Department of Biochemistry and Molecular Biology

Chang Chung Uiversity Academic Capacity Ensemble

Research Directions and Laboratory Features

Publication

1.  Yang YE, Lin YA, Ling LL, Kuo IY, Kuo WT, Liu H, Wang YC. Rab37-mediated OPN secretion
   enriches SPP1+ macrophages through autocrine-paracrine signaling to drive lung tumor progression.
   Oncogenesis. 2026 Jan 14;15(1):4. (IF: 6.4, 50/328 ONCOLOGY)
   2. Liu YH, Chen YT, Chen YC, Chin E, Lai YY, Ma CP, Chang Ian YF, Tan CM, Hsu PT, Lai YH, Tsai
   WS, Yang CY, Yu JS, Hsu HC, Liu H. Functional Dynamic Modulation of Colorectal Cancer Initiation
   and Metastatic Capacity by a Novel MiR-7974 Regulatory Axis. Biomed J. 2025 Nov 28:100934. doi:
   10.1016/j.bj.2025.100934. Online ahead of print (Corresponding author). (IF:4.5, 85/320
   BIOCHEMISTRY & MOLECULAR BIOLOGY)
   3. Sullivan SA, Orosco JC, Callejas-Hernández F, Blow F, Lee H, Ranallo-Benavidez TR, Peters A, Raidal
   SR, Girard YA, Johnson CK, Rogers KH, Gerhold R, Mangelson H, Liachko I, Srivastava H, Chandler
   C, Berenberg D, Bonneau RA, Huang PJ, Yeh YM, Lee CC, Liu H, Chen TW, Tang P, Chiu CH, Schatz
   MC, Carlton JM. Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in
   spillover from birds to humans. Nat Commun. 2025 Jul 24;16(1):6487. (IF:15.7, 7/136
   MULTIDISCIPLINARY SCIENCES)
   4. Teng W, Ku WT, Lin PT, Chen GT, Chu LJ, Liu H, Lin YC, Lin CY. Baseline serum EV-miR-1-3p as a
   protective factor and biomarker for hepatocellular carcinoma development after HCV eradication. J
   Transl Med. 2025 Jul 1;23(1):722. (IF: 7.5, 20/195 MEDICINE, RESEARCH & EXPERIMENTAL)
   5. Chang HC, Tsai CY, Hsu CL, Tai TS, Cheng ML, Chuang YM, Tang HY, Lin KJ, Chen JJ, Chang SH,
   Ko YC, Chi YW, Liu H, Tan BC, Shen CR, Yang CW, Ho PC, Yang HY. Asparagine deprivation
   enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations. Nat
   Metab. 2025 May;7(5):918-927. (IF: 20.8, 5/193 ENDOCRINOLOGY & METABOLISM)
   6. Wu CS, Li HP, Hsieh CH, Lin YT, Chang IY, Chung AK, Huang Y, Ueng SH, Hsiao YC, Chien KY, Luo
   JD, Chen CH, Liao WC, Hung JL, Yuan SN, OuYang CN, Chiang WF, Chien CY, Chuang HC, Chu LJ,
   Liu H, Yang CY, Robles AI Rodriguez H, Lin HH, Yang HY, Hsueh C, Chang KP, Yu JS, Chang YS.
   Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification
   and personalized treatment strategies. Cancer Lett. 2025 Apr 1; 614:217482. (IF: 10.1, 30/328
   ONCOLOGY)
   7. Tseng YH, Tran TTM, Chang JT, Huang YT, Nguyen AT, Chang IY, Chen YT, Hsieh HW, Juang YL,
   Chang PM, Huang TY, Chang YC, Chen YM*, Liu H*, Huang CF*. Utilizing TP53 hotspot mutations
   as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer. Cell Death
   Discov. 2025 Jan 27;11(1):26. (Corresponding author) (IF: 7.0, 40/204 CELL BIOLOGY)
   8. Chen YT, Tsai HJ, Kan CH, Ma CP, Chen HW, Chang IY, Liu H, Wu CC, Chu WY, Wu YC, Chang KP,
   Yu JS, Tan BC. Noncanonical formation of SNX5 gene-derived circular RNA regulates cancer growth.
