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林錫賢

林錫賢 / Prof. Hsi-Hsien Lin

JobTitle： Professor

CurrentJob： Institute of Immunology and Translational Medicine

E-mail： hhlin@mail.cgu.edu.tw

Phone： 03-211-8800 #3321

Education： PhD

Expertise： Function and regulation of GPCFRs; Seven-transmembrane receptors similar to epidermal growth factor and their unique structures; EMR2 and CD97 receptor signalling pathways; Adhesion GPCRs in osteoclast differentiation and function; Functional and structural characteristics of the pathogenic gene GPR56 in human brain frontal lobe disease BFPP; Substrates for GPR56 in cells; Role of GPR56 in tumor biology and immune cells; Functions of immune cells; Biological analysis methods in tumor biology

Education and experience

Education
1997 PhD Biomedical Sciences, Oak Ridge Institute for Science and Education, University of Tennessee, Knoxville
1989 MSc Biochemistry, College of Medicine, National Taiwan University
1987 BSc Biology, National Cheng Kung University

Experience
2020- Adjunct Researcher, Division of Rheumatology, Allergy, and Immunology, Keelung Chang Gung Memorial Hospital
2016-2017 Visiting Professor, Kennedy Institute of Rheumatology, University of Oxford, UK
2016- Adjunct Researcher, Department of Anatomical Pathology, Linkou Chang Gung Memorial Hospital
2013-2022 Director, Graduate Program in Molecular Medicine, College of Medicine, Chang Gung University
2011- Professor/Laboratory Director, Molecular Immunology Laboratory, Department of Microbiology and Immunology, Chang Gung University
2007-2011 Associate Professor/Laboratory Director, Molecular Immunology Laboratory, Department of Microbiology and Immunology, Chang Gung University
2004-2007 Assistant Professor/Laboratory Director, Molecular Immunology Laboratory, Department of Microbiology and Immunology, Chang Gung University
2000-2004 Group Leader/Senior Researcher, Sir William Dunn School of Pathology, University of Oxford, UK
1998-2000 Researcher, Sir William Dunn School of Pathology, University of Oxford, UK
1997-1998 Postdoctoral Researcher, Oak Ridge National Laboratory, University of Tennessee

Honors and awards

2012- Board Member, Adhesion-GPCR Consortium  
2017 Outstanding Alumnus, Department of Life Sciences, National Cheng Kung University
2017 Academic Paper Award, Shen Shui-De Foundation (Chinese Society of Immunology)
2016 Academic Paper Award, Shen Shui-De Foundation (Chinese Society of Immunology)
2016-2022 Special Outstanding Talent Award, Ministry of Science and Technology, Chang Gung University
2016 Co-Principal Investigator, Ministry of Science and Technology Mission-Oriented Team Overseas Study (Longmen) Program
2015 Co-Principal Investigator, Ministry of Science and Technology Mission-Oriented Team Overseas Study (Longmen) Program
2011-2013 Special Outstanding Talent Award, National Science Council, Chang Gung University
2002-2004 British Heart Foundation Research Fellowship, UK; Celltech Ltd. Senior Research Fellowship, U.K.  
2000-2002 Wellcome Trust Cardiovascular Research Initiative Research Fellowship, U.K.  
1998-2000 University of Tennessee - Knoxville  
1997 Chancellor's Citation for Extraordinary Professional Promise
1992-1997 UT-Oak  Ridge Graduate School of Biomedical Sciences, Pre-doctoral Fellowships

Research direction

Function and regulation of adhesion G protein-coupled receptors (GPCRs)
Study of the characteristics of seven-transmembrane receptors similar to epidermal growth factor and their unique structures
Research on the signaling pathways of EMR2 and CD97 receptors
Role of adhesion GPCRs in osteoclast differentiation and function
Investigation of the functional and structural characteristics of the pathogenic gene GPR56 in human brain frontal lobe disease BFPP
Identification of substrates for GPR56 in cells
Role of GPR56 in tumor biology
Role of GPR56 in the expression and function of immune cells
Functions of immune cells, such as macrophages and neutrophils, and various biological analysis methods in tumor biology

