生物醫學系暨臨床試驗與評估碩士班

工作經歷

2024.8-迄今      長庚大學分子醫學研究中心, 副中心主任

2023.8-迄今      長庚大學生物醫學系, 教授

2018-2023        長庚大學生物醫學系, 副教授

2013-2018        長庚大學生物醫學系, 助理教授

2007-2013        長庚大學分子醫學研究中心，副研究員

2002-2007        工業技術研究院，研究員

2001                加拿大亞伯達大學研究助理

獲獎

1.  2017  台灣質譜學會青年學者研究獎
2.  2018  財團法人李⾧榮教育基金會第八屆學術研究傑出青年教授獎

特殊成就

1. 2015.7-Present    台灣質譜學會理監事

2. 2017.11-Present  台灣蛋白體學會理事

專利

1.       陳怡婷、余兆松、陳建綸、張玉生 (2013) 膀胱癌之生物標記及其檢測方法。中華民國專利發明第I390204號。

2.       陳怡婷、余兆松、陳建綸、張玉生 (2016) 尿液生物標記作為預測膀胱及腎臟癌的用途。中華民國專利發明第I522367號。

3.       陳怡婷、張鈺、陳建綸、張英勛、陳建綸、虞凱傑、張榮興(2023)，腎臟罹癌風險之判斷方法，中華民國專利發明第I817329號。

指導學生獲獎

1.          長庚大學生物醫學所碩士班學生陳筱葳，Best poster Award (corresponding author), 2009 TPS International Proteomics Conference and 5^th AUHUPO MPI workshop, June 19-20, 2009, Taipei, Taiwan. (台灣蛋白體年會)

2.          長庚大學生物醫學所碩士班學生陳筱葳，Best poster award (corresponding author), 2^nd CGMH International Symposium on Disease Proteomics, June 6^th, 2009, Taoyuan, Taiwan.

3.          長庚大學生物醫學所碩士班學生陳筱葳，Best poster award, 2010 Disease Biomarker and TPS International Proteomics Conference, April 23-24, 2010, Taipei, Taiwan. (台灣蛋白體年會)

4.          長庚大學生物醫學所碩士班學生賴岳汎，Best poster award , 2011 Translational Medicine Conference and Taiwan Proteomics Society Annual Symposium, April 27-28, 2011, Taipei, Taiwan. (台灣蛋白體年會)

5.          長庚大學生物醫學所碩士班學生陳筱葳，Dissertation award, Chinese Chemical Society, Dec. 3-4, 2011, Hsinchu, Taiwan. (中國化學會分析化學組研究生論文獎優等)

6.          長庚大學生物醫學所碩士班學生周孟楷，Best poster award , Taiwan Proteomics Society Annual Conference & Translational and Systems Biology Symposium. Nov. 11-12, 2014. Taipei, Taiwan. (台灣蛋白體年會)

7.          長庚大學生物醫學所碩士班學生蔡逸懷，第 16 屆台塑企業應用技術研討會，研發論文獎，學校組優勝，June 6, 2018。

8.           109年度 科技部大專學生研究計畫  (長庚大學醫學系王尉軒)

9.          109年度 科技部大專學生研究計畫  (長庚大學生醫系唐羨敏 )。

10.      110年度 科技部大專學生研究計畫  (長庚大學醫學系王尉軒)。

11.      長庚大學生醫系杜祥誠(大三專題生)，第37屆生物醫學聯合年會，中華民國臨床生化學會壁報論文競賽壁報論文優勝獎 暨 2023年永信李天德醫藥基金會壁報論文優等獎，March 19, 2023.

12.      陳玟臻(大四專題生)，第28屆分析化學技術交流研討會，口頭報告優勝獎，成功大學，May14, 2023.

13.      陳玟臻(大四專題生)，111學年度食品與健康科技研討會 超濃縮研究短講競賽第一名，長庚科技大學，May 18, 2023.

14.      涂瑋儒(博士班研究生)，111學年度食品與健康科技研討會 超濃縮研究短講競賽第三名，長庚科技大學，May 18, 2023.

