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Human/Machine Interaction Team
Chuang, I.-C., Abdullahi, A., Chen, I.-C., Wu, Y.-R., & Wu, C.-Y. * (2025). Effects of immersive leisure-based virtual reality cognitive training on cognitive and physical function in community-based older adults: A randomized controlled trial. Digital Health. https://doi.org/01177/20552076251328491
Liao, W.‑W., Lin, C.-Y., Horng, Y.-S., Chen, C.-L., Lee, T.-H., & Wu, C.-Y.* (2025). Transcranial direct current stimulation over the motor and premotor cortex with mirror therapy improves motor control, muscle function, and brain activity in chronic stroke: A double-blind randomized sham-controlled trial.. Journal of NeuroEngineering and Rehabilitation, 22(1), 1-15. https://doi.org/https://101186/s12984-025-01635-7
Yen, L.-W., Chen, H.-B., Rezaei, A., Lien, H.-Y., Nikkhoo, M., & Cheng, C.-H. (2025). A comparison of conventional intervention and home-based approach with head-mounted device for cervical spondylotic myelopathy after surgery. Scientific Reports, 15(1). https://doi.org/10.1038/s41598-025-91555-2
Rezaei A, Cheng, C.-H., Schreiber A, Dashtdar B, Astudillo Potes M, Liu X, An KN, Kaufman K., &  Lu, L. (2025). Intradiscal Pressure Distributions in Degenerated Intervertebral Discs: A Biomechanical Investigation.. Journal of Medical and Biological Engineering. https://doi.org/101007/s40846-025-00929-4
Azizi S, Nikkhoo M, Rostami M., & Cheng, C.-H. (2025). Biomechanical Evaluation of the Effect of MIS and COS Surgical Techniques on Patients with Spondylolisthesis using a Musculoskeletal Model.. Journal of Biomedical Physics and Engineering, 15(1), 49-66. https://doi.org/1031661/jbpev0i02406-1781
Cheng, C.-H., Rezaei, A., & Kaufman, K.R. (2025). Effects of age/gender profiles and physical activity level on symmetry of lumbar muscle activation in pain-free older adults during various spinal movements. Gait & Posture, 117, 136-142. https://doi.org/101016/jgaitpost202412012
Liu, P.-J., Liu R, Cheng, C.-H., Wang, L.-Z., & Fan, Y. (2025). Functional brain response pattern under rubber hand illusion based on fNIRS.. Medical Engineering and Physics, 140. https://doi.org/101016/jmedengphy2025104340
Huang, C.-Y., Hsieh, Y.-W., Jhang, K.-M., Wang, W.-F., Chang, C.-C., Chuang, I.-C., Wang, P.-N., Hsu, W.-C., & Cheng, C.-H. (2025). Psychometric properties of the Chinese version of Everyday Cognition Scale (ECog) in Taiwanese older adults. The Gerontologist. https://doi.org/10.1093/geront/gnaf010
Cheng, C.-H., Chan, P.-Y. S., Chen, S.-Y., Chen, Y.-H., Lu, H., & Liu, C.-Y. (2025). Trait anxiety negatively modulates the coupling of motor event-related desynchronization and event-related synchronization. BMC Psychiatry, 25, 447. https://doi.org/10.1186/s12888-025-06901-5
Chuang, I.-C., Huang, X.-T., Chen, I.-C., Wu, Y.-R., & Wu, C.-Y. * (2025). Feasibility, usability, and effects of the leisure-based cognitive training using a fully immersive virtual reality system in older adults: Pilot single-arm pre-post study. JMIR Serious Games, 13, 1-12. doi:10.2196/66673
Cheng, C.-H., Hung, C.-C., Wu, C.-Y., Lin, C.-M., & Fang, J.-T. (2025). Beyond the pillow: Linking subjective subjective and objective sleep measures to gut microbiome composition in community-dwelling older adults. Nature and Science of Sleep, 17, 2657—2668. https://doi.org/102147/NSSS531730
