Graduate Institute of Clinical Medical Sciences

Lab

Research direction and characteristics

1. Investigating the modulation of specific viral and cellular gene expression by the KSHV latency-associated nuclear antigen (LANA) protein
2. Exploring the coordinated assembly of the KSHV lytic DNA replication complex
3. Studying the protein stability and the biological functions of the KSHV lytic switch protein
4. Characterizing the functional interactions of HuNV proteins with the host cellular machinery
5. Studying the reciprocal interactions between the EBV lytic cycle and the unfolded protein response

Publication

1. Li-Yu Chen, Lee-Wen Chen, Kuo-Ti Peng, Chien-Hui Hung, Pey-Jium Chang*, Shie-Shan Wang*. 2020. Sp3 transcription factor cooperates with the Kaposi’s sarcoma-associated herpesvirus ORF50 protein to synergistically activate specific viral and cellular gene promoters. Journal of Virology. 94(18): e01143-20. (IF: 4.501; 8/37, Virology) [* Corresponding author]
2. Dong-Ru Ho, Pey-Jium Chang, Wei-Yu Lin, Yun-Ching Huang, Jian-Hui Lin, Kuo-Tsai Huang, Wai-Nga Chan, Chih-Shou Chen. 2020. Beneficial effects of inflammatory cytokine-targeting aptamers in an animal model of chronic prostatitis. International Journal of Molecular Sciences. 21(11):3953 (IF: 4.556; 74/297, Biochemistry & Molecular Biology)
3. Geng-He Chang, Yi-Cheng Su, Ko-Ming Lin, Chia-Yen Liu, Yao-Hsu Yang, Pey-Jium Chang, Meng-Hung Lin, Chuan-Pin Lee, Cheng-Ming Hsu, Yao-Te Tsai, Ching-Yuan Wu, Ming-Shao Tsai. 2020. Deep neck infection in systemic lupus erythematosus patients: Real-World Evidence. Scientific Reports. 10(1):4133 (IF: 3.998; 17/71, Multidisciplinary Sciences)
4. Chien-Hui Hung, Ya-Fang Chiu, Wen-Hung Wang, Lee-Wen Chen, Pey-Jium Chang, Tsung-Yu Huang, Ying-Ju Lin, Wan-Ju Tsai, Chia-Ching Yang. 2020. Interaction between BGLF2 and BBLF1 is required for the efficient production of infectious Epstein-Barr virus. Frontiers in Microbiology. 10:3021. (IF: 4.235; 34/134, Microbiology)
5. Yung-Chien Hsu#, Pey-Jium Chang#, Chun-Wu Tung, Ya-Hsueh Shih, Wen-Chiu Ni, Yi-Chen Li, Takuhiro Uto, Yukihiro Shoyama, Cheng Ho, Chun-Liang Lin. 2020. De-glycyrrhizinated licorice extract attenuates high glucose-stimulated renal tubular epithelial-mesenchymal transition via suppressing the Notch2 signal pathway. Cells. 9(1):125. (IF: 4.366; 70/195, Cell Biology) [# Co-first author]
6. Geng-Ho Chang, Meng-Chang Ding, Yu-Cheng Chen, Yao-Hsu Yang, Chia-Yen Liu, Pey-Jium Chang, Chuan-Pin Lee, Meng-Hung Lin, Cheng-Ming Hsu, Ching-Yuan Wu, Ko-Ming Lin, Ming-Shao Tsai. 2020. Real-world evidence for increased deep neck infection risk in patients with rheumatoid arthritis. Laryngoscope. 130(6):1402-1407 (IF: 2.465; 10/42, Otorhinolaryngology)
7. Kuo-Ti Peng, Ju-Fang Liu, Yao-Chang Chiang, Pei-Chun Chen, Ming-Hsien Chiang, Hsin-Nung Shih, Pey-Jium Chang, Chiang-Wen Lee. 2019. Particulate matter exposure aggravates osteoarthritis severity. Clinical Science. 133: 2171-2187. (IF: 5.223; 24/138, Medicine, Research & Experimental)
