移到主要內容
Neurodegenerative Diseases Research Team 
Lee, L.-H. N., Ngan, C.-Y., Yang, C.-K., Wang, R.-W., Lai, H.-J., Chen, C.-H., Yang, Y.-C., & Kuo, C.-C. (2025). Motor cortex stimulation ameliorates parkinsonian locomotor deficits effectually and mechanistically different from subthalamic modulation. npj Parkinson's Disease, 11, 32. https://doi.org/10.1038/s41531-025-00879-3
Huang, K., Hsiao, I., Huang, C., Huang, C., Chang, H., Huang, S., Lin, K., Ma, M., Huang, C., & Chang, C. (2025). The Taiwan-ADNI workflow toward integrating plasma p-tau217 into prediction models for the risk of Alzheimer's disease and tau burden. Alzheimer's & Dementia, 21(1). https://doi.org/10.1002/alz.14297
Chang, T.-Y., Huang, K.-L., Hsiao, I.-T., & Yeh, C.-H. (2025). Abstract 34: White matter alteration after stroke is correlated with neuroinflammation: A combined fixel-based diffusion MRI analysis and 18F-THK-5351 PET study. Stroke, 56. https://doi.org/10.1161/str.56.suppl_1.3
Chiu, C.-C., Weng, Y.-H., Yeh, T.-H., Chen, W.-S., Liu, S.-Y., Chiu, T.-J., Li, A.-H.-L., & Wang, H.-L.* (2025). Absence of Rab39b-induced macroautophagy impairment increases neurotoxic alpha-synuclein and causes degeneration of substantia nigra dopaminergic neurons in a mouse model of X-linked Parkinson's disease. Life Sciences, 337, 123789–123801. https://doi.org/10.1016/j.lfs.2025.123789
Chiu, C.-C., Chen, Y.-L., Weng, Y.-H., Liu, S.-Y., Li, H.-L., Yeh, T.-H., & Wang, H.-L. (2025). Downregulation of protease cathepsin D and upregulation of pathologic α-synuclein mediate paucity of DNAJC6-induced degeneration of dopaminergic neurons. International Journal of Molecular Sciences, 25(12), 1–23. https://doi.org/10.3390/ijms25126711
Chiu, C.-C., Weng, Y.-H., Yeh, T.-H., Chen, W.-S., Liu, S.-Y., Chiu, T.-J., Li, A.-H.-L., & Wang, H.-L. (2025). Absence of Rab39b-induced macroautophagy impairment increases neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in a mouse model of X-linked Parkinson's disease. Life Sciences, 377, 123789–123803. https://doi.org/10.1016/j.lfs.2025.123789
Li, C.-H., Fan, S.-P., Shih, M.-C., Weng, Y.-H., Chen, T.-F., Li, H., Cheng, M.-F., Kuo, M.-C., Peng, P.-L., Higuchi, M., Hsiao, I.-T., Lin, K.-J., & Lin, C.-H. (2025). Subcortical tau burden correlates with regional brain atrophy and plasma markers in four-repeat tauopathy parkinsonism. Journal of Parkinson's Disease, 15(1), 214–226. https://doi.org/10.1177/1877718X241298192
Lin, Y.-N., Huang, S.-Y., Chung, M.-C., Tsai, C.-H., Wang, H.-W., Gong, E., Hsiao, I.-T., & Chen, T.-H. (2025). MRI-styled PET: A dual modality fusion approach to PET partial volume correction. IEEE Transactions on Radiation and Plasma Medical Sciences, 9(7), 939–950. https://doi.org/10.1109/TRPMS.2025.3549617
Ni, Y.-C., Yang, H.-C., Hsiao, I.-T., Tseng, F.-P., Lin, C.-Y., & Lyu, W.-B.-L.-Z.-J. (2025). Validation of automated standardization performance for ECDaim software developed using a Taiwan-specific database. Journal of Medical and Biological Engineering, 45(2), 252–263. https://doi.org/10.1007/s40846-025-00941-8
Huang, S.-Y., Lin, K.-J., Lyu, Z.-J., & Hsiao, I.-T. (2025). The development of an automatic amyloid PET quantification (AmPQ) software with MR-based and MR-free spatial normalization. Journal of Medical and Biological Engineering, 45(4), 492–501. https://doi.org/10.1007/s40846-025-00972-1