15.      112年度 科技部大專學生研究計畫  (長庚大學生醫系杜祥誠)

16.      112年度 科技部大專學生研究計畫  (長庚大學醫技系吳易昕)

17.      陳筱葳(長庚大學分醫中心助理)，2023長庚醫學週第15屆紀念王創辦人永慶先生學術研討論論文競賽，醫療學術類醫事組口頭報告-銅獎，Oct. 21, 2023。

18.      陳玟臻(五年一貫碩士班生)，2023MOPM多體學及精準醫學聯合研討會，海報競賽特優、大會優秀海報獎初選入圍，Nov.12, 2023.

19.      杜祥誠(大四專題生)，2023MOPM多體學及精準醫學聯合研討會，海報競賽特優，Nov.12, 2023.

20.      張鈺，研發論文暨海報競賽學校組優勝，台塑企業應用技術研討會，June 24, 2024.

21.      陳玟臻, Student Tavel Award, The 72^nd The annual conference of the Mass Spectrometry Society of Japan (MSSJ). 第72屆日本質譜學會年會. June. 10-12, 2024. Tsukuba City, Japan.

22.      杜祥誠, Student Tavel Award, The 72^nd The annual conference of the Mass Spectrometry Society of Japan (MSSJ). 第72屆日本質譜學會年會. June. 10-12, 2024. Tsukuba City, Japan.

23.      杜祥誠，國科會化學學門【大專生創作獎】¾112年度大專學生研究計畫研究創作獎，July 2^nd, 2024.

24.      113年度 科技部大專學生研究計畫(長庚大學醫學系麥文馨)

研究方向及研究室特色

我們實驗室之研究方向為開發偵測及定量物生物分子(包括蛋白質及代謝物)之質譜技術，這些方法已經被用來研究細胞模式及臨床組織及體液等真實樣品，並經由國際合作保持技術的新穎性。我們的研究目標在於利用本實驗室之專長(蛋白質體、代謝體及生物質譜技術)了解泌尿系統癌症之生物機制，利用體學的方法研究膀胱癌及腎臟癌細胞株、腫瘤組織及尿液，希望找尋早期診斷癌症之非侵入式生物標記。

並與泌尿科、腎臟科、婦產科、小兒科等臨床醫生合作，運用蛋白質體及代謝體等後基因體學研究方法，全面性的研究正常與疾病生物系統(細胞株及臨床收集的體液或組織)中蛋白質與代謝物之群體變化，監測各個分子在疾病所扮演的角色，探討惡性與良性泌尿系統疾病發生及惡化之生物機制，以期朝向臨床應用及個人化醫療邁進。

目前實驗室的研究方向如下 :

1.      以系統性方法找尋及驗證泌尿系統癌症之生物標誌及其生物重要性

(Using a Systems Approach to Discover and Assess Urological Cancer Biomarkers)

   我們研究了膀胱癌細胞株之分泌蛋白質體以及臨床醫生取得之腫瘤及尿液組成蛋白體，經由交叉比對，已經發現一系列可能隨著癌症的發生而產生表現量改變的分子，未來將持續驗證其重要性，並研究其與病理狀況之相關性，了解其在泌尿系統研症所扮演之角色。

System approaches for biomarker discovery and mechanism study of urological cancer

2. 發展標靶性及多重定量特性之MRM-MS技術在大量臨床樣品中驗證疾病生物標誌之重要性 (Targeted and Multiplexed Quantitation of Proteins for Verification of Biomarker Panels using Multiple-Reaction-Monitoring MS (MRM-MS) and immune MRM-MS. Collaboration with Prof. Christoph Borchers, the Director of the University of Victoria Genome BC Proteomics Centre, Canada; and clinical teams in Chang Gang Memorial Hospital)

蛋白質體學是當今疾病生物標誌研究中最熱門的研究領域之一。我們研究團隊過去的研究成功地以iTRAQ技術分析發現膀胱癌病患尿液檢體中多種蛋白質生物標誌，同時也已建立「液相層析多重反應監測質譜定量分析技術」(LC-MRM-MS)，首度完成於人類臨床尿液樣本中同步定量63個蛋白質分子的研究工作，此技術將可協助研究學者在大量檢體中驗證過去所找到的生物標記後選分子，未來將繼續發展「免疫濃縮-液相層析多重反應監測質譜定量分析技術」(immuno-MRM-MS)及生物資訊分析方法，以擴展至其他疾病或不同型態的檢體。