   Cell Death Dis. 2024 Aug 18;15(8):599. (IF: 9.6, 29/204 CELL BIOLOGY)
   9. Lei KF, Pai PC, Liu H. Development of a Folding Paper System To Enable the Analysis of Gene Profile
   of Short- and Long-Distance Cancer Cell Migration. ACS Appl Mater Interfaces. 2024 Jul
   31;16(30):38931-38941. (Corresponding author) (IF: 8.2, 83/461 MATERIALS SCIENCE,
   MULTIDISCIPLINARY)
   10. Chuang WY, Chang H, Shih LY, Lin TC, Yeh CJ, Ueng SH, Kuo MC, Kao HW, Liu H, Chang ST, Lee
   CL, Huang KP, Wang TH, Wan YL, Yu JS, Hsueh C, Chuang SS. Identification of CD5/SOX11 double-
   negative pleomorphic mantle cell lymphoma. Virchows Arch. 2024 Aug;485(2):323-334. (IF: 3.1, 26/90
   PATHOLOGY)
   11. Huang SC, Chang IY, Chang CJ, Liu H, Chen KH, Liu TT, Hsieh TY, Chuang HC, Chen CC, Lin IC, Ng
   KF, Huang HY, Chen TC. Association between hepatic angiosarcoma and end-stage renal disease:
   nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. J
   Pathol. 2023 Jun;260(2):165-176. (IF: 5.2, 7/90 PATHOLOGY)
   12. Hsieh CH, Kuan WH, Chang WL, Kuo IY, Liu H, Shieh DB, Liu H, Tan B, Wang YC. Dysregulation of
   SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in
   esophageal squamous cell carcinoma. J Biomed Sci. 2022 Oct 30;29(1):90. (IF: 12.1, 9/195 MEDICINE,
   RESEARCH & EXPERIMENTAL)
   13. Yang CK, Hsu HC, Liu YH, Tsai WS, Ma CP, Chen YT, Tan BC, Lai YY, Chang IY, Yang C, Yang CY,
   Yu JS, Liu H. (2022, Aug). EV-miRome-wide profiling uncovers miR-320c for detecting metastatic
   colorectal cancer and monitoring the therapeutic response. Cell Oncol (Dordr).;45(4):621-638.
   (Corresponding author) (IF: 4.8, 75/328 ONCOLOGY)
   14. Chen YT, Kan CH, Liu H, Liu YH, Wu CC, Kuo YP, Chang IY, Chang KP, Yu JS, Tan BC. Modular
   scaffolding by lncRNA HOXA10-AS promotes oral cancer progression. Cell Death Dis. 2022 Jul
   20;13(7):629. (IF: 9.6, 29/204 CELL BIOLOGY)
   15. Yen WC, Chang IY, Chang KP, Ouyang CN, Liu CR, Tsai TL, Zhang YC, Wang CI, Wang YH, Yu AL,
   Liu H, Wu CC, Chang YS, Yu JS, Yang CY. Genomic and Molecular Signatures of Successful Patient-
   Derived Xenografts for Oral Cavity Squamous Cell Carcinoma. Front Oncol. 2022 Apr 4; 12:792297.
   (IF: 3.3, 123/328 ONCOLOGY)
   16. Chiang SF, Huang HH, Tsai WS, Chin-Ming Tan B, Yang CY, Huang PJ, Yi-Feng Chang I, Lin J, Lu PS,
   Chin E, Liu YH, Yu JS, Chiang JM, Hung HY, You JF, Liu H. Comprehensive functional genomic
   analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III
   colorectal cancer patients. Biomed J. 2022 Apr;45(2):347-360. (Corresponding author) (IF:4.5, 85/320
   BIOCHEMISTRY & MOLECULAR BIOLOGY)
   17. Lin JH, Peng KY, Kuo YP, Liu H, Tan CB, Lin YF, Chiu HW, Lin YH, Chen YM, Chueh JS, Wu VC.
   Aldosterone-producing nodules and CYP11B1 signaling correlate in primary aldosteronism. Endocr
   Relat Cancer. 2022 Jan 10;29(2):59-69. (IF: 4.6, 43/193 ENDOCRINOLOGY & METABOLISM)
   18. Chen YT, Hsu HC, Lee YS, Liu H, Tan BC, Chin CY, Chang IY, Yang CY. Longitudinal High-
   Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic
   Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy.
