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Graduate Institute of Clinical Medical Sciences

Graduate Institute of Clinical Medical Sciences
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Ming-Yu Yang

Ming-Yu Yang

JobTitle： Associate Professor

CurrentJob： Associate Professor of CGU

E-mail： yangmy@mail.cgu.edu.tw

Phone： 407-8865

Education： Ph.D. in Kaohsiung Medical University, Taiwan

Expertise： Biotechnology 、Molecular Biology...

Lab

Molecular Circadian Rhythm Lab.

Research direction and characteristics

Altered circadian clock genes in hematological malignancies, head and neck cancers, sudden hearing loss, obstructive sleep apnea, atrial fibrosis, etc., and their clinical significance and molecular mechanisms.

The effect of circadian rhythm disruption in gut microbiota and metabolic syndromes using a constant light mice model.

Publication

  1. Yang MY, Lin PM, Yang CH, Hu ML, Chen IY, Lin SF*, Hsu CM*. Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia. Blood Cells Mol Dis. 2021.Sep; 90: 102577. (SCI; I.F.: 3.039; Hematology: 47/76 = 61.84%)
  2. Lin HY, Yang MY, Lin SF. Circadian Mechanisms in Medicine. New Engl J Med. 2021. May 20; 384(20): e76. (Correspondence) (SCI; IF: 91.245; Medicine, General & Internal: 1/169 = 0.59%)
  3. Lin YT, Wang HC, Tsai MH, Su YY, Yang MY*, Chien CY*. Angiotensin II receptor blockers valsartan and losartan improve survival rate clinically and suppress tumor growth via apoptosis related to PI3K/AKT signaling in nasopharyngeal carcinoma. Cancer. 2021. Jan 6. doi: 10.1002/cncr.33391. Epub ahead of print. (SCI; I.F.: 5.742; Oncology: 47/244 = 19.26%)
  4. Chang GH, Chou FF, Tsai MS, Tsai YT, Yang MY, Huang EI, Su HC, Hsu CM*. Real‑world evidence and optimization of vocal dysfunction in end‑stage renal disease patients with secondary hyperparathyroidism. Sci Rep. 2021. Jan 12;11(1):653. (SCI; IF: 3.998, Multidisciplinary Sciences: 15/71 = 23.94%)
  5. Chen YL, Chuang JH, Wang HT, Chen HC, Liu WH, Yang MY*. Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling. Diagnostics. 2021. Jan 7; 11(1): E90. (SCI; IF: 3.110; Medicine, General & Internal: 39/165 = 23.64%)
  6. Tsai YT, Tsai MS, Chang GH, Lee LA, Yang MY, Yang YH, Wu CY, Hsu CM*. Patient-Related Factors of Medialization Laryngoplasty with Autologous Thyroid Cartilage. Healthcare (Basel). 2020. Nov 30; 8(4): E521. (SCI; IF: 1.916; Health Care Sciences & Services: 62/102 = 60.78%)
  7. Yang CH, Hwang CF*, Chuang JH, Lian WS, Wang FS, Huang EI, Yang MY*. Constant Light Dysregulates Cochlear Circadian Clock and Exacerbates Noise-Induced Hearing Loss. Int J Mol Sci. 2020. Oct; 21(20): 7535. (SCI; IF: 4.556; Biochemistry & Molecular Biology: 77/297 = 24.92%)
  8. Hsu CM, Yang MY, Fang TJ, Wu CY, Tsai YT, Chang GH, Tsai MS*. Maximum and Minimum Phonatory Glottal Area before and after Treatment for Vocal Nodules. Healthcare. 2020. Sep; 8:326. (SCI; IF: 1.916; Health Care Sciences & Services: 62/102 = 60.78%)
  9. Chen RF, Yang MY, Wang CJ, Wang CT, Kuo YR*. Proteomic Analysis of Peri-Wounding Tissue Expressions in Extracorporeal Shock Wave Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model. Int J Mol Sci. 2020. Jul; 21 (15):5445. (SCI; IF: 4.556; Biochemistry & Molecular Biology: 77/297 = 24.92%)
  10. Lin SH, Ho JC, Li SC, Cheng YW, Yang YC, Chen JF, Hsu CY, Nakano T, Wang FS, Yang MY, Lee CH*, Hsiao CC*. Upregulation of miR-941 in Circulating CD14+ Monocytes Enhances Osteoclast Activation via WNT16 Inhibition in Patients with Psoriatic Arthritis. Int J Mol Sci. 2020. Jun; 21 (12):4301. (SCI; IF: 4.556; Biochemistry & Molecular Biology: 77/297 = 24.92%)