Development of MRM-MS assays for protein biomarker verification

3. 利用標靶定量技術同時分析生物路徑中之多種蛋白質及代謝物分子，以系統生物學的方法闡明疾病發生及進展過程中所參與的生物反應機制

(Development and Applications of Targeted Proteomic and Metabolomic Approaches in Cancer Biology to study Urological Oncology. Collaboration with Prof. Liang Li, Department of Chemistry, University of Alberta, Canada)

論文與著作

(1)    “MALDI-TOF MS”，Yi-Ting Chen、Y. C. Ling, Instruments Today, 19, 60-70, 1997.

(2)    Y. C. Ling, L. Lin and Y. T. Chen, ²Quantitative Analysis of Antibiotics by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry², Rapid Commun. Mass Spectrometry. 12, 317-327, 1998 (SCI).

(3)    Y. T. Chen and Y. C. Ling, ²An Overview of Supercritical Fluid Extraction in Chinese Herbal Medicine：from Preparation to Analysis², Journal of Food and Drug Analysis, Special Issue on Chinese Herbal Medicines, 8, 235-247, 2000 (SCI).

(4)    Y. T. Chen and Y. C. Ling, ²Detection of Water-soluble Vitamins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry using Porphyrin Matrices², J. Mass. Sepctrom. 37, 716-730, 2002 (SCI).

(5)    Y. T Chen, C. Y. Tsao, J. M Li, C. Y. Tsai, S. F. Chiu, T. L. Tseng*, ² Large-scale Protein Identification of Human Urine Proteome by Multi-dimensional Liquid Chromatography and Tandem Mass Spectrometry ², Proteomics Clin. Appl. 1, 577-587, 2007 (SCI).

(6)    Hui-Chu Hsieh, Yi-Ting Chen, Jen-Ming Li, Ting-Yu Chou, Ming-Fong Chang, See-Chang Huang, Tzu-Ling Tseng, Chung-Cheng Liu, and Sung-Fang Chen*, “Protein Profilings in Mouse Liver Regeneration after Partial Hepatectomy using iTRAQ Technology”. J. Proteome Res. 8, 1004-1043, 2009 (SCI).

(7)    Yi-Ting Chen*, Chien-Lun Chen, Hsiao-Wei Chen, Ting Chung, Chih-Ching Wu, Chi-De Chen, Chia-Wei Hsu, Meng-Chieh Chen, Ke-Hung Tsui, Phei-Lang Chang, Yu-Sun Chang, Jau-Song Yu*, ² Discovery of Novel Bladder Cancer Biomarkers by Comparative Urine Proteomics Using iTRAQ Technology ², J. Proteome Research. 9, 5803-5815, 2010 (SCI).

(8)    Shih-Yuan Chen, Yi-Ting Chen, Jey-Jau Lee, Soofin Cheng*, Tuning Pore Diameter of Platelet SBA-15 Materials for Enzyme Adsorption, J. Mater. Chem. 21, 5693-5703. 2011 (SCI).

(9)    Yi-Ting Chen, Hsiao-Wei Chen, Derek Smith, Kung-Hao Liang, Ting Chung, Chien-Lun Chen, Yu-Sun Chang, Christoph Borchers,* Jau-Song Yu.* Multiplexed quantification of 63 proteins in human urine by multiple reaction monitoring-based mass spectrometry for discovery of potential bladder cancer biomarkers. J. Proteomics. 75, 3529-3545, 2012 (SCI).