Wu, M.-J., Hsiao, I.-T., Lin, K.-J., Wu, Y.-M., & Wu, K.-Y. (2025). Cerebral amyloid-β, glucose metabolism, and hippocampal volume in major depression with and without suspected non-Alzheimer pathophysiology (SNAP). Alzheimer's Research & Therapy, 17(1), 207. https://doi.org/10.1186/s13195-025-01858-9
Hsiao, I., Lin, K., Chang, C., & Huang, H. (2025). Classification of HC, MCI, and AD based on CT using deep learning. Journal of Medical and Biological Engineering, 45(5), 766–772. https://doi.org/10.1007/s40846-025-00985-w
Lin, H., Huang, K., Chen, S., Ho, T., Huang, C., Hsu, J., Chang, C., Lin, K., & Hsiao, I. (2025). Visual interpretation of [18F]Florzolotau tau-PET imaging for differentiating Alzheimer's disease and progressive supranuclear palsy. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-025-07539-x
Maydell, D.-V., Wright, S.-E., Pao, P.-C., Staab, C., King, O., Spitaleri, A., Bonner, J.-M., Liu, L., Yu, C.-J., Chiu, C.-C., Leible, D., Scannail, A.-N., Li, M., Boix, C.-A., Mathys, H., Leclerc, G., Menchaca, G.-S., Welch, G., Graziosi, A., Leary, N., Samaan, G., Kellis, M., & Tsai, L.-H. (2025). ABCA7 variants impact phosphatidylcholine and mitochondria in neurons. Nature, 647(8089), 462–471. https://doi.org/10.1038/s41586-025-09520-y
Huang, H.-H., Chan, J.-T., You, G.-R., Li, Y.-C., Huang, Y.-F., Shen, Y.-C.-H.-E.-Y.-L., Chen, Y.-J., Chiu, C.-C., & Cheng, A.-J. (2025). Drug repurposing targeting miRNA-mRNA networks to mitigate areca nut-induced head and neck cancer. Biomedical Journal, 100886. https://doi.org/10.1016/j.bj.2025.100886
Nguyen, T.-X.-D., Chen, K.-T., Liu, H.-L., Kuo, C.-W., Peng, C.-W., Chang, M.-Y., & Hsieh, T.-H. (2025). Temporal interference stimulation over the motor cortex enhances cortical excitability in rats. Scientific Reports, 15(1), 16933. https://doi.org/10.1038/s41598-025-01008-z
Marufa, S.-A., Chin, H.-Y., Lin, B.-S., Chen, H.-C., Hsieh, T.-H., Lo, W.-L., Wu, C.-W., Li, Y.-T., Lubis, Z.-I., Rahmawati, N.-A., Utami, K.-P., & Peng, C.-W. (2025). Therapeutic effects of noninvasive technology modalities on lower-limb motor function in spinal cord injury: A systematic review. Archives of Rehabilitation Research and Clinical Translation, 7(4), 100536. https://doi.org/10.1016/j.arrct.2025.100536
Hayashi, K., Hsieh, T.-H., Huang, Y.-L., & Chuang, D.-C. (2025). Using transcranial magnetic nerve stimulation to differentiate motor and sensory fascicles in a mixed nerve: Experimental rat study. Journal of Reconstructive Microsurgery, 41(8), 649–659. https://doi.org/10.1055/a-2483-5556

Chin, W.-C., Huang, S.-Y., Liu, F.-Y., Wang, C.-H., Tang, I., Hsiao, I.-T., & Huang, Y.-S. (2024). The application of machine learning on brain imaging features of different narcolepsy subtypes. Sleep, 47(2), zsad328. https://doi.org/10.1093/sleep/zsad328

Yang, Y.-C., Wang, G.-H., Chou, P., Hsueh, S.-W., Lai, Y.-C., & Kuo, C.-C. (2024). Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesis. Proceedings of the National Academy of Sciences, 121(8), e2313042121. https://doi.org/10.1073/pnas.2313042121
Nguyen, T.-X.-D., Mai, P.-T., Chang, Y.-J., & Hsieh, T.-H. (2024). Effects of transcranial direct current stimulation alone and in combination with rehabilitation therapies on gait and balance among individuals with Parkinson's disease: A systematic review and meta-analysis. Journal of NeuroEngineering and Rehabilitation, 21(1), 27. https://doi.org/10.1186/s12984-024-01311-2
