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Graduate Institute of Clinical Medical Sciences

Graduate Institute of Clinical Medical Sciences
:::
Gwo-Jyh Chang

Gwo-Jyh Chang

JobTitle： Professor

CurrentJob： Professor of CGU

E-mail： gjchang@mail.cgu.edu.tw

Phone： 3481, 3497

Education： Ph.D. in National Taiwan University, Taiwan

Expertise： Pharmacology, Electrophysiology…

Website： https://www.researchgate.net/profile/Gwo-Jyh_Chang

Lab

Cardiovascular Electrophysiology and Pharmacology Research Lab

RESEARCH INTERESTS

The strength of my research is the characterization of the pharmacological and electrophysiological properties of new drugs with antiarrhythmic, anti-heart failure or vasorelaxant effects. In the past few years, we also devoted in the studies of novel cardioprotective agents on the pathological remodeling of the heart in pressure overload, diabetic or myocardial infarcted animals.

  The well-established patch-clamp recording technique in our Lab is one of the most convincing pathways to evaluate the function of various ionic channels on dissociated cells. The application of this unique technique combined with various in vivo and in vitro cardiovascular research techniques can help us to explore not only the acute actions of new drugs with antiarrhythmic actions but also to reveal the electrophysiological remodeling processes during chronic cardiac diseases such as cardiac hypertrophy or failure. By close cooperation with investigators of other disciplines we shall explore many complicate questions about the pathological mechanisms and find potential therapeutic strategies of modern cardiac diseases.