   Front Immunol. 2022 Jan 12;12: 743448. (IF: 5.9, 34/183 IMMUNOLOGY)
   19. Tsai WS, Hung WS, Wang TM, Liu H, Yang CY, Wu SM, Hsu HL, Hsiao YC, Tsai HJ, Tseng CP.
   Circulating tumor cell enumeration for improved screening and disease detection of patients with
   colorectal cancer. Biomed J. 2021 Dec;44(6 Suppl 2):S190-S200. (IF:4.5, 85/320 BIOCHEMISTRY &
   MOLECULAR BIOLOGY)
   20. Tseng MH, Fan WL, Liu H, Yang CY, Ding JJ, Lee HJ, Huang SM, Lin SH, Huang JL. Complement
   Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis.
   Front Med (Lausanne). 2021 Feb 5;7: 621609. (IF: 3.0, 61/332 MEDICINE, GENERAL & INTERNAL)
   21. Wu VC, Peng KY, Kuo YP, Liu H, Tan BC, Lin YH, Lai TS, Chen YM, Chueh JS. TAIPAI. Subtypes of
   Histopathologically Classical Aldosterone-Producing Adenomas Yield Various Transcriptomic Signaling
   and Outcomes. Hypertension. 2021 Dec;78(6):1791-1800. (IF: 8.2, 8/98 PERIPHERAL VASCULAR
   DISEASE)
   22. Chen YT, Chang IY, Kan CH, Liu YH, Kuo YP, Tseng HH, Chen HC, Liu H, Chang YS, Yu JS, Chang
   KP, Tan BC. circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour
   Growth-Regulating Transcriptional Response. Cells. 2020 Aug 10;9(8):1868. doi: 10.3390/cells9081868.
   23. Yang CY, Liu CR, Chang IY, OuYang CN, Hsieh CH, Huang YL, Wang CI, Jan FW, Wang WL, Tsai TL,
   Liu H, Tseng CP, Chang YS, Wu CC, Chang KP. Cotargeting CHK1 and PI3K Synergistically
   Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts.
   Cancers (Basel). 2020 Jun 29;12(7):1726. doi: 10.3390/cancers12071726. IF: 6.575, RANK: 60/245
   ONCOLOGY.
   24. Wu SM, Tsai WS, Chiang SF, Lai YH, Ma CP, Wang JH, Lin J, Lu PS, Yang CY, Tan BC, Liu H.
   Comprehensive transcriptome profiling of Taiwanese colorectal cancer implicates an ethnic basis for
   pathogenesis. Sci Rep. 2020 Mar 11;10(1):4526. doi: 10.1038/s41598-020-61273-y. IF: 4.997, RANK:
   19/74 MULTIDISCIPLINARY SCIENCES. (Corresponding author)
   25. Kuo YP, Ma CP, Chen HW, Chen YT, Lai YH, Liu H, Kuo RL, Chin-Ming Tan B. A novel antisense
   RNA ASPACT confers multi-level suppression of PACT and associated signalling. RNA Biol. 2019
   Sep;16(9):1263-1274. doi: 10.1080/15476286.2019.1624471. Epub 2019 Jun 12. IF: 4.766, RANK:
   120/297 BIOCHEMISTRY & MOLECULAR BIOLOGY.
   26. Chung AK, OuYang CN, Liu H, Chao M, Luo JD, Lee CY, Lu YJ, Chung IC, Chen LC, Wu SM, Tsang
   NM, Chang KP, Hsu CL, Li HP, Chang YS. Targeted sequencing of cancer-related genes in
   nasopharyngeal carcinoma identifies mutations in the TGF-beta pathway. Cancer Med. 2019
   Sep;8(11):5116-5127.
   27. Ma CP, Liu H, Yi-Feng Chang I, Wang WC, Chen YT, Wu SM, Chen HW, Kuo YP, Shih CT, Li CY, Tan
   BC. ADAR1 promotes robust hypoxia signaling via distinct regulation of multiple HIF-1alpha-inhibiting
   factors. EMBO Rep. 2019 May;20(5): e47107.
   28. You GR, Cheng AJ, Lee LY, Huang YC, Liu H, Chen YJ, Chang JT. Prognostic signature associated
   with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses. BMC
   Cancer. 2019 Jan 14;19(1):64.
   29. Lai CY*, Liu H*, Tin KX, Huang Y, Yeh KH, Peng HW, Chen HD, He JY, Chiang YJ, Liu CS, Weng
   SY, Tao MH, Yen JJ, Yang-Yen HF. Identification of UAP1L1 as a critical factor for protein O-
   GlcNAcylation and cell proliferation in human hepatoma cells. Oncogene. 2019 Jan;38(3):317-331.