Hsu, J.-L., Wei, Y.-C., Hsiao, I.-T., Lin, K.-J., Yen, T.-C., Lu, C.-S., Wang, H.-C., Leemans, A., Weng, Y.-H., & Huang, K.-L. (2024). Dominance of tau burden in cortical over subcortical regions mediates glymphatic activity and clinical severity in PSP. Clinical Nuclear Medicine, 49(5), 387–396. https://doi.org/10.1097/RLU.0000000000005141
Lin, K.-J., Huang, S.-Y., Huang, K.-L., & Hsiao, I.-T. (2024). Human biodistribution and radiation dosimetry for the tau tracer [18F]Florzolotau in healthy subjects. EJNMMI Radiopharmacy and Chemistry, 9(1), 27. https://doi.org/10.1186/s41181-024-00259-x
Januar, M., Lu, C.-Y., Lin, H.-C., Huang, T.-Y., Yang, C.-M., Liu, K.-K., & Liu, K.-C. (2024). Unveiling the nature of room-temperature-fabricated p-type SnO thin films: The critical role of intermediate phases, lattice disorder, and oxygen interstitials. Materials Advances. https://doi.org/10.1039/D3MA01119D
Hsieh, T.-H., Chu, P.-C., Nguyen, T.-X.-D., Kuo, C.-W., Chang, P.-K., Chen, K.-S., & Liu, H.-L. (2024). Neuromodulatory responses elicited by intermittent versus continuous transcranial focused ultrasound stimulation of the motor cortex in rats. International Journal of Molecular Sciences, 25(11), 5687. https://doi.org/10.3390/ijms25115687
Wu, C.-K., Lin, Y.-C., Chen, Y.-L., Chao, Y.-P., & Hsieh, T.-H.* (2024). The influence of dynamic taping on landing biomechanics after fatigue in young football athletes: A randomized, sham-controlled crossover trial. Bioengineering, 11(6), 631. https://doi.org/10.3390/bioengineering11060631
Chiu, C.-C., Chen, Y.-L., Weng, Y.-H., Liu, S.-Y., Li, A.-H.-L., Yeh, T.-H., & Wang, H.-L.* (2024). Downregulation of protease cathepsin D and upregulation of pathologic alpha-synuclein mediate paucity of DNAJC6-induced degeneration of dopaminergic neurons. International Journal of Molecular Sciences, 25(12), 6711. https://doi.org/10.3390/ijms25126711
Ho, S.-K., Hsiao, I.-T., Lin, K.-J., Wu, Y.-M., & Wu, K.-Y. (2024). Relationships among tumor necrosis factor-alpha levels, beta-amyloid accumulation, and hippocampal atrophy in patients with late-life major depressive disorder. Brain and Behavior, 14(9), e70016. https://doi.org/10.1002/brb3.70016
Ho, T.-Y., Huang, S.-H., Huang, C.-W., Lin, K.-J., Hsu, J.-L., Huang, K.-L., Chen, K.-T., Chang, C.-C., & Hsiao, I.-T. (2024). Differences in topography of individual amyloid brain networks by amyloid PET images in healthy controls, mild cognitive impairment, and Alzheimer's disease. Journal of Imaging Informatics in Medicine. https://doi.org/10.1007/s10278-024-01230-7
Ni, Y.-C., Lin, Z.-K., Cheng, C.-H., Pai, M.-C., Chiu, P.-Y., Chang, C.-C., Chang, Y.-T., Hung, G.-U., Lin, K.-J., Hsiao, I.-T., Lin, C.-Y., & Yang, H.-C. (2024). Classification prediction of Alzheimer's disease and vascular dementia using physiological data and ECD SPECT images. Diagnostics, 14(4). https://doi.org/10.3390/diagnostics14040365
Chen, H.-H., Huang, H.-C., Kao, W.-H., Chen, P.-J., Hsiao, T., & Chao, T.-C. (2024). Rapid calibration curve generation using single-sheet radiochromic film for proton-based stereotactic radiosurgery verification. Radiation Physics and Chemistry, 220. https://doi.org/10.1016/j.radphyschem.2024.111631
