黃國正/Guo-Jen Huang
職稱： 教授
現職： 教授
電話： 03-2118800#3802
學歷： 英國劍橋大學博士
專長領域： 基因與神經科學
工作經歷
2005-2011 博士後研究員 英國牛津大學
獲獎
中央研究院年輕學者研究著作獎 (2016)研究方向及研究室特色
研究方向
我們對於腦是如何地運作所知甚少。揭開大腦是如何運作是一個令人著迷的問題，我們實驗室目前的研究主題主要是專注在情緒焦慮，認知學習記憶，生理運動，腦創傷和腦中風方面。此外，我們也對於粒線體在神經細胞如何移動，以及其對於神經行為的重要性，也非常感興趣。我們的研究方法主要是以小鼠的動物模式，來探討基因，腦神經細胞結構，生理賀爾蒙與動物行為，希望藉此來試著解開基因與神經的運作之謎。
目前實驗室的研究有以下幾個議題:
1) 個體成年後，腦中增生的新神經細胞在生理上的功能為何?
2) 運動如何讓腦神經細胞更健康，是透過如何機制？
3) 神經細胞內的粒線體移動的機制為何，以及其對神經型態與行為的重要性？
4) 利用基因或是藥物治療來修復腦創傷或是腦中風?
As human beings, we know little about how the brain works. Unraveling its functions is one of the most fascinating challenges in science. In our lab, we use animal models to investigate how genes regulate anxiety, stress, learning, and memory. We are also interested in revealing the mechanisms of mitochondrial trafficking. Additionally, we are exploring ways to repair traumatic brain injury and stroke using mouse models.
Our current research focuses on:
1. The role of adult neurogenesis in the hippocampus.
2. The benefits of exercise for the brain and the underlying molecular mechanisms.
3. The mechanisms of mitochondrial trafficking and their importance in brain function.
4. Approaches to repair brain damage and the candidate genes involved.
論文與著作
- Wu KY, Tsao CH, Su NC, Deng SM, Huang GJ*. Stk24 deficiency causes disrupted hippocampal neurogenesis and anxiety-like behavior in mice. Communications Biology 2025 Apr 25;8(1):663.
- Chen YJ, Deng SM, Chen HW, Tsao CH, Chen WT, Cheng SJ, Huang HS, Tan BC, Matzuk MM, Flint J, Huang GJ*. Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus. Proceedings of the National Academy of Sciences 2021 Sep 28;118(39):e2109040118.
- Eu WZ, Chen YJ, Chen WT, Wu KU, Tsai CY, Cheng SJ, Carter R, Huang GJ*. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervations. Translational Psychiatry 2021 Mar 15;11(1):162
- Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ*. NPTX2 is a key component in the regulation of anxiety. Neuropsychopharmacology 2018 Aug;43(9):1943-1953
- Chang S, Bok P, Sun CP, Edwards A, Huang GJ*. Neuropsin inactivation has protective effects against depressive-like behaviours and memory impairment induced by chronic stress. PLoS Genetics 2016 Oct 4; 12(10): e1006356
- Tsai CY, Tsai CY, Arnold S, Huang GJ*. Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle. Nature Communications 2015 Sep 29;6:8373.
- Cai N,et al., Molecular signatures of major depression. Current Biology 2015 May 4;25(9):1146-56. (*co-senior author)
- Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Parent JM, Johnsen A,Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T-cells and cellular proliferation in the adult hippocampus. PLoS Biology 2010 Dec 14; 8(12):e1000561
- Huang GJ, Shifman S, Johannesson M, Yalcin B, Valdar W, Taylor J, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research 2009 Jun; 19(6):1133-40
- Arnold S, Huang GJ (equal contribution), Cheung A, Era T, Nishikawa SI, Bikoff E, Molnar E, Robertson E, Groszer M. The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone. Genes & Development 2008 Sep 15; 22(18):2479-84
- Huang GJ*, Bannerman D, Flint J. Chronic fluoxetine treatment alters behaviour, but not adult hippocampal neurogenesis, in BALB/cJ mice. Molecular Psychiatry 2008 Feb; 13, 119-121.
- Huang GJ, Herbert J. Stimulation of neurogenesis in the dentate gyrus of the adult rat by fluoxetine requires rhythmic change in corticosterone. Biological Psychiatry 2006 Apr 1; 59(7):619-24
- Huang GJ, Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology 2005 Feb 30:231-241.