(10)    Yi-Ting Chen*, Fu-Shing Wang, Zhendong Li, Liang Li*, Yong-Chien Ling*. Development of a Matrix-assisted Laser Desorption Ionization Mass Spectrometric Method for Rapid Process-Monitoring of Phthalocyanine Compounds. Analytica Chimica Acta. 736, 69–77, 2012. (SCI)

(11)    Chien-Lun Chen, Yue-Fan Lai^,, Kun-Yi Chien, Jau-Song Yu, Hsiao-Wei Chen, Petrus Tang, Chia-Wei Hsu, Chi-De Chen, Yu-Sun Chang, Phei-Lang Chang, Yi-Ting Chen*, Comparative and Targeted Proteomic Analyses of Urinary Exosomes from Bladder Cancer and Hernia Patients. J. Proteome Research. 11, 5611−5629, 2012. (SCI)

(12)    Yen-Heng Lin*, Ying-Ju Chen, Chao-Sung Lai*, Yi-Ting Chen, Chien-Lun Chen, Jau-Song Yu, and Yu-Sun Chang, A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based enzyme-linked immunosorbent assay. Biomicrofluidics 7, 024103, 2013. (SCI)

(13)    Chien-Lun Chen, Tsung-Shih, Lin, Cheng-Han, Tsai, Chih-Ching Wu, Ting Chung,  Kun-Yi Chien, Maureen Wu, Yu-Sun Chang, Jau-Song Yu*, Yi-Ting Chen*, Identification of Potential Bladder Cancer Markers in Urine by Abundant-Protein Depletion Coupled with Quantitative Proteomics. J. Proteomics. 85, 28-43, 2013. (SCI)

(14)    Chi-De Chen, Chih-Liang Wang, Chia-Jung Yu, Kun-Yi Chien, Yi-Ting Chen, Min-Chi Chen, Yu-Sun Chang, Chin-Ching Wu*, Jau-Song Yu*. Targeted Proteomics Pipeline Reveals Potential Biomarkers forthe Diagnosis of Metastatic Lung Cancer in Pleural Effusion. J. Proteome Research. 13(6):2818-29, 2014.

(15)    Jun Peng, Yi-Ting Chen, Chien-Lun Chen and Liang Li, Development of a Universal Metabolome-Standard Method for Long-term LC-MS Metabolome Profiling and Its Application for Bladder Cancer Urine-Metabolite-Biomarker Discovery. Anal. Chem. 86(13):6540-7, 2014.

(16)    Chiun-Gung Juo*, Chien-Lun Chen, Shiang-Ting Lin, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang and Jau-Song Yu. Mass accuracy improvement of ESI-RPLC-MS based urinary metabolomic analysis by post-run calibration using sodium formate cluster ions. Rapid Commun. Mass Spectrom. 28, 1813-1820, 2014.

(17)    Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Shi-Liang Chen, Min-Cong Xiao, Chien-Lun Chen, Mu-Yi Hua*. A sensitive and selective magnetic graphene composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis. Biosensors and Bioelectronics. 66, 198–207, 2015 . (Co-first author)

(18)    Yi-Ting Chen, Li-Ping Tuan, Hsiao-Wei Chen, I-An Wei, Min-Yuan Chou, Han-Min Chen,  Yu-Chang Tyan, Sung-Fang Chen*. Quantitative analysis of prostate specific antigen isoforms using immunoprecipitation and isotope dilution mass spectrometry. Anal. Chem. 2015, 87(1):545-53. (Co-first author)

(19)    Chien-Lun Chen, Ting Chung, Chih-Ching Wu, Kwai-Fong Ng, Jau-Song Yu, Cheng-Han Tsai, Yu-Sun Chang, Ying Liang, Yi-Ting Chen*. Comparative tissue proteomics of microdissected specimens reveals novel biomarkers of bladder cancer. Mol. Cell Proteomics. 2015. 14(9), 2466-2478. (Co-first and corresponding author)

(20)    Chih-Hsiang Chang, Chia-Hung Yang, Huang-Yu Yang, Tien-Hsing Chen, Chan-Yu Lin, Su-Wei Chang, Yi-Ting Chen, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen*. Urinary Biomarkers Improve the Diagnosis of Intrinsic Acute Kidney Injury in Coronary Care units. Medicine. 2015 Oct;94(40):e1703.