Rezaei, A., Cheng, C.-H., Pignolo, R. J., Lu, L., & Kaufman, K. (2025). Effects of age and muscle activation on three-dimensional spine kinematics and asymmetry in elderly adults. Journal of Clinical Medicine, 14(5). https://doi.org/10.3390/jcm14051610
Nikkhoo, M., Tsui, P. H., Chen, C. P. C., Chen, H. B., & Cheng, C.-H. (2025). Diagnostic criteria of sarcopenia and their associations with functional performance in older adults. Journal of Aging and Physical Activity, 12(1). https://doi.org/10.1123/japa.2024-0231
Cheng, C.-H., Rezaei, A., & Kaufman, K. (2025). Comparisons of hip-worn and ankle-worn accelerometers on measuring. Gait & Posture, 123. https://doi.org/10.1016/j.gaitpost.2025.110007
Azizi, S., Nikkhoo, M., Rostami, M., Niu, C. C., & Cheng, C.-H. (2025). Assessment of pre- and post-operative biomechanical changes at adjacent levels induced by muscle damage following spondylolisthesis fusion: Musculoskeletal modeling of open vs. minimally invasive surgery. Computer Methods in Biomechanics and Biomedical Engineering. https://doi.org/10.1080/10255842.2025.2552432

Chan, H.-L., Meng, L.-F., Kao, Y.-A., Chang, Y.-J.,* Chang, H.-W., Chen, S.-W., & Wu, C.-Y.*†  (2024). Myoelectric, myo-oxygenation, and myotonometry changes during robot-assisted bilateral arm exercises with varying resistances.. Sensors, 24, 1-19. https://doi.org/103390/s24041061
Khalafa, K., Nikkhoo, M., Shamse, S., Niu, C.-C., & Cheng, C.-H. (2024). Impact of osteoporosis and cement-augmented fusion on adjacent spinal levels post-fusion surgery: Patient-specific finite element analysis. Journal of Biomechanics. https://doi.org/10.1016/j.jbiomech.2024.112070
Chien, S.-Y., Wong, A. M.-K., Wu, C.-Y., & Beckman, S.-L. (2024). Interactive electronic pegboard for enhancing manual dexterity and cognitive abilities: Preliminary study. . JMIR Human Factors, 11, 1-11. https://doi.org/102196/56357
Nikkhoo, M., Wang, J.-L., Cheng, C.-H., Nikkhoo, P, & Khalaf, K. (2024). Enzymatic denaturation versus excessive fatigue loading degeneration: Effects on the time-dependent response of the intervertebral disc.. Journal of Biomechanics. https://doi.org/101016/jjbiomech2024112159
Chang, C.-S., Chen, C.-L.,* Chen, R.-S., Chen, H.-C., Chen, C.-Y., Chung, C.-Y., Wu, Katie, P.-H., Wu, C.-Y., & Lin, K.-C. (2024). Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: A double-blinded, randomized controlled trial. . Journal of NeuroEngineering and Rehabilitation, 21(1), 1-10. https://doi.org/101186/s12984-024-01341-w 
Liu, C.-L., Tu, Y.-W., Li, M.-W., Chang, K.-C., Chang, C.-H., Chen, C.-K., & Wu, C.-Y. *  (2024). Electroencephalogram alpha oscillations in stroke recovery: Insights into neural mechanisms from combined tDCS and mirror therapy in relation to activities of daily life.. Bioengineering, 11(7), 1-18. https://doi.org/103390/bioengineering11070717
Liu, C.-H., Li, K.-Y., Liao, W.-W., Chuang, I.-C., Huang, Y.-H., & Wu, C.-Y. * (2024). Memory benefits of daily-living-related contextual cuing for individuals with subjective cognitive decline and mild cognitive impairment.. Hong Kong Journal of Occupational Therapy, 1-10. https://doi.org/101177/15691861241272173