Li, C.-H., Fan, S.-P., Shih, M.-C., Weng, Y.-H., Chen, T.-F., Li, H., Cheng, M.-F., Kuo, M.-C., Peng, P.-L., Higuchi, M., Hsiao, I.-T., Lin, K.-J., & Lin, C.-H. (2024). Subcortical tau burden correlates with regional brain atrophy and plasma markers in four-repeat tauopathy parkinsonism. Journal of Parkinson's Disease. https://doi.org/10.1177/1877718X241298192
Wu, C.-W., Lin, B.-S., Zhang, Z., Hsieh, T.-H., Liou, J.-C., Lo, W.-L., Li, Y.-T., Chiu, S.-C., & Peng, C.-W. (2024). Pilot study of using transcranial temporal interfering theta-burst stimulation for modulating motor excitability in rats. Journal of NeuroEngineering and Rehabilitation, 21(1), 147. https://doi.org/10.1186/s12984-024-01451-5

Lin, H.-C., Lin, K.-J., Huang, K.-L., Chen, S.-H., Ho, T.-Y., Huang, C.-C., Hsu, J.-L., Chang, C.-C., & Hsiao, I.-T.* (2023). Visual reading for [18F]Florzolotau ([18F]APN-1607) tau PET imaging in clinical assessment of Alzheimer's disease. Frontiers in Neuroscience, 17, 1148054. https://doi.org/10.3389/fnins.2023.1148054
Wu, K.-Y., Lin, K.-J., Chen, C.-H., Liu, C.-Y., Wu, Y.-M., Chen, C.-S., Yen, T.-C., & Hsiao, I.-T.* (2023). Atrophy, hypometabolism and implication regarding pathology in late-life major depression with suspected non-Alzheimer pathophysiology (SNAP). Biomedical Journal, 46(6), 100589. https://doi.org/101016/jbj202303002 
Lo, C.-Y., Tsai, S.-W., Niu, H., Chen, F.-H., Hwang, H.-C., Chao, T.-C., Hsiao, I.-T., & Liaw, J.-W. (2023). Gold-nanoparticles-enhanced production of reactive oxygen species in cells at the spread-out Bragg peak under proton beam radiation. ACS Omega. https://doi.org/10.1021/acsomega.3c01025
Yap, W.-K., Hsiao, I.-T., Yap, W.-L., Tsai, T.-Y., Lu, Y.-A., Yang, C.-K., Peng, M.-T., Su, E.-L., & Cheng, S.-C. (2023). A radiotherapy dose map-guided deep learning method for predicting pathological complete response in esophageal cancer patients after neoadjuvant chemoradiotherapy followed by surgery. Biomedicines, 11(11), 3072. https://doi.org/10.3390/biomedicines11113072
Chiu, Y.-C., Yeh, C.-H., Jou, S.-Y., Hsiao, I.-T., Toh, C.-H., Chao, Y.-P., & Hsu, W.-C. (2023). Correlation between depression, loneliness, challenging behavior, and MRI findings among persons with high risk for cognitive impairment (PWHRCIs). Alzheimer's & Dementia, 19(55), e063434. https://doi.org/10.1002/alz.063434
Hsu, J.-L., Wei, Y.-C., Toh, C.-H., Hsiao, I.-T., Lin, K.-J., Yen, T.-C., Liao, M.-F., & Ro, L.-S. (2023). Magnetic resonance images implicate that glymphatic alterations mediate cognitive dysfunction in Alzheimer disease. Annals of Neurology, 93(1), 164–174. https://doi.org/10.1002/ana.26516
Chu, P.-C., Huang, C.-S., Chang, P.-K., Chen, R.-S., Chen, K.-T., Hsieh, T.-H., & Liu, H.-L. (2023). Weak ultrasound contributes to neuromodulatory effects in the rat motor cortex. International Journal of Molecular Sciences, 24(3), 2578. https://doi.org/10.3390/ijms24032578
Chen, H.-Y., Yang, C.-Y., Hsieh, T.-H., Peng, C.-W., Chuang, L.-L., Chang, Y.-L., Chi, H.-J., Lee, H.-M., & Liang, S.-H. (2023). Effects of transcranial direct current stimulation on improving performance of delayed-reinforcement attentional set-shifting tasks in an attention-deficit/hyperactivity disorder rat model. Behavioural Brain Research, 437. https://doi.org/10.1016/j.bbr.2022.114145