(21)    Chih-Hsiang Chang, Pei-Chun Fan, Chan-Yu Lin, Chia-Hung Yang, Yi-Ting Chen, Su-Wei Chang, Huang-Yu Yang, Chang-Chyi Jenq, Cheng-Chieh Hung, Chih-Wei Yang, and Yung-Chang Chen. Elevation of Interleukin-18 Correlates with Cardiovascular, Cerebrovascular, and Peripheral Vascular Events: A Cohort Study of Hemodialysis Patients. Medicine. 2015 Oct;94(42):e1836.

(22)    Cheng-Hung Lee , Kuo-Sheng Liu , Shang-Hung Chang , Wei-Jan Chen , Kuo-Chun Hung , Shih-Jung Liu* , Jong-Hwei S. Pang , Jyuhn-Huarng Juang , Chou Chung-Chuan , Po-Cheng Chang , Yi-Ting Chen , Fu-Shing Wang. Promoting Diabetic Wound Therapy Using Biodegradable rhPDGF-loaded Nanofibrous Membranes: CONSORT-Compliant Article. Medicine. 2015 Nov;94(47):e1873.

(23)    Chia-Hung Yang, Chih-Hsiang Chang, Tien-Hsing Chen, Pei-Chun Fan, Su-Wei Chang, Chun-Chi Chen, Pao-Hsien Chu, Yi-Ting Chen, Huang-Yu Yang, Chih-Wei Yang, Yung-Chang Chen. Combination of Urinary Biomarkers Improve Early Detection of Acute Kidney Injury in Patients with Heart Failure. Circulation Journal, 2016, 25;80(4):1017-23.

(24)    Cheng-Hung Lee, Yin-Kai Chao, Shang-Hung Chang, Wei-Jan Chen, Kuo-Chun Hung, Shih-Jung Liu,* Jyuhn-Huarng Juang, Yi-Ting Chen and Fu-Shing Wang. Nanofibrous rhPDGF-eluting PLGA–collagen hybrid scaffolds enhance healing of diabetic wounds. RSC Adv., 2016, 6, 6276–6284.

(25)    Jau-Song Yu, Yi-Ting Chen, Wei-Fang Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Cha, Kai-Ping Chang, Chih-Yen Chien, Chee-Jen Chang, John D. Young, Chia C. Pao, Yu-Sun Chang*, Leland H. Hartwell*, Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan, PNAS, 2016, 113, 11549–11554. (Co-first author).

(26)    Yi-Ting Chen*, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang, Development of a multiplexed LC-MRM/MS method for evaluation of salivary proteins as oral cancer biomarkers. Mol. Cell Proteomics. 16, 799-811. 2017.

(27)    Chi-hung Shao, Chien-Lun Chen, Chao-Jung Chen, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang, Jau-Song Yu, Chiun-Gung Juo*, Kun-Pin Wu*, Metabolite marker discovery for the detection of bladder cancer by comparative metabolomics. Oncotarget, 2017 Jun 13;8(24):38802-38810. 2017.

(28)    Yung-Chin Hsiao, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Szu-Fan Chen, Yao-Ning Chuang, Shih-Yu Lin, Chia-Chun Wu, Ya-Ting Chang, Lichieh Julie Chu, Yi-Ting Chen, Shu-Li Chia, Chih-Yen Chien, Kai-Ping Chang,Yu-Sun Chang, and Jau-Song Yu, Development of a multiplexed assay for oral cancer candidate biomarkers using peptide immunoaffinity enrichment and targeted mass spectrometry. Mol. Cell Proteomics. 2017 Oct;16(10):1829-1849.

(29)    Cheng-Han Tsai, Yi-Ting Chen*, Clinical proteomics of genitourinary cancer for the development of biomarkers. Clinics in Oncology, 2017, 2, 1326-1327. 

(30)    Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang* & Yu-Sun Chang*. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. NATURE COMMUNICATIONS. 2017, 8: 465.

(31)    Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, and Jau-Song Yu. Variability assessment of 90 salivary proteins in intra-day and inter-day samples from healthy donors by multiple reaction monitoring-mass spectrometry. Proteomics Clinical Applications, 2018 Mar;12(2). doi: 10.1002/prca.201700039. Epub 2018 Feb 7.