   (First author) (IF: 7.3, 39/320 BIOCHEMISTRY & MOLECULAR BIOLOGY)
   30. Huang YW, Chiang MF, Ho CS, Hung PL, Hsu MH, Lee TH, Chu LJ, Liu H, Tang P, Victor Ng W, Lin
   DS. A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element
   in Proline Metabolic Disorder. Aging Dis. 2018 Dec 4;9(6):1043-1057.
   31. Chao A, Lin CY, Wu RC, Lee YS, Lee LY, Tsai CL, Yang LY, Liu H, Chen SJ, Wang TH, Lai CH. The
   combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial
   cancer: molecular role of insulin-like growth factor binding protein 2. J Mol Med (Berl). 2018
   Nov;96(11):1251-1266.
   32. Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ. NPTX2 is a key component in the
   regulation of anxiety. Neuropsychopharmacology. 2018 Aug;43(9):1943-1953.
   33. Chen YT, Chang IY, Liu H, Ma CP, Kuo YP, Shih CT, Shih YH, Kang L, Tan BC. Tumor-associated
   intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation. J Biol Chem.
   2018 Jun 29;293(26):10158-10171.
   34. Yang CY, Yeh YM, Yu HY, Chin CY, Hsu CW, Liu H, Huang PJ, Hu SN, Liao CT, Chang KP, Chang
   YL. Oral Microbiota Community Dynamics Associated with Oral Squamous Cell Carcinoma Staging.
   Front Microbiol. 2018 May 3;9: 862.
   35. Tsai KW, Lo YH, Liu H, Yeh CY, Chen YZ, Hsu CW, Chen WS, Wang JH. Linc00659, a long
   noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer. Mol
   Cancer. 2018 Mar 10;17(1):72.
   36. Wu SM*, Liu H*, Huang PJ, Chang IY, Lee CC, Yang CY, Tsai WS, Tan BC. circlncRNAnet: an
   integrated web-based resource for mapping functional networks of long or circular forms of noncoding
   RNAs. Gigascience. 2018 Jan 1;7(1):1-10. (First author)
   37. Lai YH, Liu H, Chiang WF, Chen TW, Chu LJ, Yu JS, Chen SJ, Chen HC, Tan BC. MiR-31-5p-ACOX1
   Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory
   Prostaglandin E2. Theranostics. 2018 Jan 1;8(2):486-504.
   38. Chen TW*, Lee CC*, Liu H*, Wu CS, Pickering CR, Huang PJ, Wang J, Chang IY, Yeh YM, Chen CD,
   Li HP, Luo JD, Tan BC, Chan TEH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW,
   See LC, Tang P, Yu JS, Liao WC, Chiang WF, Rodriguez H, Myers JN, Chang KP, Chang YS.
   APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion
   polymorphism. Nat Commun. 2017 Sep 6;8(1):465. (First author) (IF:15.7, 7/136
   MULTIDISCIPLINARY SCIENCES)
   39. Yang CC, Chen YT, Chang YF, Liu H, Kuo YP, Shih CT, Liao WC, Chen HW, Tsai WS, Tan BC.
   ADAR1-mediated 3' UTR editing and expression control of antiapoptosis genes fine-tunes cellular
   apoptosis response. Cell Death Dis. 2017 May 25;8(5): e2833.
   40. Chen H, Hsiao YC, Chiang SF, Wu CC, Lin YT, Liu H, Zhao H, Chen JS, Chang YS, Yu JS.
   Quantitative analysis of wild-type and V600E mutant BRAF proteins in colorectal carcinoma using
   immunoenrichment and targeted mass spectrometry. Anal Chim Acta. 2016 Aug 24;933: 144-55. doi:
   10.1016/j.aca.2016.05.037. Epub 2016 Jun 2. IF: 6.911, RANK: 10/87 CHEMISTRY, ANALYTICAL.
   41. Yang XZ, Chen JY, Liu CJ, Peng J, Wee YR, Han X, Wang C, Zhong X, Shen QS, Liu H, Cao H, Chen
   XW, Tan BC, Li CY. Selectively Constrained RNA Editing Regulation Crosstalks with piRNA
   Biogenesis in Primates. Mol Biol Evol. 2015 Dec;32(12):3143-57.