Liu, C.-L., Huang, S.-H., Wang, W.-C., Chen, C.-K., Su, K.-H., & Wu, C.-Y. * (2024). Characterizing two hybrid exercise-cognitive training interventions with neurophysiological and behavioral indexes in post-stroke patients with cognitive dysfunction: A randomized controlled trial.. IEEE Transactions on Neural Systems and Rehabilitation Engineering, , 32, 3913-3920. https://doi.org/101109/TNSRE20243482328
Liu, C.-L., Su, K.-H., Hong, Y.-S., Chen, C.-L., Huang, S.-H., & Wu, C.-Y. * (2024). Theory-driven EEG indexes for tracking motor recovery and predicting the effects of hybridizing tDCS with mirror therapy in stroke patients. . IEEE Transactions on Neural Systems and Rehabilitation Engineering, 32, 4042-4051. https://doi.org/101109/TNSRE20243493926
Chien, S.-Y., Wong, A. M.-K., Wu, C.-Y., & Beckman, S.-L. (2024). Interactive electronic pegboard for enhancing manual dexterity and cognitive abilities: Instrument Usability Study.. JMIR Human Factors, 11, 1-11. https://doi.org/102196/56357
Chien, S.-Y., Wu, C.-Y., Wong, A. M.-K., Chen, C.-K., & Beckman, S.-L. (2024). Exploring the impact of an interactive electronic pegboard on manual dexterity and cognitive skills of patients with stroke: Preliminary analysis. JMIR Formative Research, 8, 1-15. https://doi.org/102196/55481
Chen, I.-C., Wu, C.-Y., Hu, Y.-L., & Huang, Y.-M. (2024). Development and Validation of Virtual Reality Cognitive Training for Older Adults with Mild Cognitive Impairment: Protocol for a Mixed-Methods Program Evaluation Study. Clinical Interventions in Aging, 19, 1855-1865. https://doi.org/102147/CIAS471547
Cheng, C.-H., Hsieh, Y.-W., Chang, C.-C., Hsiao, F.-J., Chen, L.-F., & Wang, P.-N. (2024). Effects of 6-month combined physical exercise and cognitive training on neuropsychological and neurophysiological function in older adults with subjective cognitive decline: A randomized controlled trial. Journal of Alzheimer's Disease, 100(1), 175–192. https://doi.org/10.3233/JAD-231257
Chang, W.-P., Liang, K.-J., Cheng, C.-H., Liu, C.-Y., von Leupoldt, A., & Chan, P.-Y. S. (2024). Age-related changes in the neural gating of respiratory sensations in humans. ERJ Open Research, 10(1). https://doi.org/10.1183/23120541.00821-2023
Liang, K.-J., Cheng, C.-H., Liu, C.-Y., Hsu, S.-C., von Leupoldt, A., Jelinčić, V., & Chan, P.-Y. S. (2024). Neural oscillations underlying the neural gating of respiratory sensations in generalized anxiety disorder. Respiratory Physiology & Neurobiology, 321. https://doi.org/10.1016/j.resp.2024.104215
Liang, K.-J., Cheng, C.-H., Liu, C.-Y., von Leupoldt, A., Jelinčić, V., & Chan, P.-Y. S. (2024). Neural oscillatory markers of respiratory sensory gating in human cortices. Biomedical Journal, 47(5). https://doi.org/10.1016/j.bj.2023.100683

Cheng, C.-H.,* Hung, C.-C., Chao, Y.-P., Nouchi, R., & Wang, P,-N,. (2023). Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus. Clinical Neurophysiology, 156, 281-289. https://doi.org/101016/jclinph202308015
Hung, C.-C., Chao, Y.-P., Lee, Y., Huang, C.-W., Huang, S.-H., Chang, C.-C., & Cheng, C.-H,.* (2023). Cingulate white matter mediates the effects of fecal Ruminococcus on neuropsychiatric symptoms in patients with amyloid-positive amnestic mild cognitive impairment. BMC Geriatrics, 23(1), 720. https://doi.org/101186/s12877-023-04417-9
Hsiao, W.-C., Chang, H.-I., Hsu, S.-W., Lee, C.-C., Huang, S.-H., Cheng, C.-H., Huang, C.-W., & Chang, C.-C.* (2023). Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS). Neuroscience, 524, 11–20. https://doi.org/10.1016/j.neuroscience.2023.04.004