(32)    Cheng-Han Tsai1, Yi-Ting Chen*, Ying-Hsu Chang, Chuen Hsueh, Chung-Yi Liu, Yu-Sun Chang, Chien-Lun Chen*, Jau-Song Yu*. Systematic Verification of Bladder Cancer-Associated Tissue Protein Biomarker Candidates in Clinical Urine Specimens. Oncotarget, 2018, 9:30731-30747. (Co-first author and co-corresponding author).

(33)    Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen*, Pei-Chun Fan, SuWei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai. Preoperative Risk Assessment Improves Biomarker Detection for Predicting Acute Kidney Injury After Cardiac Surgery, PLOS ONE, 2018, 13 (9), e0203447.

(34)    Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, and Li-Mei Pai*. Histidine-dependent protein methylation is required for compartmentalization of CTP Synthase, Cell Reports, 2018, 24, 2733–2745.

(35)    Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Huan Tao, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen*, Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patient. Scientific Reports, 2018, 8, Article number: 17774.

(36)    Yi-Ting Chen*, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu Chang*. Development of Biomarkers of Genitourinary Cancer using Mass Spectrometry-Based Clinical Proteomics, Journal of Food and Drug Analysis, 2019, 27, 2: 387-403.

(37)    Yi-Ting Chen*, Hsin-Chien Huang, Ya-Ju Hsieh, Shu-Hsuan Fu, Liang Li, Chien-Lun Chen, Lichieh Julie Chu, Jau-Song Yu. Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers. Journal of Food and Drug Analysis, 2019, 27(2), 460-474.

(38)    Chia-Wei Hsu, Yi-Ting Chen, Ya-Ju Hsieh, Kai-Ping Chang, Pei-Chun Hsueh, Ting-Wen Chen, Jau-Song Yu, Yu-Sun Chang, Liang Li*, Chih-Ching Wu*. Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma. Analytica Chimica Acta. 2019, 1050, 113-122. (Co-first author)

(39)    Jia-Jin Chen, Pei-Chun Fan, George Kou, Su-Wei Chang, Yi-Ting Chen, Cheng-Chia Lee, Chih-Hsiang Chang*, Meta-analysis: urinary calprotectin for discrimination of intrinsic and prerenal acute kidney injury, J. Clin. Med., 2019, 8(1), E74.

(40)    Pei-Chun Fan, Jason Chih-Hsiang Changa, Chia-Ni Lin,Cheng-Chia Leea, Yi-Ting Chen, Pao-Hsien Chu, George Koua, Yueh-An Lu, Chih-Wei Yang, Yung-Chang Chen*. Serum Indoxyl Sulfate Predicts Adverse Cardiovascular Events in Patients with Chronic Kidney Disease. Journal of the Formosan Medical Association, 2019, 118, 1099-1106.

(41)    Hao-Wei Chu, Kai-Ping Chang, Chia-Wei Hsu, Ian Yi-Feng Chang, Hao-Ping Liu, Yi-Ting Chen, and Chih-Ching Wu, Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Molecular & Cellular Proteomics. 2019, 18(9), 1796-1806.

(42)    Yi-Ting Chen*, Wei-Ting Ou Yang, Horng-Heng Juang, Chien-Lun Chen*, Hsiao-Wei Chen, Ke-Hung Tsui, Ying-Hsu Chang, Cheng-Han Tsai, Chuen Hsueh, Wei-Chao Liao, Proteomic characterization of arsenic and cadmium exposure in bladder cells", Rapid Commun Mass Spectrom. 2020;34(S1):e8578.

(43)    Cheng-Chia Lee, Chih-Hsiang Chang, Ya-Lien Cheng, George Kuo, Shao-Wei Chen, Yi-Jung Li, Yi-Ting Chen, Ya-Chung Tian*, Diagnostic performance of Cyclophilin A in cardiac surgery-associated acute kidney injury. J. Clin. Med. 2020, 9, 108; doi:10.3390/jcm9010108.