8. Ming-Shao Tsai, Geng-He Chang, Wei-Ming Chen, Chia-Yen Liu, Meng-Hung Lin, Pey-Jium Chang, Tsung-Yu Huang, Yao-Te Tsai, Ching-Yuan Wu, Cheng-Ming Hsu, Yao-Hsu Yang. 2019. The association between decompensated liver cirrhosis and deep neck infection: real-world evidence. International Journal of Environmental Research and Public Health. 16(20): 3863. (IF: 2.849; 58/193, Public, Environmental & Occupational Health)
9. Kuo-Ti Peng, Tsung-Yu Huang, Yao-Chang Chiang, Yu-Yi Hsu, Fang-Yi Chuang, Chiang-Wen Lee, Pey-Jium Chang*. 2019. Comparison of Methicillin-Resistant Staphylococcus aureus Isolates from Cellulitis and from Osteomyelitis in a Taiwan Hospital, 2016-2018. Journal of Clinical Medicine. 8(6):816 (IF: 3.303; 36/165, Medicine, General & Internal) [* Corresponding author]
10. Chun-Liang Lin, Yung-Chien Hsu, Yu-Ting Huang, Ya-Hsueh Shih, Ching-Jen Wang, Wen-Chih Chiang, Pey-Jium Chang*. 2019. A KDM6A–KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction. EMBO Molecular Medicine. 11(5): e9828. (IF: 8.821; 6/138, Medicine, Research & Experimental) [* Corresponding author]
11. Ki-Ti Peng, Yao-Chang Chiang, Tsung-Yu Huang, Pei-Chun Chen, Pey-Jium Chang, Chiang-Wen Lee. 2019. Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections. International Journal of Nanomedicine.14:469-481. (IF: 5.115; 24/270, Pharmacology & Pharmacy) 
12. Ko-Ming Lin, Wei-Ming Chen, Shui-Yi Tung, Kuo-Liang Wei, Chien-Heng Shen, Te-Sheng Chang, Pey-Jium Chang*. 2019. Prevalence and predictive value of high-positive rheumatoid factor and anti-citrullinated protein antibody levels in nonarthritic patients with chronic hepatitis C infection. International Journal of Rheumatic Diseases. 22(1):116-120 (IF: 1.980; 24/30, Rheumatology) [* Corresponding author]
13. Chun-Wu Tung, Yung-Chien Hsu, Ya-Hsueh Shih, Pey-Jium Chang, Chun-Liang Lin*. 2018. Glomerular mesangial cell and podocyte injuries in diabetic nephropathy. Nephrology. 23, suppl. 4:32-37 (IF: 1.749; 60/85, Urology & Nephrology)
14. Yu-Ling Chen, Pey-Jium Chang*, Ching-Tsan Huang*. 2018. Small P particles formed by the Taiwan-native norovirus P domain overexpressed in Komagataella pastoris. Applied Microbiology and Biotechnology. 102(22):9707-9718 (IF: 3.530; 46/156, Biotechnology & Applied Microbiology) [* Corresponding author]
15. Kuo-Ti Peng, Meng-Hsueh Tsai, Chiang-Wen Lee, Yao-Chang Chiang, Pei-Chun Chen, Chun-Chien Chen, Chih-Hsiang Chang, Hsin-Nung Shih*, Pey-Jium Chang*. 2018. Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis. PLoS One 13(8):e0202501 (IF: 2.740; 27/71, Multidisciplinary Sciences) [* Corresponding author]
16. Lee-Wen Chen, Chien-Hui Hung, Shie-Shan Wang, Ju-Bei Yen, Ann-Chi Liu, Ya-Hui Hung, Pey-Jium Chang*. 2018. Expression and regulation of the BKRF2, BKRF3 and BKRF4 genes of Epstein-Barr virus. Virus Research 256:76-89. (IF: 2.934; 18/37, Virology) [* Corresponding author]
17. Ching-Chuan Hsieh, Chun-Liang Lin, Jie-Teng He, MeiHua Chiang, Yuhsiu Wang, Yu-Chin Tsai, Chien-Hui Hung, Pey-Jium Chang. 2018. Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice. Stem Cell Research & Therapy 9(1):183 (IF: 5.116; 26/138, Medicine, Research & Experimental)