Hsiao, W.-C., Nouchi, R., Chang, H.-I., Hsu, S.-W., Lee, C.-C., Huang, S.-H., Huang, C.-W., Chang, C.-C., & Cheng, C.-H. (2023). Clinical significance of fractional anisotropy in cerebral white matter regional vulnerability caused by carbon monoxide poisoning: A systematic review and meta-analysis. Neurotoxicology, 96, 92–100. https://doi.org/10.1016/j.neuro.2023.04.005
Chan, H.-L., Meng, L.-F., Kao, Y.-A., Chang, Y.-J.,* Chang, H.-W., Chen, S.-W., & Wu, C.-Y. * (2023). Myoelectric, myo-oxygenation, and myotonometry changes during robot-assisted bilateral arm exercises with varying resistances. . Sensors, 24(4), 1061. https://doi.org/103390/s24041061
Chen, Y.-W., Li, K.-Y., Lin, C.-H., Hung, P.-H., Lai, H.-T., & Wu, C.-Y. * (2023). The effect of sequential combination of mirror therapy and robot-assisted therapy on motor function, daily function, and self-efficacy after stroke. . Scientific Reports, 13(NA), 1-10. https://doi.org/101038/s41598-023-43981-3
Yeh, T.-T., Chang, K.-C., Wang, J.-J., Lin, W.-C., & Wu, C.-Y.* (2023). Neuroplastic changes associated with hybrid exercise-cognitive training in stroke survivors with mild cognitive decline: A randomized controlled trial.. Neurorehabilitation and Neural Repair, 37(9), 662-673. https://doi.org/101177/15459683231200220
Chuang, I.-C., Chiau, H.-Y., Liao, W.-W., Wu, Y.-R., Chang, C.-H., & Wu, C.-Y. * (2023). Effects of computer-based cognitive training combined with physical training for older adults with cognitive impairment: A four-arm randomized controlled trial.. Digital Health, 9(NA), 1-11. https://doi.org/101177/20552076231203633
Lin, W.-C., Wu, C.-Y., † Liao, C.-H., Hsieh, C.-T., Zeng, R.-J., Hsieh, Y.-Y., & Hou, P.-R.  (2023). Study and implementation of fluxgate current sensor with wireless connectivity for finger exoskeleton rehabilitation.. International Journal of Circuit Theory and Applications, NA(NA), 1-15. https://doi.org/101002/cta3753
Ma, H.-I., Liao, W.‑W., Lin, C.-H., Chen I.-C., & Wu, C.-Y.* (2023). Indirect causal path from motor function to quality of life through daily use of the affected arm poststroke after task-specific training: A longitudinal mediation analysis.. Disability and Rehabilitation, NA(NA), 1-8. https://doi.org/101080/0963828820232216948
Chuang, I.-C., Chen, I.-C., Su, K.-H., Wu, Y.-R., & Wu, C.‑Y.* (2023). The effects of high versus low frequency of combined physical and cognitive training on cognitive function in older adults with cognitive decline: a quasi-experimental study.. BMC Geriatrics, 23(NA), 1-8. https://doi.org/101186/s12877-023-03802-8 
Mohapatra, S., Lee, T.-H., Sahoo, P. K. & Wu, C.-Y. (2023). Localization of early infarction on non-contrast CT images in acute ischemic stroke with deep learning approach. . Scientific Reports, 13(NA), 1-14. https://doi.org/ 101038/s41598-023-45573-7
Chen, I.-C.,  Chuang, I. C.*, Chang, K. C., Chang, C. H., & Wu, C.-Y. (2023). Dual task measures in older adults with and without cognitive impairment: Response to simultaneous cognitive-exercise training and minimal clinically important difference estimates. . BMC Geriatrics, 23(NA), 1-12. https://doi.org/101186/s12877-023-04390-3 