Publication

  1. Chang, S.H., Chan, Y.H., Chen*, W.J., Chang, G.J., Lee, J.L., Yeh*, Y.H. (2021). Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling. Heart Rhythm. Published: May 20, 2021. https://doi.org/10.1016/j.hrthm.2021.05.021. (IF 5.731, CARDIAC & CARDIOVASCULAR SYSTEMS 19/138).
  2. Lin, C.C., Hsu, K.H., Shih, C.P., Chang*, G.J. (2021). Hemodynamic and electromechanical effects of paraquat in rat heart. PLoS ONE 16(4): e0234591. Apr. 1, 2021 https://doi.org/10.1371/journal.pone.0234591 (IF 2.740; MULTIDISCIPLINARY SCIENCES 27/71).
  3. Torre, E., Arici, M., Lodrini, A.M., Ferrandi, M., Barassi, P., Hsu, S.C., Chang, G.J., Boz, E., Sala, E., Vagni, S., Altomare, C., Mostacciuolo, G., Bussadori, C., Ferrari, P., Bianchi, G., Rocchetti*, M. (2021). SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy. Cardiovasc. Res. Apr. 1, 2021. https://doi.org/10.1093/cvr/cvab123 (IF 8.168, CARDIAC & CARDIOVASCULAR SYSTEMS 12/138).
  4. Chou, C.C., Lee, H.L., Chang, G.J., Wo, H.T., Yen, T.H., Wen, M.S., Chu, Y., Liu, H.T., Chang*, P.C. (2020). Mechanisms of ranolazine pretreatment in preventing ventricular tachyarrhythmias in diabetic db/db mice with acute regional ischemia-reperfusion injury. Scientific Reports 10(1):20032. P1-P11. Nov 18 2020. doi: 10.1038/s41598-020-77014-0.  (SCI). (IF 3.998, MULTIDISCIPLINARY SCIENCES 17/71).
  5. Hsieh, M.J., Lee, C.H., Chueh, H.Y., Chang, G.J., Huang, H.Y., Lin, Y., Pang*, J.H.S. (2020). Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Scientific Reports  10, 17078. P1-P11. Oct 13 2020. doi: 10.1038/s41598-020-74022-y.  (SCI). (IF 3.998, MULTIDISCIPLINARY SCIENCES 17/71).
  6. Hsu*, L.A., Tsai, F.C., Yeh, Y.H., Chang, C.J., Kuo, C.T., Chen, W.J., Tsai, H.Y., Chang, G.J. (2020). Aldehyde dehydrogenase 2 ameliorates chronic alcohol consumption-induced atrial fibrillation through detoxification of 4-HNE. Int. J. Mol. Sci. 21(18), 6678; 13 pages; doi:10.3390/ijms21186678. Sep. 12 (SCI) (IF 4.556; BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297).
  7. Tsai, F.C., Chang, G.J., Lai, Y.J., Chang, S.H., Chen, W.J., Yeh*, Y.H. (2020). Ubiquitin pathway is associated with worsening left ventricle function after mitral valve repair: A global gene expression study. Int. J. Mol. Sci. 21(14), 5073, 16 pages. https://doi.org/10.3390/ijms21145073. 2020 Jul. (SCI) (IF 4.556; BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297).
  8. Chiu, C.H., Chang, T.H., Chang, S.S., Chang, G.J., Chen, A.C.Y., Cheng, C.Y., Chen, S.C., Fu, J.F., Wen, C.J., Chan*, Y.S. (2020). Application of bone marrow–derived mesenchymal stem cells for muscle healing after contusion injury in mice. The American Journal of Sports Medicine. 48(5):1226–1235. DOI: 10.1177/0363546520905853. 2020 Apr. (SCI) (IF 5.810, ORTHOPEDICS 1/82).
  9. Chiu, C.H., Chang, S.S., Chang, G.J., Chen, A.C.Y., Cheng, C.Y., Chen, S.C., Chan*, Y.S. (2020). The effect of hyperbaric oxygen treatment on myoblasts and muscles after contusion injury. Journal of Orthopaedic Research. 38(2):329–335. doi: 10.1002/jor.24478. Feb. (IF 2.728, ORTHOPEDICS 23/82).
  10. Chuang, W.Y., Chang, S.T., Yuan, C.T., Chang, G.J., Chang, H., Yeh, C.J., Ueng, S.H., Kao, H.W., Wang, T.H., Wan, Y.L., Shih, L.Y., Chuang, S.S., Hsueh*, C. (2020). Identification of CD5/cyclin D1 double-negative pleomorphic mantle cell lymphoma: A clinicopathologic, genetic and gene expression study. American Journal of Surgical Pathology. 44(2): 232-240. doi: 10.1097/PAS.0000000000001390. 2020 Feb. (SCI) (IF 4.958, PATHOLOGY 10/78).
  11. Hsu*, L.A., Ko, Y.S., Yeh, Y.H., Chang, C.J., Chan, Y.H., Kuo, C.T., Tsai, H.Y., Chang, G.J. (2019). A novel DES L115F mutation identified by whole exome sequencing is associated with inherited cardiac conduction disease. International Journal of Molecular Sciences 20(24): 6227. 13 pages. Dec 10. doi:10.3390/ijms20246227. (SCI) (IF 4.556; BIOCHEMISTRY & MOLECULAR BIOLOGY 74/297).
  12. Chen*, W.J., Chang, S.H., Chan, Y. H., Lee, J.L., Lai, Y.J., Chang, G.J., Tsai, F.C., Yeh*, Y.H. (2019). Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling. Journal of Molecular and Cellular Cardiology. 135: 67–78. Oct. (SCI) (IF 4.133, CARDIAC & CARDIOVASCULAR SYSTEMS 36/138).
  13. Chan, Y.H., Chang, G.J., Lai, Y.J., Chen, W.J., Chang, S.H., Hung, L.M, Kuo*, C.T., Yeh*, Y.H. (2019). Atrial fibrillation and its arrhythmogenesis associated with insulin resistance. Cardiovasc. Diabetol. 18: article no. 125, 14 pages. Sep 26. (SCI) (IF 7.332, ENDOCRINOLOGY & METABOLISM 11/143).
  14. Liu, Y.Y., Chen, N.H., Chang, C.H., Lin, S.W., Kao, K.C., Hu, H.C., Chang, G.J., Li*, L.F. (2019). Ethyl pyruvate attenuates ventilation-induced diaphragm dysfunction through high-mobility group box-1 in a murine endotoxaemia model. J. Cell. Mol. Med. 23(8): 5679-5691. doi: 10.1111/jcmm.14478. Aug 23. (SCI) (IF 4.486, MEDICINE, RESEARCH & EXPERIMENTAL 35/138).