Rajneesh, C.-P., Hsieh, T.-H., Chen, H.-C., Liou, J.-C., Lin, B.-S., Wu, C.-W., Lai, C.-H., & Peng, C.-W. (2023). A time-course study of urodynamic analyses in rat models with dopaminergic depletion induced through unilateral and bilateral 6-hydroxydopamine injections. Journal of the Formosan Medical Association, 122(3), 239–248. https://doi.org/10.1016/j.jfma.2022.09.009
Nguyen, T.-X.-D., Kuo, C.-W., Peng, C.-W., Liu, H.-L., Chang, M.-Y., & Hsieh, T.-H.* (2023). Transcranial burst electrical stimulation contributes to neuromodulatory effects in the rat motor cortex. Frontiers in Neuroscience, 17, 1303014. https://doi.org/10.3389/fnins.2023.1303014
Wang, H.-L., Cheng, Y.-C., Yeh, T.-H., Liu, H.-F., Weng, Y.-H., Chen, R.-S., Chen, Y.-C., Lu, J.-C., Huang, C.-C., Hwang, T.-L., Wei, K.-C., Liu, Y.-C., Wang, Y.-T., Hsu, C.-C., Chiu, T.-J., & Chiu, C.-C. (2023). HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease. Biochemical Pharmacology, 212. https://doi.org/10.1016/j.bcp.2023.115524
Chen, Y.-C., Chang, S.-C., Lee, Y.-S., Ho, W.-M., Huang, Y.-H., Wu, Y.-Y., Chu, Y.-C., Wu, K.-H., Wei, L.-S., Wang, H.-L.*, & Chiu, C.-C. (2023). TOMM40 genetic variants cause neuroinflammation in Alzheimer's disease. International Journal of Molecular Sciences, 24(4), 4085. https://doi.org/10.3390/ijms24044085
Chiu, C.-C., Weng, Y.-H., Yeh, T.-H., Lu, J.-C., Chen, W.-S., Li, A.-H.-R., Chen, Y.-L., Wei, K.-C., & Wang, H.-L. (2023). Deficiency of RAB39B activates endoplasmic reticulum stress-induced pro-apoptotic pathways and causes mitochondrial dysfunction and oxidative stress in dopaminergic neurons by impairing autophagy and upregulating α-synuclein. Molecular Neurobiology, 60(5), 2706. https://doi.org/10.1007/s12035-023-03238-6
Huang, K.-L., Hsiao, I.-T., Chang, T.-Y., Yang, S.-Y., Chang, Y.-J., Wu, H.-C., Liu, C.-H., Wu, Y.-M., Lin, K.-J., Ho, M.-Y., & Lee, T.-H. (2022). Neurodegeneration and vascular burden on cognition after midlife: A plasma and neuroimaging biomarker study. Frontiers in Human Neuroscience, 15, 1–9. https://doi.org/10.3389/fnhum.2021.735063
Hsiao, I.-T., Chang, Y.-T., Weng, Y.-H., Hsu, S.-W., Lin, K.-J., Lu, C.-S., & Chang, C.-C. (2022). Comparisons of vesicular monoamine transporter type 2 signals in Parkinson's disease and parkinsonism secondary to carbon monoxide poisoning. NeuroToxicology, 88, 178–186. https://doi.org/10.1016/j.neuro.2021.11.004
Tsao, C.-H., & Huang, J.-F. (2022). Influence of diurnal phase on behavioral tests of sensorimotor performance, anxiety, learning, and memory in mice. Scientific Reports, 12, 432. https://doi.org/10.1038/s41598-021-03155-5
Wu, K.-Y., Lin, K.-J., Chen, C.-H., Liu, C.-Y., Wu, Y.-M., Chen, C.-S., Yen, T.-C., & Hsiao, I.-T. (2022). Decreased cerebral amyloid-β deposition in patients with a lifetime history of major depression with suspected non-Alzheimer pathophysiology. Frontiers in Aging Neuroscience, 14, 857940. https://doi.org/10.3389/fnagi.2022.857940
Hsu, J.-L., Wei, Y.-C., Toh, C.-H., Hsiao, I.-T., Lin, K.-J., Yen, T.-C., Liao, M.-F., & Ro, L.-S. (2022). Magnetic resonance images implicate that glymphatic alterations mediate cognitive dysfunction in Alzheimer disease. Annals of Neurology, 93(1), 164–174. https://doi.org/10.1002/ana.26516
Yang, J.-J, & Huang, R.-C. (2022). Afterhyperpolarization Potential Modulated by Local [K+]o in K+ Diffusion-Restricted Extracellular Space in the Central Clock of Suprachiasmatic Nucleus. Biomedical Journal, 21, 1-14. https://doi.org/101016/jbj202207005