  11. Yang MY, Lin PW, Lin HC*, Lin PM, Chen IY, Friedman M, Hung CF, Salapatas AM, Lin MC, Lin SF. Alternations of Circadian Clock Genes Expression and Oscillation in Obstructive Sleep Apnea. J Clin Med. 2019. Oct; 8 (10). pii: E1634. (SCI; IF: 3.303; Medicine, General & Internal: 36/165 = 21.82%)
  12. Chen RF, Chang CH, Wang CT, Yang MY, Wang CJ, Kuo YR. Modulation of VEGF and MAPK-related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing. Wound Repair Regen. 2019. Jan; 27(1):69-79. (SCI; I.F.: 2.471; Surgery: 70/210 = 33.33%)
  13. Lin YT, Wang HC, Chuang HC, Hsu YC, Yang MY*, Chien CY*. Pre-treatment with angiotensin-(1–7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts. J Mol Med. 2018. Dec; 96(12): 1407-1418. (SCI; I.F.: 4.427; Medicine, Research & Experimental: 36/138 = 26.09%)
  14. Hsu CM, Lin PM, Lin HC, Tsai YT, Tsai MS, Li SH, Wu CY, Yang YH, Lin SF*, Yang MY*. NVP-BEZ235 attenuated cell proliferation and migration in the squamous-cell carcinoma of oral cavities and p70S6K inhibition mimics its effect. Int J Mol Sci. 2018. Nov; 19(11). pii: E3546. (SCI; IF: 4.556; Biochemistry & Molecular Biology: 77/297 = 24.92%)
  15. Tsai HJ, Jiaang WT, Shih NY, Fletcher JA, Lin MJ, Yang MY, Chen CT, Hsu TJ, Wu CC, Lin HY, Chen LT. BPR1J373, a novel multi-targeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor. Cancer Sci. 2018 Nov; 109(11):3591-3601. (SCI; I.F.: 4.966; Oncology: 63/244 = 26.64%)
  16. Hsu CM, Lin PM, Tsai YT, Tsai MS, Tseng CH, Lin SF, Yang MY*. NVP-BEZ235, a dual PI3K-mTOR inhibitor, suppresses the growth of FaDu hypopharyngeal squamous cell carcinoma and has a synergistic effect with Cisplatin. Cell Death Discov. 2018 May 10; 4:57. (SCI; I.F.: 4.114; Cell Biology: 76/195 = 38.97%)
  17. Hsu CM, Lin PM, Chang JG, Lin HC, SH Li, Lin SF*, Yang MY*. Upregulated SLC22A3 has a potential for improving survival of patients with head and neck squamous cell carcinoma receiving cisplatin treatment. Oncotarget. 2017. Sep 26; 8(43): 74348-74358. (2016 SCI; IF: 5.168; Oncology: 44/217 = 20.28%)
  18. Yang MY, Hsiao HH, Liu YC, Hsu CM*, Lin SF*, Lin PM*. Phe354Leu polymorphism of LKB1 is a potential prognostic factor for cytogenetically normal acute myeloid leukemia. In Vivo. 2017.  Sep-Oct; 31(5):841-847. (SCI; I.F.: 1.609; Medicine, Research & Experimental: 110/138 = 79.71%)
  19. Tsai MS, Yang MY, Chang GH, Tsai YT, Lin MH, Hsu CM*. Autologous thyroid cartilage graft implantation in medialization laryngoplasty: a modified approach for treating unilateral vocal fold paralysis. Sci Rep. 2017. Jul 6; 7(1):4790. (SCI; IF: 3.998, Multidisciplinary Sciences: 15/71 = 23.94%)
  20. Lin YT, Wang HC, Hsu YC, Cho CL, Yang MY*, Chien CY*. Capsaicin induces autophagy and apoptosis in human nasopharyngeal carcinoma cells by downregulating the PI3K/AKT/mTOR pathway. Int J Mol Sci. 2017. Jun 23; 18(7): 1343. (SCI; IF: 4.556; Biochemistry & Molecular Biology: 77/297 = 24.92%)
  21. Chang LS, Lo MH, Li SC, Yang MY*, Hsieh KS*, Kuo HC*. The effect of FcγRIIA and FcγRIIB on coronary artery lesion formation and intravenous immunoglobulin treatment responses in children with Kawasaki disease. Oncotarget. 2017. Jan 10; 8(2):2044-2052. (2016 SCI; IF: 5.168; Oncology: 44/217 = 20.28%)
  22. Yang MY*, Lin SF*. The role of circadian clock genes in leukemia. Transl Cancer Res. 2016. Aug; 5(S2): S196-S198. (SCI; IF: 0.986; Oncology: 235/244 = 96.31%)
  23. Hsu CM, Lin PM, Lin HC, Lai CC, Yang CH, Lin SF*, Yang MY*. Altered expression of imprinted genes in squamous cell carcinoma of the head and neck. Anticancer Res. 2016. May; 36(5): 2251-2258. (SCI; IF: 1.994; Oncology: 203/244 = 83.20%)