Lin, W.-C., Wu, C.-Y., Liao, C.-H., Hsieh, C.-T., Zeng, R.-J., Hsieh, Y.-Y., Chang, M.-C., Hou, P.-R., & Yeh, C.-W. (2023). Feasibility study of joint exoskeleton device without boeden cables based on highly integrated wireless fluxgate sensor..  IEEE Sensors Journal, 23(14), 16303-16312. https://doi.org/ 101109/JSEN20233284476
Lee, M.-T., Howe, T.-H., Chen, C.-C., Wu, C.-Y., & Hsieh, Y.-W.* (2023). Grip strength differences in middle-aged and older adults and individuals with stroke. . European Journal of Physical and Rehabilitation Medicine,, 59(3), 294-302. https://doi.org/https:// 1023736/S1973-90872307729-8
Nikkhoo, M., Chen, W.-C., Lu, M.-L., Fu, C.-J., Niu, C.-C., Lien, H.-Y., & Cheng, C.-H. (2023). Anatomical parameters alter the biomechanical responses of adjacent segments following lumbar fusion surgery: Personalized poroelastic finite element modelling investigations. Frontiers in Bioengineering and Biotechnology, 11. https://doi.org/10.3389/fbioe.2023.1110752
Liu, X.-T., Nikkhoo, M., Wang, L., Chen, C. P. C., Chen, H.-B., Chen, C.-J., & Cheng, C.-H. (2023). Feasibility of a Kinect-based system in assessing physical function of the elderly for home-based care. BMC Geriatrics, 23(1). https://doi.org/10.1186/s12877-023-04179-4
Cheng, C.-H., Chiu, P.-Y., Chen, H.-B., Niu, C.-C., & Nikkhoo, M. (2023). The influence of over-distraction on biomechanical response of cervical spine post anterior interbody fusion: A comprehensive finite element study. Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2023.1217274
Nikkhoo, M., Wang, L., Hsu, C.-C., & Cheng, C.-H. (2023). Editorial: Advancements in biomechanical modeling of injuries, diseases, diagnoses, and treatments of lower extremities. Frontiers in Bioengineering and Biotechnology, 11. https://doi.org/10.3389/fbioe.2023.1178336
Khalaf, K., Azhang, A., Cheng, C.-H., & Nikkhoo, M. (2023). Biomechanical investigation of bone screw head design for extracting stripped screw heads: Integration of mechanical tests and finite element analyses. Materials. https://doi.org/10.3390/ma16155470
Hung, C.-C., Chang, C.-C., Huang, C.-W., Nouchi, R., & Cheng, C.-H.* (2022). Gut microbiota in patients with Alzheimer's disease spectrum: A systematic review and meta-analysis. Aging, 14(1), 477–496. https://doi.org/10.18632/aging.203826
Chan, P.-Y.*, Cheng, C.-H., Wu, Y.-T., Wu, C.-W., Hsu, A.-L., Liu, C.-Y., Liu, H.-L., & Davenport, P. W. (2022). Neural substrates of respiratory sensory gating: A human fMRI study. Biological Psychology, 169, 1–9. https://doi.org/10.1016/j.biopsycho.2022.108277
Chan, P.-Y., Cheng, C.-H., Liu, C.-Y., & Davenport, P. W. (2022). Cortical sources of respiratory mechanosensation, laterality, and emotion: An MEG study. Brain Sciences, 12, 249. https://doi.org/10.3390/brainsci12020249
Chao, Y.-P., Liu, P.-T., Wang, P.-N., & Cheng, C.-H.* (2022). Reduced inter-voxel white matter integrity in subjective cognitive decline: Diffusion tensor imaging with tract-based spatial statistics analysis. Frontiers in Aging Neuroscience, 14, 1–10. https://doi.org/10.3389/fnagi.2022.810998
Chuang, I.-C., Liao, W.-W., Wu, C.-Y.*, Yeh T.-T., Chen C.-L., Lin C.-H., Huang, T.-H., & Pei, Y.-C. (2022). Baseline global cognitive function impacts cognitive and functional outcomes of combined physical and cognitive training in older adults with cognitive decline.. American Journal of Occupational Therapy, 76(2), 1-9. https://doi.org/105014/ajot2021042218 