18. Chun-Wu Tung, Yung-Chien Hsu, Ya-Hsueh Shih, Pey-Jium Chang, Chun-Liang Lin. 2018. Dipstick proteinuria and reduced estimated glomerular filtration rate as independent risk factors for osteoporosis. American Journal of the Medical Sciences 355(5):434-441(IF: 1.911; 76/165, Medicine, General & Internal)  
19. Ju-Bei Yen, Ling-Huei Wei, Lee-Wen Chen, Li-Yu Chen, Chien-Hui Hung, Shie-Shan Wang, Pey-Jium Chang*. 2018. Subcellular localization and functional characterization of GII.4 norovirus-encoded NTPase. Journal of Virology 92(5) pii:e01824-17 (IF: 4.501; 8/37, Virology) [* Corresponding author]
20. Chun-Wu Tung, Yung-Chien Hsu, Chang-Jhih Cai, Ya-Hsueh Shih, Ching-Jen Wang, Pey-Jium Chang*, Chun-Liang Lin*. 2017. Trichostatin A ameliorates renal tubulointestitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway. Scientific Reports. 7(1):14495 (IF: 4.011; 15/69, Multidisciplinary Sciences) [* Corresponding author]
21. Kuo-Ti Peng, Ching-Chuan Hsieh, Tsung-Yu Huang, Pei-Chun Chen, Hsin-Nung Shih, Mel S. Lee*, Pey-Jium Chang*. 2017. Staphylococcus aureus biofilm elicits the expansion, activation and polarization of myeloid-derived suppressor cells in vivo and in vitro. PLoS One. 12(8): e183271. (IF: 2.766; 15/64, Multidisciplinary Sciences) [*corresponding author]
22. Pey-Jium Chang*, Lee-Wen Chen, Li-Yu Chen, Chien-Hui Hung, Ying-Ju Shih, Shie-Shan Wang*. 2017. Effects of the NEDD8-activating enzyme inhibitor MLN4924 on lytic reactivation of Kaposi’s sarcoma-associated herpesvirus. Journal of Virology. 91(19): e00505-17. (IF: 4.324; 8/36, Virology) [*corresponding author]
23. Pey-Jium Chang*, Yao-Hsu Yang, Pau-Chung Chen, Lee-Wen Chen, Shie-Shan Wang, Ying-Ju Shih, Li-Yu Chen, Chien-Hui Hung, Chun-Liang Lin*. 2017. Diabetes and risk of Kaposi’s sarcoma: effects of high glucose on reactivation and infection of Kaposi’s sarcoma-associated herpesvirus. Oncotarget. 8(46):80595-80611 (IF: 5.168; 44/217, Oncology) [*corresponding author]
24. Ming-Horng Tsai, Jen-Fu Hsu, Shih-Ming Chu, Pey-Jium Chang, Mei-Yin Lai, I-Hsyuan Wu, Hsuan-Rong Huang, Ming-Chou Chiang, Ren-Huei Fu, Jang-Jih Lu. 2017. Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia. Scientific Reports. 7(1):1083. (IF: 4.011; 15/69, Multidisciplinary Sciences)
25. Jiann-Der Lee, Kuang-Ming Hsiao, Pey-Jium Chang, Chih-Cheng Chen, Ya-Wen Kuo, Yen-Chu Huang, Huan-Lin Hsu, Ya-Hui Lin, Chih-Ying Wu, Ying-Chih Huang, Meng Lee, Chia-Yu Hsu, Yi-Ting Pan, Chih-Yu Kuo, Chun-Hsien Lin. 2017. A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels. BBA-Molecular Basis of Disease. 1863(6):1690-1698. (IF: 5.108; 49/293, Biochemistry & Molecular Biology)
26. Ming-Horng Tsai, Chiang-Wen Lee, Lee-Fen Hsu, Shu-Yu Li, Yao-Chang Chiang, Ming-Hsueh Lee, Chun-Han Chen, Hwey-Fang Liang, Jia-Mei How, Pey-Jium Chang, Ching-Mei Wu, I-Ta Lee. 2017. CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinase-9 expression. Redox Biology. 12:377-388. (IF: 7.793; 28/297, Biochemistry & Molecular Biology)
27. Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu*, Pey-Jium Chang*. 2016. Regulation of the abundance of Kaposi’s sarcoma-associated herpesvirus ORF50 protein by oncoprotein MDM2. PLoS Pathogens. 12(10):e1005918. (IF: 6.463; 3/36, Virology) [*corresponding author]
28. Wei-Ming Chen, Cheng-Shyong Wu, Jing-Lan Liu, Chia-Ming Yeh, Libby Tseng, Hao-Chun Huang, Pey-Jium Chang, Shu-Fen Wu. 2016. Expression of Helios in gastric tumor cells predicts better survival in gastric cancer patients. J Cancer Res Clin Oncol. 142:2375-2382. (IF: 3.282; 108/223, Oncology)
29. Yung-Chien Hsu#, Pey-Jium Chang#, Cheng Ho, Yu-Ting Huang, Ya-Hsueh Shih, Ching-Jen Wang, Chun-Liang Lin. 2016. Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/b-catenin signaling. Scientific Reports. 6:30575. (IF: 4.122; 12/64, Multidisciplinary Sciences) [# co-first author]
30. Kuo-Ti Peng, Meng-Yow Hsieh, Carl T. Lin, Chin-Fu Chen, Mel S. Lee, Yi-You Huang*, Pey-Jium Chang*. 2016. Treatment of critically sized femoral defect with recombinant BMP-2 delivered by a modified mPEG-PLGA biodegradable thermosensitive hydrogel. BMC Musculoskeletal Disorders. 17:286 (IF: 2.002; 34/76, Orthopedics) [*corresponding author]
31. Wei-Ming Chen, Kuo-Liang Wei, Yi-Shing Chen, Pey-Jium Chang, Shui-Yi Tung, Te-Sheng Chang, Hao-Chun Huang, Chein-Heng Shen, Yung-Yu Hsieh, Cheng-Shyong Yu. 2016. Transpapillary biliary biopsy for malignant biliary strictures: comparison between cholangiocarcinoma and pancreatic cancer. World Journal of Surgical Oncology. 14 (1): 140. (IF: 1.792; 101/200, Surgery)
32. Wei-Ming Chen, Wayne H-H Sheu, Pei-Chi Tseng, Tzong-Shyuan Lee, Wen-Jane Lee, Pey-Jium Chang and An-Na Chiang. 2016. Modulation of microRNA expression in subjects with metabolic syndrome and decrease of cholesterol efflux from macrophages via microRNA-33-mediated attenuation of ATP-binding cassette transporter A1 expression by statins. PLoS One. 11(5): e0154672. (IF: 2.766; 15/64, Multidisciplinary Sciences)
33. Wei-Ming Chen, Lee-Hsin Shaw, Pey-Jium Chang, Shui-Yi Tung, Te-Sheng Chang, Chein-Heng Shen, Yung-Yu Hsieh and Kuo-Liang Wei. 2016. Hepatoprotective effect of resveratrol against ethanol-induced oxidative stress through induction of superoxide dismutase in vivo and in vitro. Experimental and Therapeutic Medicine 11: 1231-1238 (IF: 1.410; 108/133, Medicine, Research & Experimental)
34. Huang-Shen Lin, Chun-Wen Cheng, Ming-Shyan Lin, Yen-Li Chou, Pey-Jium Chang, Jing-Chi Lin and Jung-Jr Ye. 2016. The clinical outcomes of oldest patients with tuberculosis treated by regimens containing rifampicin, isoniazid and pyrazinamide. Clinical Interventions in Aging 11: 299-306 (IF: 2.505; 30/53, Geriatrics & Gerontology)
35. Hung-Chih Hsu, Wen-Ming Chag, Jin-Yi Wu, Chin-Chin Huang, Fung-Jou Lu, Yi-Wen Chuang, Pey-Jium Chang, Kai-Hua Chen, Chang-Zern Hong, Rang-Hui Yeh, Tsan-Zon Liu and Ching-Hsein Chen. 2016. Folate deficiency triggered apoptosis of synoviocytes: role of overproduction of reactive oxygen species generated via NADPH oxidase/Mitochondrial Complex II and calcium perturbation. PLoS One 11(1): e0146440. (IF: 2.766; 15/64, Multidisciplinary Sciences)