  15. Chang, C.J., Hsu, H.C., Ho, W.J., Chang, G.J., Pang, J.H.S., Chen, W.J., Huang, C.C., Lai*, Y.J. (2019). Cathepsin S promotes the development of pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 317(1):L1-L13. Jul 1, 2019. doi: 10.1152/ajplung.00530.2018. (SCI) (IF 4.406, PHYSIOLOGY 12/81).
  16. Chang*, G.J., Yeh, Y.H., Chen, W.J., Ko, Y.S., Pang, J.H.S., Lee, H.Y. (2019). Inhibition of advanced glycation end products formation attenuates cardiac electrical and mechanical remodeling and vulnerability to tachyarrhythmias in diabetic rats. J. Pharmacol. Exp. Ther. 368(1): 66-78. DOI: https://doi.org/10.1124/jpet.118.252080. Jan. (SCI) (IF 3.561, PHARMACOLOGY & PHARMACY 79/270).
  17. Chang, P.C., Huang, Y.C., Lee, H.L., Chang, G.J., Chu, Y., Wen, M.S., Chou*, C.C. (2018). Inhomogeneous downregulation of INa underlies piceatannol proarrhythmic mechanism in regional ischemia-reperfusion. Pacing Clin. Electrophysiol. 41(9): 1116-1122. doi: 10.1111/pace.13424. Sep. (SCI). (IF 1.303, ENGINEERING, BIOMEDICAL 69/87).
  18. Liu, G.H., Tsai, M.Y., Chang, G.J., Wu, C.M., Lin, S.K., Chen*, Y.S., Lee*, T.Y. (2018). Safety assessment of the auto manipulation device for acupuncture in sprague-dawley rats: Preclinical evaluation of the prototype. Evidence-based Complementary & Alternative Medicine. 2018: 9 pages. Article ID 5708393. https://doi.org/10.1155/2018/5708393. Aug. (SCI). (IF 1.813, INTEGRATIVE  & COMPLEMENTARY MEDICINE 16/28).
  19. Tsai, W.C., Yu, T.Y., Chang, G.J., Lin, L.P., Lin, M.S., Pang*, J.H.S. (2018). Platelet-rich plasma releasate promotes regeneration and decreases inflammation and apoptosis of injured skeletal muscle. Am. J. Sports Med. 46(8):1980-1986. doi: 10.1177/0363546518771076. Jul. (SCI). (IF 5.810, ORTHOPEDICS 1/82).
  20. Chou, W.C., Wu, M.H., Chang, P.H., Hsu, H.C., Chang, G.J., Huang, W.K., Wu, C.E., Hsieh*, Jason C.H. (2018). A prognostic model based on circulating tumour cells is useful for identifying the poorest survival outcome in patients with metastatic colorectal cancer. Int. J. Bio. Sci. 14(2): 137-146. doi: 10.7150/ijbs.2318. Jan. (SCI). (IF 4.858, BIOCHEMISTRY & MOLECULAR BIOLOGY 65/297).
  21. Li, H.H., Hsu, H.H., Chang, G.J., Chen, I.C., Ho, W.J., Hsu, P.C., Chen, W.J., Pang, J.H.S., Huang, C.C., Lai*, Y.J. (2018). Prostanoid EP4 agonist, L-902,688, activates PPARγ and attenuates pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 314(3): L349-L359. 2018 Mar 1. (SCI). (IF 4.406, PHYSIOLOGY 12/81).
  22. Chen*, C.N., Liao, Y.H., Lin, S.Y., Yu, J.X., Li, Z.J., Lin, Y.C., Chang, G.J., Lin, C.H., Wong, A.M. (2017) Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum. Am. J. Physiol. Regul. Integr. Comp. Physiol. 313 (5): R601-R607. 2017 Nov 1. (SCI). (IF 2.992, PHYSIOLOGY 27/81).
  23. Lai*, Y.J., Hsu, H.H., Chang, G.J., Lin, S.H., Chen, W.J., Huang, C.C., Pang, J.H.S. (2017) Prostaglandin E1 attenuates pulmonary artery remodeling by activating phosphorylation of the CREB and PTEN signaling pathway. Sci. Rep. 7(1): 9974. 2017 Aug 30 (SCI). (IF 3.998, MULTIDISCIPLINARY SCIENCES 17/71).
  24. Chuang, W.Y., Chang, H., Chang, G.J., Wang, T.H., Chang, Y.S., Wang, T.H., Yeh, C.J., Ueng, S.H., Chien, H.P., Chang, C.Y., Wan, Y.L., Hsueh*, C. (2017). Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B-cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall. Histopathology. 70(6): 986-999. (SCI). (IF 3.626, PATHOLOGY 18/78).
  25. Tsai, F.C., Lin, Y.C., Chang, S.H., Chang, G.J., Hsu, Y.J., Lin, Y.M., Lee, Y.S., Wang, C.L., Yeh*, Y.H. (2016) Differential left-to-right atria gene expression ratio in human sinus rhythm and atrial fibrillation: Implications for arrhythmogenesis and thrombogenesis. Int. J. Cardiol. 222: 104–112. (SCI). (IF 3.229, CARDIAC & CARDIOVASCULAR SYSTEMS 55/138).
  26. Yeh, Y.H., Hsu, L.A., Chen, Y.H., Kuo, C.T., Chang, G.J., Chen*, W.J. (2016). Protective role of heme oxygenase-1 in atrial remodeling. Basic Res. Cardiol. 111:58 (13 pages) (SCI). (IF 11.981, CARDIAC & CARDIOVASCULAR SYSTEMS 8/138).
  27. Li, L.F., Chang Y.L., Chen, N.H., Wang, C.Y., Chang, G.J., Lin, M.C., Chang, C.H., Huang, C.C., Chung, J.H., Yang, Y.P., Chiou, S.H., Liu*, Y.Y. (2016). Inhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction. Translational Res. 173: 131–147.e1. (SCI). (IF 5.411, MEDICAL LABORATORY TECHNOLOGY 2/29).
  28. Tsai, F.C., Chang, G.J., Hsu, Y.J., Lin, Y.M., Lee, Y.S., Chen, W.J., Kuo*, C.T., Yeh*, Y.H. (2016). Proinflammatory gene expression in patients undergoing mitral valve surgery and Maze ablation for atrial fibrillation. J. Thorac. Cardiovasc. Surg. 151(6): 1673-1682. (SCI). (IF 4.451, SURGERY 17/210).
  29. Wu, L.S., Chang, S.H., Chang, G.J., Liu, J.R., Chan, Y.H., Lee, H.F., Wen, M.S., Chen, W.J., Yeh, Y.H., Kuo, C.T., See*, L.C. (2016). A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients: a population-based dynamic cohort study in Taiwan. Cardiovasc. Diabetol. 15:56. (SCI). (IF 7.332, ENDOCRINOLOGY & METABOLISM 11/143).