(44)    Pei-Chun Hsueh; Kuo-An Wu; Chia-Yu Yang; Chia-Wei Hsu; Chih-Liang Wang; Chu-Mi Hung; Yi-Ting Chen; Jau-Song Yu; Chih-Ching Wu*. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Analytica Chimica Acta. 2020, 1128, 238-250.

(45)    Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash & Jau-Song Yu*. Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses. Sci. Rep. 11, 9583 (2021). https://doi.org/10.1038/s41598-021-89089-4.

(46)    Jia‑You Lin, Bao‑Rong Juo, Yu‑Hsuan Yeh, Shu‑Hsuan Fu, Yi‑Ting Chen, Chien‑Lun Chen* and Kun‑Pin Wu*. Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics, BMC Bioinformatics. 2021, 22, 305. https://doi.org/10.1186/s12859‑021‑04235‑z.

(47)    Ming-Yu Fang, Kuan-Hsun Huang, Wei-Ju Tu, Yi-Ting Chen, Pei-Yun Pan, Wan-Chi Hsiao, Yi-Yu Ke, Lun K. Tsou, Mingzi M. Zhang*. Chemoproteomic profiling reveals cellular targets of nitro-fatty acids. Redox Biology. 46, 102126 (2021). https://doi.org/10.1016/j.redox.2021.102126.

(48)    Ya-Ju Hsieh, Kun-Yi Chien, Chun-Ming Chang, Cheng-Yu Hung, Liang Li, Wei-Fan Chiang5, Cheng-Chia Lee, Chih-Hsiang Chang, Ying-Hsu Chang, Jau-Song Yu*, Yi-Ting Chen*. Development of a Method for Dansylation of Metabolites Using Organic Solvent-Compatible Buffer Systems for Amine/Phenol Submetabolome Analysis. Analytica Chimica Acta. 2022, 1189, 339218. https://doi.org/10.1016/j.aca.2021.339218

(49)    Eric Yi-Hsiu Huang, Yu-Kuang Chen, Chen-Pu Ou, Yi-Ting Chen, Sung-Fang Chen, William J. Huang, Kung-Hao Liang * Oncogenic roles of Polycomb Repressive Complex 2 in bladder cancer and upper tract urothelial carcinoma. Biomedicines. 2022 Nov 14;10(11):2925. doi: 10.3390/biomedicines10112925.

(50)    Yi-Ting Chen, Wan-Rou Liao, Hsueh-Ting Wang, Hsiao-Wei Chen, Sung-Fang Chen*. Targeted Protein Quantitation in Human Body Fluids by Mass Spectrometry. Mass Spectrom Rev. 2023.; 42(6):2379-2403. doi: 10.1002/mas.21788.

(51)    Chien-Lun Chen, Yi-Ting Chen, Wen-Yu Liao, Yu-Sun Chang, Jau-Song Yu, and Bao-Rong Juo*, Urinary Metabolomic Analysis of Prostate Cancer by UPLC-FTMS and UPLC-Ion Trap MSⁿ. Diagnostics. 2023, 13, 2270. https://doi.org/10.3390/diagnostics13132270

(52)    Yi-Ting Chen*, Wei-Ju Tu, Zong-Han Ye, Chih-Ching Wu, Shir-Hwa Ueng, Kai-Jie Yu, Chien-Lun Chen, Pei-Hua Peng, Jau-Song Yu, Ying-Hsu Chang*, Integration of the cancer cell secretome and transcriptome reveals potential noninvasive diagnostic markers for bladder cancer. Proteomics Clin. Appl. 2024 Jan 9:e2300033. https://onlinelibrary.wiley.com/doi/10.1002/prca.202300033.

(53)    Chih-Hsiang Chang, Cheng-Chia Lee, Yung-Chang Chen, Pei-Chun Fan, Pao-Hsien Chu, Lichieh Julie Chu, Jau-Song Yu, Hsiao-Wei Chen, Chih-Wei Yang, Yi-Ting Chen*. Identification of endothelial cell protein c receptor by urinary proteomics as a novel prognostic marker in non-recovery kidney injury, International Journal of Molecular Sciences, 2024, 25(5), 2783; https://doi.org/10.3390/ijms250527834.