Selected research

  • Tai-Ying Chu&, Celine Zheng-Gerard&, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Chien-Hao Huang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R Henderson, Alan Salama, Elena Seiradake*, and Hsi-Hsien Lin* 2022 GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nat. Commun. 13(1):6385 (doi.org/10.1038/s41467-022-34083-1) (co-corresponding author)
  • Hsi-Hsien Lin*, Kwai-Fong Ng, Tse-Ching Chen, Wen-Yi Tseng* 2022 Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharm. 15(2), 219 (doi.org/10.3390/ph15020219)  (co-corresponding author).
  • Yi-Shu Huang, Wen-Yi Tseng, Joy Ogbechi, Louise M. Topping, Felix Clanchy, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhongtian Xue, Leif G. Salford, Hans-Olov Sjögren, Trevor W. Stone, Hsi-Hsien Lin, Shue-Fen Luo* and Richard O. Williams* 2021 Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. PNAS May 11, 118 (19) e2100939118; (doi:10.1073/pnas2100939118) 
  • Kuan-Yu I&, Wen-Yi Tseng&, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng and Hsi-Hsien Lin* 2021 Stimulation of vibratory urticaria-associated adhesion-GPCR, EMR2/ADGRE2, triggers the NLRP3 inflammasome activation signal in human monocytes. Front. immunol 11: 602016 (doi: 10.3389/fimmu.2020.602016) (corresponding author)
  • Kwai-Fong Ng&, Tse-Ching Chen&, Martin Stacey, and Hsi-Hsien Lin* 2021 Role of ADGRG1/GPR56 in tumor progression. Cells 10, 3352 (doi.org/10.3390/cells10123352) (corresponding author).
  • Abhishek Kumar Singh and Hsi-Hsien Lin* 2021 The role of GPR56/ADGRG1 in health and disease. Biomed. J. 44(5):534-547 (doi:10.1016/j.bj.2021.04.012) (corresponding author)
  • Hsi-Hsien Lin*, Yu-Ling Lo, Wen-Chih Wang, Kuan-Yeh Huang, Kuan-Yu I, and Gin-Wen Chang 2020  Overexpression of FAM46A, a non-canonical poly(A) polymerase, promotes hemin-induced hemoglobinization in K562 cells. Front. Cell Dev. Biol. 8: 414 (doi: 10.3389/fcell.2020.00414 )(corresponding author)
  • Po-Hsiang Chen, Yi-Tung Chen, Tai-Ying Chu, Tian-Hsiang Ma, Mei-Hsuan Wu, Hsi-Hsien Lin, Yu-Sun Chang*, Bertrand Chin-Ming Tan* and Szecheng J. Lo* 2020 Nucleolar size control by a non-apoptotic p53-caspases-deubiquitylase axis confers bacterial resistance. FASEB J. 2020; 34(1):1107-1121. (doi.org/10.1096/fj.201901959R)
  • Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The role of the RGD-motif in CD97/ADGRE5- and EMR2/ADGRE2-modulated tumor angiogenesis. BBRC  520:243-249 (doi:10.1016/j.bbrc.2019.09.113) (corresponding author)
  • Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci. Rep. 9:1517 (doi:10.1038/s41598-018-38045-w) (corresponding author)
  • Cheng-Chih Hsiao#, Tai-Ying Chu#, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst, Josée Hébert, Taco W. Kuijpers, Brendon P. Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann*, and Hsi-Hsien Lin* 2018 The adhesion G protein-coupled receptor GPR97/ADGRG3 is expressed in human granulocytes and triggers antimicrobial effector functions. Front. immunol 9: 2830  (doi:10.3389/fimmu.2018.02830) (co-corresponding author)
  • Wen-Yi Tseng, Yeong-Jian Jan Wu, Tai-Yun Yang, Nien-Yi Chiang, Wen-Pin Tsai, Siamon Gordon, Gin-Wen Chang, Chang-Fu Kuo, Shue-Fen Luo*, Hsi-Hsien Lin* 2018 High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis. J. Microbiol. Immunol. Infect. 51(4):485-491(co-corresponding author (http://dx.doi.org/10.1016/j.jmii.2016.11.010)
  • Kuan-Yeh Huang and Hsi-Hsien Lin* 2018 The activation and signaling mechanisms of GPR56/ADGRG1 in melanoma cell. Front. Oncol. 8: 304 (doi:10.3389/fonc.2018.00304) (corresponding author)
  • Yi-Shu Huang, Nien-Yi Chiang, Gin-Wen Chang, Hsi-Hsien Lin* 2018 Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation. Sci. Rep. 8: 4532 (doi:10.1038/s41598-018-22849-x) (SCI, IF=4.996) (corresponding author)
  • Wen-Yi Tseng, I-Shu Huang, Hsi-Hsien Lin, Shue-Fen Luo, Kay McNamee, Felix Clanchy, Richard Williams 2018 TNFR1 and TNFR2 signalling and its clinical implications. Cytokine 101:19-25 (http://dx.doi.org/10.1016/j.cyto.2016.08.027) 
  • Hsi-Hsien Lin*, Cheng-Chih Hsiao, Caroline Pabst, Josée Hébert, Torsten Schöneberg and Jörg Hamann* 2017 Adhesion GPCRs in regulating immune responses and inflammation. Adv. Immunol.  136:163-201 (co-corresponding author) 
  • Kuo-An Wu#, Chih-Ching Wu#, Chi-De Chen, Chi-Ming Chu, Li-Jane Shih, Yu-Ching Liu, Chia-Jung Yu, Hsi-Hsien Lin*, Chia-Yu Yang* 2017 Proteome profiling reveals novel biomarkers to identify parapneumonic effusions. Sci. Rep. 7 (1): 4026 (doi:10.1038/s41598-017-04189-4)(co-corresponding author)
  • Kuan-Yu I, Yi-Shu Huang, Ching-Hsun Hu, Wen-Yi Tseng, Chia-Hsin Cheng, Martin Stacey, Siamon Gordon, Gin-Wen Chang, Hsi-Hsien Lin* 2017 Activation of EMR2/ADGRE2 induces macrophage differentiation and inflammatory responses via Ga16/Akt/MAPK/NF-kB signaling pathways. Front. immunol  8:373 (doi:10.3389/fimmu.2017.00373)  (corresponding author)
  • Nien-Yi Chiang&, Yen-Ming Peng&, Horng-Heng Juang, Tse-Ching Chen, Hsiao-Lin Pan, Gin-Wen Chang, Hsi-Hsien Lin* 2017 GPR56/ADGRG1 activation promotes melanoma cell migration via NTF dissociation and CTF-mediated Gα12/13/RhoA signaling. JID 137:727-736 (corresponding author)