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Graduate Institute of Clinical Medical Sciences

Graduate Institute of Clinical Medical Sciences
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Hong-Yo Kang

Hong-Yo Kang

JobTitle： Professor

CurrentJob： Professor of CGU

E-mail： hkang3@mail.cgu.edu.tw

Phone： 407-8898, 8851

Education： Ph.D. in University of Wisconsin–Madison, USA

Expertise： Sex Hormone, Bone Physiology...

Website： https://www.researchgate.net/profile/Hong-Yo_Kang

Lab

Chang Gung Memorial Hospital /Hormone and Reproductive Medicine Laboratory

Research interests

My research has focused on sex hormones and sex differences in health and diseases. The major research contribution is to elucidate the critical roles of male gonadal steroid hormones, especially the contribution of androgen receptor (AR) actions in androgens-mediated diseases by coordinating the multidisciplinary teams with several integrated program projects to decipher the roles of AR by using NGS, interactome and transcriptome. Results from my teams reveal that androgens/AR signaling is essential for organ development in the embryonic stage as well as the maintenance of normal function of adult cells in a sex-specific manner throughout individual life and have become important drug targets for many diseases.

Publication

  1. Chiang TI, Hung YY, Wu MK, Huang YL and Kang HY*. TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder. Brain Behav Immun. 2021 Apr. 95:454-461. (IF:6.633; R/C=24/159，IMMUNOLOGY)
  2. Chang KT, Su YT, Tsai YR, Lan KC, Hsuuw YD, Kang HY, Chan WH, Huang FJ. High levels estradiol affect blastocyst implantation and post-implantation development directly in mice. Biomed. J. 2021 Jan. DOI: 10.1016/j.bj.2021.01.004. (IF:3.697; R/C=114/297，BIOCHEMISTRY & MOLECULAR BIOLOGY)
  3. Chou CK, Chi SY, Chou FF, Huang SC, Wang JH, Chen CC and Kang HY*. Aberrant Expression of Androgen Receptor Associated with High Cancer Risk and Extrathyroidal Extension in Papillary Thyroid Carcinoma. Cancers (Basel). 2020 Apr. 12(5):1109. (IF:6.126; R/C=37/244，ONCOLOGY)
  4. Lan KC, Lin PY, Chang YC, Chen YJ, Tsai YR, Mohamed I. S. I., Kang HY. Growth hormone supplementation may improve the pregnancy rate and endometrial receptivity among women aged more than 40 years undergoing in vitro fertilization. Biomed. J. 2019 Dec. 42(6):411-416. (IF:3.697; R/C=114/297，BIOCHEMISTRY & MOLECULAR BIOLOGY)
  5. Chen JF, Lin PW, Tsai YR, Yang YC, Kang HY*. Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy. Cells 2019 Oct 25;8, 1318. (IF:4.366; R/C=70/195，CELL BIOLOGY)
  6. Hung YY, Huang YL, Chang C, Kang HY*. Deficiency in Androgen Receptor Aggravates the Depressive-Like Behaviors in Chronic Mild Stress Model of Depression. Cells. 2019 Sep 2;8(9):1021. (IF:4.366; R/C=70/195，CELL BIOLOGY)
  7. Hung YY, Wu MK, Tsai MC, Huang YL, Kang HY*. Aberrant Expression of Intracellular let-7e, miR-146a, and miR-155 Correlates with Severity of Depression in Patients with Major Depressive Disorder and Is Ameliorated after Antidepressant Treatment. Cells. 2019 Jun 27;8(7):647. (IF:4.366; R/C=70/195，CELL BIOLOGY)
  8. Lan KC, Lin YC, Chang YC, Lin HJ, Tsai YR, Kang HY*. Limited relationships between reactive oxygen species levels in culture media and zygote and embryo development. J. Assist. Reprod. Genet. 2019 Feb. 36(2):325-334. (IF:2.829; R/C=21/82，OBSTETRICS & GYNECOLOGY)
  9. Lin PW, Lan KC, Tsai MY, Shyr CR, Chang C, Huang KE*, Kang HY*. The Differential Effects of Sex Hormones on the Bone Metabolism in Mice with Androgen Receptor Deficiency. Adaptive Medicine. 2018. 10(4): 148-159.
  10. Fu HC, Chuang IC, Yang YC, Chuang PC, Lin H, Ou YC, Chang Chien CC, Huang HS, Kang HY*. Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy. Int J Mol Sci. 2018. 19(9):E2541. (IF:4.556; R/C=74/297，BIOCHEMISTRY & MOLECULAR BIOLOGY)
  11. Lee IN, Huang TL, Huang YL, Hung YY, Kang HY*. Sex Differences of NOD2 and TOLLIP in Patients with Major Depressive Disorder and Human Volunteers: Role of Androgen and Androgen Receptor. Neuropsychiatry (London) 2017. 7(7), 739–746. (IF:4.778; R/C=21/142，PSYCHIATRY)
  12. Lin TH, Su HH, Kang HY*, Chang TH. The Interactive Roles of Lipopolysaccharides and dsRNA/Viruses on Respiratory Epithelial Cells and Dendritic Cells in Allergic Respiratory Disorders: The Hygiene Hypothesis. Int. J. Mol. Sci. 2017. 18:E2219. (IF:4.556; R/C=74/297，BIOCHEMISTRY & MOLECULAR BIOLOGY)
  13. Chou CK, Liu RT, Kang HY*. MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer. Int. J. Mol. Sci. 2017 Mar. 18(3):E636. (IF:4.556; R/C=74/297，BIOCHEMISTRY & MOLECULAR BIOLOGY)
  14. Wu CY, Yang YH, Lin YY, Kuan FC, Lin YS, Lin WY, Tsai MY, Yang JJ, Cheng YC, Shu LH, Lu MC, Chen YJ, Lee KD, Kang HY*. Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway. Oncotarget. 2017 Feb 1. 8:40246-40263 (IF:5.168; R/C=44/217，ONCOLOGY)
  15. Hung YY, Lin CC, Kang HY*, Huang TL. TNFAIP3, a negative regulator of the TLR signaling pathway, is a potential predictive biomarker of response to antidepressant treatment in major depressive disorder. Brain Behav Immun. 2017 59:265-272. (IF:6.633; R/C=24/159，IMMUNOLOGY)