang, RB Hsu, FC Chang, NK Chou, TS Chu, YC Yeh, PR Tsai, JW Huang, SL Lin, YM Chen, WJ Ko and KD Wu. Journal of the American Society of Nephrology 2010 Nov 22(1):156-63. Preoperative Proteinuria Predicts Adverse Renal Outcomes after Coronary Artery Bypass Grafting.
27. CC Shiao, VC Wu, WY Li, YF Lin, FC Hu, GH Young. CC Kuo, TW Kao, DM Huang, YM Chen, PR Tsai, SL Lin, NK Chou, TH Lin, YC Yeh, CH Wang, Anne Chou, WJ Ko, KD Wu. Critical Care 2009 Oct 13(5): R171. Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury after major abdominal surgery.
28. GH Young, HM Chen, CT Lin, KC Tseng, JS Wu, RH Juang. Planta 2006 Feb 223:468-478. Site-specific phosphorylation of L-form starch phosphorylase by the protein kinase activity from sweet potato roots.