   42. Chen WY, Shih HT, Liu KY, Shih ZS, Chen LK, Tsai TH, Chen MJ, Liu H, Tan BC, Chen CY, Lee HH,
   Loppin B, Aït-Ahmed O, Wu JT. Intellectual disability-associated dBRWD3 regulates gene expression
   through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. EMBO Rep. 2015
   Apr;16(4):528-38.
   43. Huang PJ, Lee CC, Tan BC, Yeh YM, Huang KY, Gan RC, Chen TW, Lee CY, Yang ST, Liao CS, Liu
   H*, Tang P*. Vanno: a visualization-aided variant annotation tool. Hum Mutat. 2015 Feb;36(2):167-74.
   (Corresponding author)
   44. Huang PJ, Lee CC, Tan BC, Yeh YM, Julie Chu L, Chen TW, Chang KP, Lee CY, Gan RC, Liu H*, Tang
   P*. CMPD: cancer mutant proteome database. Nucleic Acids Res. 2015 Jan;43(Database issue): D849-55. (Corresponding author)
   45. Liu H, Ma CP, Chen YT, Schuyler SC, Chang KP, Tan BC. Functional Impact of RNA editing and
   ADARs on regulation of gene expression: perspectives from deep sequencing studies. Cell Biosci. 2014
   Aug 19;4: 44. (First author)
   46. Liu YC, Kuo RL, Lin JY, Huang PN, Huang Y, Liu H, Arnold JJ, Chen SJ, Wang RY, Cameron CE, Shih
   SR. Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by
   entering the nucleus and interfering with Prp8. PLoS Pathog. 2014 Jun 26;10(6): e1004199.
   47. C-L Hsieh, Liu H, Y Huang, L Kang, H-W Chen, Y-T Chen, Y-R Wee, S-J Chen, B C-M Tan. ADAR1
   deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions. Cell
   Death Differ. 2014 May;21(5):707-19.
   48. Chen HW, Yang CC, Hsieh CL, Liu H, Lee SC, Tan BC. A functional genomic approach reveals the
   transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. Biochim
   Biophys Acta. 2013 Dec;1829(12):1309-19.
   49. Huang PJ, Yeh YM, Gan RC, Lee CC, Chen TW, Lee CY, Liu H, Chen SJ, Tang P. CPAP. Cancer Panel
   Analysis Pipeline. Hum Mutat. 2013 Oct;34(10):1340-6.
   50. Lo SJ, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ,
   Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-associated X protein regulating
   death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013 May;57(5):1893-905.
   51. Tan BC, Yang CC, Hsieh CL, Chou YH, Zhong CZ, Yung BY, Liu H. Epigeneitc silencing of ribosomal
   RNA genes by Mybbp1a. J Biomed Sci. 2012 Jun 11;19(1):57. (Corresponding author)
   52. Yang CC*, Liu H*, Chen SL, Wang TH, Hsieh CL, Huang Y, Chen SJ, Chen HC, Yung BY, Chin-Ming
   Tan B. Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses
   myogenesis. EMBO J. 2012 Apr 4;31(7):1739-51. (First author)
   53. Lin CY, Tan BC, Liu H, Shih CJ, Chien KY, Lin CL, Yung BY. WDHD1 modulates the post-
   transcriptional step of the centromeric silencing pathway. Nucleic Acids Res. 2011 May;39(10):4048-62.
   54. Lin CY, Tan BC, Liu H, Shih CJ, Chien KY, Lin CL, Yung BY. Dephosphorylation of nucleophosmin by
   PP1beta facilitates pRB binding and consequent E2F1-dependent DNA repair. Mol Biol Cell. 2010
   Dec;21(24):4409-17.
   55. Tan BC*, Liu H*, Lin CL, Lee SC. Functional cooperation between FACT and MCM is coordinated
   with cell cycle and differential complex formation. J Biomed Sci. 2010 Feb 16;17(1):11. (First author)
   56. Liu H, Tan BC, Tseng KH, Chuang CP, Yeh CW, Chen KD, Lee SC, Yung BY. Nucleophosmin acts as a
   novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007
   Apr;8(4):394-400. (First author)
   57. Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY, Yang-Yen HF. A knockout mouse approach
   reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell
   type-specific manner. Mol Biol Cell. 2007 Jul;18(7):2525-32.
   58. Liu H, Peng HW, Cheng YS, Yuan HS, Yang-Yen HF. Stabilization and enhancement of the
   antiapoptotic activity of mcl-1 by TCTP. Mol Cell Biol. 2005 Apr;25(8):3117-26. (First author)
   

Patents and Technology Transfer