Lin, S.-H., Yang, T.‑R., Chuang, I.-C., Chen, C.‑L., & Wu, C.-Y.* (2022). Upper extremity motor abilities and cognitive capability mediate the causal dependency between somatosensory capability and daily function in stroke individuals.. Scientific Reports, 12, 1-11. https://doi.org/101038/s41598-021-04491-2
Chen, Y.-W., Chiang, W.-C., Chang, C.-L., Lo, S.-M., & Wu, C.-Y.*  (2022). Comparative effects of EMG-driven robot-assisted therapy versus task-oriented training on motor and daily function in patients with stroke: A randomized cross-over trial. . Journal of NeuroEngineering and Rehabilitation, 19(6), 1-9. https://doi.org/101186/s12984-021-00961-w
Lee, M. T., Wu, C. Y., Chen, C. W., Cheng, H. L., Chen, C. C. & Hsieh, Y. W. (2022). Age and sex differences in the biomechanical and viscoelastic properties of upper limb muscles in middle-aged and older adults: A pilot study.. Journal of Biomechanics, 134(-), 1-8. https://doi.org/101016/jjbiomech2022111002 
Yeh, T.-T., Chang, K.-C., Wu, C.-Y.*, Chena, C.-J., & Chuang, I.-C. (2022).  Clinical efficacy of aerobic exercise combined with computer-based cognitive training in stroke: A multicenter randomized controlled trial.. Topics in Stroke Rehabilitation, 29(4), 255-264. https://doi.org/101080/1074935720211922045 
Hung J.-W.,  Yen, C.-L.*, Chang, K.-C., Chiang, W.-C., Chuang, I.-C., Pong, Y.-P., Wu, W.-C., & Wu, C.-Y.* (2022). A pilot randomized controlled trial of botulinum toxin treatment combined with robot-assisted therapy, mirror therapy, or active control treatment in patients with spasticity following stroke.. Toxin, 14(6), 415. https://doi.org/103390/toxins14060415
Liao, W.‑W., Hsieh, Y.‑W., Lee, T.‑H., Chen, C.‑L., & Wu, C.‑Y.* (2022). Machine learning predicts clinically significant health related quality of life improvement after sensorimotor rehabilitation interventions in chronic stroke.. Scientific Reports, 12(1), 11235. https://doi.org/101038/s41598-022-14986-1
Ito, E., Nouchi, R., Dinet, J., Cheng, C.-H., & Husebø, B. S. (2022). The effect of music-based intervention on general cognitive and executive functions, and episodic memory in people with mild cognitive impairment and dementia: A systematic review and meta-analysis of recent randomized controlled trials. Healthcare, 10(8), 1462. https://doi.org/10.3390/healthcare10081462
Lin, L-j., & Li, K-y* (2022). Comparing the effects of olfactory-based sensory stimulation and board game training on cognition, emotion, and blood biomarkers among individuals with dementia: A pilot randomized controlled trial. . Frontiers in Psychology, 13(-), 1003325. https://doi.org/103389/fpsyg20221003325  
Li, K.-Y., Wu, Y.-H., & Chen, H.-Y. (2022). Predictors of personal recovery for individuals with schizophrenia spectrum disorders living in the community. Clinical Psychology & Psychotherapy, 30(1), 179–187. https://doi.org/10.1002/cpp.2791
Chen, P., Hung, H.-Y., & Goh, J. O.  (2023). Age-related differences in ERP correlates of value-based decision making.. Neurobiology of Aging, 123, 10-22. https://doi.org/101016/jneurobiolaging202211008
Sahoo, P. K., Mohapatra, S., Wu, C.-Y., Huang, K.- L., Chang, T.-Y., & Lee, T.- H. (2022). Automatic identification of early ischemic lesions on non-contrast CT with deep learning approach.. Scientific Reports, 12, 18054. https://doi.org/101038/s41598-022-22939-x